Hepatic epithelioid haemangioendothelioma: challenges in diagnosis and management.

Abstract:

BACKGROUND:  Hepatic epithelioid haemangioendothelioma (HEH) is a rare, low grade malignant neoplasm of endothelial origin which is difficult to diagnose and has a variable outcome. We review five HEH cases from our centre with the aim of identifying clinical predictors of outcome and various therapeutic options. METHODS:  A search was made on the WA Liver Transplant registry for cases with histologically confirmed HEH. Their medical records were reviewed. A literature search was conducted through Medline using terms to compare the results from this series with those of other series. RESULTS:  Five patients were identified to have HEH. The mean age was 44.2years (range 34-53years). Four of five patients presented with dyspepsia and two patients had clinical evidence of portal hypertension with ascites. Two patients had radiologically diffuse disease and three patients had discrete nodular liver involvement. The mean duration from presentation of symptoms to diagnosis of HEH was 26.8months. Liver transplantation was performed in one patient with diffuse HEH who is alive with no disease recurrence at 3years. Three patients with radiologically stable disease followed with 6monthly surveillance imaging are currently alive and well. The median survival of all five patients was 5years (range 1.5-16years) at the time of follow up. CONCLUSIONS:  These results support the role of surveillance alone for patients with focal and radiologically stable disease. Patients with diffuse HEH with hepatic decompensation should be considered for transplantation. However, numbers are small and an international registry is required to make firm comparisons.

journal_name

Intern Med J

authors

Thin LW,Wong DD,De Boer BW,Ferguson JM,Adams L,Macquillan G,Delriviere L,Mitchell A,Jeffrey GP

doi

10.1111/j.1445-5994.2009.02043.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

710-5

issue

10

eissn

1444-0903

issn

1445-5994

pii

IMJ2043

journal_volume

40

pub_type

杂志文章
  • Beneficial effect of awake prone position in hypoxaemic patients with COVID-19: case reports and literature review.

    abstract::We hereby present two case reports of moderate coronavirus disease patients, suffering from profound hypoxaemia, further deteriorating later on. A schedule pre-planned awake prone position manoeuvres were executed during their hospital stay. Following this, the patients' saturation improved, later to be weaned from ox...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14926

    authors: Cohen D,Wasserstrum Y,Segev A,Avaky C,Negru L,Turpashvili N,Anani S,Zilber E,Lasman N,Athamna A,Segal O,Shenhav-Saltzman G,Segal G

    更新日期:2020-08-01 00:00:00

  • Prognostic value of trisomy 8 in primary myelodysplastic syndrome.

    abstract:BACKGROUND:  According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be cate...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2009.02061.x

    authors: Ma Y,Wang X,Xu X,Lin G

    更新日期:2010-10-01 00:00:00

  • Royal College of Physicians of London: a 1793 entrant, fabled fellow or member malcontent.

    abstract::The adverse fallout following the Royal Australasian College of Physician's (RACP) introduction to computer-based testing that was disrupted in the February 2018 examinations, aroused great sympathy for the candidates and perhaps rekindled worrying memories by the College fellowship. The RACP's entrance procedures hav...

    journal_title:Internal medicine journal

    pub_type: 历史文章,杂志文章

    doi:10.1111/imj.14206

    authors: H Short B

    更新日期:2019-02-01 00:00:00

  • Characteristics of adrenal incidentalomas in a New Zealand centre.

    abstract:BACKGROUND:Management of adrenal incidentalomas (AI) is becoming more conservative, based on international data showing a low incidence of functional or malignant lesions. The clinical characteristics of AI in New Zealand are unknown. Therefore, whether the AI guidelines apply to the New Zealand population is also unkn...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13651

    authors: Goh Z,Phillips I,Hunt PJ,Soule S,Cawood TJ

    更新日期:2018-02-01 00:00:00

  • Neurological manifestations of cardiac myxoma: a review of the literature and report of cases.

