Radiolabeled immunotherapy in non-Hodgkin's lymphoma treatment: the next step.

Abstract:

:Radiolabeled immunotherapy (RIT) is becoming a significant step forward in the treatment management of non-Hodgkin's lymphoma (NHL). In this state-of-the-art review article, general details, practical and health economic aspects, and next steps of RIT in NHL are reviewed from the existing literature and latest abstracts. As 90Y-ibritumomab tiuxetan is the only marketed RIT in NHL in Europe, the special focus of this review is on 90Y-ibritumomab tiuxetan, although the whole spectrum of available RIT concepts is highlighted. There is strong evidence to suggest that RIT is not only a safe and efficacious add-on treatment option in third or second line to chemotherapy, but is also a convincing asset as first-line therapy in various indications of lymphoma.

journal_name

Nucl Med Commun

authors

Otte A,van de Wiele C,Dierckx RA

doi

10.1097/MNM.0b013e328313e565

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

5-15

issue

1

eissn

0143-3636

issn

1473-5628

journal_volume

30

pub_type

杂志文章,评审
  • Radiopharmaceutical dosage of 99Tcm-HMPAO for cerebral blood flow SPET studies in children.

    abstract::Four methods of calculating the activity of 99Tcm-hexamethylpropyleneamine oxime to be administered in cerebral blood flow investigations of children were evaluated in patient studies. Three of the methods were based on the size of the child. We also constructed a theoretical dosage model based on physiological data a...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199605000-00012

    authors: Vestergren E,Jacobsson L,Bjure J,Sixt R,Mattsson S

    更新日期:1996-05-01 00:00:00

  • Validation of a dual-isotope technique using 123I-MIBG and 201Tl in the assessment of sympathetic reinnervation following heart transplantation: phantom and patient studies.

    abstract::Dual-isotope studies using 123I and 201Tl allow the assessment of sympathetic reinnervation in patients following heart transplantation. 123I-meta-iodobenzyl guanidine (123I-MIBG) serves as a tracer of the integrity of the sympathetic nervous system. 201Tl is used for landmarking to allow better delineation of the myo...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199508000-00009

    authors: Krause BJ,Gürtner C,Kranert WT,Maul FD,Baum RP,Hör G

    更新日期:1995-08-01 00:00:00

  • Performance of a single crystal digital gamma camera for first pass cardiac studies.

    abstract::First pass radionuclide angiocardiography (FPRNA) has gained increasing interest because of the development of new 99Tcm-labelled perfusion agents and of new 191Os/191Irm generator systems. The aim of the study was to evaluate the performance capacities of a small field of view single crystal digital gamma camera for ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199101000-00004

    authors: Dobbeleir A,Franken PR,Ham HR,Brihaye C,Guillaume M,Knapp FF,Vandevivere J

    更新日期:1991-01-01 00:00:00

  • Role of 18F-FDG PET/CT in evaluating molecular subtypes and clinicopathological features of primary breast cancer.

    abstract:OBJECTIVE:In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) v...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000856

    authors: Arslan E,Çermik TF,Trabulus FDC,Talu ECK,Başaran Ş

    更新日期:2018-07-01 00:00:00

  • A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes.

    abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001305

    authors: Haddad T,Fard-Esfahani A,Vali R

    更新日期:2021-01-01 00:00:00

  • A method of radionuclide angiography and comparison with contrast aortography in the assessment of aorto-iliac disease.

    abstract::Forty-four patients with symptoms of lower limb arterial insufficiency were examined by radionuclide angiography using 99Tcm in vivo red cell labelling and by contrast aortography. The results of the study indicate that radionuclide angiography may well have a useful role to play in determining the type of contrast st...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198601000-00006

    authors: Grime JS,Critchley M,Whitehouse GH,Zavras G

    更新日期:1986-01-01 00:00:00

  • Bone marrow scintigraphy in small cell carcinoma of the lung.

    abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199401000-00006

    authors: Li DJ,Maughan TS,Miles KA,Wraight EP

    更新日期:1994-01-01 00:00:00

  • Yttrium-90 dosimetry and implications on tumour response and survival after radioembolisation of chemo-refractory hepatic metastases from breast cancer.

