Long-term follow-up of the thyroid gland after treatment with 131I-Metaiodobenzylguanidine in children with neuroblastoma: importance of continuous surveillance.

Abstract:

BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. MATERIALS AND METHODS:All long-term survivors of childhood NBL treated with (131) I-MIBG in the period 1989-1999 in our center (n = 16 of 43) were evaluated. During exposure to (131) I-MIBG, patients received 100 mg KI per day as thyroid protection. All MIBG images were evaluated for thyroid uptake of radio-iodine. Thyroid dysfunction was defined as a plasma thyrotropin concentration above the institutional age-related reference ranges (thyrotropin elevation, TE) or using thyroxine at last moment of follow-up. In all, ultrasound investigation of the thyroid was performed. RESULTS:Fifteen years after treatment with (131) I-MIBG, in 81% (n = 13) thyroid disorders were diagnosed. Eight survivors (50%) were treated with thyroxine. Thyroid nodules were found in nine survivors, of which two were diagnosed with papillary thyroid carcinoma. In 28% of (131) I-MIBG-images radio-iodine uptake in the thyroid gland was seen, but no correlation was found between thyroidal radio-iodine uptake and thyroid disorders. CONCLUSIONS:Despite protection with KI during exposure to (131) I-MIBG in childhood, the occurrence of thyroid disorders is high and increases in time. Continuous screening for thyroid dysfunction and nodules in these survivors is recommended. Other ways to protect the thyroid gland should be further evaluated.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

doi

10.1002/pbc.24681

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1833-8

issue

11

eissn

1545-5009

issn

1545-5017

journal_volume

60

pub_type

杂志文章
  • Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child.

    abstract::Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his chest. He was d...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24284

    authors: Sugalski A,Davis M,Prasannan L,Saldivar V,Hung JY,Tomlinson GE

    更新日期:2013-01-01 00:00:00

  • Clinical practice guideline improves the treatment of sickle cell disease vasoocclusive pain.

    abstract:BACKGROUND:Pain is the most common complication of sickle cell disease requiring emergency department (ED) visits and hospitalization. A Clinical Practice Guideline (CPG) to manage acute sickle cell pain offers clinicians a standardized approach for the provision of evidence-based, cost-effective care. After CPG implem...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21847

    authors: Morrissey LK,Shea JO,Kalish LA,Weiner DL,Branowicki P,Heeney MM

    更新日期:2009-03-01 00:00:00

  • A persistent epidural mass in a child with B-lineage ALL.

    abstract::Epidural spinal cord compression as the initial presentation of acute lymphoblastic leukemia (ALL) is a rare and serious complication. Extramedullary disease is rarely reported in patients with ALL. The most common sites are bone, followed by soft tissue, skin and lymph nodes. We describe a child with common B-lineage...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22682

    authors: Molina B,Lassaletta A,Andion M,Gonzalez-Vicent M,López-Pino MA,Madero L

    更新日期:2010-10-01 00:00:00

  • DIVERGT screening procedure predicts general cognitive functioning in adult long-term survivors of pediatric acute lymphoblastic leukemia: A PETALE study.

    abstract:BACKGROUND:Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Because of major improvements in treatment protocols, the survival rate now exceeds 80%. However, ALL treatments can cause long-term neurocognitive sequelae, which negatively impact academic achievement and quality of life. Therefore, ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.27259

    authors: Boulet-Craig A,Robaey P,Laniel J,Bertout L,Drouin S,Krajinovic M,Laverdière C,Sinnett D,Sultan S,Lippé S

    更新日期:2018-09-01 00:00:00

  • Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).

    abstract::Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25482

    authors: Sekimizu M,Mori T,Kikuchi A,Mitsui T,Sunami S,Kobayashi R,Fujita N,Inada H,Takimoto T,Saito AM,Watanabe T,Fujimoto J,Nakazawa A,Ohshima K,Horibe K,Tsurusawa M,Lymphoma Committee of the Japanese Pediatric Leukemia\/Lymphom

    更新日期:2015-07-01 00:00:00

  • No improvement in clinical trial enrollment for adolescents and young adults with cancer at a children's hospital.

