Abstract:
:The purpose of this investigation is to determine if intraosseous infusion (IO) is a suitable method for the delivery of recombinant human factor VIIa (rFVIIa) during hemorrhagic shock. The measures that were used to evaluate IO delivery suitability included: (1) determination of clinically significant local or systemic toxicity and (2) demonstration that systemic blood levels of rFVIIa increased rapidly following administration. Our results indicate that there was no evidence of significant local or systemic toxicity following infusion and that the systemic blood concentration of rFVIIa peaks immediately after the end of infusion. This result suggests that the systemic blood level profiles of rFVIIa delivered by IO infusion are similar to those that could be produced by intravenous (IV) administration. Furthermore, in all 25 test animals, access to the systemic circulation during shock was achieved as evidenced by rapid increase in a marker dye (flourescein) or rFVIIa in the blood. We conclude that administration of rFVIIa via IO infusion is a reasonable safe method and is likely to produce blood levels required for improved hemostasis during shock.
journal_name
Mil Medjournal_title
Military medicineauthors
Wright JK,Christy RJ,Tharp RV,Kalns JEdoi
10.7205/milmed-d-58-7608subject
Has Abstractpub_date
2009-02-01 00:00:00pages
119-23issue
2eissn
0026-4075issn
1930-613Xjournal_volume
174pub_type
杂志文章abstract:INTRODUCTION:Obesity and overweight, defined as body mass index (BMI) of 30.0 and above or 25.0-29.9, respectively, are of significant concern to the military population, due to their associated comorbidities and potential for impaired readiness. In 2016, the US Army reported a prevalence of 17.3% obesity and 52.9% ove...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz032
更新日期:2019-10-01 00:00:00
abstract::The objective of this study was to compare military suicide rates with civilian suicide rates, adjusting for age and sex differences that exist between the two populations. The number of active component (AC) service members whose manner of death was certified as suicide was determined for specific age and sex groups ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx209
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Current military operations in the Middle East involve active duty, National Guard, and reserve troops from all services. Despite common misconceptions, the desert environment in this region has significant aeroallergen seasons that may exacerbate allergic rhinitis. OBJECTIVE:To review perennial and seasona...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.170.12.1026
更新日期:2005-12-01 00:00:00
abstract:INTRODUCTION:While previous studies have examined the stress of the military training environment, studies have not systematically examined the stress associated with attending the Defense Language Institute Foreign Language Center (DLIFLC). Service members assigned to DLIFLC endure intense academic pressure to succeed...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usy359
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Addition of an oxygen concentrator into a control loop furthers previous work in autonomous control of oxygenation. Software integrates concentrator and ventilator function from a single control point, ensuring maximum efficiency by placing a pulse of oxygen at the beginning of the breath. We sought to verif...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00150
更新日期:2016-05-01 00:00:00
abstract::A 26-year-old suspected Iraqi insurgent is brought to a Troop Medical Clinic in Baghdad, Iraq, with curious marks on his body. On questioning, he describes productive cough, subjective fever, drenching night sweats, and unintentional weight loss. This case shows a condition with which Western physicians are generally ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-12-00219
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:This was a pilot study to determine (1) whether it is feasible to effectively blind human subjects to the presence of the insect repellents N,N-diethyl-m-toluamide (DEET) and permethrin; (2) whether DEET affects the absorption of permethrin; and (3) whether combat videotape viewing and mental arithmetic are ...
journal_title:Military medicine
pub_type: 杂志文章,随机对照试验
doi:10.7205/milmed.171.2.122
更新日期:2006-02-01 00:00:00
abstract::The clinical entity of chronic low back pain is not well understood at present. Disparate spinal conditions can result in symptoms of low back pain, and various treatment options have been proposed in the literature including surgical intervention and prolonged nonoperative therapy. Low back pain, as well as lumbar de...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/milmed-d-10-00397
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) is one of the more commonly occurring mental disorders following potentially traumatizing events soldiers may encounter when deployed abroad. One of the first-line recommended treatment options is eye movement desensitization and reprocessing (EMDR). The number of studie...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00307
更新日期:2017-05-01 00:00:00
abstract::Severely injured patients have difficulty recalling their intensive care unit (ICU) experience which may contribute to emotional trauma. An ICU patient journal contains a short summary of key events during the ICU stay, and has been shown to improve emotional well-being. This project evaluated the feasibility and perc...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00210
更新日期:2016-08-01 00:00:00
abstract::Post-conflict hospitalization rates of active duty Marines deployed to the Persian Gulf War were compared with hospitalization rates of similar Marine Corps units returning from the Vietnam conflict. The aggregated Gulf War units exhibited lower hospitalization rates than their Vietnam counterparts. Examined separatel...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract:INTRODUCTION:Obesity is prevalent among users of Veteran's Health Administration services, where it is comorbid with depression, post-traumatic stress disorder, type 2 diabetes, cardiovascular disease, colon, and breast cancer. Among obese subjects, severe obesity represents a subpopulation with the highest risk of dep...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz475
更新日期:2020-06-08 00:00:00
abstract:OBJECTIVE:This study examined soldier attitudes about postdeployment mental health screening, treatment, barriers to care, strategies for overcoming barriers, and settings, personnel and timing for conducting postdeployment mental health screening. METHODS:Deploying soldiers participated in a voluntary anonymous surve...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.173.6.563
更新日期:2008-06-01 00:00:00
