Vincristine induced peripheral neuropathy potentiated by voriconazole in a patient with previously undiagnosed CMT1X.

abstract：BACKGROUND:Advanced irradiation techniques, including intensity-modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well-defined volume. In intracranial germinomas, whole-ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study exa...

journal_title：Pediatric blood & cancer

authors： Toll SA,Jones MT,Yoshida EJ,Dhall G,Olch AJ,Wong KK

更新日期：2019-12-01 00:00:00

abstract：:Germline DICER1 pathogenic variants predispose to numerous benign and malignant tumors. In this report, we describe DICER1 gene analysis in an adolescent diagnosed with multinodular goiter, ovarian Sertoli-Leydig cell tumor, and lung cyst. DICER1 mutational screening at the DNA level failed to detect any pathogenic va...

journal_title：Pediatric blood & cancer

authors： Verrier F,Dubois d'Enghien C,Gauthier-Villars M,Bonadona V,Faure-Conter C,Dijoud F,Stoppa-Lyonnet D,Houdayer C,Golmard L

更新日期：2018-06-01 00:00:00

abstract：:The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the f...

journal_title：Pediatric blood & cancer

authors： Barg AA,Ifrah AD,Strauss T,Simchen MJ,Orvieto R,Rosenberg N,Kenet G

更新日期：2017-08-01 00:00:00

abstract：:In Wilms tumor (WT), mutations in the gene encoding p53, TP53, are correlated with anaplasia; however TP53 variants have not been studied in favorable histology (FH) WTs. A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior. Therefore, we ...

journal_title：Pediatric blood & cancer

authors： Cost NG,Mitui M,Khokhar S,Wickiser JE,Baker LA,Rakheja D

更新日期：2012-08-01 00:00:00

abstract：:We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high-quality clinical practice guideline....

journal_title：Pediatric blood & cancer

authors： Loeffen EAH,van Dalen EC,Mulder RL,van de Wetering MD,Kremer LCM,Tissing WJE,Anthracycline Cardiotoxicity Working Group.

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The improved survival rates for childhood acute lymphoblastic leukemia (ALL) may be jeopardized by the development of a second cancer, which has been associated with thiopurine therapy. PROCEDURE:We retrospectively analyzed three sequential Nordic Society of Paediatric Haematology and Oncology's protocols c...

journal_title：Pediatric blood & cancer

authors： Nielsen SN,Eriksson F,Rosthoej S,Andersen MK,Forestier E,Hasle H,Hjalgrim LL,Aasberg A,Abrahamsson J,Heyman M,Jónsson ÓG,Pruunsild K,Vaitkeviciené GE,Vettenranta K,Schmiegelow K

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC AML 10) protocol incorporating high-dose anthracycline therapy has improved outcome of children with acute myeloid leukemia (AML). In this study, we review the results of childhood AML therapy in a Singapore university hosp...

journal_title：Pediatric blood & cancer

authors： Tan RM,Quah TC,Aung L,Liang S,Kirk RC,Yeoh AE

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The median age of patients with Ewing sarcoma (EwS) at diagnosis is around 14-15 years. Older age is associated with a worse outcome. The correlation of age at diagnosis on sites of disease has not been fully described. OBJECTIVE:The goal of this study was to evaluate the differences in sites of primary tum...

journal_title：Pediatric blood & cancer

authors： Worch J,Ranft A,DuBois SG,Paulussen M,Juergens H,Dirksen U

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatri...

journal_title：Pediatric blood & cancer

authors： Overman RE,Kartal TT,Cunningham AJ,Fialkowski EA,Naik-Mathuria BJ,Vasudevan SA,Malek MM,Kalsi R,Le HD,Stafford LC,Lautz TB,Many BT,Jones RE,Bütter A,Davidson J,Williams A,Dasgupta R,Lewis J,Troutt M,Aldrink JH,Man

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Although weight loss and lack of linear growth occur in children with cancer, growth history is not included in research that aims to determine nutritional status in children newly diagnosed with cancer. Therefore, this study aimed to determine weight loss and lack of linear growth in this patient group. PR...

journal_title：Pediatric blood & cancer

authors： Brinksma A,Roodbol PF,Sulkers E,Hooimeijer HL,Sauer PJ,van Sonderen E,de Bont ES,Tissing WJ

更新日期：2015-02-01 00:00:00

abstract：:A rare case of primary intestinal T-cell lymphoma (ITL) of an 8-year-old boy is reported. Medium- to large-sized tumor cells were betaF1+, CD3+, CD8+. TIA-1+, but CD4-, CD5-, CD30-, CD56-, CD20-, CD79a-, TdT-, consistent with an intraepithelial lymphocyte (IEL) origin. They showed monoclonal rearrangement of the T-cel...

