Abstract:
BACKGROUND:Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. METHODS:We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42 weeks) born to 723 mothers with pregnancy-induced thrombocytopenia to define risk factors predicting thrombocytopenia in this group. RESULTS:Thrombocytopenia was diagnosed in 2.2% of the infants. Multivariate analysis showed that infants with thrombocytopenia were more likely to be male, to be born at lower gestational age and to have lower birth weight associated with lower maternal platelets counts. Maternal platelet counts of 100-149 x 10(9)/L, 50-99 x 10(9)/L, and <50 x 10(9)/L corresponded respectively to 1.7%, 4.3%, and 12.5% of neonatal thrombocytopenia (P = 0.031). CONCLUSIONS:Routine blood counts are recommended, in particular for male infants with low birth weight born to mothers with moderate-to-severe thrombocytopenia.
journal_name
Pediatr Blood Cancerjournal_title
Pediatric blood & cancerauthors
Maayan-Metzger A,Leibovitch L,Schushan-Eisen I,Strauss T,Kenet G,Kuint Jdoi
10.1002/pbc.22514subject
Has Abstractpub_date
2010-07-15 00:00:00pages
145-8issue
1eissn
1545-5009issn
1545-5017journal_volume
55pub_type
杂志文章abstract:BACKGROUND:Children with acute lymphoblastic leukemia (ALL) who fail to achieve complete remission (CR) after induction therapy (induction failure: IF) have a poor prognosis; however, there have been few prospective studies in patients with IF. PATIENTS AND METHODS:Between April 1997 and March 2005, 27 of 1,237 leukem...
journal_title:Pediatric blood & cancer
pub_type: 杂志文章
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journal_title:Pediatric blood & cancer
pub_type: 临床试验,杂志文章
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章,多中心研究
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journal_title:Pediatric blood & cancer
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更新日期:2008-02-01 00:00:00
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2009-01-01 00:00:00
abstract::Immunotherapy with the anti-GD2 monoclonal antibody ch14.18, or dinutuximab, represents an important therapeutic advance in the treatment of pediatric high-risk neuroblastoma and is now considered part of standard of care in this patient population. To date, transverse myelitis as a result of dinutuximab therapy has n...
journal_title:Pediatric blood & cancer
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更新日期:2018-01-01 00:00:00
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章,多中心研究
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更新日期:2010-05-01 00:00:00
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章
doi:10.1002/pbc.21564
更新日期:2008-09-01 00:00:00
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journal_title:Pediatric blood & cancer
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2009-12-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2010-01-01 00:00:00
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2021-02-01 00:00:00
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journal_title:Pediatric blood & cancer
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更新日期:2018-02-01 00:00:00
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journal_title:Pediatric blood & cancer
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journal_title:Pediatric blood & cancer
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更新日期:2013-03-01 00:00:00
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