Emerging therapies in traumatic hemorrhage control.

Abstract:

PURPOSE OF REVIEW:Care of the injured patient is a dynamic process. Hemorrhage remains the primary cause of preventable death after trauma. Rapid and effective early care can improve survival and outcomes. Emerging therapies to address traumatic hemorrhage will be discussed. RECENT FINDINGS:Current concepts in trauma care include damage control resuscitation with rapid surgical correction of bleeding; prevention of the development of the lethal triad; limitation of crystalloid administration and application of high ratios of plasma and platelets to packed red blood cells. Prehospital resuscitation strategies can effect care of the hemorrhaging trauma patient, as well. The goal should be to preserve vital functions without increasing the risk for further bleeding. The concept of hypotensive resuscitation has been formulated to address this issue. The type of resuscitation fluid also plays an important role, with novel fluids currently being studied for routine use. Compressible hemorrhage constitutes an important component of potentially survivable injury. Hemostatic dressings and tourniquets can prove essential to the management of combat and civilian wounds. SUMMARY:Given the potential to preserve life with appropriate attention applied to the bleeding trauma victim, it is vitally important to explore the options currently available and continue to make improvements in care.

journal_name

Curr Opin Crit Care

authors

Sambasivan CN,Schreiber MA

doi

10.1097/MCC.0b013e328331f57c

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

560-8

issue

6

eissn

1070-5295

issn

1531-7072

journal_volume

15

pub_type

杂志文章,评审
  • Uncertainty in end-of-life care.

    abstract:PURPOSE OF REVIEW:Uncertainty surrounding medical decision-making is particularly important during end-of-life decision-making. Doubts about the patient's best interests and prognostic accuracy may lead to conflict. RECENT FINDINGS:Many authors have suggested recently that medical attitudes to uncertainty need review....

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000030

    authors: Ridley S,Fisher M

    更新日期:2013-12-01 00:00:00

  • Novelties in pharmacological management of cardiopulmonary resuscitation.

    abstract:PURPOSE OF REVIEW:The ultimate goal of cardiopulmonary resuscitation is long-term neurologically intact survival. Despite numerous well-designed studies, the medications currently used in advanced cardiac life support have not demonstrated success in this regard. This review describes the novel therapeutics under inves...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e328364d7b1

    authors: Bartos JA,Yannopoulos D

    更新日期:2013-10-01 00:00:00

  • Current use of the pulmonary artery catheter.

    abstract:PURPOSE OF REVIEW:The pulmonary artery catheter is one of the most scrutinized monitors used in intensive care today. Pulmonary artery catheter use is declining due to limited demonstrated beneficial outcomes and the advancement of less invasive monitoring. This study discusses the current use of the pulmonary artery c...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e32832b302b

    authors: Greenberg SB,Murphy GS,Vender JS

    更新日期:2009-06-01 00:00:00

  • Outcome prediction in critical care: the Mortality Probability Models.

    abstract:PURPOSE OF REVIEW:The comparison of morbidity, mortality, and length-of-stay outcomes in patients receiving critical care requires adjustment based on their presenting illness. These adjustments are made with severity-of-illness models. These models must be periodically updated to reflect current medical practices. Thi...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e3283101643

    authors: Higgins TL,Teres D,Nathanson B

    更新日期:2008-10-01 00:00:00

  • Overview of ventilator-induced lung injury mechanisms.

    abstract:PURPOSE OF REVIEW:Mechanical ventilation is the main supportive therapy for patients with acute respiratory distress syndrome. As with any therapy, mechanical ventilation has side effects and may induce lung injury. This review will focus on stretch-dependent activation of alveolar epithelial and endothelial cells and ...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/00075198-200502000-00013

    authors: Lionetti V,Recchia FA,Ranieri VM

    更新日期:2005-02-01 00:00:00

  • Paralytics in critical care: not always the bad guy.

