Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor.

abstract：BACKGROUND:Children with sickle cell disease (SCD) and abnormal transcranial Doppler (TCD) ultrasonography have a high risk of stroke, but this risk is greatly reduced when chronic transfusion therapy is administered. The change in TCD velocities during chronic transfusion therapy and rate and frequency of normalizatio...

journal_title：Pediatric blood & cancer

authors： Kwiatkowski JL,Yim E,Miller S,Adams RJ,STOP 2 Study Investigators.

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Bleomycin is associated with pulmonary toxic side effects including pneumonitis and pulmonary fibrosis. We evaluated the prevalence of long-term pulmonary function abnormalities in children receiving bleomycin therapy in the context of current chemotherapeutic regimens. METHODS:A retrospective review of pat...

journal_title：Pediatric blood & cancer

authors： De A,Guryev I,LaRiviere A,Kato R,Wee CP,Mascarenhas L,Keens TG,Venkatramani R

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To report the final analysis of survival outcomes for children with newly diagnosed high-grade glioma (HGG) treated on the "Head Start" (HS) II and III protocols with chemotherapy and intent to avoid irradiation in children <6 years old. PATIENTS AND METHODS:Between 1997 and 2009, 32 eligible children were enr...

journal_title：Pediatric blood & cancer

authors： Espinoza JC,Haley K,Patel N,Dhall G,Gardner S,Allen J,Torkildson J,Cornelius A,Rassekh R,Bedros A,Etzl M,Garvin J,Pradhan K,Corbett R,Sullivan M,McGowage G,Stein D,Jasty R,Sands SA,Ji L,Sposto R,Finlay JL

更新日期：2016-10-01 00:00:00

abstract：:We report two survivors of Wilms tumor (WT) who developed inflammatory myofibroblastic tumor (IMT). The first patient had IMT in the mainstem bronchus 1 year after WT therapy that included vincristine, dactinomycin, doxorubicin (VDA) and whole lung radiation therapy (XRT). The second patient had IMT in the cecum 7 yea...

journal_title：Pediatric blood & cancer

authors： Ortiz MV,Rossi CT,Hill DA,Guzzetta PC,Qureshi F,Dome JS

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) are at increased risk of death from invasive bacterial infections. Emergent evaluation of fever allows early treatment of potentially fatal infections. Limited data exist regarding caregiver adherence to physician recommendations of prompt medical evaluation of fever i...

journal_title：Pediatric blood & cancer

authors： Schultz CL,Tchume-Johnson T,Schapira MM,Bellamy S,Smith-Whitley K,Ellison A

更新日期：2015-11-01 00:00:00

abstract：:Although awareness of implicit bias and its influence on providers and patients is increasing, the effects of implicit bias on the field of pediatric hematology-oncology are less clear. This Special Report reviews the literature on implicit bias in pediatrics and medical oncology and further provides case examples and...

journal_title：Pediatric blood & cancer

authors： Tsai JW,Kesselheim JC

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Hemophagocytic Lymphohistiocytosis (HLH) is characterized by uncontrolled inflammation that is generally fatal without immune modulating chemotherapy. At Texas Children's Hospital, we have observed significant central nervous system (CNS) toxicity in several patients treated for HLH according to the Histiocy...

journal_title：Pediatric blood & cancer

authors： Thompson PA,Allen CE,Horton T,Jones JY,Vinks AA,McClain KL

更新日期：2009-05-01 00:00:00

abstract：:A 17-year-old girl with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with persistent minimal residual disease (MRD) who underwent standard chemotherapy was found to have a BCR-ABL1-like gene expression pattern. Genome sequencing revealed a JAK2 mutation not previously described in BCP-ALL and a potential th...

journal_title：Pediatric blood & cancer

authors： Mayfield JR,Czuchlewski DR,Gale JM,Matlawska-Wasowska K,Vasef MA,Nickl C,Pickett G,Ness SA,Winter SS

更新日期：2017-05-01 00:00:00

abstract：:Under and overweight, usually secondary to energy imbalance, are common complications of childhood chronic disease. A simple energy balance paradigm has been helpful in understanding the etiology of underweight and overweight in chronic disease, including malignant disease, particularly when measurements of total ener...

journal_title：Pediatric blood & cancer

authors： Reilly JJ

更新日期：2008-02-01 00:00:00

abstract：:Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

journal_title：Pediatric blood & cancer

authors： Powers JM,Daniel CL,McCavit TL,Buchanan GR

更新日期：2016-04-01 00:00:00

abstract：:We report on an acute myeloid leukemia in a neonate whose mother was exposed to diethylstilboestrol in utero. The newborn presented with leukemia cutis, hemorrhagic skin lesions, hyperleucocytosis and disseminated intravascular coagulation. A bone marrow examination confirmed the diagnosis of acute monocytic leukemia ...

