Abstract：
:Atrial fibrillation is the most common cardiac arrhythmia. It increases the risk of death and thromboembolic events. Vitamin K antagonists reduce these risks. Disadvantages of vitamin K antagonist therapy are narrow therapeutic range and interactions with drugs and food. In a single center prospective study, we enrolled 249 patients with atrial fibrillation over a 12-month period. The aim of our study was to evaluate vitamin K antagonist use regarding the indication and adequate dose. Data on 249 consecutive patients with atrial fibrillation were collected before general availability of novel oral anticoagulants. Out of 249 patients, 160 (64.2%) had indication for oral anticoagulant therapy. Only 81 (50.6%) patients had vitamin K antagonist in therapy, 12 (14.8%) of them in adequate dose. We also analyzed 129 patients aged over 75, of which 109 (84.4%) had absolute indication for oral anticoagulant therapy. Only 34 (31.2%) patients aged over 75 had been receiving vitamin K antagonist therapy and 6 (17.6%) had the International Normalized Ratio values within the proposed therapeutic interval. We found a significantly higher rate of anticoagulant therapy introduction in patients under 75 years (p=0.03), but there were no significant differences in the adequacy of anticoagulant therapy (p=0.89) between these two populations. Our results showed clear inadequacies of vitamin K antagonist treatment with a growing need for a wider use of novel oral anticoagulants.
journal_name
Acta Clin Croatjournal_title
Acta clinica Croaticaauthors
Stipinović M,Letilović T,Počanić D,Aćamović Stipinović B,Kurtić E,Sertić Z,Jerkić Hdoi
10.20471/acc.2019.58.04.22subject
Has Abstractpub_date
2019-12-01 00:00:00pages
744-750issue
4eissn
0353-9466issn
1333-9451pii
acc-58-744journal_volume
58pub_type
杂志文章abstract：:Multiple sclerosis is a chronic, immune-mediated disease of the central nervous system that typically strikes young adults. It is often associated with a wide range of functional deficits and progressive disability. Common symptoms of multiple sclerosis include vision problems, spasticity, weakness, ataxia, bladder an...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2013-03-01 00:00:00
abstract：:The aim was to assess whether standard automated perimetry (SAP) and frequency doubling technology (FDT) perimetry are able to detect the effect of diabetes mellitus (DM) on retinal function in DM patients in the early stage of disease and to analyze which method is more specific and sensitive. A randomized cross-sect...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2020.59.01.02
更新日期：2020-03-01 00:00:00
abstract：:Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that usually affects children and young adults. It most commonly has a monophasic course, although relapses are reported. Clinical presentation of the disease includes encephalopathy and multifocal neurol...
journal_title：Acta clinica Croatica
pub_type：
doi：10.20471/acc.2019.58.01.22
更新日期：2019-03-01 00:00:00
abstract：:Unicameral bone cysts (UBC) are benign bone tumor-like lesions. Mostly they are located in the metaphyseal-diaphyseal region of long bones in children and adolescents. The etiology of UBC is still unclear. There is no consensus about the protocol of UBC treatment. The aim of this study was to evaluate the effectivenes...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.03.01
更新日期：2019-09-01 00:00:00
abstract：:Airway management in a polytraumatized patient with severe spinal and thoracic deformities demands detailed investigation of anatomical characteristics of the head, neck and airways, as well as thoracic configuration, before attempting endotracheal intubation. This enables the physician to predict a difficult airway a...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:The aim of the study was to define the effects of daily hospice team's activities on depression and anxiety in breast cancer patients having undergone mastectomy after three-month therapy. This prospective study included 35 patients that underwent mastectomy for breast cancer, followed by 3-month treatment at daily ho...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:A case of a 66-year-old man with West Nile neuroinvassive disease manifested with fever, weakness, fatigue, consciousness disorders and underlying diabetes mellitus type 2 and cardiovascular diseases is presented. Laboratory data showed elevated erythrocyte sedimentation rate and fibrinogen. Serological tests revealed...
