Abstract:
:We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Ryu GM,Song P,Kim KW,Oh KS,Park KJ,Kim JHdoi
10.1093/nar/gkn1008subject
Has Abstractpub_date
2009-03-01 00:00:00pages
1297-307issue
4eissn
0305-1048issn
1362-4962pii
gkn1008journal_volume
37pub_type
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