Abstract：
:The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients with relapsing-remitting multiple sclerosis (RRMS) that were continuously treated with interferon beta-1b during a three-year period and to compare the results obtained with literature data available. Additionally, dropouts and side effects were assessed. The annual relapse rate at three years of treatment as the primary study end-point decreased by 60.5% compared with the relapse rate throughout the pretherapeutic course of disease (0.39 +/- 0.55 vs. 0.97 +/- 0.46; P<0.001) and by 71.3% compared with the relapse rate one year prior to treatment (0.39 +/- 0.55 vs. 1.34 +/- 0.65; P<0.001). The mean Extended Disability Status Scale (EDSS) increased significantly from 2.46 +/- 0.86 at baseline to 2.90 +/- 1.30 (P<0.01) at three years of treatment, whereas the mean progression index (EDSS/disease duration) decreased significantly from 0.76 +/- 0.50 prior to treatment to 0.43 +/- 0.24 (P<0.001), yielding a 56.6% improvement and proving the disease modifying effect of interferon beta-1b. Seventeen (53.12%) patients remained relapse-free during the course of therapy. Among patients that experienced disease relapse, the mean time to first exacerbation was 11.5 +/- 8.34 months. Our study results were consistent with similar studies performed worldwide, clearly indicating that Interferon beta-1b therapy decreased the disease activity and had a beneficial effect on the progression of RRMS, with low incidence and severity of serious side effects. This study has paved way for further long-term follow up studies at our institution.
journal_name
Acta Clin Croatjournal_title
Acta clinica Croaticaauthors
Jesić A,Stefanović D,Delibasić N,Semnic M,Sakallasz L,Dobrenov D,Zivanović Z,Rabi-Zikić T,Zikić Msubject
Has Abstractpub_date
2009-06-01 00:00:00pages
183-6issue
2eissn
0353-9466issn
1333-9451journal_volume
48pub_type
杂志文章abstract：:The early child development, from birth until the age of one year is, amongst other changes, characterized by intense motor learning. During that period, the voluntary learning patterns evolve from reflexive patterns to coordinated voluntary patterns. All of the child's voluntary movements present active forms in whic...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:In the light of some new information based on clinical evidence, current therapeutic approach to patients with acute coronary syndrome especially focusing on oral therapy is being considered. The initial stage of treatment does not differ greatly among patients with unstable angina pectoris (UA), non-ST-elevation myoc...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-01 00:00:00
abstract：:Thrombolysis with intravenous recombinant tissue plasminogen activator (rtPA) is the first evidence based treatment for acute ischemic stroke, which aims to reduce the cerebrovascular lesion. At University Department of Neurology, Sestre milosrdnice University Hospital, Zagreb, thrombolytic therapy with intravenous rt...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,多中心研究
doi：
更新日期：2009-09-01 00:00:00
abstract：:Pulmonary hamartoma is the most common benign tumor of the lung. It accounts for 77% of all benign lung tumors but less than 1% of all lung tumors. Malignant alteration is -extremely rare. Surgical removal is therapy of choice. Uniportal video-assisted thoracic surgery is an easy-to-learn variant of video-assisted tho...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.04.32
更新日期：2017-12-01 00:00:00
abstract：:In the last several decades, a great number of studies have pointed to a dramatic increase of type 1 diabetes mellitus (T1DM) incidence in the whole world, especially in younger age groups. Therefore, the aim of the study was to assess changes in the age distribution at onset of T1DM in Montenegro children aged < 15 y...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.01.10
更新日期：2016-03-01 00:00:00
abstract：:The aim of this in vitro study was to evaluate cytotoxicity and genotoxicity of six different dental nanocomposite materials, three conventional ones and three flowable composite resin materials, in human lymphocytes. The following materials were tested: Tetric EvoCeram, Tetric EvoFlow, Filtek Ultimate, Filtek Ultimat...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2018.57.02.07
更新日期：2018-06-01 00:00:00
abstract：:Multiply injured patients with severe chest trauma have different combinations of associated extra thoracic injuries making their treatment complex. Severe pain is a prominent symptom in a vast majority of severe chest injuries and causes deterioration of respiratory function. Epidural analgesia provides efficient pai...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2019.58.s1.18
更新日期：2019-06-01 00:00:00
abstract：:Nurses distinguish continuous professional development intended for career improvement and personal development from continuous professional development intended for improvement of skills and knowledge. Too many requests are put in front of an individual unacceptably stretching it onto the life outside work. Students ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:The aim of our retrospective study was to compare the performance of transvaginal sonography in relation to histologic diagnosis of samples obtained by hysteroscopy through analysis of data collected over 16 years. Data on suspected formation of endometrial polyp or submucosal fibroid found on ultrasound examination w...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.02.07
更新日期：2019-06-01 00:00:00
abstract：:Despite decades of experience in tracheotomy, there still exists a controversy over its ideal timing. The aim of our study was to compare the impact of early and late percutaneous tracheotomy in terms of their ability to reduce mechanical ventilation duration and length of stay in Intensive Care Unit, as well as the f...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Renal artery embolism is a disease that is easily missed due to its infrequent and nonspecific presentations. Although early diagnosis and optimal thrombolytic treatment can sometimes restore renal function, therapeutic guidelines have not yet been established. However, early anticoagulant therapy is beneficial and se...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:Triple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progression. Due to the ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2020.59.01.12
