Abstract：
OBJECTIVE:To determine the extent and nature of off-label drug use in children admitted to a pediatric general ward in a tertiary health care centre METHODS:Consecutive patients aged 1 mo-12 years admitted to the general wards in a tertiary care center in Mumbai over a two-month period were prospectively enrolled in the study. British National Formulary [BNF] version 2005 was used to ascertain if the drug use was "off-label". The off-label use was categorized as: administration of a greater/lesser dose, administration at a higher/lower frequency than indicated, administration for indications not described, administration of a drug not licensed for use in that age group and/ or use of alternative routes of administration. Descriptive statistics was used for calculating the off-label drug use. RESULTS:Two thousand prescriptions received by 600 subjects (M:F= 1.47:1) were analyzed. One thousand and forty-five (50.62%) prescriptions were off-label. The off-label drug use rate was 1.74+/-1.56 per patient. The maximum rate of off-label drugs was in infants (2.33/patient). 'alteration in dosage' was by far the commonest reason for off-label use; followed by 'age' and 'indication'. Furosemide (i. v.), diazepam (i.v), cefotaxime (i.v), ethambutol (tab) and prednisolone (tab) were the five commonest off-label drugs used in the study population. CONCLUSIONS:Off-label drug use was highly prevalent in general pediatric ward of a tertiary care hospital in India.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Jain SS,Bavdekar SB,Gogtay NJ,Sadawarte PAdoi
10.1007/s12098-008-0188-1subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1133-6issue
11eissn
0019-5456issn
0973-7693journal_volume
75pub_type
杂志文章abstract：:The authors report a case of 13-y-old boy who presented with pain in bilateral knee and ankle joints accompanied by petechiae all over the body and hematochezia. On investigation, he had pancytopenia, which on subsequent evaluation revealed aplastic anemia. On investigation for short stature, he was diagnosed as a cas...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0579-6
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To field test the Individualised Color Coded Any Day (ICCAD) growth monitoring charts at primary health care level in three districts of Maharashtra. METHODS:The present study was conducted in three districts of Maharashtra - Pune, Satara and Kolhapur and included newborns with weight ≥ 1500 g born during 1s...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-015-2027-5
更新日期：2016-07-01 00:00:00
abstract：:Ocular manifestations that occur directly or indirectly as result of a pathologic process that involves other parts of the body, in a pediatric population, will be discussed here. While a myriad number of systemic conditions have ocular manifestations, its importance cannot be undermined because it has implications fo...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2623-2
更新日期：2018-03-01 00:00:00
abstract：:A 9-y-old boy was referred to authors' institute for the management of insulin dependent diabetes mellitus. He was the product of third degree consanguineous marriage and was delivered by full term vaginal delivery with a birth weight of 2.75 kg. At 3 mo of age, he had presented with diabetic ketoacidosis and was on i...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1422-7
更新日期：2014-11-01 00:00:00
abstract：:Microvillous inclusion disease (MVID), also known as congenital microvillus atrophy, was first described by Davidson et al. in 1978. Till date, only a handful of cases with MVID have been described in English literature. It is an autosomal recessive disorder with no sex predisposition and more commonly noted in countr...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-02963-y
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To document the immunization rates, factors associated with incomplete immunization, and missed opportunities for immunizations in children affected by HIV presenting for routine outpatient follow-up. METHODS:A cross-sectional study of immunization status of children affected by HIV presenting for routine ou...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1049-0
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To analyze the infection outbreaks, control measures and outcomes of the outbreak in the NICU of a tertiary care centre in the year 2018. METHODS:This study was conducted in a 30 bedded tertiary care NICU from January 2018 through December 2018. The study design was an Outbreak investigation, based on a prog...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03201-6
更新日期：2020-05-01 00:00:00
abstract：:In this review, the clinical features and management of most commonly encountered acyanotic, left-to-right shunt lesions are discussed. Patients with small defects, especially in childhood, are usually asymptomatic while moderate to large defects in infancy may present with symptoms. Hyperdynamic precordium, widely sp...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724429
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To study the prevalence of depression among caregivers of children with cystic fibrosis and its impact on the health and well being of these children. METHODS:This cross-sectional study was conducted in a tertiary care hospital from September 2015 through August 2016. Forty one parents of children receiving ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-018-2695-z
更新日期：2018-11-01 00:00:00
abstract：:The major causes of emergence of multidrug-resistant organisms (MDRO) in neonatal sepsis include empiric antibiotic prescriptions, unregulated use of over-the-counter drugs, high incidence of healthcare associated infections (HAI), lack of awareness about antibiotic stewardship program and under staffing of neonatal i...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-019-03106-z
更新日期：2020-02-01 00:00:00
abstract：:This editorial provides information on the first draft of the human genome, and examines the impact this will have on the practice of medicine, with special reference to India. It examines what is currently possible in India, what we should do in the immediate future, and what is in store in the long run. The future i...