    abstract:PURPOSE:The aim of the study was to evaluate the effects of tumour dose on tumour response and overall survival (OS) in patients with chemo-refractory metastatic breast cancer (MBC) to the liver undergoing yttrium-90 radioembolisation (Y90 RE). MATERIALS AND METHODS:In 20 consecutive patients with chemo-refractory MBC...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001345

    authors: Cheng B,Sethi I,Davisson N,Brandon D,Barron B,Galt J,Bercu Z,Schuster DM,Kokabi N

    更新日期:2020-12-09 00:00:00

  • Evaluation of 99Tcm-teboroxime scintigraphy for the differentiation of reversible from fixed defects: comparison with 201T1 redistribution and reinjection imaging.

    abstract::The aim of this study was to compare 99Tcm-teboroxime and 201T1 myocardial studies with particular regard to the classification of perfusion defects as reversible or fixed. Twenty patients with a history of previous myocardial infarction and suspected effort ischaemia underwent exercise 201T1 scintigraphy with early (...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199307000-00002

    authors: Bisi G,Sciagrà R,Santoro GM,Zerauschek F,Fazzini PF

    更新日期:1993-07-01 00:00:00

  • Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.

    abstract::Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198608000-00006

    authors: Crawley JC,Crow TJ,Johnstone EC,Oldland SR,Owen F,Owens DG,Smith T,Veall N,Zanelli GD

    更新日期:1986-08-01 00:00:00

  • Relationship between myocardial counts and patient weight: adjusting the injected activity in myocardial perfusion scans.

    abstract::It is generally accepted that the quality of myocardial images deteriorates with increasing patient weight. This is attributed to a reduction of counts detected from the myocardium. In this paper we have looked at the count reduction in obese patients and suggest a workable algorithm to increase the injected activity ...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006231-200301000-00015

    authors: Notghi A,Williams N,Smith N,Goyle S,Harding LK

    更新日期:2003-01-01 00:00:00

  • A technique for lung ventilation-perfusion SPECT in neonates and infants.

    abstract:BACKGROUND:Single photon emission tomography (SPECT) of the lung is a well-established non-invasive technique for quantitative assessment of regional lung ventilation and perfusion distribution in children and in adults. However, its application in neonates as well as infants has been scarce because of several practica...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3282f25905

    authors: Sánchez-Crespo A,Rohdin M,Carlsson C,Bergström SE,Larsson SA,Jacobsson H,Lindahl S,Jonsson B

    更新日期:2008-02-01 00:00:00

  • Intraperitoneal 131I- and 111In-791T/36 monoclonal antibody in recurrent ovarian cancer: imaging and biodistribution.

    abstract::An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following admin...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198908010-00006

    authors: Perkins AC,Pimm MV,Gie C,Marksman RA,Symonds EM,Baldwin RW

    更新日期:1989-08-01 00:00:00

  • Immediate 201Tl reinjection: an alternative approach in myocardial perfusion scintigraphy? A comparison with contrast angiographic findings.

    abstract::Thallium-201 (201Tl) stress-redistribution/reinjection imaging provides a reliable diagnostic approach in patients evaluated for myocardial ischaemia. Immediate reinjection of 201Tl after completing the stress images followed by imaging 1 h later shortens the investigation time to 2.5 h and may provide a novel approac...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:

    authors: van Eck-Smit BL,van der Wall EE,Zwinderman AH,Pauwels EK

    更新日期:1995-10-01 00:00:00

  • A new method for the radiochemical purity measurement of ¹¹¹In-pentetreotide.

    abstract:OBJECTIVES AND METHODS:The recommended method for the measurement of radiochemical purity (RCP) of ¹¹¹In-labelled pentetreotide is thin-layer chromatography with a silica gel as the stationary phase and a 0.1 N sodium citrate solution (pH 5) as the mobile phase. According to the supplier's instructions, the mobile phas...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32834a7003

    authors: Salgado-Garcia C,Montoza-Aguado M,Luna-Alcaide AB,Segovia-Gonzalez MM,de Mora ES,Lopez-Martin J,Ramos-Font C,Jimenez-Heffernan A

    更新日期:2011-12-01 00:00:00

  • Accuracy of gated equilibrium radioventriculography in measuring left ventricular function in dogs.

