Endoscopic imaging and size estimation of colorectal adenomas in the multiple intestinal neoplasia mouse.

Abstract:

BACKGROUND:The scientific potential of animal models of carcinogenesis has not been fully realized because of our limited ability to monitor tumor growth in vivo. OBJECTIVE:To develop an endoscopy-based protocol for the accurate estimation of adenoma size in vivo from images obtained during colonoscopy. DESIGN:To compare estimates of lesion size acquired during endoscopy with those obtained from magnetic resonance imaging (MRI) and at necropsy. SETTING:A small-animal imaging facility. SUBJECTS:Adenomatous polyposis coli multiple intestinal metaplasia Fox Chase Cancer Center mice that develop multiple colorectal adenomas. METHODS:The mice received colonoscopic examination by using a rigid endoscope, and high-resolution images of colon adenomas were captured by using a charge-coupled-device camera. Lesion size was estimated by comparing the dimensions of the adenoma relative to a reference rod by using a novel geometric construction. The resulting areas were compared with estimates from MRIs and validated at necropsy. MAIN OUTCOME MEASUREMENTS:Cross-sectional area of colon adenomas. RESULTS:The cross-sectional area of 20 adenomas was measured in vivo during colonoscopy and compared with the size as measured at necropsy, which yielded a Pearson correlation coefficient of 0.94 (P = 6.52 x 10(-9)). Assessment of interoperator variability, when using measurements from 11 adenomas, yielded a Pearson correlation coefficient of 0.85 (P = 4.35 x 10(-3)) and demonstrated excellent reproducibility. LIMITATIONS:Only the distal colon could be viewed, and endoscopic measurements were 2-dimensional. CONCLUSIONS:An endoscopic method for the reliable measurement of colorectal adenomas in vivo was established. The application of this technique to mouse models of colon carcinogenesis will provide unique insight into the dynamics of adenoma growth.

journal_name

Gastrointest Endosc

authors

Hensley HH,Merkel CE,Chang WC,Devarajan K,Cooper HS,Clapper ML

doi

10.1016/j.gie.2008.09.054

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

742-9

issue

3 Pt 2

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(08)02679-5

journal_volume

69

pub_type

杂志文章
  • ERCP guide wires.

    abstract::Guide wires have become an essential part of therapeutic biliary and pancreatic endoscopy. The Teflon-painted stainless steel wire still remains the standard guide wire. However, special situations call for the use of some of the more specialized guide wires mentioned in this article. The endoscopist needs to be famil...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,评审

    doi:10.1016/s0016-5107(96)70262-6

    authors: Jacob L,Geenen JE

    更新日期:1996-01-01 00:00:00

  • Characteristics, goals, and motivations of applicants pursuing a fourth-year advanced endoscopy fellowship.

    abstract:BACKGROUND:The number of applications to advanced endoscopy fellowships has increased in past years. There is limited knowledge regarding why gastroenterology fellows pursue interventional/advanced endoscopy (AE) as a career. OBJECTIVE:To explore the characteristics, goals, and motivations of applicants applying for A...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2012.07.025

    authors: Trindade AJ,Gonzalez S,Tinsley A,Kim M,Dimaio CJ

    更新日期:2012-11-01 00:00:00

  • A comparison of 2 distal attachment mucosal exposure devices: a noninferiority randomized controlled trial.

    abstract:BACKGROUND AND AIMS:Endocuff (Arc Medical Design, Leeds, UK) and Endocuff Vision (Arc Medical Design, Leeds, UK) are effective mucosal exposure devices for improving polyp detection during colonoscopy. AmplifEYE (Medivators Inc, Minneapolis, Minn, USA) is a device that appears similar to the Endocuff devices but has re...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2019.06.046

    authors: Rex DK,Sagi SV,Kessler WR,Rogers NA,Fischer M,Bohm ME,Dewitt JM,Lahr RE,Searight MP,Sullivan AW,McWhinney CD,Garcia JR,Broadley HM,Vemulapalli KC

    更新日期:2019-11-01 00:00:00

  • Cutting the defiant lower esophageal ring.

