Bevacizumab for symptomatic radiation-induced tumor enlargement in pediatric low grade gliomas.

abstract：OBJECTIVES:The aim of this study was to assess glomerular and tubular renal function after HSCT in children in a prospective trial. METHODS:Renal function was assessed prospectively before HSCT (on day -10), on days +30, +100, and at least 6 months after transplantation in 34 patients (21 females/13 males) with a mean...

journal_title：Pediatric blood & cancer

authors： Hazar V,Gungor O,Guven AG,Aydin F,Akbas H,Gungor F,Tezcan G,Akman S,Yesilipek A

更新日期：2009-08-01 00:00:00

abstract：:Limited high-quality evidence supports the management of iron deficiency anemia (IDA). To assess our institutional performance in this area, we retrospectively reviewed IDA treatment practices in 195 consecutive children referred to our center from 2006 to mid-2010. The majority of children were ≤4 years old (64%) and...

journal_title：Pediatric blood & cancer

authors： Powers JM,Daniel CL,McCavit TL,Buchanan GR

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Robatumumab (19D12; MK-7454 otherwise known as SCH717454) is a fully human antibody that binds to and inhibits insulin-like growth factor receptor-1 (IGF-1R). This multiinstitutional study (P04720) determined the safety and clinical efficacy of robatumumab in three separate patient groups with resectable ost...

journal_title：Pediatric blood & cancer

authors： Anderson PM,Bielack SS,Gorlick RG,Skubitz K,Daw NC,Herzog CE,Monge OR,Lassaletta A,Boldrini E,Pápai Z,Rubino J,Pathiraja K,Hille DA,Ayers M,Yao SL,Nebozhyn M,Lu B,Mauro D

更新日期：2016-10-01 00:00:00

abstract：:Post-transplant lymphoproliferative disease (PTLPD), due to the reactivation of Epstein-Barr virus (EBV), is a serious complication. The risk of the disorder increases with T-cell depletion methods, mismatched hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD), and immunosuppression. In c...

journal_title：Pediatric blood & cancer

authors： Kasow KA,Leung W,Horwitz EM,Woodard P,Handgretinger R,Hale GA

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Conflicting data exist regarding whether low bone mineral density (BMD) is associated with Fanconi anemia (FA). The current study identified the frequency of low BMD in FA, expecting low BMD even in childhood and before HCT. PROCEDURE:Thirty-seven FA patients (18 prior HCT, 19 no prior HCT), participating i...

journal_title：Pediatric blood & cancer

authors： Rose SR,Rutter MM,Mueller R,Harris M,Hamon B,Bulluck AF,Smith FO

更新日期：2011-12-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a rare disease in children. Different from that in adults, childhood CML involves transformative events occurring over a short time period. CML transformation to lymphoid blast phase (BP) is associated with copy number abnormalities, characteristic of BCR-ABL1 positive acute lymphobla...

journal_title：Pediatric blood & cancer

authors： Klumb CE,Barbosa TDC,Nestal de Moraes G,Schramm MT,Emerenciano M,Maia RC

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Survival for childhood acute lymphoblastic leukemia (ALL) has reached 80-90%. Future improvement in treatment success will involve new technologies and medication, adding to the pressure on limited financial resources. Therefore a retrospective cost-effectiveness analysis of ALL treatment with chemotherapy o...

journal_title：Pediatric blood & cancer

authors： van Litsenburg RR,Uyl-de Groot CA,Raat H,Kaspers GJ,Gemke RJ

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Choroid plexus tumors (CPT) are rare, and predominate in early childhood. An association with the Li-Fraumeni syndrome (LFS) has been reported, but the biological and clinical implications of this association remain poorly defined. We have investigated the clinical features and overall survival of all CPT pa...

journal_title：Pediatric blood & cancer

authors： Gozali AE,Britt B,Shane L,Gonzalez I,Gilles F,McComb JG,Krieger MD,Lavey RS,Shlien A,Villablanca JG,Erdreich-Epstein A,Dhall G,Jubran R,Tabori U,Malkin D,Finlay JL

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:We assessed the safety and efficacy of ifosfamide and vinorelbine (IV) as a less toxic and effective reinduction regimen for pediatric patients with relapsed or refractory Hodgkin Lymphoma. PROCEDURE:This multi-center Children's Oncology Group phase II pilot study enrolled patients <30 years of age with bio...

journal_title：Pediatric blood & cancer

authors： Trippett TM,Schwartz CL,Guillerman RP,Gamis AS,Gardner S,Hogan S,London WB,Chen L,de Alarcon P

更新日期：2015-01-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes ar...

