Abstract:
:Stem cells are classically defined by their multipotent, long-term proliferation, and self-renewal capabilities. Here, we show that increased antioxidant capacity represents an additional functional characteristic of muscle-derived stem cells (MDSCs). Seeking to understand the superior regenerative capacity of MDSCs compared with myoblasts in cardiac and skeletal muscle transplantation, our group hypothesized that survival of the oxidative and inflammatory stress inherent to transplantation may play an important role. Evidence of increased enzymatic and nonenzymatic antioxidant capacity of MDSCs were observed in terms of higher levels of superoxide dismutase and glutathione, which appears to confer a differentiation and survival advantage. Further when glutathione levels of the MDSCs are lowered to that of myoblasts, the transplantation advantage of MDSCs over myoblasts is lost when transplanted into both skeletal and cardiac muscles. These findings elucidate an important cause for the superior regenerative capacity of MDSCs, and provide functional evidence for the emerging role of antioxidant capacity as a critical property for MDSC survival post-transplantation.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Urish KL,Vella JB,Okada M,Deasy BM,Tobita K,Keller BB,Cao B,Piganelli JD,Huard Jdoi
10.1091/mbc.e08-03-0274subject
Has Abstractpub_date
2009-01-01 00:00:00pages
509-20issue
1eissn
1059-1524issn
1939-4586pii
E08-03-0274journal_volume
20pub_type
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