journal_title：Pediatric blood & cancer

authors： Friedrich C,Schrum J,Chott A,Janka-Schaub G,Kabisch H

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To determine the safety, efficacy, and PK profile of intravenous busulfan (Bu) in the context of a Bu and cyclophosphamide (IVBuCy) preparative regimen in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS:Twenty-four children were enrolled in an open-label, multicenter tria...

journal_title：Pediatric blood & cancer

authors： Wall DA,Chan KW,Nieder ML,Hayashi RJ,Yeager AM,Kadota R,Przepiorka D,Mezzi K,Kletzel M,Pediatric Blood, Marrow Transplant Consortium.

更新日期：2010-02-01 00:00:00

abstract：:Ependymoblastoma (EBL) is a rare malignant CNS tumor of early childhood, listed as a subgroup of primitive neuroectodermal tumors (PNET) in the 2007 WHO Classification of Tumours of the Central Nervous System. Histologically, EBL can be defined by multilayered, mitotically active "ependymoblastic" rosettes with centra...

journal_title：Pediatric blood & cancer

authors： Nowak J,Seidel C,Pietsch T,Friedrich C,von Hoff K,Rutkowski S,Warmuth-Metz M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:The role of the neutropenic diet in the development of infections in oncology and stem cell transplant (SCT) patients is controversial. There is no data on the use of the neutropenic diet among pediatric oncologists. METHODS:A self-administered electronic survey was sent to 1,639 pediatric oncologists at 19...

journal_title：Pediatric blood & cancer

authors： Braun LE,Chen H,Frangoul H

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Children treated with cranial radiotherapy (CRT) for leukemia are at risk of developing central nervous system injuries. Magnetic resonance imaging (MRI) represents the examination method of choice for evaluating radiation-induced brain complications. The purpose of this report is to describe the spectrum of...

journal_title：Pediatric blood & cancer

authors： Faraci M,Morana G,Bagnasco F,Barra S,Polo P,Hanau G,Fioredda F,Caruso S,Rossi A,Spaziante R,Haupt R

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Corticosteroids increase risk for decreased bone mineral density, which can be worsened by vitamin D insufficiency (VDI) or deficiency (VDD). PROCEDURE:In the Vanderbilt cancer survivorship clinic, we obtained screening total 25-hydroxy vitamin D levels (VDL) in 171 cancer survivors <23 years old who were t...

journal_title：Pediatric blood & cancer

authors： Esbenshade AJ,Sopfe J,Zhao Z,Li Z,Campbell K,Simmons JH,Friedman DL

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The high cost, coupled with the need for continuous infusion, renders Desferrioxamine (DFO), a non-feasible option for iron-chelation in a large majority of patients with β-thalassemia major in developing countries. Monotherapy with deferiprone (DFP) or deferasirox (DFX) may not always attain optimal control...

journal_title：Pediatric blood & cancer

authors： Totadri S,Bansal D,Bhatia P,Attri SV,Trehan A,Marwaha RK

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Robatumumab (19D12; MK-7454 otherwise known as SCH717454) is a fully human antibody that binds to and inhibits insulin-like growth factor receptor-1 (IGF-1R). This multiinstitutional study (P04720) determined the safety and clinical efficacy of robatumumab in three separate patient groups with resectable ost...

journal_title：Pediatric blood & cancer

authors： Anderson PM,Bielack SS,Gorlick RG,Skubitz K,Daw NC,Herzog CE,Monge OR,Lassaletta A,Boldrini E,Pápai Z,Rubino J,Pathiraja K,Hille DA,Ayers M,Yao SL,Nebozhyn M,Lu B,Mauro D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Alveolar soft part sarcomas (ASPS) are generally chemo- and radio-resistant mesenchymal tumours, with no standardized treatment guidelines. We describe the clinical behaviour of paediatric ASPS and compare these features to previously reported adult series. PATIENTS AND METHODS:The clinical data of 51 child...

journal_title：Pediatric blood & cancer

authors： Orbach D,Brennan B,Casanova M,Bergeron C,Mosseri V,Francotte N,Van Noesel M,Rey A,Bisogno G,Pierron G,Ferrari A

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Understanding factors that affect the decisions of caregivers of African children to enroll their children in clinical trials would lead to more fully informed consent. METHODS:During the NOHARM study (NCT01976416), a placebo-controlled clinical trial of hydroxyurea for Ugandan children with sickle cell a...