journal_title：Pediatric blood & cancer

authors： de Oliveira JC,Brassesco MS,Scrideli CA,Tone LG,Narendran A

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the value of follow-up investigations of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell non-Hodgkin's lymphoma (T-NHL), including cerebrospinal fluid (CSF) examination, bone marrow (BM) aspiration, peripheral blood (PB) count, serum lactate dehydrogenase (LDH) an...

journal_title：Pediatric blood & cancer

authors： Huang L,Lequin M,Pieters R,van den Heuvel-Eibrink MM

更新日期：2007-04-01 00:00:00

abstract：:Primary choriocarcinoma of the liver is an extremely rare childhood malignancy frequently associated with clinical instability at initial presentation. It often mimics other benign and malignant childhood liver tumors. Prompt diagnosis and initiation of treatment are necessary to attain a successful outcome. We descri...

journal_title：Pediatric blood & cancer

authors： Yoon JM,Burns RC,Malogolowkin MH,Mascarenhas L

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Pediatric cancer-induced financial burden is source of stress for parents, particularly mothers, single parents, and parents with lower incomes. This financial burden has been linked to poorer family quality of life (QOL) in terms of new onset material hardships, and could also affect individual QOL in terms...

journal_title：Pediatric blood & cancer

authors： Santacroce SJ,Kneipp SM

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Transcranial Doppler ultrasound (TCD) has been demonstrated to be a powerful predictor of stroke risk due to sickle cell disease (SCD) in pediatric populations. Little is known about how this healthcare innovation has disseminated into preventive care for SCD. The objective of this study was to determine TCD...

journal_title：Pediatric blood & cancer

authors： Raphael JL,Shetty PB,Liu H,Mahoney DH,Mueller BU

更新日期：2008-11-01 00:00:00

abstract：:Dry eye disease is a well-known late complication of radiation therapy and is often difficult to treat. We evaluated the usefulness of cyclosporine 0.05% ophthalmic emulsion for the treatment of radiation-associated dry eye in children. Eleven children received cyclosporine 0.05% emulsion twice daily after failure of ...

journal_title：Pediatric blood & cancer

authors： Hoehn ME,Kelly SR,Wilson MW,Walton RC

更新日期：2013-07-01 00:00:00

abstract：:Ovarian tumors have a low incidence in childhood, accounting for 1% of malignancies within the ages of 0-17 years. Small cell carcinoma of the ovary is a rare histology and historically has a poor prognosis. We report a case of an 11-year-old female diagnosed with small cell carcinoma of the ovary and hypercalcemia (S...

journal_title：Pediatric blood & cancer

authors： Martinez-Borges AR,Petty JK,Hurt G,Stribling JT,Press JZ,Castellino SM

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Sickle cell anaemia (SCA) is the leading genetic disorder in Nigeria. Elevated velocities ≥170 cm/sec occur in about a third of Nigerian children with SCA. Chronic blood transfusion for stroke prevention is faced with a myriad of challenges in our practice. OBJECTIVES:To evaluate the effectiveness of hydrox...

journal_title：Pediatric blood & cancer

authors： Lagunju I,Brown BJ,Sodeinde O

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Patients with relapsed or refractory Ewing sarcoma have a poor outcome with conventional therapies. Cytarabine decreases EWS/FLI1 protein levels in Ewing sarcoma cells and has demonstrated preclinical activity against Ewing sarcoma in vitro and in vivo. The purpose of this phase II clinical trial was to esti...

journal_title：Pediatric blood & cancer

authors： DuBois SG,Krailo MD,Lessnick SL,Smith R,Chen Z,Marina N,Grier HE,Stegmaier K,Children's Oncology Group.

更新日期：2009-03-01 00:00:00

abstract：:Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation. We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO i...

journal_title：Pediatric blood & cancer

authors： Chao MM,Levine JE,Ferrara JL,Cooling L,Cooke KR,Hutchinson RJ,Yanik GA

更新日期：2008-04-01 00:00:00

abstract：:Enrollment of patients in sickle cell intervention trials has been challenging due to difficulty in obtaining consent from a legal guardian and lack of collaboration between emergency medicine and hematology. We utilized education and preconsent in a pediatric multisite sickle cell intervention trial to overcome these...

journal_title：Pediatric blood & cancer

authors： Nimmer M,Czachor J,Turner L,Thomas B,Woodford AL,Carpenter K,Gonzalez V,Liem RI,Ellison A,Casper TC,Brousseau DC,sickle cell working group of the Pediatric Emergency Care Applied Research Network (PECARN).