    abstract:PURPOSE OF REVIEW:The use of neuromuscular blocking agents (NMBAs) in patients with acute respiratory distress syndrome (ARDS) and acute lung injury remains controversial, although frequent. This review analyzes the effects of NMBAs on thoracopulmonary mechanics, gas exchange, patient outcome and their potential advers...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/mcc.0b013e3283220e60

    authors: Forel JM,Roch A,Papazian L

    更新日期:2009-02-01 00:00:00

  • Mental and physical disorders after ICU discharge.

    abstract:PURPOSE OF REVIEW:Research and studies related to the long-term consequences of intensive care are increasing. This review focuses on some of the most recent knowledge in this field. RECENT FINDINGS:Still studies regarding the health-related quality of life (HRQOL) in survivors after intensive care are frequently publ...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e32833cc90b

    authors: Flaatten H

    更新日期:2010-10-01 00:00:00

  • Critical care management of acute ischemic stroke.

    abstract:PURPOSE OF REVIEW:To review and examine the efficacy of recently described medical and surgical interventions after acute ischaemic stroke using data from well conducted, clinical trials and systematic reviews. This review will consider recently published or updated articles. RECENT FINDINGS:As therapeutic options evo...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/00075198-200404000-00006

    authors: Andrews PJ

    更新日期:2004-04-01 00:00:00

  • Update in intensive care medicine: acute liver failure. Initial management, supportive treatment and who to transplant.

    abstract:PURPOSE OF REVIEW:Acute liver failure (ALF) is associated with significant mortality. Although specific therapies may be available, the evidence base for these and for many aspects of supportive therapy has been slow to emerge. Liver transplantation continues to be a cornerstone of treatment, and the management of ALF,...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000073

    authors: Willars C

    更新日期:2014-04-01 00:00:00

  • Effect of ICU interventions on gastrointestinal motility.

    abstract:PURPOSE OF REVIEW:Early detection of gastrointestinal motility disturbances is a major goal to reduce the incidence of this potentially disastrous event by prophylactic managements and early goal-directed therapy in patients at risk. RECENT FINDINGS:Gastroparesis frequently results in the inability to feed critically ...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e3283356679

    authors: Fruhwald S,Kainz J

    更新日期:2010-04-01 00:00:00

  • Inflammation and cardiovascular diseases: lessons that can be learned for the patient with cardiogenic shock in the intensive care unit.

    abstract:PURPOSE OF REVIEW:In the past 12 years, atherosclerosis and the acute coronary syndromes have turned out to be thromboinflammatory diseases. Recent data suggest that inflammation also plays an important role in the pathogenesis and outcome of cardiogenic shock. This review will summarize recent advances in the understa...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccx.0000139364.53198.fd

    authors: Geppert A,Huber K

    更新日期:2004-10-01 00:00:00

  • Can we safely restrict transfusion in trauma patients?

    abstract:PURPOSE OF REVIEW:Transfusion of red blood cells in the trauma patient can be lifesaving. The question is how much and when? It is important to weigh the risks and benefits of red blood cell transfusions, as well alternatives to transfusion as these products are not benign. RECENT FINDINGS:We explore the evidence, and...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e32801067f0

    authors: McIntyre LA,Hebert PC

    更新日期:2006-12-01 00:00:00

  • Refractory status epilepticus.

    abstract:PURPOSE OF REVIEW:Although conventional anticonvulsant agents can terminate status epilepticus in most cases, a substantial minority of patients develops medically refractory status and requires more aggressive care. This review explores the options available. RECENT FINDINGS:Increasing numbers of previously unexpecte...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccx.0000157079.72999.87

    authors: Bleck TP

    更新日期:2005-04-01 00:00:00

  • Bone metabolism and fracture risk during and after critical illness.

