Abstract：
:Triple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progression. Due to the lack of biomarkers or any valid treatment targets, it can only be treated with classic cytotoxic chemotherapy. We analyzed a cohort of 152 patients, median age 58 years, diagnosed with and treated for early stage TNBC at the University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia, during the 2009-2012 period. Patients were treated with primary surgical approach, adjuvant chemotherapy and adjuvant irradiation. We observed a relatively large proportion of locally advanced TNBC at diagnosis, with large tumor size and nodal involvement, with high grade and high proliferation index Ki67. Patient age, tumor size and lymph node involvement, as expected, were significant and clinically most important prognostic factors for 5-year disease-free survival (67%; 95% CI 60%-75%) and overall absolute survival rate (74%; 95% CI 66%-81%).
journal_name
Acta Clin Croatjournal_title
Acta clinica Croaticaauthors
Tečić Vuger A,Šeparović R,Vazdar L,Pavlović M,Lepetić P,Šitić S,Bajić Ž,Šarčević B,Vrbanec Ddoi
10.20471/acc.2020.59.01.12subject
Has Abstractpub_date
2020-03-01 00:00:00pages
97-108issue
1eissn
0353-9466issn
1333-9451pii
acc-59-97journal_volume
59pub_type
杂志文章abstract：:Two cases of osteoid osteoma tumor (OO) are presented and our early experience with intraoperative gamma probing to localize OO during surgery is reported. The concept of radioguided surgery was developed 60 years ago and the gamma detection probe technology for radioguided biopsy and/or resection of bone lesions has ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：:Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms most frequently found in the stomach and presenting without symptoms or with unspecific ones such as hemorrhage and abdominal pain. The malignant potential of GIST is variable and there are several prognostic indexes for treatment and follow up. The sup...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:We present an isolate of Klebsiella pneumoniae OXA-48 isolated in a 68-year-old man who underwent radical prostatectomy due to prostate cancer. The antibiotic susceptibility testing to a wide range of antibiotics was performed by disk diffusion method and determination of minimal inhibitory concentrations. The isolate...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.01.23
更新日期：2017-03-01 00:00:00
abstract：:The aim of the study was to determine the incidence of strabismus in preterm infants born between 2002 and 2005 in Split-Dalmatia County, and to compare it with term infants. Data were collected from Department of Public Health, Split-Dalmatia County and Strabology Outpatient Department, University Department of Ophth...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:In the past few decades, the survivor rate from childhood cancers has significantly increased due to constant modifications and improvements in treatment protocols, so the estimates are that childhood cancer occurs in 1 per 600 children, and that 1 per 450 adolescents or young adults is a long-term cancer survivor. Ne...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:The first beginnings of ophthalmic echography in Croatia started at the turn of the 1960s and 1970s. When the two largest medical institutions in Croatia, Sestre milosrdnice University Hospital (former Dr. Mladen Stojanović General Hospital) and Zagreb University Hospital Center, both in Zagreb, were supplied with ult...
journal_title：Acta clinica Croatica
pub_type： 历史文章,杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Two clinical forms of the "white spot" syndrome in patients with posterior uveitis in definitive and presumable ocular sarcoidosis were analyzed. Group 1 was characterized by periphlebitis and discrete white spots around the vein of the retina, so-called "candle-wax", whereas group 2 showed yellow-orange solitary nodu...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:The aim of the study was to investigate the association between some lifestyle-attributable risk factors of atherosclerosis, such as body mass index (BMI), oral contraceptives, hormone replacement therapy, smoking and alcohol consumption with breast arterial calcification (BAC) and its intensity on mammograms, and to ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：:Endocrinopathies are relatively rare causes of erectile dysfunction. Cases of hyperprolactinemia and pituitary adenomas have been previously reported. We present a clinical case of a 27-year-old male with suspected infertility and recent symptoms of erectile dysfunction. Additional radiological and endocrinologic work...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2020.59.01.22
更新日期：2020-03-01 00:00:00
abstract：:Helicobacter pylori (H. pylori) is a common problem and a significant cause of chronic gastric inflammation. H. pylori, ongoing gastric inflammation and its severity are the most critical component of precursors of gastric cancer. Hypothetically, every chronic tissue injury activates platelets, and the mean platelet v...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2019.58.04.02
更新日期：2019-12-01 00:00:00
abstract：:- This study aimed to investigate the impact of posture and anesthesia techniques on blood pressure changes, heart rate and regional cerebral oxygen saturation during shoulder arthroscopy in the beach chair position (BCP). Sixty patients were included in this prospective cohort study: 30 patients mechanically ventilat...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2018.57.03.10
更新日期：2018-09-01 00:00:00
abstract：:Acute stroke is one of the leading causes of morbidity and mortality worldwide, and as the most important cause of morbidity and long-term disability imposes an enormous economic burden. Stroke units (SU) are an effective option to fight stroke. According to the European Stroke Organization, SU should provide coordina...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:Although the incidence of ventilator-associated pneumonia (VAP) is very high, there are still many uncertainties about clinical course of VAP among tracheotomized patients. The goal of the present study was to determine the impact of tracheotomy on VAP incidence and etiology, as well as outcome of VAP patients with tr...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.01.15
更新日期：2017-03-01 00:00:00