journal_title：Pediatric blood & cancer

authors： Chantrain CF,Sauvage D,Brichard B,Dupont S,Poirel HA,Ameye G,De Weer A,Vandenberghe P,Detaille T,Anslot C,de Cléty SC,Vermylen C

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Because of major improvements in treatment protocols, the survival rate now exceeds 80%. However, ALL treatments can cause long-term neurocognitive sequelae, which negatively impact academic achievement and quality of life. Therefore, ...

journal_title：Pediatric blood & cancer

authors： Boulet-Craig A,Robaey P,Laniel J,Bertout L,Drouin S,Krajinovic M,Laverdière C,Sinnett D,Sultan S,Lippé S

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Hepatic sinusoidal obstruction syndrome (SOS) is a serious complication of autologous stem cell transplant (ASCT) in children with historically high mortality rates. Defibrotide has shown proven benefit in its treatment and may have a modest role in prevention. We report our experience with SOS in children u...

journal_title：Pediatric blood & cancer

authors： Roy Moulik N,Johnson I,Van Bruggen L,Petterson T,Mycroft J,Vaidya SJ

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Alveolar soft-part sarcoma (ASPS), a rare vascular sarcoma with a clinically indolent course, frequently presents with metastases. Vascular endothelial growth factor (VEGF) is a promising therapeutic target. In a phase-II trial of the VEGF receptor inhibitor cediranib for adults with ASPS, the partial respon...

journal_title：Pediatric blood & cancer

authors： Cohen JW,Widemann BC,Derdak J,Dombi E,Goodwin A,Dompierre J,Onukwubiri U,Steinberg SM,O'Sullivan Coyne G,Kummar S,Chen AP,Glod J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas (STS) are a heterogeneous group of mesenchymal malignancies that occur throughout the lifespan. The impact of age on disease features and outcome is unclear. METHODS:We analyzed the clinical features and outcome of all STS cases registered between 1973 and 2006 in the SEER database. RE...

journal_title：Pediatric blood & cancer

authors： Ferrari A,Sultan I,Huang TT,Rodriguez-Galindo C,Shehadeh A,Meazza C,Ness KK,Casanova M,Spunt SL

更新日期：2011-12-01 00:00:00

abstract：:A 6-year-old male with chronic granulomatous disease, who was transplanted with bone marrow and exhibited increasing mixed chimerism, subsequently received two donor lymphocyte infusions (DLI). Two weeks after the second DLI, the patient developed acute graft-versus-host disease (GVHD) and progressive pancytopenia tha...

journal_title：Pediatric blood & cancer

authors： Kato I,Umeda K,Awaya T,Yui Y,Niwa A,Fujino H,Matsubara H,Watanabe K,Heike T,Adachi N,Endo F,Mizukami T,Nunoi H,Nakahata T,Adachi S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Asparaginase (Asp) and corticosteroid (CS) treatment in patients with acute lymphoblastic leukaemia (ALL) is associated with an increased risk of thrombotic events. OBJECTIVE:Characterization of global haemostatic phenotypes of patients with ALL during Asp therapy. PROCEDURE:Thrombin generation (TG) was mo...

journal_title：Pediatric blood & cancer

authors： Rozen L,Noubouossie D,Dedeken L,Huybrechts S,Lê PQ,Ferster A,Demulder A

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Pediatric cancer-induced financial burden is source of stress for parents, particularly mothers, single parents, and parents with lower incomes. This financial burden has been linked to poorer family quality of life (QOL) in terms of new onset material hardships, and could also affect individual QOL in terms...

journal_title：Pediatric blood & cancer

authors： Santacroce SJ,Kneipp SM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra-adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline ...

journal_title：Pediatric blood & cancer

authors： Virgone C,Andreetta M,Avanzini S,Chiaravalli S,De Pasquale D,Crocoli A,Inserra A,D'Angelo P,Alaggio R,Opocher G,Cecchetto G,Ferrari A,Bisogno G,Dall'Igna P

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Undernutrition impacts clinical outcome adversely in children with cancer. This study aimed to validate a nutritional algorithm with specific application to the low- and middle-income country (LMIC) setting. PROCEDURE:Fifty children with a new diagnosis of cancer were enrolled in this randomized interventio...