    abstract:PURPOSE OF REVIEW:There is growing evidence that bone health is impacted during and after critical illness in multiple ways. In this review, we provide a practical update on postcritical care bone loss with an insight on identification of persons at risk, prevention and treatment strategies. RECENT FINDINGS:Critical i...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000734

    authors: Rousseau AF,Kerschan-Schindl K,Scherkl M,Amrein K

    更新日期:2020-08-01 00:00:00

  • Microcirculatory disorders during septic shock.

    abstract:PURPOSE OF REVIEW:Despite the progress made over the past 20 years in the treatment of septic shock, mortality remains high. Microcirculatory disorders raise considerable interest aiming to improve the understanding of the physiopathology of septic shock and its management. RECENT FINDINGS:Numerous experimental and cl...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000217

    authors: Ait-Oufella H,Bourcier S,Lehoux S,Guidet B

    更新日期:2015-08-01 00:00:00

  • Health-related quality of life: implications for critical care interventional studies and why we need to collaborate with patients.

    abstract:PURPOSE OF REVIEW:Health-related quality of life (HRQoL) is an important patient-reported outcome measure following critical illness. 'Validated' and professionally endorsed generic measures are widely used to evaluate critical care intervention and guide practice, policy and research. Although recognizing that they ar...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e32834a4bd4

    authors: Ramsay P

    更新日期:2011-10-01 00:00:00

  • Statins in the intensive care unit.

    abstract:PURPOSE OF REVIEW:Statins are effective lipid-lowering agents used extensively in medical practice. This review summarizes the evidence for statin treatment of cardiovascular patients in the intensive care unit and briefly discusses the role of statins in prevention and treatment of sepsis as a potential future applica...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccx.0000235207.00322.96

    authors: Merx MW,Weber C

    更新日期:2006-08-01 00:00:00

  • Urgent chemotherapy in hematological patients in the ICU.

    abstract:PURPOSE OF REVIEW:Over the past decades, survival of critically ill hematological patients has dramatically improved, and these patients are more frequently referred to the ICU for intensive treatment, including a rising need for administering anticancer-therapy in this setting. RECENT FINDINGS:The scarce literature o...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000254

    authors: Moors I,Pène F,Lengline É,Benoit D

    更新日期:2015-12-01 00:00:00

  • Diagnosis of intra-abdominal infection in the critically ill patient.

    abstract::Intra-abdominal infection continues to pose a significant threat to critically ill patients in the year 2000. A review of the current literature reveals that despite remarkable developments in critical care medicine and extensive study of patients with tertiary peritonitis, the associated mortality rate remains nearly...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/00075198-200104000-00010

    authors: Evans HL,Raymond DP,Pelletier SJ,Crabtree TD,Pruett TL,Sawyer RG

    更新日期:2001-04-01 00:00:00

  • Stress ulcer prophylaxis in the intensive care unit.

    abstract:PURPOSE OF REVIEW:Stress ulcer prophylaxis (SUP) is considered standard of care in the majority of critically ill patients in the ICU. In this review, we will present the current evidence for the use of SUP in ICU patients, including data on the prevalence of gastrointestinal bleeding and the balance between benefits a...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000290

    authors: Krag M,Perner A,Møller MH

    更新日期:2016-04-01 00:00:00

  • Renal dysfunction and fluid and electrolyte disturbances.

    abstract:PURPOSE OF REVIEW:To examine recent developments in preventing and treating postoperative acute renal dysfunction. To review contemporary issues concerning perioperative fluid and electrolyte management. RECENT FINDINGS:Renal dysfunction remains a major postoperative morbidity despite the advent of intermittent and co...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e328348bef5

    authors: Hashem R,Weissman C

    更新日期:2011-08-01 00:00:00

  • Patient-related risk factors for postoperative adverse events.

    abstract:PURPOSE OF REVIEW:The risk of adverse outcome in patients undergoing major surgery is affected both by cardiorespiratory fitness, and the presence and severity of comorbidities. Accurate risk stratification is essential for the identification of patients who may benefit from specific perioperative management strategies...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0b013e32832e067c

    authors: Moonesinghe SR,Mythen MG,Grocott MP

    更新日期:2009-08-01 00:00:00

  • Esophageal pressure monitoring: why, when and how?

