Abstract：
:Both the cellular prion protein (PrP(c)) and the amyloid precursor protein (APP) are physiologically subjected to complex proteolytic processing events. While for APP the proteinases involved--alpha-, beta- and gamma-secretase--have been identified in vitro and in vivo, the cleavage of PrP(c) by now has been linked only to the shedding activity of the metalloproteinase ADAM10 and/or ADAM17 in cell culture. Here we show that neuronal overexpression of the alpha-secretase ADAM10 in mice reduces all PrP(c) species detected in the brain instead of leading to enhanced amounts of specific cleavage products of PrP(c). Additionally, the incubation time of mice after scrapie infection is significantly increased in mice moderately overexpressing ADAM10. This indicates that overexpression of ADAM10 rather influences the amount of the cellular prion protein than its processing in vivo.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Endres K,Mitteregger G,Kojro E,Kretzschmar H,Fahrenholz Fdoi
10.1016/j.nbd.2009.07.015subject
Has Abstractpub_date
2009-11-01 00:00:00pages
233-41issue
2eissn
0969-9961issn
1095-953Xpii
S0969-9961(09)00175-2journal_volume
36pub_type
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