    abstract::To assess the precision of gated equilibrium radioventriculography in measuring changes in left ventricular stroke volume (LVSV), we studied five dogs each with a chronically implanted electromagnetic flowmeter on the ascending aorta. Per cent changes in left ventricular stroke counts (LVSC) were compared to those in ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198812000-00009

    authors: Valette H,Bourguignon MH,Apoil E,Moyse D,Wise RA,Buchanan JW,Wagner HN Jr,Syrota A

    更新日期:1988-12-01 00:00:00

  • Spontaneous variability of left ventricular ejection fraction assessed with the Cardioscint.

    abstract::A miniature, non-imaging caesium iodide nuclear probe optically coupled to a photodiode (the 'Cardioscint') has been developed which, in conjunction with a modified personal computer, is capable of continuous on-line monitoring of left ventricular function and ST-segment level at the bedside. The purpose of this study...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199205000-00004

    authors: Broadhurst P,Liu XJ,Cashman PM,Raftery EB,Lahiri A

    更新日期:1992-05-01 00:00:00

  • 99Tcm-MAG3 for quantitation of differential renal function.

    abstract::We studied two different methods for the evaluation of differential renal function in a group of 100 patients with various kidney disorders whose effective renal plasma flow (ERPF) had been calculated previously by single 125I-orthoiodohippurate (OIH) injection and multiple blood sampling. Patients were divided into t...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198910000-00008

    authors: Llamas-Elvira JM,Martinez-Paredes M,Jimenez-Heffernan A,Sopena R,Requena MJ,Gonzalez FM,Torres M,Mateo A

    更新日期:1989-10-01 00:00:00

  • Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts.

    abstract:BACKGROUND:Image-derived input function (IDIF) from carotid arteries is an elegant alternative to full arterial blood sampling for brain PET studies. However, a recent study using blood-free IDIFs found that this method is particularly vulnerable to patient motion. The present study used both simulated and clinical [11...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328356185c

    authors: Zanotti-Fregonara P,Liow JS,Comtat C,Zoghbi SS,Zhang Y,Pike VW,Fujita M,Innis RB

    更新日期:2012-09-01 00:00:00

  • Detection of CBF deficits in neuropsychiatric disorders by an expert system: a 99Tcm-HMPAO brain SPET study using automated image registration.

    abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199901000-00006

    authors: Imran MB,Kawashima R,Sato K,Kinomura S,Ono S,Qureshy A,Fukuda H

    更新日期:1999-01-01 00:00:00

  • Analysis of the early blood kinetics of 99mTc-GSA and its verification: new one-compartment model and regression equation.

    abstract::Technetium-99m-galactosyl human serum albumin (99mTc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors in the hepatocyte membrane; the level of 99mTc-GSA accumulation in the liver correlates well with the parameters of hepatic function tests. We hypothesized that the early blood kinetics of 99mT...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200107000-00008

    authors: Sugai Y,Komatani A,Hosoya T,Takahashi K

    更新日期:2001-07-01 00:00:00

  • Predicting the response to cardiac resynchronization therapy using 99mTc-tetrofosmin myocardial scintigraphy in patients with drug-refractory heart failure: additional value of the washout of 99mTc-tetrofosmin.

    abstract:OBJECTIVE:A lack of response to cardiac resynchronization therapy (CRT) has been reported in 20-40% of heart failure patients with left ventricular (LV) dyssynchrony who underwent treatment based on the established guidelines. The study aimed to investigate the relationship between (99m)Tc-tetrofosmin ((99m)Tc-TF) myoc...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/MNM.0000000000000150

    authors: Shigeru M,Fujiwara S,Takamine S,Yoshida A,Kawai H,Shiotani H,Hirata K

    更新日期:2014-09-01 00:00:00

  • Evaluating the use of optimally respiratory gated 18F-FDG-PET in target volume delineation and its influence on radiation doses to the organs at risk in non-small-cell lung cancer patients.

