Outcome of young children with high-grade glioma treated with irradiation-avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials.

abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common HIV-associated malignancy in sub-Saharan Africa. The presentation and outcomes of pediatric KS are not well understood. PROCEDURE:We performed a retrospective cohort analysis of 81 HIV-infected children with KS at the Baylor Children's Clinical Centres of Excellence in...

journal_title：Pediatric blood & cancer

authors： Cox CM,El-Mallawany NK,Kabue M,Kovarik C,Schutze GE,Kazembe PN,Mehta PS

更新日期：2013-08-01 00:00:00

abstract：:While encapsulated bacterial agents, particularly Streptococcus pneumoniae, are recognized as important microbes that are associated with serious illness in hosts with sickle cell disease (SCD), multiple pathogens are implicated in infectious manifestations of SCD. Variations in clinical practice have been an obstacle...

journal_title：Pediatric blood & cancer

authors： Obaro SK,Iroh Tam PY

更新日期：2016-05-01 00:00:00

abstract：:Imatinib can be safely discontinued in adults with chronic myeloid leukemia (CML) where there is a prolonged complete molecular response (CMR). No data are available in the pediatric population. Six children with CML discontinued imatinib by themselves. Only three of them were in CMR but for <2 years. A significant in...

journal_title：Pediatric blood & cancer

authors： Millot F,Claviez A,Leverger G,Corbaciglu S,Groll AH,Suttorp M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Outcomes for childhood brain tumors are now associated with a five-year survival rate of 75%. Endocrine effects of brain tumors are common, occurring in 43% of patients by 10 years from tumor diagnosis. Optimal timing of screening for endocrinopathies remains undefined. We aim to identify incidence and timin...

journal_title：Pediatric blood & cancer

authors： Lawson SA,Horne VE,Golekoh MC,Hornung L,Burns KC,Fouladi M,Rose SR

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Robatumumab (19D12; MK-7454 otherwise known as SCH717454) is a fully human antibody that binds to and inhibits insulin-like growth factor receptor-1 (IGF-1R). This multiinstitutional study (P04720) determined the safety and clinical efficacy of robatumumab in three separate patient groups with resectable ost...

journal_title：Pediatric blood & cancer

authors： Anderson PM,Bielack SS,Gorlick RG,Skubitz K,Daw NC,Herzog CE,Monge OR,Lassaletta A,Boldrini E,Pápai Z,Rubino J,Pathiraja K,Hille DA,Ayers M,Yao SL,Nebozhyn M,Lu B,Mauro D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:As pegylated asparaginase is becoming the preferred first-line asparaginase preparation in the chemotherapy regimens of childhood acute lymphoblastic leukemia (ALL), there is a need to evaluate this treatment. METHODS:The aim of this study was to evaluate the pharmacokinetics of prolonged upfront biweekly P...

journal_title：Pediatric blood & cancer

authors： Tram Henriksen L,Gottschalk Højfeldt S,Schmiegelow K,Frandsen TL,Skov Wehner P,Schrøder H,Klug Albertsen B,Nordic Society of Pediatric Hematology and Oncology, NOPHO Group.

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Partial nephrectomy (NSS) for unilateral nephroblastoma may be beneficial, although in case of regional lymph node (LN) involvement, radiotherapy counteracts the functional benefit of NSS. The aim is to verify whether decrease of tumor volume under preoperative chemotherapy implies clearance of regional LN. ...

journal_title：Pediatric blood & cancer

authors： Godzinski J,van Tinteren H,de Kraker J,Graf N,Bergeron C,Heij H,von Schweinitz D,Fuchs J,Cecchetto G,Audry G,Gauthier F,Sandstedt B,SIOP Nephroblastoma Trial & Study Committee.

更新日期：2011-12-15 00:00:00

abstract：:During ALL chemotherapy, a 4-year-old patient presented with febrile neutropenia and abdominal pain. Ultrasound examinations were repeatedly normal. Computerized tomography on day 7 demonstrated appendicitis and multiple hepatic foci identified as mucormycosis (Absidia corymbifera). Successful outcome was achieved by ...

journal_title：Pediatric blood & cancer

authors： Lüer S,Berger S,Diepold M,Duppenthaler A,von Gunten M,Mühlethaler K,Wolf R,Aebi C

更新日期：2009-07-01 00:00:00

abstract：:Enrollment of patients in sickle cell intervention trials has been challenging due to difficulty in obtaining consent from a legal guardian and lack of collaboration between emergency medicine and hematology. We utilized education and preconsent in a pediatric multisite sickle cell intervention trial to overcome these...

journal_title：Pediatric blood & cancer

authors： Nimmer M,Czachor J,Turner L,Thomas B,Woodford AL,Carpenter K,Gonzalez V,Liem RI,Ellison A,Casper TC,Brousseau DC,sickle cell working group of the Pediatric Emergency Care Applied Research Network (PECARN).

