Abstract:
BACKGROUND:Vibrio cholerae is the causative agent of cholera. Extensive studies reveal that complicated regulatory cascades regulate expression of virulence genes, the products of which are required for V. cholerae to colonize and cause disease. In this study, we investigated the expression of the key virulence regulator ToxR under different conditions. RESULTS:We found that compared to that of wild type grown to stationary phase, the toxR expression was lower in an aphB mutant strain. AphB has been previously shown to be a key virulence regulator that is required to activate the expression of tcpP. When expressed constitutively, AphB is able to activate the toxR promoter. Furthermore, gel shift analysis indicates that AphB binds toxR promoter region directly. We also characterize the effect of AphB on the levels of the outer membrane porins OmpT and OmpU, which are known to be regulated by ToxR. CONCLUSIONS:Our data indicate that V. cholerae possesses an additional regulatory loop that use AphB to activate the expression of two virulence regulators, ToxR and TcpP, which together control the expression of the master virulence regulator ToxT.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Xu X,Stern AM,Liu Z,Kan B,Zhu Jdoi
10.1186/1471-2180-10-3subject
Has Abstractpub_date
2010-01-06 00:00:00pages
3issn
1471-2180pii
1471-2180-10-3journal_volume
10pub_type
杂志文章相关文献
BMC MICROBIOLOGY文献大全abstract:BACKGROUND:Despite the importance of the B. cereus group as major foodborne pathogens that may cause diarrheal and/or emetic syndrome(s), no study in Tunisia has been conducted in order to characterize the pathogenic potential of the B. cereus group. The aim of this study was to assess the sanitary potential risks of 1...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1571-y
更新日期:2019-08-24 00:00:00
abstract:BACKGROUND:The gut comprises an essential barrier that protects both invertebrate and vertebrate animals from invasion by microorganisms. Disruption of the balanced relationship between indigenous gut microbiota and their host can result in gut bacteria eliciting host responses similar to those caused by invasive patho...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-129
更新日期:2010-04-27 00:00:00
abstract:BACKGROUND:Antimicrobial helper-compounds may reverse antimicrobial resistance. Sertraline, a antidepressant drug, has been suggested as a tetracycline helper-compound. Tetracycline is the preferred antimicrobial for treatment of enteric diseases in pigs. This study is the first to evaluate the potency of sertraline as...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1383-5
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:Modifiable lifestyle factors (e.g. dietary intake and physical activity) are important contributors to weight gain during college. The purpose of this study was to evaluate whether associations exist between body mass index, physical activity, screen time, dietary consumption (fat, protein, carbohydrates, an...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1362-x
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:Microbial biofilms are known to cause an increasing number of chronic inflammatory and infectious conditions. A classical example is chronic periodontal disease, a condition initiated by the subgingival dental plaque biofilm on gingival epithelial tissues. We describe here a new model that permits the examin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-280
更新日期:2009-12-31 00:00:00
abstract:BACKGROUND:Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elderly care home residents are considered particularly vulnerable to the infection. The main objecti...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-016-0848-7
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Rhodosporidium toruloides is a β-carotenoid accumulating, oleaginous yeast that has great biotechnological potential. The lack of reliable and efficient genetic manipulation tools have been a major hurdle blocking its adoption as a biotechnology platform. RESULTS:We report for the first time the development...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-50
更新日期:2014-02-27 00:00:00
abstract:BACKGROUND:Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) fol...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-97
更新日期:2011-05-11 00:00:00
abstract:BACKGROUND:Bacillus sp. H2O-1, isolated from the connate water of a Brazilian reservoir, produces an antimicrobial substance (denoted as AMS H2O-1) that is active against sulfate reducing bacteria, which are the major bacterial group responsible for biogenic souring and biocorrosion in petroleum reservoirs. Thus, the u...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-252
更新日期:2012-11-07 00:00:00
abstract:BACKGROUND:Bacteria release a wide variety of small molecules including cell-to-cell signaling compounds. Gram-negative bacteria use a variety of self-produced autoinducers such as acylated homoserine lactones (acyl-HSLs) as signal compounds for quorum sensing (QS) within and between bacterial species. QS plays a signi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-70
更新日期:2012-05-10 00:00:00
abstract:BACKGROUND:Hypervirulent K. pneumoniae (hvKp) causes severe community acquired infections, predominantly in Asia. Though initially isolated from liver abscesses, they are now prevalent among invasive infections such as bacteraemia. There have been no studies reported till date on the prevalence and characterisation of ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1148-6
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:The aminoglycoside antibiotic gentamicin was supposed to induce a crosstalk between the Cpx- and the Arc-two-component systems (TCS). Here, we investigated the physical interaction of the respective TCS components and compared the results with their respective gene expression and protein abundance. The findi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1100-9
更新日期:2017-09-18 00:00:00
abstract:BACKGROUND:Alpha (alpha)-hemolysin is a pore forming cytolysin and serves as a virulence factor in intestinal and extraintestinal pathogenic strains of E. coli. It was suggested that the genes encoding alpha-hemolysin (hlyCABD) which can be found on the chromosome and plasmid, were acquired through horizontal gene tran...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-193
更新日期:2010-07-19 00:00:00
abstract:BACKGROUND:Candida parapsilosis typically is a commensal of human skin. However, when host immune defense is compromised or the normal microflora balance is disrupted, C. parapsilosis transforms itself into an opportunistic pathogen. Candida-derived lipase has been identified as potential virulence factor. Even though ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-122