journal_title：Acta clinica Croatica
pub_type：
doi：10.20471/acc.2019.58.03.21
更新日期：2019-09-01 00:00:00
abstract：:Secondary angiosarcoma is an aggressive tumor that can develop in breast cancer patients treated with conserving therapy and radiotherapy. The symptoms can be misleading, whereas mammography and fine-needle aspiration (FNA) are typically negative in early stage of the disease. A high grade of clinical suspicion is ver...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:In the light of some new information based on clinical evidence, current therapeutic approach to patients with acute coronary syndrome especially focusing on oral therapy is being considered. The initial stage of treatment does not differ greatly among patients with unstable angina pectoris (UA), non-ST-elevation myoc...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-01 00:00:00
abstract：:Although the incidence of ventilator-associated pneumonia (VAP) is very high, there are still many uncertainties about clinical course of VAP among tracheotomized patients. The goal of the present study was to determine the impact of tracheotomy on VAP incidence and etiology, as well as outcome of VAP patients with tr...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.01.15
更新日期：2017-03-01 00:00:00
abstract：:- Mycological analysis is considered the gold standard in the diagnosis of very common fungal diseases of nails. The purpose of the article is to present the prevalence of onychomycosis obtained by using direct microscopic examination (DME) and cultivation on Sabouraud media without cycloheximide. The quantitative ret...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2018.57.04.15
更新日期：2018-12-01 00:00:00
abstract：:Angiogenesis is essential for the development, growth and progression of tumors. Although vascular endothelial growth factor (VEGF) is a well-known proangiogenic factor, its impact on lymphoma has not yet been fully clarified. The aim of this study was to evaluate VEGF-A -expression and microvessel density (MVD) in ag...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.04.02
更新日期：2017-12-01 00:00:00
abstract：:In the past few decades, the survivor rate from childhood cancers has significantly increased due to constant modifications and improvements in treatment protocols, so the estimates are that childhood cancer occurs in 1 per 600 children, and that 1 per 450 adolescents or young adults is a long-term cancer survivor. Ne...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:The aim of this prospective study was to evaluate whether cytokine levels in nasal secretions may be clinical parameters of severity of nasal polyposis. Forty nasal polyp patients (20 asthmatic and 20 nonasthmatic) requiring surgical treatment were included. Nasal secretion samples were collected from nasal cavities o...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：:Autoimmune polyglandular syndrome by definition consists of two or more endocrinological insufficiencies or two organ specific autoimmune diseases. There are no stringent criteria for endocrinological evaluation of patients with one endocrine insufficiency. However, detailed endocrinological evaluation should be under...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-12-01 00:00:00
abstract：:Fetal alcohol syndrome is defined by a triad of symptoms such as facial dysmorphology, prenatal and postnatal growth deficiency, and central nervous system dysfunction. It is the result of teratogenic effects of alcohol consumption in pregnancy. The prevalence of fetal alcohol syndrome is 1 to 3 per 1000 live births. ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:Reverse shoulder prosthesis has become one of the most often used prosthetic implants in shoulder replacement surgery. It has a wide spectrum of indications, starting from comminuted humeral fractures and posttraumatic arthritis to arthritis caused by the rotator cuff loss. Its application at our hospital began in 200...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:The aim of our retrospective study was to compare the performance of transvaginal sonography in relation to histologic diagnosis of samples obtained by hysteroscopy through analysis of data collected over 16 years. Data on suspected formation of endometrial polyp or submucosal fibroid found on ultrasound examination w...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.02.07
更新日期：2019-06-01 00:00:00
abstract：:The early child development, from birth until the age of one year is, amongst other changes, characterized by intense motor learning. During that period, the voluntary learning patterns evolve from reflexive patterns to coordinated voluntary patterns. All of the child's voluntary movements present active forms in whic...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:Heart rate variability (HRV) gives information on the sympathetic-parasympathetic autonomic balance. The aim of the study was to analyze sympathovagal balance after acute spinal cord injury (SCI), demonstrated by linear measures in time and frequency domain of HRV and to analyze the effect of corticosteroids on HRV pa...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.02.08
更新日期：2016-06-01 00:00:00
abstract：:Foreign body ingestion is a common problem in children, but magnet ingestion is relatively rare. However, when it occurs, it tends to have a high rate of complications. This is a case report of a 3-year-old child who swallowed multiple magnetic toys, subsequently developing jejunoileal perforation and volvulus. This c...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Stress is the key psychological activator of the hypothalamic-pituitary-adrenal axis and therefore an important risk factor for diminished immunocompetence. The aim of the study was to assess the connection between the strategies of coping with stress and lymphocyte counts in soldiers. Coping strategies were evaluated...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：:The first beginnings of ophthalmic echography in Croatia started at the turn of the 1960s and 1970s. When the two largest medical institutions in Croatia, Sestre milosrdnice University Hospital (former Dr. Mladen Stojanović General Hospital) and Zagreb University Hospital Center, both in Zagreb, were supplied with ult...
journal_title：Acta clinica Croatica
pub_type： 历史文章,杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:The objective of this clinical update, based on recently published literature, was to discuss incidence and characteristics of the most relevant clinical adverse effects associated with local anesthetic and steroid use in regional anesthesia and treatment of acute or chronic pain. A comprehensive review of the English...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2019.58.s1.08
更新日期：2019-06-01 00:00:00
abstract：:Findings obtained by fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG PET) and computed tomography (CT) were compared in patients with malignant lymphoma and colorectal carcinoma. In 14 malignant lymphoma patients, 16 18F-FDG PET procedures were performed to assess chemotherapy and/or radiotherapy ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：:The management of postoperative pain after carpal tunnel syndrome surgical treatment at a tertiary hospital was analyzed and compared with the guidelines for perioperative pain management. This retrospective study included 579 patients operated on for carpal tunnel syndrome at the Split University Hospital Center in S...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.03.11
更新日期：2017-09-01 00:00:00
abstract：:Previous findings on peripartum anxiety are inconsistent in respect to the prevalence and course of peripartum anxiety with comorbidity of depression. Our aim was threefold: (1) to examine the course of elevated anxiety during pregnancy, immediately after childbirth, and six weeks postpartum; (2) to establish comorbid...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.04.05
更新日期：2018-03-01 00:00:00
abstract：:The aim of our study was to describe and interpret national trends in thyroid cancer in Croatian men and women during the 1988-2010 period, to better understand the incidence and mortality trends in comparison with other populations, and to determine the proportion of certain histologic subtypes of thyroid cancer and ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:- Infections are well-known complications of radical prostatectomy. In the United States and Europe, the rates of surgical site infections are generally less than 1% and of other infections up to 3%. We report a case of a 62-year-old man who developed severe sepsis with renal insufficiency, paralytic ileus and polyser...
journal_title：Acta clinica Croatica
pub_type：
doi：10.20471/acc.2018.57.04.25
更新日期：2018-12-01 00:00:00
abstract：:- This study aimed to investigate the impact of posture and anesthesia techniques on blood pressure changes, heart rate and regional cerebral oxygen saturation during shoulder arthroscopy in the beach chair position (BCP). Sixty patients were included in this prospective cohort study: 30 patients mechanically ventilat...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2018.57.03.10
更新日期：2018-09-01 00:00:00