更新日期：2016-09-01 00:00:00

abstract：:Thrombocytopenia and autoimmune hemolytic anemia (Evans syndrome) with the presence of both warm and cold autoantibodies (mixed type) are rare in the pediatric age group. This condition may be associated with other autoimmune disorders and is notoriously difficult to treat. This case describes an adolescent male who p...

journal_title：Pediatric blood & cancer

authors： Jubinsky PT,Rashid N

更新日期：2005-09-01 00:00:00

abstract：:A male patient diagnosed with severe congenital protein C (PC) deficiency during the neonatal period was treated with long-term warfarin but frequently developed purpura fulminans and bleeding. At four years of age, edoxaban was initiated (direct oral anticoagulant [DOAC]). His d-dimer and fibrin/fibrinogen degradatio...

journal_title：Pediatric blood & cancer

authors： Watanabe K,Arakawa Y,Yanagi M,Isobe K,Mori M,Koh K

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess glomerular and tubular renal function after HSCT in children in a prospective trial. METHODS:Renal function was assessed prospectively before HSCT (on day -10), on days +30, +100, and at least 6 months after transplantation in 34 patients (21 females/13 males) with a mean...

journal_title：Pediatric blood & cancer

authors： Hazar V,Gungor O,Guven AG,Aydin F,Akbas H,Gungor F,Tezcan G,Akman S,Yesilipek A

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Drug shortages require clinical teams to decide how to allocate drugs in limited supply among their patients. Ethical frameworks are invaluable for promoting rational approaches to drug distribution, but gaps remain between ethical theory and clinical application. The goal of this work was to explore how dec...

journal_title：Pediatric blood & cancer

authors： Russell HV,Bernhardt MB,Berg S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Childhood germ cell tumors (cGCTs), believed to arise from transformed primordial germ cells by an unknown mechanism, provide a unique model system for investigating cell signaling, pluripotency, and the microenvironment of neoplastic stem cells (NSCs) in vivo. This is the first report of proteomics of cGCTs...

journal_title：Pediatric blood & cancer

authors： Haskins WE,Eedala S,Jadhav YL,Labhan MS,Pericherla VC,Perlman EJ

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Radiation therapy (RT)-induced effects in children treated for low grade glioma (LGG) can result in worsening of neurologic symptoms and clinical and radiographic deterioration. Treatment for radiation-induced tumor enlargement is based on symptom control and usually involves steroids. PROCEDURE:We conducte...

journal_title：Pediatric blood & cancer

authors： Foster KA,Ares WJ,Pollack IF,Jakacki RI

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm2 ), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing throu...

journal_title：Pediatric blood & cancer

authors： Cox CL,Zhu L,Kaste SC,Srivastava K,Barnes L,Nathan PC,Wells RJ,Ness KK

更新日期：2018-04-01 00:00:00

abstract：:We describe five cases of children who completed chemotherapy for infantile acute lymphoblastic leukemia (ALL) and soon after were diagnosed with severe T-cell, non-HIV immunodeficiency, with varying B-cell and NK-cell depletion. There was near absence of CD3(+) , CD4(+) , and CD8(+) cells. All patients developed mult...

journal_title：Pediatric blood & cancer

authors： Geerlinks AV,Issekutz T,Wahlstrom JT,Sullivan KE,Cowan MJ,Dvorak CC,Fernandez CV

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Knowledge about their past medical history is central for childhood cancer survivors to ensure informed decisions in their health management. Knowledge about information provision and information needs in this population is still scarce. We thus aimed to assess: (1) the information survivors reported to have...

journal_title：Pediatric blood & cancer

authors： Gianinazzi ME,Essig S,Rueegg CS,von der Weid NX,Brazzola P,Kuehni CE,Michel G,Swiss Paediatric Oncology Group (SPOG).

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:PG11047 is a novel conformationally restricted analog of the natural polyamine, spermine that lowers cellular endogenous polyamine levels and competitively inhibits natural polyamine functions leading to cancer cell growth inhibition. The activity of PG11047 was evaluated against the PPTP's in vitro and in v...

journal_title：Pediatric blood & cancer

authors： Smith MA,Maris JM,Lock R,Kolb EA,Gorlick R,Keir ST,Carol H,Morton CL,Reynolds CP,Kang MH,Houghton PJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. METHODS:We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42 weeks) born to 723 mothers with pregnancy-induced thrombo...

journal_title：Pediatric blood & cancer

authors： Maayan-Metzger A,Leibovitch L,Schushan-Eisen I,Strauss T,Kenet G,Kuint J