abstract::The purpose of this study was to examine physical work performance, energy cost, and physiological fatigue in military personnel during simulated operational conditions. Using a within-subject, repeated-measures design, 34 military personnel volunteered to undergo two experimental conditions: with body armor (BA+) and...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.173.9.817
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:The Beck Depression Inventory-II (BDI-II) is widely used as a screening instrument for depressive symptomatology in clinical settings. The factor structure has been researched in a variety of settings with results ranging from a single factor to a five-factor structure. The purpose of this study was to examin...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00048
更新日期:2014-08-01 00:00:00
abstract::Military commanders frequently mention that communicating difficult or taboo information is especially challenging. In the context of gender-integrated ground combat service there may be additional communication challenges for military commanders who may be unaccustomed to leading both men and women. Often, military c...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00201
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Cervical spine clearance requires clinicians to assess the reliability of physical examination based on a patient's mental status and distracting injuries. Distracting injuries have never been clearly defined in military casualties. METHODS:Retrospective review was conducted of patients entered into Departm...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00635
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:Occupational noise threatens U.S. worker health and safety and commands a significant financial burden on state and federal government worker compensation programs. Previous studies suggest that hearing conservation programs have contributed to reduced occupational hearing loss for noise-exposed workers. M...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx112
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To derive job condition scales for future studies of the effects of job conditions on soldier health and job functioning across Army Military Occupation Specialties (MOSs) and Areas of Concentration (AOCs) using Department of Labor (DoL) Occupational Information Network (O*NET) ratings. METHODS:A consolidat...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-13-00446
更新日期:2014-07-01 00:00:00
abstract::The United States Army is committed to providing quality health care for active-duty service members, their dependents, and retired service members. Historically, the Army has never had enough active-duty physicians to provide care for all its beneficiaries. Alternatives utilizing civilian health care providers have b...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:Post-traumatic headache (PTH) is a commonly experienced symptom after mild traumatic brain injury (mTBI). Blast injury- or blunt injury-related mechanisms for mTBI in veterans can also affect musculoskeletal structures in the neck, resulting in comorbid neck pain (NP). However, it is unknown whether the pres...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa532
更新日期:2020-12-11 00:00:00
abstract::Disseminated fungal infections are normally opportunistic infections in the immunocompromised population. Current literature has documented a high mortality rate with these infections in civilian trauma or as complications of severe burns. There is only one published case of fungal infection in a combat-injured indivi...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-12-00322
更新日期:2013-04-01 00:00:00
abstract::Hypothermia increases mortality rates and should be treated aggressively in the forward echelons of care, but no practical solution exists to accomplish such treatment. The enormous energy burden for this task requires maximal thermodynamic efficiency for a practical portable solution. This review article presents an ...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/milmed.173.8.743
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:Complete occlusion of the contralateral carotid artery has been thought to increase the risk of carotid endarterectomy (CEA). This study was conducted to determine whether contralateral occlusion (CO) leads to a higher rate of complications among patients undergoing CEA or alters long-term outcomes. METHODS:...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.170.12.1069
更新日期:2005-12-01 00:00:00
abstract::Foreign bodies, in particular sand and soil particles, can cause considerable reaction in wounds and remain in tissues indefinitely. The introduction of foreign material as a contaminant in wounds and intracavitary injuries to military personnel deployed in the Persian Gulf region can be a complicating factor in treat...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:Little is known about the numbers of children who will be left without one or both parents because of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome. This report evaluates childbearing patterns among U.S. Army reserve component members, a group largely made up of men with limited conta...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::This paper describes issues in the psychological assessment of individuals for security clearances, special duty, and sensitive positions. Using assessment for access to sensitive compartmented information as an example, the paper identifies, and explicates problems in criterion validity (the NEXUS issue), practical a...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract::In response to the end of the cold war, the United States developed new foreign policy and national security strategies. As a result, many medical support concepts that were operative during the cold war were invalidated. Recently, the Chairman of the Joint Chiefs of Staff provided direction and guidance for long-rang...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:1998-05-01 00:00:00
abstract:INTRODUCTION:Dual-task performance, in which an individual performs two tasks simultaneously, is compromised following mild traumatic brain injury (mTBI). Proficient dual-task performance is essential in a military setting for both military member safety and execution of skilled tasks. To address the unique needs of mi...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa404
更新日期:2021-01-25 00:00:00
abstract::The United States Army Europe Stress Management Team (USAREUR SMT) is designed to assist victims of hostage, terrorist, and disaster situations. Early intervention is intended to prevent the development of chronic posttraumatic stress disorder. This paper describes the operation of the SMT following the missile attack...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00