Initial evaluation of N,N-diethyl-m-toluamide and permethrin absorption in human volunteers under stress conditions.

Abstract:

OBJECTIVES:This was a pilot study to determine (1) whether it is feasible to effectively blind human subjects to the presence of the insect repellents N,N-diethyl-m-toluamide (DEET) and permethrin; (2) whether DEET affects the absorption of permethrin; and (3) whether combat videotape viewing and mental arithmetic are stressful. METHODS:Ten volunteers were exposed to DEET, permethrin, and stress (1-hour combat videotape plus mental arithmetic) in a double-blind, randomized, placebo-controlled trial. Outcome measurements included hemodynamics, plasma DEET and permethrin levels, and questionnaires to assess blinding. RESULTS:Highly sensitive serologic assays readily detected DEET but not permethrin. Staff members and subjects were effectively blinded to both. The videotape-math combination was stressful by both self-report and hemodynamic measures. CONCLUSIONS:It is possible to blind subjects with respect to DEET and permethrin. Permethrin on clothing does not enter the bloodstream at appreciable levels. Combat videotapes and mental arithmetic can be stressful.

journal_name

Mil Med

journal_title

Military medicine

authors

Roy MJ,Kraus PL,Cooper JA,Cherstniakova S,Coll R,Seegers CA,Deuster PA,Koslowe P,Law WA,Krantz DS,Cantilena L

doi

10.7205/milmed.171.2.122

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

122-7

issue

2

eissn

0026-4075

issn

1930-613X

journal_volume

171

pub_type

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