    abstract::A symptomatic lower esophageal ring generally responds to standard bougienage therapy. However, a subset of patients with a lower esophageal ring defy dilation therapy. We have evaluated the efficacy of electrocautery incision of "defiant" lower esophageal rings, the data of which forms the basis of this report. Seven...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(93)70210-2

    authors: Burdick JS,Venu RP,Hogan WJ

    更新日期:1993-09-01 00:00:00

  • Efficacy and safety of 1-step transnasal endoscopic nasobiliary drainage for the treatment of acute cholangitis in patients with previous endoscopic sphincterotomy (with videos).

    abstract:BACKGROUND:Endoscopic nasobiliary drainage (NBD) for the treatment of acute cholangitis is an accepted method. A recently developed ultrathin transnasal videoendoscope is minimally invasive, even for patients who are critically ill. OBJECTIVE:To evaluate the clinical efficacy and safety of 1-step NBD by transnasal vid...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2007.11.050

    authors: Itoi T,Kawai T,Sofuni A,Itokawa F,Tsuchiya T,Kurihara T,Kusano C,Saito Y,Gotoda T

    更新日期:2008-07-01 00:00:00

  • A prospective, double-blind trial of somatostatin analog (octreotide) versus glucagon for the inhibition of small intestinal motility during endoscopic retrograde cholangiopancreatography.

    abstract:BACKGROUND:Glucagon is effective when used as an antimotility agent during ERCP, but at high doses it may cause nausea and vomiting. Octreotide acetate, a long-acting synthetic analog of somatostatin, inhibits contractility of the small intestine and is generally well tolerated. The purpose of this study was to determi...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0016-5107(95)70130-3

    authors: Van Dam J,Catalano MF,Ferguson DR,Barnes DS,Zuccaro G Jr,Sivak MV Jr

    更新日期:1995-10-01 00:00:00

  • Recanalization of tube overgrowth: a useful new indication for laser in palliation of malignant dysphagia.

    abstract::Overgrowth of an esophageal prosthesis by cancer is a late complication of insertion which presents a difficult management problem. We have treated 14 such patients; 9 had Celestin tubes and 5 Atkinson tubes in situ for a median of 7 months. The median patient age was 75 years; 3 had squamous cell carcinomas and 11 ad...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(92)70383-6

    authors: Sargeant IR,Loizou LA,Tulloch M,Thorpe S,Brown SG

    更新日期:1992-03-01 00:00:00

  • Adenoma recurrence after piecemeal colonic EMR is predictable: the Sydney EMR recurrence tool.

    abstract:BACKGROUND AND AIMS:EMR is the primary treatment of large laterally spreading lesions (LSLs) in the colon. Residual or recurrent adenoma (RRA) is a major limitation. We aimed to identify a robust method to stratify the risk of RRA. METHODS:Prospective multicenter data on consecutive LSLs ≥20 mm removed by piecemeal EM...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2016.11.027

    authors: Tate DJ,Desomer L,Klein A,Brown G,Hourigan LF,Lee EY,Moss A,Ormonde D,Raftopoulos S,Singh R,Williams SJ,Zanati S,Byth K,Bourke MJ

    更新日期:2017-03-01 00:00:00

  • Do it yourself: building an ERCP training system within 30 minutes (with videos).

    abstract:BACKGROUND:Ex vivo training of ERCP by using simulators is desirable before trainees perform endoscopy in patients. OBJECTIVE:We aimed to construct a simple and inexpensive but realistic simulator for ERCP training. DESIGN:Construction and establishment of an ERCP simulator. SETTING:Endoscopy suite. INTERVENTION:An...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2014.01.006

    authors: Schneider AR,Schepp W

    更新日期:2014-05-01 00:00:00

  • Optimization of light dosimetry for photodynamic therapy of Barrett's esophagus: efficacy vs. incidence of stricture after treatment.