journal_title：Pediatric blood & cancer

authors： Totadri S,Trehan A,Mahajan D,Viani K,Barr R,Ladas EJ

更新日期：2019-12-01 00:00:00

abstract：:Undifferentiated embryonal sarcoma of the liver (UESL) is a rare aggressive mesenchymal pediatric tumor. Previously, reported outcomes have been very poor. Here, we report a single-center experience of five patients with UESL treated with upfront gross total resection and adjuvant chemotherapy. We have a median follow...

journal_title：Pediatric blood & cancer

authors： Mathias MD,Ambati SR,Chou AJ,Slotkin EK,Wexler LH,Meyers PA,Magnan H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Nephrogenic rests (NRs) are abnormally persistent foci of embryonal cells, thought to be the precursor lesion of Wilms tumors (WTs). To date, their presence has not been systematically examined in WTs treated with preoperative chemotherapy. METHODS:A systematic analysis of the data on NRs in WTs treated wit...

journal_title：Pediatric blood & cancer

authors： Vujanić GM,Apps JR,Moroz V,Ceroni F,Williams RD,Sebire NJ,Pritchard-Jones K

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Survivors of childhood brain tumors are at increased risk for neurocognitive impairments, including deficits in abilities supported by frontal brain regions. Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and b...

journal_title：Pediatric blood & cancer

authors： Howarth RA,Adamson AM,Ashford JM,Merchant TE,Ogg RJ,Schulenberg SE,Ogg S,Li J,Wu S,Xiong X,Conklin HM

更新日期：2014-01-01 00:00:00

abstract：:The youngest siblings may be both emotionally vulnerable and often neglected members of the family of a childhood cancer patient. The prompt identification of signs of distress in these subjects allows trained caregivers to intervene with personalized, age-appropriate, attention, and care. A narrative approach, based ...

journal_title：Pediatric blood & cancer

authors： Massimo LM,Wiley TJ

更新日期：2008-03-01 00:00:00

abstract：:The provision of tele-practice symptom management is often without the provision of evidence-based guidelines. Under the auspices of the Pediatric Oncology Group of Ontario, a nursing task force was established to appraise the evidence and develop guidelines. Promising new efforts to enhance symptom management through...

journal_title：Pediatric blood & cancer

authors： Tsimicalis A,De Courcy MJ,Di Monte B,Armstrong C,Bambury P,Constantin J,Dagelman B,Eves M,Jansen P,Honeyford L,Stregger D,Pediatric Oncology Group of Ontario.

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:SIOPEL protocols have recommended liver transplantation for unresectable hepatoblastoma (HBL) after chemotherapy in absence of visible extrahepatic disease. METHODS:This retrospective single center study includes 13 children treated following SIOPEL 3 or 4 protocols who underwent orthotopic liver transplant...

journal_title：Pediatric blood & cancer

authors： Héry G,Franchi-Abella S,Habes D,Brugières L,Martelli H,Fabre M,Pariente D,Gauthier F,Jacquemin E,Branchereau S

更新日期：2011-12-15 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES), a highly aggressive tumor of children and young adults, is characterized most commonly by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in ES have been extensively re...

journal_title：Pediatric blood & cancer

authors： Nestheide S,Bridge JA,Barnes M,Frayer R,Sumegi J

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

journal_title：Pediatric blood & cancer

authors： Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

更新日期：2013-11-01 00:00:00

abstract：:We report the results of a protocol for the diagnosis and treatment of pediatric non-Hodgkin lymphomas (NHL) conducted in Nicaragua in the context of an international collaborative program. Fifty-three children with NHL treated between 1996 and 2003 were retrospectively evaluated. Therapy was designed based on local d...

journal_title：Pediatric blood & cancer

authors： Baez F,Pillon M,Manfredini L,Ocampo E,Mendez G,Ortiz R,Palacios R,Gutierrez T,Tridello G,Conter V,Valsecchi M,Fossati Bellani F,Cavalli F,Masera G,Rosolen A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Extramedullary infiltration (EMI) is an occasional clinical symptom in childhood acute myelogenous leukemia (AML), but there is considerable controversy regarding the prognostic significance of EMI in AML. PROCEDURE:We evaluated the frequency and prognostic significance of EMI at diagnosis of AML in childre...

journal_title：Pediatric blood & cancer

authors： Kobayashi R,Tawa A,Hanada R,Horibe K,Tsuchida M,Tsukimoto I,Japanese childhood AML cooperative study group.

更新日期：2007-04-01 00:00:00