    abstract:PURPOSE OF REVIEW:Esophageal manometry has shown its usefulness to estimate transpulmonary pressure, that is lung stress, and the intensity of spontaneous effort in patients with acute respiratory distress syndrome. However, clinical uptake of esophageal manometry in ICU is still low. Thus, the purpose of review is to ...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000494

    authors: Yoshida T,Brochard L

    更新日期:2018-06-01 00:00:00

  • Advanced extracorporeal therapy in trauma.

    abstract:PURPOSE OF REVIEW:The purpose is to review the current application of extracorporeal life support (ECLS) in trauma patients. In addition, programmatic development is described. RECENT FINDINGS:ECLS use is increasing among trauma patients. Several recent studies among trauma patients report survival rates of 65-79%. De...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000366

    authors: Zonies D,Merkel M

    更新日期:2016-12-01 00:00:00

  • Implications of arterial pressure variation in patients in the intensive care unit.

    abstract::Positive-pressure ventilation alters stroke volume by transiently increasing intrathoracic pressure and thereby decreasing preload. This phasic variation in stroke volume results in a cyclic fluctuation in arterial pressure with a phase length equal to the respiratory rate. Measuring ventilation-induced arterial press...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/00075198-200106000-00012

    authors: Gunn SR,Pinsky MR

    更新日期:2001-06-01 00:00:00

  • Nutritional and metabolic supplementation for the injured brain: an update.

    abstract:PURPOSE OF REVIEW:Energy dysfunction is increasingly recognized as a key factor in the pathogenesis of acute brain injury (ABI). This one characterized by a high metabolic rate and nitrogen loss is often associated with an undernutrition support. We review the metabolism evolution and nutritional status in brain injure...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000588

    authors: Quintard H,Ichai C

    更新日期:2019-04-01 00:00:00

  • Optimal and responsible use of antibiotics.

    abstract:PURPOSE OF REVIEW:In this review, we focus on the dual face of antibiotic therapy in the critically ill that must harmonize the need for early, appropriate and adequate antibiotic therapy in the individual-infected patient with the obligation to limit antibiotic selection pressure as much as possible to preserve its fu...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000645

    authors: Depuydt P,De Waele JJ

    更新日期:2019-10-01 00:00:00

  • Post-conditioning to improve cardiopulmonary resuscitation.

    abstract:PURPOSE OF REVIEW:Despite decades of advances in prehospital and in-hospital medical care, patients with out-of-hospital cardiac arrest continue to have poor neurologic and cardiac function following otherwise successful resuscitation. This review examines the mechanisms and therapeutic strategies currently under devel...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/MCC.0000000000000087

    authors: Bartos JA,Debaty G,Matsuura T,Yannopoulos D

    更新日期:2014-06-01 00:00:00

  • A history of outcome prediction in the ICU.

    abstract:PURPOSE OF REVIEW:There are few first-hand accounts that describe the history of outcome prediction in critical care. This review summarizes the authors' personal perspectives about the development and evolution of Acute Physiology and Chronic Health Evaluation over the past 35 years. RECENT FINDINGS:We emphasize what...

    journal_title:Current opinion in critical care

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/MCC.0000000000000138

    authors: Zimmerman JE,Kramer AA

    更新日期:2014-10-01 00:00:00

  • Severe cardiac disease in pregnancy, part II: impact of congenital and acquired cardiac diseases during pregnancy.

    abstract:PURPOSE OF REVIEW:Part II of this review gives an overview of the different maternal cardiac problems during pregnancy and their management, and developments over recent years. RECENT FINDINGS:Many studies published over the last 5 years provided new insights on different cardiac diseases in pregnancy. Publications di...

    journal_title:Current opinion in critical care

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccx.0000179806.15328.b9

    authors: van Mook WN,Peeters L

    更新日期:2005-10-01 00:00:00