    abstract:BACKGROUND:We have previously published data from 2001 to 2006 showing that adolescent and young adult (AYA) oncology patients have significantly lower therapeutic clinical trial enrollment rates than younger patients. Our objective was to determine if the enrollment of AYA patients on therapeutic studies at the same i...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26638

    authors: Jacob SA,Shaw PH

    更新日期:2017-12-01 00:00:00

  • Quality of life in young patients after bone tumor surgery around the knee joint and comparison with healthy controls.

    abstract:BACKGROUND:This study aimed to compare the health related quality of life (HRQoL) of children and adolescents after malignant bone tumor surgery of the leg with healthy controls. PROCEDURE:Patients between 8 and 25 years old were cross-sectional recruited. Patients under 16 years of age received the TNO (Netherlands O...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.22439

    authors: Bekkering WP,Vliet Vlieland TP,Koopman HM,Schaap GR,Schreuder HW,Beishuizen A,Tissing WJ,Hoogerbrugge PM,Anninga JK,Taminiau AH

    更新日期:2010-05-01 00:00:00

  • Bone marrow aspiration technique may have an impact on therapy stratification in children with acute lymphoblastic leukaemia.

    abstract:BACKGROUND:Morphological evaluation of early response to chemotherapy and measurement of minimal residual disease by flow cytometry or PCR are being used for evaluation of prognosis and treatment stratification in children with acute lymphoblastic leukaemia (ALL). PROCEDURE:In a series of 14 consecutive bone marrow in...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.23081

    authors: Helgestad J,Rosthøj S,Johansen P,Varming K,Østergaard E

    更新日期:2011-08-01 00:00:00

  • Management of adrenal masses in patients with Beckwith-Wiedemann syndrome.

    abstract::Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome, associated with both benign and malignant adrenal findings. Literature review and an institutional case series elucidate the wide spectrum of adrenal findings in BWS patients. The altered expression of the 11p15 region is lik...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.26432

    authors: MacFarland SP,Mostoufi-Moab S,Zelley K,Mattei PA,States LJ,Bhatti TR,Duffy KA,Brodeur GM,Kalish JM

    更新日期:2017-08-01 00:00:00

  • Childhood cancer survivorship and late effects: The landscape in India in 2020.

    abstract::Survivorship care is a major area of focus in the holistic management of childhood cancer with current knowledge and information almost exclusively from high-income countries. In this review, we summarize the state of scientific knowledge, service delivery, advocacy initiatives, and research efforts in this field in I...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.28556

    authors: Arora RS,Arora PR,Seth R,Sharma S,Kumar C,Dhamankar V,Kurkure P,Prasad M

    更新日期:2020-09-01 00:00:00

  • Patient and hospital factors associated with induction mortality in acute lymphoblastic leukemia.

    abstract:BACKGROUND:Deaths during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL) account for one-tenth of ALL-associated mortality and half of ALL treatment-related mortality. We sought to ascertain patient- and hospital-level factors associated with induction mortality. PROCEDURE:We performed a retros...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24855

    authors: Seif AE,Fisher BT,Li Y,Torp K,Rheam DP,Huang YS,Harris T,Shah A,Hall M,Fieldston ES,Kavcic M,Vujkovic M,Bailey LC,Kersun LS,Reilly AF,Rheingold SR,Walker DM,Aplenc R

    更新日期:2014-05-01 00:00:00

  • Poikiloderma with neutropenia in a Tunisian patient with a novel C16orf57 gene mutation.

    abstract::Poikiloderma with neutropenia (PN) is a genodermatosis characterized by poikiloderma, permanent neutropenia, recurrent infections, nail abnormalities, and palmoplantar hyperkeratosis. We report the case of a Tunisian patient with PN. Skin lesions started from the face and spread to the extremities and trunk. Neutropen...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27262

    authors: Sakka R,Mahjoub B,Kerkeni E,Werdani A,Boussoffara R,Ben Cheikh H,M'rad R,Sfar MT

    更新日期:2018-09-01 00:00:00

  • Rubinstein-Taybi syndrome predisposing to non-WNT, non-SHH, group 3 medulloblastoma.

    abstract::Medulloblastomas (MB) are classified in four subgroups: the well defined WNT and Sonic Hedgehog (SHH) subgroups, and the less defined groups 3 and 4. They occasionally occur in the context of a cancer predisposition syndrome. While germline APC mutations predispose to WNT MB, germline mutations in SUFU, PTCH1, and TP5...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24765

    authors: Bourdeaut F,Miquel C,Richer W,Grill J,Zerah M,Grison C,Pierron G,Amiel J,Krucker C,Radvanyi F,Brugieres L,Delattre O