    abstract:BACKGROUND AND AIMS:Cardiac myxoma is a rare but important cause of stroke, which affects young people. More recently the diagnosis has been enhanced by the use of echocardiograms. We aimed to review the neurological presentations, including stroke, of cardiac myxoma in this modern era of diagnosis and management. MET...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1444-0903.2004.00563.x

    authors: Ekinci EI,Donnan GA

    更新日期:2004-05-01 00:00:00

  • Development of teaching, mentoring and supervision skills for basic training registrars - a frustrated apprenticeship?

    abstract:BACKGROUND:Teaching, mentoring and supervision (TMS) are fundamental skills with a specific commitment within the Royal Australasian College of Physicians (RACP) professional practice framework. The new basic training standards include 'use of appropriate educational techniques to facilitate the learning of peers, juni...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14935

    authors: Chapman L,Mysko C,Coombridge H

    更新日期:2020-06-08 00:00:00

  • Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand.

    abstract::Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.13804

    authors: Fox LC,Cohney SJ,Kausman JY,Shortt J,Hughes PD,Wood EM,Isbel NM,de Malmanche T,Durkan A,Hissaria P,Blombery P,Barbour TD

    更新日期:2018-06-01 00:00:00

  • Perioperative management of new oral anticoagulants in patients undergoing elective surgery at a tertiary hospital.

    abstract:BACKGROUND:Increasing numbers of patients receiving new oral anticoagulants (NOAC) are undergoing elective surgery. The extent to which perioperative interruption of NOAC therapy and use of bridging heparin are concordant with best evidence is uncertain. AIMS:To determine: (i) concordance of NOAC and bridging heparin ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13513

    authors: Wamala H,Scott IA,Caney X

    更新日期:2017-12-01 00:00:00

  • Evaluation of clinical guidelines for the management of Staphylococcus aureus bacteraemia.

    abstract:BACKGROUND:While treatment guidelines have been developed to guide the management of Staphylococcus aureus bacteraemia, there is a need to validate these guidelines in different clinical settings and to relate the effect of compliance to clinical outcome. AIMS:To assess the impact of adherence to treatment guidelines ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1046/j.1445-5994.2001.00205.x

    authors: Blyth CC,Darragh H,Whelan A,O'Shea JP,Beaman MH,McCarthy JS

    更新日期:2002-05-01 00:00:00

  • Malignancy screening in autoimmune myositis among Australian rheumatologists.

    abstract:BACKGROUND:The international literature advocates for cancer screening in newly diagnosed patients with autoimmune myositis; however, there is no widely accepted consensus or guideline to outline the optimal cancer screening strategy and the evidence is currently insufficient to support any recommendation. AIM:Our stu...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13556

    authors: Dutton K,Soden M

    更新日期:2017-12-01 00:00:00

  • The mind of a failing heart: a systematic review of the association between congestive heart failure and cognitive functioning.

    abstract:BACKGROUND:Congestive heart failure (CHF) is a frequent complication of most diseases of the heart. CHF is associated with impairment in several aspects of the quality of life of patients, including mood and cognitive performance. Early reports indicated that patients with CHF display deficits in memory and other intel...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1046/j.1445-5994.2001.00067.x

    authors: Almeida OP,Flicker L

    更新日期:2001-07-01 00:00:00

  • Role of long-term mechanical circulatory support in patients with advanced heart failure.

    abstract::Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.12817

    authors: Stokes MB,Bergin P,McGiffin D

    更新日期:2016-05-01 00:00:00

  • Acute pulmonary embolism: a concise review of diagnosis and management.

    abstract::An acute pulmonary embolism (aPE) is characterised by occlusion of one or more pulmonary arteries. Physiological disturbance may be minimal, but often cardiac output decreases as the right ventricle attempts to overcome increased afterload. Additionally, ventilation-perfusion mismatches can develop in affected vascula...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.14145

    authors: Hepburn-Brown M,Darvall J,Hammerschlag G

    更新日期:2019-01-01 00:00:00

  • CHA2 DS2 VASc score predicts unsuccessful electrical cardioversion in patients with persistent atrial fibrillation.

    abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia occurring in 2% of the population. It is known that AF increases morbidity and limits quality of life. The CHA2 DS2 VASc score (congestive heart failure/left ventricular dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular d...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13319

    authors: Mlodawska E,Tomaszuk-Kazberuk A,Lopatowska P,Kaminski M,Musial WJ

    更新日期:2017-03-01 00:00:00

  • Sputum bacteriology in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease and concomitant pneumonia in Hong Kong.

    abstract:AIM:To study the sputum microbiology of patients admitted to a teaching hospital with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with concomitant pneumonia. METHODS:This was a retrospective study in a tertiary university hospital in Hong Kong. All episodes of AECOPD with pneumonia, patient d...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2005.00956.x

    authors: Ko FW,Lam RK,Li TS,Fok JP,Chan MC,Ng TK,Chan DP,Hui DS

    更新日期:2005-11-01 00:00:00

  • Spontaneous pneumothorax: time for some fresh air.

    abstract::Conventional teaching on the mechanisms and treatment of spontaneous pneumothorax is either obviously wrong or based on a misunderstanding of the natural history of the condition. Spontaneous pneumothorax is a generally benign, self-limiting condition where conservative management should be considered. If intervention...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2009.02155.x

    authors: Simpson G

    更新日期:2010-03-01 00:00:00

  • Pandemics in ancient Greek and Roman coinage: medical memories at the service of hope.

    abstract::Medical goddesses and gods invoked in the Hippocratic Oath were called on in times of pandemics along with Greek physicians such as Galen of Pergamum. Ancient Greek and Roman coinage provide insights into the coexisting religious and rational approaches to medicine rooted in Classical Antiquity, portraying medical sym...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15111

    authors: Iniesta I

    更新日期:2020-12-01 00:00:00

  • Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections.

    abstract::ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1444-0903.2004.00541.x

    authors: Slavin MA,Szer J,Grigg AP,Roberts AW,Seymour JF,Sasadeusz J,Thursky K,Chen SC,Morrissey CO,Heath CH,Sorrell T

    更新日期:2004-04-01 00:00:00

  • Survival after the initiation of combination therapy in patients with pulmonary arterial hypertension: an Australian collaborative report.

    abstract:BACKGROUND:  Several cellular pathways are implicated in the pathogenesis of pulmonary arterial hypertension (PAH) and attempts to arrest disease progression with a single drug would not be expected to succeed in the medium term. In clinical practice, combination therapy is often used in patients deteriorating on monot...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1445-5994.2010.02403.x

    authors: Keogh A,Strange G,Kotlyar E,Williams T,Kilpatrick D,Macdonald P,Brown K,Pidoux A,Kermeen F,Steele P,Dalton B,Gabbay E

    更新日期:2011-03-01 00:00:00

  • No effect of sleeved arms on the accuracy of blood pressure measurement.

    abstract:BACKGROUND:It is recommended that blood pressure should be measured on a bare upper arm with an appropriately sized cuff. However, in practice, it is more convenient to measure blood pressure on sleeved arms. AIMS:We aim to examine the effect of sleeved arms on the accuracy of blood pressure measurement. METHODS:Pati...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15071

    authors: Li Y,Li Y,Li F,Liu D,Zhang Y,Cui X,Cui W

    更新日期:2020-09-25 00:00:00

  • Ethics and public health.

    abstract::This paper examines the differences between clinical and public health ethics and provides several examples of contemporary public health challenges that pose ethical questions. The relations among ethics, rights and obligations are explored, because public health philosophers propose these as different ways for publi...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2004.00643.x

    authors: Leeder SR

    更新日期:2004-07-01 00:00:00

  • Unrelated umbilical cord blood transplantation for adults with haematological malignancies: results from a single Australian centre.