更新日期：2020-03-01 00:00:00
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journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2018.57.03.20
更新日期：2018-09-01 00:00:00
abstract：:We hypothesized that the integration of forensic psychiatrists and the forensic system into the general stream of mental health should lead to better reintegration of forensic patients into the society. The aims of the study were to explore the link between violence, murder, psychiatric disorders and other variables, ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:In this article, we document a conclusive case of nebivolol-induced hyperkalemia for the first time in the known medical literature. Hyperkalemia is associated with serious conditions such as cardiac arrhythmias and sudden cardiac death. Nebivolol was not known to cause hyperkalemia, and this event is not listed in it...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.04.20
更新日期：2016-12-01 00:00:00
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journal_title：Acta clinica Croatica
pub_type：
doi：10.20471/acc.2019.58.03.21
更新日期：2019-09-01 00:00:00
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journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.03.05
更新日期：2016-09-01 00:00:00
abstract：:The Bethesda System for Reporting Thyroid Cytopathology from 2009 introduced a new category in thyroid nodule fine-needle aspiration (FNA) findings named atypia of undetermined significance (AUS), which usually appears in around 5% of FNA findings. Our study aimed to assess the utility of AUS finding in determining th...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.02.17
更新日期：2019-06-01 00:00:00
abstract：:The aim of the study was to define the effects of daily hospice team's activities on depression and anxiety in breast cancer patients having undergone mastectomy after three-month therapy. This prospective study included 35 patients that underwent mastectomy for breast cancer, followed by 3-month treatment at daily ho...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Helicobacter pylori (H. pylori) is a common problem and a significant cause of chronic gastric inflammation. H. pylori, ongoing gastric inflammation and its severity are the most critical component of precursors of gastric cancer. Hypothetically, every chronic tissue injury activates platelets, and the mean platelet v...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2019.58.04.02
更新日期：2019-12-01 00:00:00
abstract：:We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.01.23
更新日期：2017-03-01 00:00:00
abstract：:Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typically strikes young adults. It is often associated with a wide range of functional deficits and progressive disability. Common symptoms of multiple sclerosis include vision problems, spasticity, weakness, ataxia, bladder an...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2013-03-01 00:00:00
abstract：:Lumbar discectomy is the most common surgical treatment for intervertebral disc extrusion. Postoperative pain is a common clinical problem that greatly affects the length of hospitalization, functional status and patient quality of life. Th e aim of this study was to compare the postoperative analgesic effi cacy of pa...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,随机对照试验
doi：10.20471/acc.2017.56.02.06
更新日期：2017-06-01 00:00:00
abstract：:The rate of periprosthetic femoral fractures following total hip replacement has been growing steadily in the last 20 years and ranges from 0.1% to 2.1%. These fractures are mostly related to older patients with the presence of chronic diseases and frequently poor bone quality. The treatment is surgically very complex...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.03.21
更新日期：2017-09-01 00:00:00
abstract：:The aim was to determine the validity of the international normalized ratio (INR) and prothrombin time (PT) as a monitor for warfarin therapy in patients with lupus anticoagulants and recurrent thrombosis, and to investigate alternative approaches to monitoring warfarin therapy and new treatment options in these patie...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：:The aim of our study was to describe and interpret national trends in thyroid cancer in Croatian men and women during the 1988-2010 period, to better understand the incidence and mortality trends in comparison with other populations, and to determine the proportion of certain histologic subtypes of thyroid cancer and ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:The aim of the study was to assess how children and adolescents experience hospitalization and separation from their parents, their home and daily activities, in order to improve the psychosocial quality of hospital stay. Emotions and experiences reported by hospitalized children and adolescents are presented and disc...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:Atrial fibrillation is the most common cardiac arrhythmia. It increases the risk of death and thromboembolic events. Vitamin K antagonists reduce these risks. Disadvantages of vitamin K antagonist therapy are narrow therapeutic range and interactions with drugs and food. In a single center prospective study, we enroll...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.04.22
更新日期：2019-12-01 00:00:00
abstract：:There are many false assumptions, both in the general population and among physicians, regarding the influence of radiation on pregnant patients and the fetus during diagnostic procedures, in spite of scientific facts based on studies. These false assumptions are mostly based on the idea that every diagnostic procedur...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.02.10
更新日期：2016-06-01 00:00:00
abstract：:- This study aimed to investigate the impact of posture and anesthesia techniques on blood pressure changes, heart rate and regional cerebral oxygen saturation during shoulder arthroscopy in the beach chair position (BCP). Sixty patients were included in this prospective cohort study: 30 patients mechanically ventilat...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2018.57.03.10
更新日期：2018-09-01 00:00:00