    更新日期:2014-02-01 00:00:00

  • How I approach expressing condolences and longitudinal remembering to a family after the death of a child.

    abstract::Bereaved families fear their child being forgotten by those who knew their loved child, including their child's oncology team. Thoughtfully timed, family-centric condolences shared by pediatric oncology team members have the potential to extend our compassion and kindness toward a family during the darkness of grief. ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27489

    authors: Weaver MS,Lichtenthal WG,Larson K,Wiener L

    更新日期:2019-02-01 00:00:00

  • Gastrostomy Complications in Pediatric Cancer Patients: A Retrospective Single-Institution Review.

    abstract:BACKGROUND:Complications in pediatric cancer patients after a gastrostomy (GT) placement have not been widely investigated. We aimed to evaluate the complication rate and nature of complications in this specific population. PROCEDURE:Medical records of pediatric cancer patients having a GT placed at our institution fr...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25968

    authors: Fernandez-Pineda I,Sandoval JA,Jones RM,Boateng N,Wu J,Rao BN,Davidoff AM,Shochat SJ

    更新日期:2016-07-01 00:00:00

  • Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a child.

    abstract::A 6-year-old female was admitted with abdominal pain and a mass in the right abdomen. Her lactose dehydrogenase level was 1,200 IU/L, and neuron specific enolase was 120 ng/ml. Computed tomography scan confirmed a large right renal mass with necrosis. A right radical nephrectomy was performed. The tumor was completely...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20831

    authors: Maeda M,Tsuda A,Yamanishi S,Uchikoba Y,Fukunaga Y,Okita H,Hata J

    更新日期:2008-01-01 00:00:00

  • Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome.

    abstract::Clinically apparent jaundice is unusual in patients with beta-thalassemia major. Co-inheritance of Gilbert syndrome has been reported to cause hyperbilirubinemia in these subjects. Crigler-Najjar syndrome is another rare disorder of bilirubin metabolism caused by mutation in the gene coding the enzyme UGT1A1. We repor...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22313

    authors: Aggarwal V,Seth A,Sharma S,Aneja S,Sammarco P,Fabiano C

    更新日期:2010-04-01 00:00:00

  • Pilomyxoid astrocytoma treated successfully with vemurafenib.

    abstract::The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kin...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25084

    authors: Skrypek M,Foreman N,Guillaume D,Moertel C

    更新日期:2014-11-01 00:00:00

  • Relapse after localized rhabdomyosarcoma: Evaluation of the efficacy of second-line chemotherapy.

    abstract:PURPOSE:About one-third of patients with rhabdomyosarcoma relapse despite appropriate treatment and experience a poor outcome. Little meaningful improvement in the outcome of this disease has been observed over the last 30 years. There is no clear international recommendation concerning the use of salvage chemotherapy ...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/pbc.25622

    authors: Winter S,Fasola S,Brisse H,Mosseri V,Orbach D

    更新日期:2015-11-01 00:00:00

  • A case of natural killer cell lymphoma presenting with bilateral pleural effusions and hemophagocytic lymphohistocytosis.

    abstract::Natural killer (NK) cell lymphoma of lung is very rare. We report a case of NK cell lymphoma presented in a 17-year-old male with bilateral pleural effusions and hemophagocytic lymphohistocytosis. Morphologic and immunohistochemical tests revealed an association of NK cell lymphoma with Epstein-Barr virus. A literatur...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21943

    authors: Tai CF,Chang LY,Lin DT,Lin KH,Jou ST,Yang YL

    更新日期:2009-05-01 00:00:00

  • Hodgkin lymphoma, HIV, and Epstein-Barr virus in Malawi: Longitudinal results from the Kamuzu Central Hospital Lymphoma study.

    abstract:BACKGROUND:Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub-Saharan Africa where human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) are prevalent. METHODS:We describe a prospective cHL cohort in Malawi enrolled from 2013 to 2015. Patients received standardized treatment a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26302

    authors: Westmoreland KD,Stanley CC,Montgomery ND,Kaimila B,Kasonkanji E,El-Mallawany NK,Wasswa P,Mtete I,Butia M,Itimu S,Chasela M,Mtunda M,Chikasema M,Makwakwa V,Kampani C,Dhungel BM,Sanders MK,Krysiak R,Tomoka T,Liomba NG