journal_title：Pediatric blood & cancer

authors： Carman AS,Sautter C,Anyanwu JN,Ssemata AS,Opoka RO,Ware RE,Rujumba J,John CC

更新日期：2020-02-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopenia (CAMT) is characterised by neonatal thrombocytopenia, with reduced or absent bone marrow megakaryocytes, leading eventually to pancytopenia. The mean age for progression to bone marrow failure is four years, with the earliest reported being six months. We describe a CAMT pat...

journal_title：Pediatric blood & cancer

authors： Stoddart MT,Connor P,Germeshausen M,Ballmaier M,Steward CG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Sorafenib is an inhibitor of multiple kinases (e.g., VEGF receptors, PDGFR, FLT3, RET, BRAF, KIT) and is approved by FDA for treatment of two adult cancers. The activity of sorafenib was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES:Sorafenib was evaluated against the PPTP in vitro pa...

journal_title：Pediatric blood & cancer

authors： Keir ST,Maris JM,Lock R,Kolb EA,Gorlick R,Carol H,Morton CL,Reynolds CP,Kang MH,Watkins A,Houghton PJ,Smith MA

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Primary hemophagocytic lymphohistiocytosis (HLH) represents a group of inherited hyperinflammatory immunodeficiencies, including familial HLH (FHL), Griscelli syndrome type 2 (GS2), and X-linked lymphoproliferative syndrome (XLP). We previously reported an annual incidence of suspected primary HLH in Sweden ...

journal_title：Pediatric blood & cancer

authors： Meeths M,Horne A,Sabel M,Bryceson YT,Henter JI

更新日期：2015-02-01 00:00:00

abstract：:To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strong...

journal_title：Pediatric blood & cancer

authors： Sood R,Wong W,Jeng M,Zehnder JL

更新日期：2006-10-15 00:00:00

abstract：:Chronic granulomatous disease (CGD) is an immune deficiency characterized by defective neutrophil function and increased risk of life-threatening infections. Allogeneic hematopoietic cell transplantation is curative for CGD, and conditioning regimen impacts transplant-related outcomes. We report a single-center prospe...

journal_title：Pediatric blood & cancer

authors： Bhatt ST,Schulz G,Hente M,Slater A,Murray L,Shenoy S,Bednarski JJ

更新日期：2020-01-01 00:00:00

abstract：:Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissu...

journal_title：Pediatric blood & cancer

authors： Rosen GP,Nguyen HT,Shaibi GQ

更新日期：2013-12-01 00:00:00

abstract：:Germline or acquired mutations involving the GATA-binding protein gene (GATA2) have been linked to a variety of clinical conditions. In addition, patients harboring GATA2 mutations have a striking predisposition to develop myeloid malignancies, such as myelodysplastic syndrome or acute myeloid leukemia, but not acute ...

journal_title：Pediatric blood & cancer

authors： Esparza O,Xavier AC,Atkinson TP,Hill BC,Whelan K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. METHODS:A retrospective records review was...

journal_title：Pediatric blood & cancer

authors： Radulescu VC,Gerrard M,Moertel C,Grundy PE,Mathias L,Feusner J,Diller L,Dome JS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:More than 60% of children with acute myeloid leukemia (AML) become long-term survivors. Most are cured using chemotherapy without hematopoietic stem cell transplantation (HSCT). We report on pubertal development and compare self-reported parenthood among AML survivors and their siblings. PROCEDURE:We includ...

journal_title：Pediatric blood & cancer

authors： Molgaard-Hansen L,Skou AS,Juul A,Glosli H,Jahnukainen K,Jarfelt M,Jónmundsson GK,Malmros J,Nysom K,Hasle H,Nordic Society of Pediatric Hematology and Oncology.

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Severe congenital neutropenia is a rare disease, and autosomal dominantly inherited ELANE mutation is the most frequently observed genetic defect in the registries from North America and Western Europe. However, in eastern countries where consanguineous marriages are common, autosomal recessive forms might b...

journal_title：Pediatric blood & cancer

authors： Yılmaz Karapınar D,Patıroğlu T,Metin A,Çalışkan Ü,Celkan T,Yılmaz B,Karakaş Z,Karapınar TH,Akıncı B,Özkınay F,Onay H,Yeşilipek MA,Akar HH,Tüysüz G,Tokgöz H,Özdemir GN,Aslan Kıykım A,Karaman S,Kılınç Y,Oymak Y,Küpe

更新日期：2019-10-01 00:00:00