    abstract:BACKGROUND:A number of haematological malignancies can be cured by allogeneic stem cell transplantation but only approximately 30% of Australians have a suitable histocompatible related donor. Matched donors can be found on international registries of unrelated volunteers for a proportion of the remaining patients. For...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2006.01079.x

    authors: Bradstock KF,Hertzberg MS,Kerridge IH,Svennilson J,McGurgan M,Huang G,Antonenas V,Gottlieb DJ

    更新日期:2006-06-01 00:00:00

  • Hypocognition and evidence-based medicine.

    abstract::The enthusiasm for evidence-based medicine (EBM) has not been accompanied by the same success in bridging the gap between theory and practice. This paper advances the hypothesis that the phenomenon psychologists call hypocognition may hinder the development of EBM. People tend to respond to frames rather than to facts...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2009.02086.x

    authors: Mariotto A

    更新日期:2010-01-01 00:00:00

  • "I'm glad I'm not young anymore".

    abstract::The author, a physician in late middle age reflects on his own medical career, the aging of those who have taught him and also of those whom he has taught. He describes the sense of ennui and déjà vu. The things that seemed important as a younger doctor seem less important. He has adopted a different paradigm and has ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2006.01256.x

    authors: Allen RK

    更新日期:2006-12-01 00:00:00

  • The occurrence of asthma in hospitalized patients with type 2 diabetes mellitus.

    abstract::Diabetes mellitus (DM) has been found to be associated with cardiovascular disease. The goal of this study is to evaluate the prevalence of asthma in patients with type II DM after adjusting for other comorbid conditions. We used patient treatment files of inpatients' admissions containing discharge diagnosis (Classif...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2009.01976.x

    authors: Hashemzadeh M,Movahed MR

    更新日期:2009-10-01 00:00:00

  • Cardiac involvement in Henoch-Schönlein purpura.

    abstract::Cardiac involvement is not regarded as a feature of Henoch-Schönlein purpura (HSP). We report a patient with HSP who developed significant cardiac symptoms, which resolved with immunosuppression. We review previous cases of HSP with cardiac features, none of which showed a response to treatment, and discuss evidence t...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2006.01061.x

    authors: Polizzotto MN,Gibbs SD,Beswick W,Seymour JF

    更新日期:2006-05-01 00:00:00

  • Cognitive function during exacerbations of chronic obstructive pulmonary disease.

    abstract:BACKGROUND:The reported prevalence of cognitive impairment in patients with stable chronic obstructive pulmonary disease (COPD) ranges 36-77%. Few studies report the prevalence of cognitive impairment in acutely unwell COPD patients. AIMS:To determine the prevalence and time course of cognitive impairment in patients ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14259

    authors: Poot B,Travers J,Weatherall M,McGinty M

    更新日期:2019-10-01 00:00:00

  • Informed consent and medical ordeal: a qualitative study.

    abstract:BACKGROUND:Informed consent is a mainstay of clinical practice, with both moral and legal forces. Material disclosure about extreme treatments, however, is unlikely to convey the full impact of the experience of treatment. Informed consent may be flawed under such circumstances. The aims of this study were to compare e...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2008.01700.x

    authors: Little M,Jordens CF,McGrath C,Montgomery K,Lipworth W,Kerridge I

    更新日期:2008-08-01 00:00:00

  • Prescribing in the oldest old inpatients: a retrospective analysis of patients referred for specialist geriatric consultation.

    abstract:BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13526

    authors: Ilango S,Pillans P,Peel NM,Scott I,Gray LC,Hubbard RE

    更新日期:2017-09-01 00:00:00

  • Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis.

    abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, enters human cells by binding of its viral protein to the aminopeptidase angiotensin-converting enzyme 2 (ACE2). This has led to speculation whether treatment with renin-angiotensin system (RAS) inhibitors was asso...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,meta分析

    doi:10.1111/imj.15002

    authors: Koshy AN,Murphy AC,Farouque O,Ramchand J,Burrell LM,Yudi MB

    更新日期:2020-12-01 00:00:00