    abstract:BACKGROUND:Photodynamic therapy (PDT) may be used to ablate high-grade dysplasia/early stage cancer (HGD/T1) in patients with Barrett's esophagus. PDT may result in esophageal stricture. This nonrandomized, unblinded, dose de-escalation study in consecutive patients was designed to determine the lowest light dose effec...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0016-5107(04)02394-6

    authors: Panjehpour M,Overholt BF,Phan MN,Haydek JM

    更新日期:2005-01-01 00:00:00

  • Stent-guided sphincterotomy.

    abstract::Performing sphincterotomy when either Billroth II gastrectomy or complicated periampullary diverticula are present may increase the risk of complications. In addition a sphincterotomy on the main pancreatic sphincter or the papilla of Santorini presents complicated problems. Stent-guided sphincterotomy has been utiliz...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(94)70254-3

    authors: Siegel JH,Cohen SA,Kasmin FE,Veerappan A

    更新日期:1994-09-01 00:00:00

  • Ongoing colorectal cancer risk despite surveillance colonoscopy: the Polyp Prevention Trial Continued Follow-up Study.

    abstract:BACKGROUND:Despite regular colonoscopy, interval colorectal cancer (CRC) may occur. Long-term studies examining CRC rates in patients with previous colonoscopy are lacking. OBJECTIVE:We examined the rate of interval CRC in the Polyp Prevention Trial Continued Follow-up Study (PPT-CFS), an observational study of PPT pa...

    journal_title:Gastrointestinal endoscopy

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.gie.2009.05.010

    authors: Leung K,Pinsky P,Laiyemo AO,Lanza E,Schatzkin A,Schoen RE

    更新日期:2010-01-01 00:00:00

  • Treatment of ring slippage after gastric bypass: long-term results after endoscopic dilation with an achalasia balloon (with videos).

    abstract:BACKGROUND:Silastic rings are used in gastric bypass procedures for the treatment of obesity, but ring slippage may lead to gastric pouch outlet stenosis (GPOS). Conventional management has been ring removal through abdominal surgery. OBJECTIVE:To describe a novel, safe, minimally invasive, endoscopic technique for th...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.gie.2010.01.057

    authors: Campos JM,Evangelista LF,Ferraz AA,Galvao Neto MP,De Moura EG,Sakai P,Ferraz EM

    更新日期:2010-07-01 00:00:00

  • Endoscopic photodynamic diagnosis: oral aminolevulinic acid is a marker of GI cancer and dysplastic lesions.

    abstract:BACKGROUND:Dysplasia and early cancer of the upper gastrointestinal (GI) tract often are undetected at white-light endoscopy. We describe oral administration of 5-aminolevulinic acid for the in vivo photodynamic diagnosis of premalignant and malignant lesions during endoscopy. METHODS:Four patients with known gastric ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(99)70232-4

    authors: Mayinger B,Reh H,Hochberger J,Hahn EG

    更新日期:1999-08-01 00:00:00

  • Bacteremia during esophageal variceal sclerotherapy: its cause and prevention.

    abstract::Eleven consecutive patients underwent a total of 34 esophageal variceal sclerotherapy (EVS) sessions for bleeding esophageal varices. Blood cultures were drawn pre-, intra-, and post-EVS. All pre- and post-EVS blood cultures were negative. Five of the initial nine patients studied were found to have positive blood cul...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(85)71955-4

    authors: Brayko CM,Kozarek RA,Sanowski RA,Testa AW

    更新日期:1985-02-01 00:00:00

  • Colorectal surveillance interval assignment based on in vivo prediction of polyp histology: impact of endoscopic quality improvement program.

    abstract:BACKGROUND:Validated training methods are needed before in vivo optical diagnosis can be used to guide colorectal cancer surveillance interval assignments. OBJECTIVES:To assess the impact of endoscopist training on accuracy of surveillance intervals based on in vivo optical diagnosis. DESIGN:Prospective, randomized s...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.gie.2012.03.007

    authors: Coe SG,Thomas C,Crook J,Ussui V,Diehl N,Wallace MB

    更新日期:2012-07-01 00:00:00

  • Is MRCP equivalent to ERCP for diagnosing biliary obstruction in orthotopic liver transplant recipients? A meta-analysis.

