Abstract:
BACKGROUND:The temporal pattern of effects of summertime ozone (O(3)) in total, cardiovascular and respiratory mortality were investigated in 21 European cities participating in the APHEA-2 (Air Pollution and Health: a European Approach) project, which is fundamental in determining the importance of the effect in terms of life loss. METHODS:Data from each city were analysed separately using distributed lag models with up to 21 lags. City-specific air pollution estimates were regressed on city-specific covariates to obtain overall estimates and to explore sources of possible heterogeneity. RESULTS:Stronger effects on respiratory mortality that extend to a period of 2 weeks were found. A 10 microg/m(3) increase in O(3) was associated with a 0.36% (95% CI -0.21% to 0.94%) increase in respiratory deaths for lag 0 and with 3.35% (95% CI 1.90% to 4.83%) for lags 0-20. Significant adverse health effects were found of summer O(3) (June-August) on total and cardiovascular mortality that persist up to a week, but are counterbalanced by negative effects thereafter. CONCLUSIONS:The results indicate that studies on acute health effects of O(3) using single-day exposures may have overestimated the effects on total and cardiovascular mortality, but underestimated the effects on respiratory mortality.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Samoli E,Zanobetti A,Schwartz J,Atkinson R,LeTertre A,Schindler C,Pérez L,Cadum E,Pekkanen J,Paldy A,Touloumi G,Katsouyanni Kdoi
10.1136/jech.2008.084012subject
Has Abstractpub_date
2009-12-01 00:00:00pages
960-6issue
12eissn
0143-005Xissn
1470-2738pii
jech.2008.084012journal_volume
63pub_type
杂志文章,多中心研究abstract:STUDY OBJECTIVE:The aim of the study was to examine a cohort of cases of childhood cancer occurring in a defined geographical area to try to identify clustering and possible causative factors. DESIGN:Data were analysed using the close pair method developed by Knox for signs of clustering in relation to date and place ...
journal_title:Journal of epidemiology and community health
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journal_title:Journal of epidemiology and community health
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