    abstract:OBJECTIVE:This radiotherapy planning study evaluated tumour delineation using both optimally respiratory gated and nongated fluorine-18 fluorodeoxyglucose-PET (F-FDG-PET). METHODS:For 22 non-small-cell lung tumours, both scans were used to create the nongated and gated (g) gross tumour volumes (GTVg) together with the...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000409

    authors: Wijsman R,Grootjans W,Troost EG,van der Heijden EH,Visser EP,de Geus-Oei LF,Bussink J

    更新日期:2016-01-01 00:00:00

  • A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia.

    abstract:OBJECTIVE:The purpose of this study was to compare the sensitivity of single-photon emission computed tomography/computed tomography (SPECT/CT) using 99mTc-sestamibi (MIBI) with that of PET/CT using 11C-methionine (MET) for localization of parathyroid adenomas/hyperplasia in primary hyperparathyroidism. MATERIALS AND ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000216

    authors: Hayakawa N,Nakamoto Y,Kurihara K,Yasoda A,Kanamoto N,Miura M,Inagaki N,Togashi K

    更新日期:2015-01-01 00:00:00

  • Formulation and characterization of lutetium-177-labeled stannous (tin) colloid for radiosynovectomy.

    abstract:OBJECTIVE:Easy large-scale production, easy availability, cost-effectiveness, long half-life, and favorable radiation characteristics have made lutetium-177 (Lu) a preferred radionuclide for use in therapy. Lutetium-177-labeled stannous (Lu-Sn) colloid particles were formulated for application in radiosynovectomy, foll...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000684

    authors: Arora G,Singh M,Jha P,Tripathy S,Bal C,Mukherjee A,Shamim SA

    更新日期:2017-07-01 00:00:00

  • In-vivo quantification of dose-dependent dopamine transporter blockade in the rat striatum with small animal SPECT.

    abstract:OBJECTIVE:This study investigated dopamine transporter blockade in the rat striatum after treatment with various doses of methylphenidate using a high-resolution small animal SPECT ('TierSPECT') and I-FP-CIT. METHODS:I-FP-CIT was administered intravenously 1 h after intraperitoneal injection of methylphenidate (3 mg.k...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328014a0df

    authors: Nikolaus S,Antke C,Beu M,Kley K,Larisch R,Wirrwar A,Müller HW

    更新日期:2007-03-01 00:00:00

  • 'Early' thyroid 123I uptake: correction for extrathyroidal neck radioactivity.

    abstract::Should one correct for extrathyroidal neck radioactivity ('neck background') when interpreting perchlorate discharge test results? A new background correction method was developed using a linear probe. 123I produces photon peaks at two energy levels: 159 keV (gamma-rays) and 28 keV (X-rays), with an attenuation of 15 ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199211000-00013

    authors: Arntzenius AB,van der Heide D,Meinders AE

    更新日期:1992-11-01 00:00:00

  • Quantitation of skeletal muscle necrosis using 99Tcm-pyrophosphate with SPECT in a canine model.

    abstract::Patients with acute arterial occlusion may suffer from significant muscle necrosis. It is important to determine the amount of regional muscle necrosis for prognostic purposes and evaluation of therapy. We have used technetium-99m-pyrophosphate (PPi) with single photon emission computed tomography (SPECT) to quantitat...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199002000-00009

    authors: Yip TC,Houle S,Hayes G,Forrest I,Nelson L,Walker PM

    更新日期:1990-02-01 00:00:00

  • Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging.

    abstract::Optical luciferase gene imaging is emerging as a method to monitor gene expression in small animals. However, there is concern over how regional availability of exogenously administered substrate may affect photon emission. We thus synthesized [125I]iodo-D-luciferin, which demonstrated substrate characteristics for fi...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200309000-00009

    authors: Lee KH,Byun SS,Paik JY,Lee SY,Song SH,Choe YS,Kim BT

    更新日期:2003-09-01 00:00:00

  • Breast milk radioactivity following injection of 99Tcm-pertechnetate and 99Tcm-glucoheptonate.

    abstract::Measurements were made of the concentration of radioactivity in the breast milk of two patients: one following 100 MBq (2.7 mCi) 99Tcm-pertechnetate administration, and the other following administration of 550 MBq (15 mCi) 99Tcm-glucoheptonate. The fractional activity concentrations in the former case were about two ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198710000-00011

    authors: Mountford PJ,Coakley AJ

    更新日期:1987-10-01 00:00:00