更新日期：2010-07-15 00:00:00

abstract：:Survivorship care is a major area of focus in the holistic management of childhood cancer with current knowledge and information almost exclusively from high-income countries. In this review, we summarize the state of scientific knowledge, service delivery, advocacy initiatives, and research efforts in this field in I...

journal_title：Pediatric blood & cancer

authors： Arora RS,Arora PR,Seth R,Sharma S,Kumar C,Dhamankar V,Kurkure P,Prasad M

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Progressive/recurrent high-grade and diffuse intrinsic pontine gliomas (DIPGs) are fatal. Treatments targeting molecular pathways critical for these cancers are needed. METHODS:We conducted a phase 1 study (rolling-six design) to establish the safety and maximum tolerated dose (MTD) of dasatinib, an oral pl...

journal_title：Pediatric blood & cancer

authors： Broniscer A,Jia S,Mandrell B,Hamideh D,Huang J,Onar-Thomas A,Gajjar A,Raimondi SC,Tatevossian RG,Stewart CF

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Survival of osteosarcoma patients has reached a plateau with the addition of chemotherapy and in part predicted based on histologic response. Risk-adapted therapy might be an alternative approach. We aimed to identify risk groups using clinical variables available at time of diagnosis in order to better pred...

journal_title：Pediatric blood & cancer

authors： Lee JA,Kim MS,Kim DH,Lim JS,Park KD,Song WS,Cho WH,Lee SY,Jeon DG

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Malignant peripheral nerve sheath tumor (MPNST) is an aggressive form of soft-tissue sarcoma (STS) in children. Despite intensive therapy, relatively few children with metastatic and unresectable disease survive beyond three years. RAS pathway activation is common in MPNST, suggesting MEK pathway inhibition ...

journal_title：Pediatric blood & cancer

authors： Butler E,Schwettmann B,Geboers S,Hao G,Kim J,Nham K,Sun X,Laetsch TW,Xu L,Williams NS,Skapek SX

更新日期：2020-12-01 00:00:00

abstract：:Data on prognostic factors in pelvic PNET are minimal. We analyzed patients with pelvic PNET treated between June 2003 and November 2011 for prognostic factors. Forty-eight (13%) of 374 patients with PNET were pelvic PNET with median age 14.5 years (range: 5-33); 31 (65%) had metastases. After median follow-up of 20.4...

journal_title：Pediatric blood & cancer

authors： Biswas B,Agarwala S,Rastogi S,Khan SA,Mohanti BK,Sharma DN,Pathy S,Bakhshi S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (ES), a highly aggressive tumor of children and young adults, is characterized most commonly by an 11;22 chromosomal translocation that fuses EWSR1 located at 22q12 with FLI1, coding for a member of the ETS family of transcription factors. Although genetic changes in ES have been extensively re...

journal_title：Pediatric blood & cancer

authors： Nestheide S,Bridge JA,Barnes M,Frayer R,Sumegi J

更新日期：2013-09-01 00:00:00

abstract：:Treatment recommendations for endemic Burkitt lymphoma (BL) in settings with only minimum requirements for curative treatment (PODC setting 1) are described. The reported cure rate for endemic BL is usually <50%. Facilities within setting 1 differ. Three treatment schedules are proposed based on: (1) when accurate sta...

journal_title：Pediatric blood & cancer

authors： Hesseling P,Israels T,Harif M,Chantada G,Molyneux E,Pediatric Oncology in Developing Countries.

更新日期：2013-03-01 00:00:00

abstract：:Thymic epithelial neoplasms consist of thymomas, thymic carcinoids, and thymic carcinomas. Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia. They constitute only 4%-14% of thymic epithelial neoplams. Thymic carcinoma rarely occurs in children. Research in the English literat...

journal_title：Pediatric blood & cancer

authors： Yaris N,Nas Y,Cobanoglu U,Yavuz MN

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Currently, there is no standardized treatment for adolescents, aged 15 years or older, with mature B-cell non-Hodgkin lymphoma (B-NHL), although this age group has been reported to have a poorer prognosis than younger patients. PROCEDURE:The present study analyzed the data of 321 patients with B-NHL, enroll...

journal_title：Pediatric blood & cancer

authors： Sekimizu M,Hashimoto H,Mori T,Kobayashi R,Horibe K,Tsurusawa M

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Sickle cell anaemia (SCA) is the leading genetic disorder in Nigeria. Elevated velocities ≥170 cm/sec occur in about a third of Nigerian children with SCA. Chronic blood transfusion for stroke prevention is faced with a myriad of challenges in our practice. OBJECTIVES:To evaluate the effectiveness of hydrox...

journal_title：Pediatric blood & cancer

authors： Lagunju I,Brown BJ,Sodeinde O

更新日期：2015-09-01 00:00:00