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To report the final analysis of survival outcomes for children with newly diagnosed high-grade glioma (HGG) treated on the "Head Start" (HS) II and III protocols with chemotherapy and intent to avoid irradiation in children <6 years old. PATIENTS AND METHODS:Between 1997 and 2009, 32 eligible children were enr...

journal_title：Pediatric blood & cancer

authors： Espinoza JC,Haley K,Patel N,Dhall G,Gardner S,Allen J,Torkildson J,Cornelius A,Rassekh R,Bedros A,Etzl M,Garvin J,Pradhan K,Corbett R,Sullivan M,McGowage G,Stein D,Jasty R,Sands SA,Ji L,Sposto R,Finlay JL

更新日期：2016-10-01 00:00:00

abstract：:The efficacy of hydroxyurea in hemoglobin SC (HbSC) patients is not well documented. We describe the long-term response to hydroxyurea in children with clinically severe HbSC. In 15 patients, hydroxyurea resulted in a significant increase in mean corpuscular volume (MCV) and fetal hemoglobin (HbF) and a significant de...

journal_title：Pediatric blood & cancer

authors： Yates AM,Dedeken L,Smeltzer MP,Lebensburger JD,Wang WC,Robitaille N

更新日期：2013-02-01 00:00:00

abstract：:Thrombocytopenia and autoimmune hemolytic anemia (Evans syndrome) with the presence of both warm and cold autoantibodies (mixed type) are rare in the pediatric age group. This condition may be associated with other autoimmune disorders and is notoriously difficult to treat. This case describes an adolescent male who p...

journal_title：Pediatric blood & cancer

authors： Jubinsky PT,Rashid N

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Population-based evidence suggests that lower socioeconomic status (SES) negatively impacts the overall survival (OS) of children with leukemia; however, the relationships between SES and treatment-related mortality, relapse, and timing of relapse remain unclear. PROCEDURE:We examined OS, event-free surviva...

journal_title：Pediatric blood & cancer

authors： Bona K,Blonquist TM,Neuberg DS,Silverman LB,Wolfe J

更新日期：2016-06-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor of childhood, and the outcomes for children with high-risk and relapsed disease remain poor. However, new international strategies for risk stratification and for treatment based on novel tumor targets and including immunotherapy are being employed in attempts ...

journal_title：Pediatric blood & cancer

authors： Zage PE,Louis CU,Cohn SL

更新日期：2012-07-01 00:00:00

abstract：:Hemophilia is an excellent example in medicine where clinical translation of basic science discoveries has transformed the gloomy outlook of the disease. This review provides an overview of clinical advances in hemophilia management with a specific focus on the molecular heterogeneity of the disease and progress in ma...

journal_title：Pediatric blood & cancer

authors： Sharathkumar AA,Carcao M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Compared with healthy children, pediatric oncology patients have impaired sleep and engage in less physical activity (PA). Socioeconomic status (SES) may be one determinant of PA and sleep among pediatric oncology patients. PROCEDURE:Between November 12, 2009 and March 27, 2013, 50 pediatric oncology patien...

journal_title：Pediatric blood & cancer

authors： Orsey AD,Wakefield DB

更新日期：2016-11-01 00:00:00

abstract：:A major hallmark of NF1 is the development of benign tumors, including peripheral neurofibromas, plexiform neurofibromas, gliomas of the optic tract, other low grade gliomas, and pheochromocytomas. Hepatoblastoma have not been previously reported in patients with neurofibromatosis type 1. We present a case of a 9-mont...

journal_title：Pediatric blood & cancer

authors： Uçar C,Calişkan U,Toy H,Günel E

更新日期：2007-09-01 00:00:00

abstract：:Survivorship care is a major area of focus in the holistic management of childhood cancer with current knowledge and information almost exclusively from high-income countries. In this review, we summarize the state of scientific knowledge, service delivery, advocacy initiatives, and research efforts in this field in I...

journal_title：Pediatric blood & cancer

authors： Arora RS,Arora PR,Seth R,Sharma S,Kumar C,Dhamankar V,Kurkure P,Prasad M

更新日期：2020-09-01 00:00:00

abstract：:We report the results of a protocol for the diagnosis and treatment of pediatric non-Hodgkin lymphomas (NHL) conducted in Nicaragua in the context of an international collaborative program. Fifty-three children with NHL treated between 1996 and 2003 were retrospectively evaluated. Therapy was designed based on local d...

journal_title：Pediatric blood & cancer

authors： Baez F,Pillon M,Manfredini L,Ocampo E,Mendez G,Ortiz R,Palacios R,Gutierrez T,Tridello G,Conter V,Valsecchi M,Fossati Bellani F,Cavalli F,Masera G,Rosolen A

更新日期：2008-01-01 00:00:00