Genetically determined susceptibility to neurodegeneration is associated with expression of inflammatory genes.

abstract：:Attention deficit hyperactivity disorder (ADHD) is characterized by hyperactivity, inattention, and impulsivity. The coloboma mouse model of ADHD exhibits profound hyperactivity. To determine whether coloboma mice exhibit other signs of ADHD, we assessed latent inhibition as a test of attention, and impulsivity in a d...

journal_title：Neurobiology of disease

authors： Bruno KJ,Freet CS,Twining RC,Egami K,Grigson PS,Hess EJ

更新日期：2007-01-01 00:00:00

abstract：:T cells are believed to be key effector cells in multiple sclerosis (MS). In this study, we examined the roles of T cell ephrinB1 (EFNB1) and ephrinB2 (EFNB2) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and MS. We provide evidence that animals with T cell specific double deletion of EFNB1 an...

journal_title：Neurobiology of disease

authors： Luo H,Broux B,Wang X,Hu Y,Ghannam S,Jin W,Larochelle C,Prat A,Wu J

更新日期：2016-07-01 00:00:00

abstract：:Background While significant advances have been made in uncovering the aetiology of Alzheimer's disease and related dementias at the genetic level, molecular events at the epigenetic level remain largely undefined. Emerging evidence indicates that small non-coding RNAs (sncRNAs) and their associated RNA modifications ...

journal_title：Neurobiology of disease

authors： Zhang X,Trebak F,Souza LAC,Shi J,Zhou T,Kehoe PG,Chen Q,Feng Earley Y

更新日期：2020-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are reported to possess immunomodulatory properties. Previous reports have demonstrated the beneficial effects of MSC-transplantation in focal cerebral ischemia animal models. In this study, we have investigated the neuroimmunomodulatory functions of human MSCs, transplanted in a rat foca...

journal_title：Neurobiology of disease

authors： Sheikh AM,Nagai A,Wakabayashi K,Narantuya D,Kobayashi S,Yamaguchi S,Kim SU

更新日期：2011-03-01 00:00:00

abstract：:Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphata...

journal_title：Neurobiology of disease

authors： Xu B,Park D,Ohtake Y,Li H,Hayat U,Liu J,Selzer ME,Longo FM,Li S

更新日期：2015-01-01 00:00:00

abstract：:Glutamate excitotoxicity is a consolidated hypothesis in neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor mediated effects. In brain microvascular endothelial cell (nBMEC) cultures from neonates, t-PA content and release upon glutamate are h...

journal_title：Neurobiology of disease

authors： Henry VJ,Lecointre M,Laudenbach V,Ali C,Macrez R,Jullienne A,Berezowski V,Carmeliet P,Vivien D,Marret S,Gonzalez BJ,Leroux P

更新日期：2013-02-01 00:00:00

abstract：:It is well established that the conversion of PrP(C) to PrP(Sc) is the key event in prion disease biology. In addition, several lines of evidence suggest that glycosaminoglycans (GAGs) and in particular heparan sulfate (HS) may play a role in the PrP(C) to PrP(Sc) conversion process. It has been proposed that PrP(Sc) ...

journal_title：Neurobiology of disease

authors： Mayer-Sonnenfeld T,Zeigler M,Halimi M,Dayan Y,Herzog C,Lasmezas CI,Gabizon R

更新日期：2005-12-01 00:00:00

abstract：:Possible roles of the complement (C) system in the normal and injured brain were explored with inbred mice that carried a frameshift mutation in the C5 gene. A congenic pair was used: the C5-sufficient (C5+) B10.D2/nSnJ strain with the functional allele (Hc1) from the C57BL/10J donor strain was compared with the C5-de...

journal_title：Neurobiology of disease

authors： Pasinetti GM,Tocco G,Sakhi S,Musleh WD,DeSimoni MG,Mascarucci P,Schreiber S,Baudry M,Finch CE

更新日期：1996-01-01 00:00:00

abstract：:Levodopa (L-DOPA) remains the most effective pharmacological treatment for Parkinson Disease (PD) but its use is limited by the development of debilitating drug-related side effects, particularly L-DOPA induced dyskinesia (LID). LID is a consequence of long-term L-DOPA use, and in model systems is characterized by a "...

journal_title：Neurobiology of disease

authors： A Figge D,Standaert DG

更新日期：2017-06-01 00:00:00

abstract：:Sleep plays a critical role in the process of memory consolidation. In particular, during non-rapid eye movement (NREM) slow wave sleep, slow-oscillations, spindles, hippocampal sharp wave ripples, and their phase coupling are involved in the process of transferring and consolidating information recently encoded and t...