更新日期:2011-05-29 00:00:00
abstract:BACKGROUND:Fusobacterium nucleatum, a well studied bacterium in periodontal diseases, appendicitis, gingivitis, osteomyelitis and pregnancy complications has recently gained attention due to its association with colorectal cancer (CRC) progression. Treatment with berberine was shown to reverse F. nucleatum-induced CRC ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-016-0700-0
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:Participation of renal cells in the pathogenesis of staphylococcal enterotoxin B (SEB) is critical for late cleansing and sequestration of the antigens facilitated by CD1d mediated antigen sensing and recognition. This is a noted deviation from the typical antigen recognition process that recruits the major ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0344-5
更新日期:2015-02-04 00:00:00
abstract:BACKGROUND:The date palm root borer Oryctes agamemnon (Coleoptera: Scarabaeidae) is one of the major pests of palms. In Saudi Arabia, both larvae and adults of Oryctes are particularly troublesome, especially during the establishment of young date palm orchards. Endosymbiotic bacteria are known to have a key role in fo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0422-8
更新日期:2015-04-22 00:00:00
abstract:BACKGROUND:Famous Chinese strong-flavored liquor (CSFL) is brewed by microbial consortia in a special fermentation pit (FT). However, the fermentation process was not fully understood owing to the complicate community structure and metabolism. In this study, the process-related dynamics of microbial communities and mai...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1106-3
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND:Chlamydia pneumoniae is a common human pathogen that is associated with upper and lower respiratory tract infections. It has also been suggested that C. pneumoniae infection can trigger or promote a number of chronic inflammatory conditions, including asthma and atherosclerosis. Several strains of C. pneumon...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0569-3
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:A disrupted cell cycle progression of hepatocytes was reported in chronic hepatitis C virus (HCV) infection, which can contribute significantly in the associated pathogenesis. The present study aimed to further elaborate these disruptions by evaluating the expression of key cell cycle and apoptotic proteins ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-133
更新日期:2008-08-05 00:00:00
abstract:BACKGROUND:The catabolite control protein CcpA is a transcriptional regulator conserved in many Gram-positives, controlling the efficiency of glucose metabolism. Here we studied the role of Bacillus cereus ATCC 14579 CcpA in regulation of metabolic pathways and expression of enterotoxin genes by comparative transcripto...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-62
更新日期:2008-04-16 00:00:00
abstract:BACKGROUND:The kinetoplast DNA (kDNA) of trypanosomatids consists of an unusual arrangement of circular molecules catenated into a single network. The diameter of the isolated kDNA network is similar to that of the entire cell. However, within the kinetoplast matrix, the kDNA is highly condensed. Studies in Crithidia f...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-120
更新日期:2009-06-04 00:00:00
abstract:BACKGROUND:H-NS is a DNA-binding protein with central roles in gene regulation and nucleoid structuring in Escherichia coli. There are over 60 genes that are influenced by H-NS many of which are involved in metabolism. To determine the significance of H-NS-regulated genes in metabolism and stress tolerance, an hns muta...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-6-72
更新日期:2006-08-15 00:00:00
abstract:BACKGROUND:Poorly understood but highly diverse microbial communities exist within anoxic and oxygen-depleted marine sediments. These communities often harbour single-celled eukaryotes that form symbiotic associations with different prokaryotes. During low tides in South-western British Columbia, Canada, vast areas of ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-145
更新日期:2010-05-19 00:00:00
abstract:BACKGROUND:Microorganisms of different species interact in several ecological niches, even causing infection. During the infectious process, a biofilm of single or multispecies can develop. Aspergillus fumigatus and Staphyloccocus aureus are etiologic agents that can cause infectious keratitis. We analyzed in vitro sin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0363-2
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Klebsiella pneumoniae can be found in environmental habitats as well as in hospital settings where it is commonly associated with nosocomial infections. One of the factors that contribute to virulence is its capacity to form biofilms on diverse biotic and abiotic surfaces. The second messenger Bis-(3'-5')-cy...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-139
更新日期:2012-07-09 00:00:00
abstract:BACKGROUND:Bacteria excrete costly toxins to defend their ecological niche. The evolution of such antagonistic interactions between individuals is expected to depend on both the social environment and the strength of resource competition. Antagonism is expected to be weak among highly similar genotypes because most ind...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-40
更新日期:2012-03-22 00:00:00
abstract:BACKGROUND:Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores. Although iron transport systems involved in the pathogenesis of APEC or UPEC ha...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-143
更新日期:2012-07-20 00:00:00
abstract:BACKGROUND:Non-structural protein 1 (NS1) is a multifunctional protein and a crucial regulatory factor in the replication and pathogenesis of avian influenza virus (AIV). Studies have shown that NS1 can interact with a variety of host proteins to modulate the viral life cycle. We previously generated a monoclonal antib...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1097-0
更新日期:2017-09-11 00:00:00
abstract:ERRATUM:Upon publication of the original article (1) it was highlighted by the authors that a grant awarded to support the research work of the study was missed in the acknowledgements. It should also be acknowledged that the grant titled "Genotyping and Molecular Epidemiological Characteristic of Bacillus anthracis in...
journal_title:BMC microbiology
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12866-018-1172-1
更新日期:2018-04-12 00:00:00