Abstract:
AIM:To assess the age-related change in plasma androgen levels in healthy middle-aged men and whether any clinical parameters are associated with the hormonal change. METHODS:The study was comprised of male Japanese office-workers aged 40-64 years, who had undergone an annual health check-up in 2002 and 2007 (96 and 76 men, respectively). Body mass index and blood pressure were measured, and serum concentration of lipids, glucose and uric acid in addition to plasma total testosterone, free testosterone and dehydroepiandrosterone sulfate (DHEA-S) levels were determined in the morning after an overnight fast. The 5-year hormonal changes and their associations with clinical parameters were analyzed in 33 men who repeated the examination at both check-ups. The cross-sectional associations of hormonal levels with clinical parameters were also investigated. RESULTS:Age was negatively associated with free testosterone (r = -0.399, P < 0.001 in 2002; r = -0.458, P < 0.001 in 2007) and DHEA-S (r = -0.233, P = 0.02 in 2002; r = -0.336, P < 0.01 in 2007) but not with total testosterone, while the 5-year changes of free testosterone and DHEA-S levels were not significant and showed no associations with major cardiovascular risk factors. Cross-sectionally, after adjustment for age, linear regression analysis showed a positive association between free testosterone and blood hemoglobin and a negative association between total testosterone and serum uric acid. CONCLUSION:In Japanese middle-aged men, 5-year androgen decline is too subtle to detect, and endogenous androgen levels seem to have relatively weak association with cardiovascular risk profiles.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Fukai S,Akishita M,Miyao M,Ishida K,Toba K,Ouchi Ydoi
10.1111/j.1447-0594.2009.00552.xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
32-9issue
1eissn
1444-1586issn
1447-0594pii
GGI552journal_volume
10pub_type
杂志文章abstract:AIM:Low alanine aminotransferase (ALT) level is associated with frailty in the older adult population. We investigated the usefulness of ALT in predicting low muscle strength among older patients with diabetes. METHODS:We included 550 men aged ≥50 years and 525 postmenopausal women. All participants had diabetes, and ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13868
更新日期:2020-04-01 00:00:00
abstract:AIM:To determine if hospital treatment in residential care facilities, led by a geriatric team, might be a viable alternative to inpatient admission for selected patients. METHODS:Case series with a new intervention were compared with historical controls receiving the conventional treatment. Treatment in residential c...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00910.x
更新日期:2013-04-01 00:00:00
abstract:AIM:Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the rela...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12040
更新日期:2013-10-01 00:00:00
abstract::A series of our studies on the development of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items (DASC-21) were reviewed. Study 1: to examine the distribution of scores and internal reliability of DASC-21, trained nurses and researchers visited the homes of 1341 participants aged 65 year...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.12727
更新日期:2016-03-01 00:00:00
abstract:AIM:The aim of the present study was to clarify the relationship between sarcopenia, as defined by the European Working Group on Sarcopenia in Older People, and the recovery of the capability to carry out activities of daily living in convalescent stroke patients who completed a rehabilitation program. METHODS:This re...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13780
更新日期:2019-11-01 00:00:00
abstract:AIM:This pilot study aimed to analyze the cost-effectiveness of visiting nursing care, to establish a new evaluation method considering both the quality and cost of visiting nursing care. METHOD:Participants were 384 caregivers from 10 certified home-visit nursing agencies that support patients in severe conditions in...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13816
更新日期:2020-01-01 00:00:00
abstract:AIM:The purpose of this study was to determine the reference value for the Timed Up and Go test (TUG) in healthy Japanese elderly people using the methodology of meta-analysis, and to determine the value for different measurement protocols. METHODS:Relevant research articles were identified from electronic databases: ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,meta分析
doi:10.1111/j.1447-0594.2011.00704.x
更新日期:2011-10-01 00:00:00
abstract:AIMS:Inflammatory processes might play a significant role at the pathophysiology of Alzheimer's disease (AD). Neuroinflammation is characterized by activation of microglia and the release of inflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α. Although, it is unknown what the real cont...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12704
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Geriatricians are physicians who work primarily with the elderly and deal with diseases that often accompany old age, such as Alzheimer's disease. In the last few years, data from questionnaires have demonstrated increasing criticism of geriatricians regarding their working conditions in geriatric medicine. ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1447-0594.2011.00714.x
更新日期:2012-01-01 00:00:00
abstract:AIM:Chronic diseases are frequent in older adults, particularly hypertension and diabetes. The relationship between frailty and these two conditions is still unclear. The aim of the present analyses was to explore the association between frailty with diabetes and hypertension in Mexican older adults. METHODS:Analyses ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12805
更新日期:2017-06-01 00:00:00
abstract::The imbalance between cholinergic activity and dopaminergic activity in the striatum causes a variety of neurological disorders, such as Parkinson's disease. During sensorimotor learning, the arrival of a conditioned stimulus reporting a reward evokes a pause response in the firing of the tonically active cholinergic ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/j.1447-0594.2010.00588.x
更新日期:2010-07-01 00:00:00
abstract:AIM:Musculoskeletal degenerative disease (MSD; osteoporosis, knee arthritis and lumbar spondylosis) decreases the quality of life (QOL) of older people. The objective of the present study was to identify the factors related to the absence of MSD in multivariate logistic regression analysis. METHODS:The participants we...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13786
更新日期:2019-11-01 00:00:00
abstract:AIM:Atrial fibrillation (AF) is the most common underlying cause of cardiogenic cerebral embolism. To prevent cardiogenic cerebral embolism, it is important to determine the level of awareness of AF in Japan. METHODS:We used survey monitor attribute data to sample 172 824 Japanese adults aged ≥50 years from all 47 Jap...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13318