    更新日期:2017-05-01 00:00:00

  • Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion.

    abstract::Acute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22850

    authors: Oliveira JL,Kumar R,Khan SP,Law ME,Erickson-Johnson M,Oliveira AM,Ketterling RP,Dogan A

    更新日期:2011-03-01 00:00:00

  • Health-related quality of life in children with sickle cell disease: a report from the Comprehensive Sickle Cell Centers Clinical Trial Consortium.

    abstract:BACKGROUND:Pediatric health-related quality of life (HRQOL) questionnaires have been validated in children with sickle cell disease (SCD), but small sample sizes in these studies have limited clinical comparisons. We used the baseline clinical data from the Collaborative Data (C-Data) Project of the Comprehensive Sickl...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.22497

    authors: Dampier C,Lieff S,LeBeau P,Rhee S,McMurray M,Rogers Z,Smith-Whitley K,Wang W,Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC).

    更新日期:2010-09-01 00:00:00

  • Pheochromocytomas and paragangliomas in children: Data from the Italian Cooperative Study (TREP).

    abstract:BACKGROUND:Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra-adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline ...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/pbc.28332

    authors: Virgone C,Andreetta M,Avanzini S,Chiaravalli S,De Pasquale D,Crocoli A,Inserra A,D'Angelo P,Alaggio R,Opocher G,Cecchetto G,Ferrari A,Bisogno G,Dall'Igna P

    更新日期:2020-08-01 00:00:00

  • New targets for antibody therapy of pediatric B cell lymphomas.

    abstract::Antibody therapy has become standard of care for adult B cell lymphoma patients. It is a potentially less toxic and more targeted approach for lymphoma therapy and should therefore be applied to treat pediatric B cell lymphoma patients as well. In pediatric lymphoma patients, however, clinical experience with monoclon...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.25193

    authors: van Vuren A,Meyer-Wentrup F

    更新日期:2014-12-01 00:00:00

  • Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade gliomas.

    abstract:BACKGROUND:Radiation therapy (RT)-induced effects in children treated for low grade glioma (LGG) can result in worsening of neurologic symptoms and clinical and radiographic deterioration. Treatment for radiation-induced tumor enlargement is based on symptom control and usually involves steroids. PROCEDURE:We conducte...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25277

    authors: Foster KA,Ares WJ,Pollack IF,Jakacki RI

    更新日期:2015-02-01 00:00:00

  • Prevalence of Symptomatic and Asymptomatic Thrombosis in Pediatric Oncology Patients With Tunneled Central Venous Catheters.

    abstract:BACKGROUND:Pediatric oncology patients with tunneled central venous catheters (CVCs) are at increased risk to develop venous thromboembolic events (VTEs), but the true prevalence of (a)symptomatic VTE is unknown. Aim of this study was to evaluate the prevalence of (a)symptomatic VTE in pediatric oncology patients with ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/pbc.26036

    authors: Schoot RA,van de Wetering MD,Stijnen T,Tissing WJ,Michiels E,Abbink FC,Raphael MF,Heij HA,Zwaan M,Lieverst JA,Caron HN,van Ommen H,DCOG-Aristocaths Supportive Care Working Group.

    更新日期:2016-08-01 00:00:00

  • Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea.

    abstract::Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly a...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21480

    authors: Singh SA,Koumbourlis AC,Aygun B

    更新日期:2008-06-01 00:00:00

  • Presentation of acute promyelocytic leukemia as granulocytic sarcoma.

    abstract::Granulocytic sarcoma (GS) is a localized tumor composed of immature myeloid cells. This extramedullary tumor can present before, concurrent with or after the diagnosis of acute myeloid leukemia. GS is extremely uncommon in acute promyelocytic leukemia (APL). As a proportion of patients never develop systemic disease, ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21190

    authors: Worch J,Ritter J,Frühwald MC

    更新日期:2008-03-01 00:00:00

  • Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: A prospective, observational study.

    abstract:BACKGROUND:The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS:Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by thei...

    journal_title:Pediatric blood & cancer

    pub_type: 评论,杂志文章

    doi:10.1002/pbc.26603

    authors: Flank J,Nadeem K,Moledina S,Khanna M,Schindera C,Punnett A,Dupuis LL

    更新日期:2017-10-01 00:00:00