    abstract:BACKGROUND:Biliary complications are the second leading cause of morbidity and mortality in orthotopic liver transplant (OLT) recipients. Endoscopic retrograde cholangiography (ERC) is considered the diagnostic criterion standard for post-orthotopic liver transplantation biliary obstruction, but incurs significant risk...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.gie.2010.12.014

    authors: Jorgensen JE,Waljee AK,Volk ML,Sonnenday CJ,Elta GH,Al-Hawary MM,Singal AG,Taylor JR,Elmunzer BJ

    更新日期:2011-05-01 00:00:00

  • Endoscopic retrograde cholangiography in the diagnosis of biliary malformations in infants.

    abstract::The differentiation of infantile biliary malformations from primary parenchymal diseases is difficult. The recent development of a pediatric side-viewing endoscope (PJF Endoscope; Olympus Corporation of America) provided an opportunity to investigate the usefulness of endoscopic retrograde cholangiography (ERC) for pr...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(88)71432-7

    authors: Heyman MB,Shapiro HA,Thaler MM

    更新日期:1988-11-01 00:00:00

  • EUS in cirrhotic patients with and without prior variceal hemorrhage in comparison with noncirrhotic control subjects.

    abstract:BACKGROUND:Endoscopic ultrasound (EUS) was used to evaluate cirrhotic patients with and without prior variceal hemorrhage. The findings were compared with those of EUS in noncirrhotic control subjects to determine EUS features indicative of cirrhosis and of a risk for variceal hemorrhage. METHODS:Patients with cirrhos...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1067/mge.2000.107297

    authors: Faigel DO,Rosen HR,Sasaki A,Flora K,Benner K

    更新日期:2000-10-01 00:00:00

  • Midazolam with meperidine or fentanyl for colonoscopy: results of a randomized trial.

    abstract:BACKGROUND:A combination of midazolam and opioid is usually used to achieve sedation and analgesia during colonoscopy. Two commonly used opioids are meperidine and fentanyl, but few studies have compared their efficacy. OBJECTIVE:This randomized trial aimed to compare the efficacy and recovery time of 2 sedation regim...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.gie.2008.09.033

    authors: Hayee B,Dunn J,Loganayagam A,Wong M,Saxena V,Rowbotham D,McNair A

    更新日期:2009-03-01 00:00:00

  • Introducer method of percutaneous endoscopic cecostomy and antegrade continence enema by use of the Chait Trapdoor cecostomy catheter in patients with adult neurogenic bowel.

    abstract:BACKGROUND:Previous reports on percutaneous endoscopic cecostomy (PEC) for the delivery of antegrade continence enema (ACE) in adults have been presented in the form of case reports. Heretofore the tubes used in the pull method of PEC have been thick bolster catheters. The author performed PEC by using the introducer m...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2005.12.035

    authors: Uno Y

    更新日期:2006-04-01 00:00:00

  • Snare cautery debridement prior to Nd:YAG photoablation improves treatment efficiency of broad-based adenomas of the colorectum.

    abstract::Forty-six patients who underwent piecemeal resection of large, sessile villous adenomas followed by immediate laser photoablative therapy are presented. In contrast to previously published series utilizing laser alone, prior snare resection of such lesions provides copious tissue for histologic analysis, decreases the...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(89)72793-0

    authors: Low DE,Kozarek RA

    更新日期:1989-07-01 00:00:00

  • Accuracy of contrast-enhanced harmonic EUS with a second-generation perflutren lipid microsphere contrast agent (with video).

    abstract:BACKGROUND:EUS-FNA has limitations in cancer diagnosis/staging. New contrast agents, transducers, and processors have improved the potential of contrast-enhanced harmonic (CEH)-EUS. OBJECTIVE:To determine optimal settings and preliminary accuracy of CEH-EUS by using a second-generation perflutren lipid microsphere con...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2010.09.014

    authors: Romagnuolo J,Hoffman B,Vela S,Hawes R,Vignesh S

    更新日期:2011-01-01 00:00:00

  • Treatment of "obstructive" pain by endoscopic drainage in patients with pancreatic head carcinoma.

