Abstract：
:In this article, we document a conclusive case of nebivolol-induced hyperkalemia for the first time in the known medical literature. Hyperkalemia is associated with serious conditions such as cardiac arrhythmias and sudden cardiac death. Nebivolol was not known to cause hyperkalemia, and this event is not listed in its summary of product characteristics (SmPC). For older beta blockers, hyperkalemia is recognized as a rare adverse event linked to cytochrome P450 2D6 (CYP2D6) polymorphism and poor drug degradation. Our patient, a 47-year-old woman taking nebivolol for hypertension developed persistent hyperkalemia, with serum potassium levels up to 6.4 mmol/L. After extensive diagnostic evaluation and exclusion of other known conditions leading to hyperkalemia, its cause remained occult. Since hyperkalemia coincided with increased doses of nebivolol, dose reduction and discontinuation were attempted, resulting in normalized serum potassium. Poor drug metabolism could not explain this adverse effect, since pharmacogenetic testing showed no relevant aberrations. In conclusion, hyperkalemia is a harmful adverse event with possible lethal outcome, and it may be caused by nebivolol. Therefore, medical professionals have to be aware of this side effect and hyperkalemia should be listed as an adverse event in nebivolol SmPC.
journal_name
Acta Clin Croatjournal_title
Acta clinica Croaticaauthors
Altabas K,Altabas V,Gulin Tdoi
10.20471/acc.2016.55.04.20subject
Has Abstractpub_date
2016-12-01 00:00:00pages
663-666issue
4eissn
0353-9466issn
1333-9451journal_volume
55pub_type
杂志文章abstract：:Chemical peels are growing in popularity with new agents, formulas and methods giving them greater reliability and safety. Although the operative procedure may seem relatively simple, proper knowledge and skills of the physician and education of the patient is crucial. It is very important for the physician to know ch...
journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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pub_type： 历史文章,杂志文章
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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journal_title：Acta clinica Croatica
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