Abstract：
:Solid tumors show an altered metabolism with respect to glycolysis in comparison to normal tissue. Recently, the determination of different glycolytic metabolites for tumor diagnosis and therapeutic decision-making became the focus of interest for various research groups. In particular an increased lactate concentration in tumor tissue appears to be a predictor of an adverse prognosis. Imaging of induced bioluminescence in rapidly frozen tumor biopsies is an established technique for the detection of selected substances. In this method the metabolites of interest are biochemically linked to luciferases. A microscopic photon counting system registers the light intensity and after calibration reflects the concentration distribution of metabolites. In contrast to other methods it is possible to detect different metabolites from one specific area of tissue. Preliminary results of a pilot study on oral cancer patients suggest a prognostic impact in terms of high lactate concentrations being associated with poor survival. This technique could increase the validity and significance of tumor grading and might be supportive decision guidance for tumor therapy in the future.
journal_name
HNOjournal_title
HNOauthors
Ziebart T,Walenta S,Sattler U,Kunkel M,Wagner W,Müller-Klieser Wdoi
10.1007/s00106-009-2030-0subject
Has Abstractpub_date
2010-01-01 00:00:00pages
31-4issue
1eissn
0017-6192issn
1433-0458journal_volume
58pub_type
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