    abstract::Obstruction of the main pancreatic duct with secondary upstream ductal hypertension is one cause of pain in patients with pancreatic cancer. Pancreatic endoscopic stenting and decompression of the pancreatic duct have been effective in the treatment of pain secondary to chronic calcifying pancreatitis and in one case ...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(93)70263-1

    authors: Costamagna G,Gabbrielli A,Mutignani M,Perri V,Crucitti F

    更新日期:1993-11-01 00:00:00

  • Decision analysis of prophylactic treatment for patients with high-risk esophageal varices.

    abstract:BACKGROUND:Clinical decision analyses were conducted to quantify the uncertainty and to identify important factors in selection of prophylactic therapy for patients with esophageal varices. METHODS:A Markov model compared variceal ligation, beta-blockers, and "watchful waiting" strategies in terms of bleeding-free lif...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1067/mge.2000.110729

    authors: Aoki N,Kajiyama T,Beck JR,Cone RW,Soma K,Fukui T

    更新日期:2000-12-01 00:00:00

  • Cost-effectiveness analysis of management strategies for obscure GI bleeding.

    abstract:BACKGROUND AND AIMS:Of patients who are seen with GI hemorrhage, approximately 5% will have a small-bowel source. Management of these patients entails considerable expense. We performed a decision analysis to explore the optimal management strategy for obscure GI hemorrhage. METHODS:We used a cost-effectiveness analys...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2008.01.035

    authors: Gerson L,Kamal A

    更新日期:2008-11-01 00:00:00

  • Negative capsule endoscopy in patients with obscure GI bleeding predicts low rebleeding rates.

    abstract:BACKGROUND:Wireless capsule endoscopy (CE) is the investigation of choice in obscure GI bleeding (OGIB), with a high diagnostic yield when compared with other modalities. It enables specific treatment to be instigated in a significant proportion of cases, with the aim of reducing rebleeding rates. Little evidence is cu...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2008.06.054

    authors: Macdonald J,Porter V,McNamara D

    更新日期:2008-12-01 00:00:00

  • Endosonography-guided cholangiopancreatography.

    abstract:BACKGROUND:Detailed imaging of the common bile duct and main pancreatic duct is possible with endosonography. Utilizing a custom manufactured flexible needle, we have developed a technique of performing endosonography-guided cholangiopancreatography (EGCP). METHODS:Of 205 patients undergoing ERCP, complete ductography...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/s0016-5107(06)80108-2

    authors: Wiersema MJ,Sandusky D,Carr R,Wiersema LM,Erdel WC,Frederick PK

    更新日期:1996-02-01 00:00:00

  • Abdominal compression during endoscopy (the Bolster technique) demonstrates hidden Schatzki rings (with videos).

    abstract:BACKGROUND AND AIMS:Schatzki rings are found in the distal esophagus, are associated with hiatal hernias, and present with intermittent dysphagia to solid foods. They can be identified by radiology (GI series or barium swallow studies) or endoscopy. Rings are not always visualized during endoscopy in patients in whom t...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2015.10.041

    authors: Jouhourian C,Bonis PA,Guelrud M

    更新日期:2016-05-01 00:00:00

  • Laparoscopy-assisted versus balloon enteroscopy-assisted ERCP in bariatric post-Roux-en-Y gastric bypass patients.

    abstract:BACKGROUND:Data on balloon enteroscopy-assisted ERCP (BEA-ERCP) versus laparoscopy-assisted ERCP (LA-ERCP) in post-Roux-en-Y gastric bypass (RYGB) patients are lacking. OBJECTIVES:To compare BEA-ERCP with LA-ERCP in post-RYGB patients and to identify factors that predict therapeutic success with BEA-ERCP. DESIGN:Retr...

    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章

    doi:10.1016/j.gie.2011.11.019

    authors: Schreiner MA,Chang L,Gluck M,Irani S,Gan SI,Brandabur JJ,Thirlby R,Moonka R,Kozarek RA,Ross AS

    更新日期:2012-04-01 00:00:00