journal_title：Neurobiology of disease

authors： Grimaldi D,Papalambros NA,Zee PC,Malkani RG

更新日期：2020-07-01 00:00:00

abstract：:The activation of soluble guanylate cyclase by nitric oxide is increased in the frontal cortex but is reduced in the cerebellum of patients who died with liver cirrhosis. The aims of this work were to assess whether hyperammonemia is responsible for the region-selective alterations in guanylate cyclase modulation in l...

journal_title：Neurobiology of disease

authors： Rodrigo R,Erceg S,Felipo V

更新日期：2005-06-01 00:00:00

abstract：:Recently an aspartyl protease with beta-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT(2) neurons to the two classical pro-oxidant stimuli ascorbate/FeSO(4) and H(2)O(2)/FeSO(4) resulted in a si...

journal_title：Neurobiology of disease

authors： Tamagno E,Bardini P,Obbili A,Vitali A,Borghi R,Zaccheo D,Pronzato MA,Danni O,Smith MA,Perry G,Tabaton M

更新日期：2002-08-01 00:00:00

abstract：:Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado-Joseph disease...

journal_title：Neurobiology of disease

authors： Duarte-Neves J,Pereira de Almeida L,Cavadas C

更新日期：2016-11-01 00:00:00

abstract：:Huntington's disease (HD) and Dentatorubral and pallidoluysian atrophy (DRPLA) are autosomal dominant, neurodegenerative disorders caused by the expansion of polyglutamine tracts in their respective proteins, huntingtin and atrophin-1. We have previously generated mouse models of these disorders, using transgenes expr...

journal_title：Neurobiology of disease

authors： Schilling G,Jinnah HA,Gonzales V,Coonfield ML,Kim Y,Wood JD,Price DL,Li XJ,Jenkins N,Copeland N,Moran T,Ross CA,Borchelt DR

更新日期：2001-06-01 00:00:00

abstract：:Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links, but the basis for this association remains unknown. Retromer-depen...

journal_title：Neurobiology of disease

authors： Morabito MV,Berman DE,Schneider RT,Zhang Y,Leibel RL,Small SA

更新日期：2014-05-01 00:00:00

abstract：:Parkinson disease (PD) is a systemic disease with variegated non-motor deficits and neurological symptoms, including impaired olfaction, autonomic failure, cognitive impairment and psychiatric symptoms, in addition to the classical motor symptoms. Many non-motor symptoms appear before or in parallel with motor deficit...

journal_title：Neurobiology of disease

authors： Ferrer I,López-Gonzalez I,Carmona M,Dalfó E,Pujol A,Martínez A

更新日期：2012-06-01 00:00:00

abstract：:Microglia, a type of immune cell in the brain, are in a ramified status with branched processes in normal conditions. Upon pathological stimulation, microglia retract their processes and become activated. Searching methods to make the activated microglia return to ramified status would help cope with injuries induced ...

journal_title：Neurobiology of disease

authors： Wang P,Zhang Y,Gong Y,Yang R,Chen Z,Hu W,Wu Y,Gao M,Xu X,Qin Y,Huang C

更新日期：2018-03-01 00:00:00

abstract：:Neural stem cells (NSCs) are multipotent, self-renewing progenitors that generate progeny that differentiate into neurons and glia. NSCs in the adult mammalian brain are generally quiescent. Environmental stimuli such as learning or exercise can activate quiescent NSCs, inducing them to proliferate and produce new neu...

journal_title：Neurobiology of disease

authors： Otsuki L,Brand AH

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Generalized spike and wave discharges (SWD) are generated within the cortico-thalamo-cortical system. However the exact interactions between cortex and different thalamic nuclei needed for the generation and maintenance of SWD are still to be elucidated. This study aims to shed more light on these interactions ...

journal_title：Neurobiology of disease

authors： Lüttjohann A,van Luijtelaar G

更新日期：2012-07-01 00:00:00

abstract：:Carriers of FMR1 premutation alleles have 55-200 CGG repeats in the 5' untranslated region of the gene. These individuals are at risk for fragile X associated primary ovarian insufficiency (females) and, in late life, fragile X associated tremor and ataxia syndrome (males, and to a lesser extent, females). Premutation...

journal_title：Neurobiology of disease

authors： Qin M,Entezam A,Usdin K,Huang T,Liu ZH,Hoffman GE,Smith CB

更新日期：2011-04-01 00:00:00

abstract：:To decipher the pathway of apoptosis induction downstream to caspase-8 activation by exogenous expression of Hippi, an interactor of huntingtin-interacting protein Hip1, we studied apoptosis in HeLa and Neuro2A cells expressing GFP-tagged Hippi. Nuclear fragmentation, caspase-1, caspase-8, caspase-9/caspase-6 and casp...