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the intensity of pain and levels of disability at different times through the day in patients with burning mouth syndrome (BMS) over a 14-day period. METHODS:This was a prospective clinical study of 30 patients with BMS, 26 of whom completed the study. The parameters studied were pain intensity (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12303
更新日期:2015-04-01 00:00:00
abstract:AIM:The purposes of the present study were to investigate risk factors for incident disability in activities of daily living (ADL) among middle-aged and older women, and to determine whether there are differences in risk factors according to age groups. METHODS:The participants were 264 Japanese women aged 40 years an...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12834
更新日期:2017-07-01 00:00:00
abstract:AIM:Lactoferrin and lactoperoxidase have antimicrobial effects against oral pathogens. This randomized, double-blinded, placebo-controlled parallel group study tested the efficacy of a lactoferrin and lactoperoxidase-containing tablet (LF + LPO tablet) in improving the oral hygiene status of older individuals. METHODS...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.12776
更新日期:2017-05-01 00:00:00
abstract:AIM:Calf circumference, which is a known simple indicator of muscle mass, increases during edema. However, the extent to which edema increases calf circumference in older adults is unclear. METHODS:This retrospective cross-sectional study included patients aged ≥65 years whose nutritional status was assessed by nutrit...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13756
更新日期:2019-10-01 00:00:00
abstract:AIM:Functional status at one moment in time is a determinant of future functional status and survival. Physical deterioration tends to occur early in the disabling process; however, etiological questions remain. This study investigated the association between physical performance characteristics and functioning indepen...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00890.x
更新日期:2013-04-01 00:00:00
abstract:AIM:The study was carried out on elderly nursing home residents in Taiwan. We assessed whether the serial QuantiFERON-TB Gold (QFT-G) assay and serial tuberculin skin test (TST) were reliable tools to predict or exclude the development of active tuberculosis (TB). METHODS:This prospective observational cohort study in...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12416
更新日期:2015-10-01 00:00:00
abstract:AIM:In the present study, we aimed to update the data of frailty status in the European community-dwelling population of older adults, based on the latest data released (wave 6) of the Survey of Health, Aging and Retirement in Europe database, and to study the impact of each criterion on frailty assessment. METHODS:Fr...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13689
更新日期:2019-08-01 00:00:00
abstract:AIM:Family function is an essential factor affecting older adults' health. However, there has been no appropriate method to assess the family function of most older adults with fragility or poor health status. The present study aimed to explore the differences and relevance of family function estimated by home care nur...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12544
更新日期:2016-06-01 00:00:00
abstract:AIM:Falls are a prevalent issue for the older population, and for the healthcare system in terms of emergency department (ED) access and hospitalizations. There is still a lack of knowledge and guidelines, however, regarding the need to hospitalize older patients accessing the ED after a fall. In the present study, we ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13497
更新日期:2018-09-01 00:00:00
abstract:AIM:The purpose of the present study was to examine the effects of knee taping on perceived pain, difficulty and stability during functional activities (squat, step-down, and stair up and down) in older adults with knee osteoarthritis (OA). METHODS:A total of 50 older participants with knee OA participated in this stu...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.13448
更新日期:2018-08-01 00:00:00
abstract:AIM:As the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged ≥80 years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling o...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13091
更新日期:2017-12-01 00:00:00
abstract:AIM:The association between polypharmacy and the development of frailty is unknown. The present study assessed the longitudinal relationship between polypharmacy and frailty risk in Japanese community-dwelling older adults. METHODS:Participants included 299 non-frail older Japanese adults aged 65-81 years who particip...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13507
更新日期:2018-10-01 00:00:00
abstract:AIM:Delirium is responsible for up to 56% of hospital admissions in the elderly. Epilepsy and delirium share most risk factors and are both associated with confusion. The aim of this work was to study whether a link between epileptic activity (EA) and delirium existed, and if this link was relevant. METHODS:Charts of ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12128
更新日期:2014-04-01 00:00:00
abstract:AIM:Polypharmacy is a major problem for elderly patients in developed countries. We investigated whether a multidisciplinary medication review using electronic medical records could reduce the number of drugs administered to elderly patients receiving polypharmacy. METHODS:The present study included 432 elderly patien...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12764
更新日期:2017-04-01 00:00:00
abstract:AIM:In Japan, many elderly patients are managed at home, and fever is a common problem. This study examined the incidence of fever events in elderly patients on home medical management, and underlying disorders from the pragmatic standpoint. This study also investigated whether the care-need level determined at the sta...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12024
更新日期:2013-10-01 00:00:00
abstract:AIM:The prevalence of constipation and prevalence of pollakisuria among older patients receiving home medical care have not been reported, and risk factors for these symptoms are not clear in this setting. The present study sought to determine the prevalence and risk factors of constipation and pollakisuria among older...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13610
更新日期:2019-04-01 00:00:00
abstract:AIM:The aim of this study was to investigate the prevalence of self-reported oral complaints in older hospitalized mentally ill patients and relate them to the primary psychiatric diagnosis. METHODS:A total of 89 older hospitalized psychiatric patients consented to participate in the study, and were interviewed and cl...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00907.x
更新日期:2013-04-01 00:00:00