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Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.

Abstract：

:The mechanism of status epilepticus-induced neuronal death in the immature brain is not fully understood. In the present study, we examined the contribution of caspases in our lithium-pilocarpine model of status epilepticus in 14 days old rat pups. In CA1, upregulation of caspase-8, but not caspase-9, preceded caspase-3 activation in morphologically necrotic cells. Pretreatment with a pan-caspase inhibitor provided neuroprotection, showing that caspase activation was not an epiphenomenon but contributed to neuronal necrosis. By contrast, upregulation of active caspase-9 and caspase-3, but not caspase-8, was detected in apoptotic dentate gyrus neurons, which were immunoreactive for doublecortin and calbindin-negative, two features of immature neurons. These results suggest that, in cells which are aligned in series as parts of the same excitatory hippocampal circuit, the same seizures induce neuronal death through different mechanisms. The regional level of neuronal maturity may be a determining factor in the execution of a specific death program.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Lopez-Meraz ML,Wasterlain CG,Rocha LL,Allen S,Niquet J

doi

10.1016/j.nbd.2009.10.019

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

394-402

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(09)00305-2

journal_volume

37

pub_type

杂志文章

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