journal_title：Neurobiology of disease

authors： Majumder P,Chattopadhyay B,Mazumder A,Das P,Bhattacharyya NP

更新日期：2006-05-01 00:00:00

abstract：:Mutations in the DNA-binding domain of EGR2 are associated with severe autosomal dominant forms of peripheral neuropathy. In this study, we show that one such Egr2 mutant (S382R, D383Y), when expressed in Schwann cells in vitro, is not transcriptionally inactive but retains residual wild-type Egr2 functions, including...

journal_title：Neurobiology of disease

authors： Arthur-Farraj P,Mirsky R,Parkinson DB,Jessen KR

更新日期：2006-10-01 00:00:00

abstract：:Studies have showed that prenatal cocaine exposure (PCOC) can impair cognitive function and social behavior of the offspring; however, the mechanism underlying such effect is poorly understood. Insulin-like growth factor II (Igf-II), an imprinted gene, has a critical role in memory consolidation and enhancement. We hy...

journal_title：Neurobiology of disease

authors： Zhao Q,Hou J,Chen B,Shao X,Zhu R,Bu Q,Gu H,Li Y,Zhang B,Du C,Fu D,Kong J,Luo L,Long H,Li H,Deng Y,Zhao Y,Cen X

更新日期：2015-10-01 00:00:00

abstract：:The mechanism of status epilepticus-induced neuronal death in the immature brain is not fully understood. In the present study, we examined the contribution of caspases in our lithium-pilocarpine model of status epilepticus in 14 days old rat pups. In CA1, upregulation of caspase-8, but not caspase-9, preceded caspase...

journal_title：Neurobiology of disease

authors： Lopez-Meraz ML,Wasterlain CG,Rocha LL,Allen S,Niquet J

更新日期：2010-02-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) is a genetic disorder that can be caused by aberrations in >80 genes. CMT has heterogeneous modes of inheritance, including autosomal dominant, autosomal recessive, X-linked dominant, and X-linked recessive. Over 95% of cases are dominantly inherited. In this study, we investigated wh...

journal_title：Neurobiology of disease

authors： Lee JS,Chang EH,Koo OJ,Jwa DH,Mo WM,Kwak G,Moon HW,Park HT,Hong YB,Choi BO

更新日期：2017-04-01 00:00:00

abstract：:Premature stop codons in CACNA1A, which encodes the alpha(1A) subunit of neuronal P/Q-type (Ca(V)2.1) Ca(2+) channels, cause episodic ataxia type 2 (EA2). CACNA1A undergoes extensive alternative splicing, which contributes to the pharmacological and kinetic heterogeneity of Ca(V)2.1-mediated Ca(2+) currents. We identi...

journal_title：Neurobiology of disease

authors： Graves TD,Imbrici P,Kors EE,Terwindt GM,Eunson LH,Frants RR,Haan J,Ferrari MD,Goadsby PJ,Hanna MG,van den Maagdenberg AM,Kullmann DM

更新日期：2008-10-01 00:00:00

abstract：:Deep brain stimulation for epilepsy has garnered attention from epileptologists due to its well-documented success in treating movement disorders and the low morbidity associated with the implantation of electrodes. Given the large proportion of patients who fail medical therapy and are not candidates for surgical ame...

journal_title：Neurobiology of disease

authors： Lega BC,Halpern CH,Jaggi JL,Baltuch GH

更新日期：2010-06-01 00:00:00

abstract：:Identified as the cause of some familial forms of Parkinson disease (PD) and as one of the major component of Lewy bodies, alpha-synuclein (alpha-syn) became the molecular hallmark of several neurodegenerative conditions now designated as synucleinopathies. Transgenic models have been generated to elucidate its physio...

journal_title：Neurobiology of disease

authors： Fernagut PO,Chesselet MF

更新日期：2004-11-01 00:00:00

abstract：:The worldwide proliferation of mobile phones raises the question of the effects of 900-MHz electromagnetic fields (EMF) on the brain. Using a head-only exposure device in the rat, we showed that a 15-min exposure to 900-MHz pulsed microwaves at a high brain-averaged power of 6 W/kg induced a strong glial reaction in t...

journal_title：Neurobiology of disease

authors： Mausset-Bonnefont AL,Hirbec H,Bonnefont X,Privat A,Vignon J,de Sèze R

更新日期：2004-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic, inflammatory autoimmune disease that affects the central nervous system (CNS) for which there is no cure. In MS, encephalitogenic T cells infiltrate the CNS causing demyelination and neuroinflammation; however, little is known about the role of regulatory T cells (Tregs) in CNS ti...

journal_title：Neurobiology of disease

authors： McIntyre LL,Greilach SA,Othy S,Sears-Kraxberger I,Wi B,Ayala-Angulo J,Vu E,Pham Q,Silva J,Dang K,Rezk F,Steward O,Cahalan MD,Lane TE,Walsh CM

更新日期：2020-07-01 00:00:00