abstract：:The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a biomarker in patients with aortic valve stenosis (AS) in relation to heart failure and symptomatic status. This was a case control study, which included 51 patients with AS and 39 control subjects. At the time of study enrolment, detailed ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.04.22
更新日期：2017-12-01 00:00:00
abstract：:Anticoagulant therapy may cause the onset of a spontaneous intramural hematoma of the small bowel, in the jejunum, ileum or duodenum. A 53-year-old woman on therapy with heparin for previous pulmonary embolism was admitted for abdominal pain and vomit. Computed tomography scan visualized an intramural hematoma of the ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
abstract：:The early child development, from birth until the age of one year is, amongst other changes, characterized by intense motor learning. During that period, the voluntary learning patterns evolve from reflexive patterns to coordinated voluntary patterns. All of the child's voluntary movements present active forms in whic...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-09-01 00:00:00
abstract：:The aim was to evaluate sexual function of healthy women in Croatia and the possible impact of depression, anxiety, and sociodemographic factors. A total of 204 healthy women filled in a basic sociodemographic questionnaire, the Patient Health Questionnaire-9, Anxiety Disorder-7, and Female Sexual Function Index (FSFI...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.04.12
更新日期：2019-12-01 00:00:00
abstract：:Nurses distinguish continuous professional development intended for career improvement and personal development from continuous professional development intended for improvement of skills and knowledge. Too many requests are put in front of an individual unacceptably stretching it onto the life outside work. Students ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:In this article, we document a conclusive case of nebivolol-induced hyperkalemia for the first time in the known medical literature. Hyperkalemia is associated with serious conditions such as cardiac arrhythmias and sudden cardiac death. Nebivolol was not known to cause hyperkalemia, and this event is not listed in it...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2016.55.04.20
更新日期：2016-12-01 00:00:00
abstract：:Head injuries are very common in children and are the most frequent cause of disability and death among children. This retrospective study included 350 children hospitalized for injury of neurocranium over a 5-year period at Dr Josip Bencević General Hospital in Slavonski Brod. Boys were more commonly injured (63.4%) ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:The aim of this study was to determine the correlation between the static and dynamic occlusal factors in patients with anterior disk displacement (DD) and to compare it with occlusion in asymptomatic individuals. The study included a group of 40 patients with DD (median age 35.5) and a control group of 25 students of...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Angiogenesis is essential for the development, growth and progression of tumors. Although vascular endothelial growth factor (VEGF) is a well-known proangiogenic factor, its impact on lymphoma has not yet been fully clarified. The aim of this study was to evaluate VEGF-A -expression and microvessel density (MVD) in ag...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2017.56.04.02
更新日期：2017-12-01 00:00:00
abstract：:The aim of this study was to evaluate the quantitative sonoelastographic values recorded on shear-wave sonoelastography (SWE) of high-risk breast lesions and ductal carcinoma in situ (DCIS). We retrospectively analyzed histopathologic and SWE data (quantitative maximum, minimum and mean stiffness, lesion-to-fat ratio ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：10.20471/acc.2019.58.01.02
更新日期：2019-03-01 00:00:00
abstract：:Renal artery embolism is a disease that is easily missed due to its infrequent and nonspecific presentations. Although early diagnosis and optimal thrombolytic treatment can sometimes restore renal function, therapeutic guidelines have not yet been established. However, early anticoagulant therapy is beneficial and se...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:- Peripheral nerve injuries in sports are rare. Peripheral nerve injuries in sports are caused by pressure, stretching, or bone fracture. Peripheral nerve injuries are more frequent on upper limbs, and the type of injury is determined by the type of sport. According to Seddon, we distinguish 3 levels of injury: 1) neu...
journal_title：Acta clinica Croatica
pub_type： 杂志文章,评审
doi：10.20471/acc.2018.57.03.20
更新日期：2018-09-01 00:00:00
abstract：:Primary mesenteric liposarcomas are very rare, especially when they are of mixed histologic pattern. Patient prognosis is based upon the most aggressive histologic type of liposarcoma. A case is reported of a 77-year-old man with a history of slowly increasing abdominal volume over 3 years. The diagnosis of giant intr...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
abstract：:Snoring is an acoustic phenomenon, which is a consequence of vibrations of the soft tissue caused by partial obstruction of the upper breathing pathway while sleeping. It is estimated that 20% of men and 5% of women between 30 and 35 years of age snore and this rate increases to 50% of men and 30% of women over 60 yea...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:Chronic wounds on lower extremities most commonly result from chronic venous insufficiency. Chronic leg ulcer impacts the quality of life in a number of ways such as reduced mobility, pain, unpleasant odor, sleep disturbances, social isolation, etc. This study included 100 patients with chronic wounds/lower leg ulcer ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：:The aim of the study was to assess how children and adolescents experience hospitalization and separation from their parents, their home and daily activities, in order to improve the psychosocial quality of hospital stay. Emotions and experiences reported by hospitalized children and adolescents are presented and disc...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:Gallstone ileus with impaction of gallstone in distal duodenum is an extremely rare complication of cholecystolithiasis. Gallstone ileus in itself accounts for less than 1% of these complications with 800 cases described so far. However, there are less than 15 cases described with the impaction of gallstone in distal ...
journal_title：Acta clinica Croatica
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