journal_title：Indian journal of pediatrics
pub_type： 社论
doi：10.1007/BF02726224
更新日期：2000-11-01 00:00:00
abstract：:Vaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of li...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2377-2
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:To examine the prevalence of school bullying and to investigate the behavioral, emotional, socio-economic and demographic correlates of bullying behaviors among Indian school going adolescents. METHODS:Self-reports on bullying involvement were collected from 9th to 10th class students (N = 209; Mean = 14.82...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1378-7
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To study the prevalence of celiac disease in Indian children with Down syndrome and evaluate its clinical and laboratory predictors. METHODS:Prevalence of celiac disease (CD) was assessed in 100 patients with Down syndrome (DS) attending pediatric genetic clinic at All India Institute of Medical Sciences,in ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-012-0838-1
更新日期：2013-02-01 00:00:00
abstract：:A pair of female thoraco-omphalopagus twins, with two pairs of lungs, common diaphragm and separate pleural cavities was separated at the age of 5(1/2) months after a parasitic relationship had developed between them. Before separation both the babies developed recurrent respiratory tract infection and frequent diarrh...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02730669
更新日期：2004-08-01 00:00:00
abstract：:The suitability of Clinical Assessment of Nutritional Status Score (CANSCORE) for the assessment of foetal malnutrition among 372 local Hyderabad newborns was studied. Details of length, weight and body mass index (BMI) at birth were related to total CANSCORE which consisted of scores ranging from 1 to 4 based on the ...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02727152
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low dose vasopressin on the hemodynamics of neonates with persistent pulmonary hypertension and catecholamine refractory shock. METHODS:This retrospective study was conducted in a level III NICU of a tertiary care teaching hospital, south India. Eighteen neonates with hypoxemic resp...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03519-1
更新日期：2020-10-08 00:00:00
abstract：:Japanese encephalitis (JE)-epidemics have been reported in many parts of the country. The incidence has been reported to be high among pediatric group with high mortality. The incidence of JE in recent times is showing an increasing trend. It appears that JE may become one of the major public health problems in India,...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02724120
更新日期：2004-07-01 00:00:00
abstract：:Functional abdominal pain (FAP) is one of the most common functional gastrointestinal disorders (FGIDs) of childhood. Only a minority of patients with FAP seek medical attention, often presenting to the primary care physician while symptoms are still evolving. The bio-psychosocial model of treatment not only aims to a...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-016-2111-5
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To determine the possible risk factors for severe acute malnutrition (SAM) in children below 5 y admitted in a hospital in north India. METHODS:This case-control study was conducted in a medical college hospital in children below 5 y of age. All cases of SAM (diagnosed as per WHO definition) between 6 and 59...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-013-1127-3
更新日期：2014-08-01 00:00:00
abstract：:Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of morbidity and mortality in these infants. In this article, the authors review the pathophysiology and clinical presentation of NEC and provide a critical appraisal of t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-014-1388-5
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:To assess the prevalence of decreased glomerular filtration rate (GFR) in Tibetan children with congenital heart disease (CHD) and its associated risk factors. METHODS:A total of 207 Tibetan children attending authors' center for treatment of CHD from May 2012 through November 2012, were included in the stu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1351-5
更新日期：2014-10-01 00:00:00
abstract：:Kocher-Debre-Semelaigne syndrome is a rare association of muscular pseudohypertrophy and hypothyroidism in children. We report two cases of this syndrome in this communication. The first case was a seven-years-old female who presented with features of hypothyroidism and muscle pseudohypertrophy. The second child had s...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724260
更新日期：2003-08-01 00:00:00
abstract：:Cystic fibrosis (CF) is one of the common life limiting inherited diseases in Caucasian population. Recent reports suggest that the diagnosis of cystic fibrosis in Indian children is missed or delayed due to low index of suspicion. The diagnosis of cystic fibrosis is suspected by the typical clinical features and shou...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02723869
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the epidemiology of rotavirus gastroenteritis in Haryana post-introduction of rotavirus vaccine. Expanded National rotavirus surveillance network in India reported high burden of rotavirus diarrhea in India. The Government of India introduced the monovalent rotavirus vaccine made in India by Bhara...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03614-3
更新日期：2021-01-14 00:00:00
abstract：:Antimicrobial resistance is a key factor leading to emerging/ re-emerging infections. Rational antimicrobial therapy or antimicrobial stewardship is one of the important interventions to prevent emergence of resistance. Choosing correct empiric therapy is crucial not only to prevent antimicrobial resistance but also t...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-019-03144-7
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:A) To study the frequency of perceived breast milk insufficiency in mothers of hospitalized neonates. b) To assess subsequent duration of exclusive breast feeding and growth (upto three months) in neonates whose mothers perceived breast milk insufficiency. METHODS:Neonates whose mothers were willing to breas...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-009-0204-0
更新日期：2009-10-01 00:00:00
abstract：UNLABELLED:In about 10% cases of Duchenne muscular dystrophy (DMD), death is due to cardiac dysfunction. The recognition of cardiomyopathy in DMD is thus important. OBJECTIVE:To assess cardiac involvement in DMD patients by clinical, radiographic, electrocardiographic (ECG) and echocardiographic monitoring and correla...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02731732
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To assess the need and feasibility of a Transition Clinic in the care of adolescents with chronic illness. METHODS:A qualitative study, piloted by a questionnaire-based survey, followed by Focus Group Discussions was conducted in the Department of Pediatrics in a government teaching hospital in Kerala. The p...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03189-z
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:Hydrocarbons are a common cause of accidental poisoning in children, with kerosene being the most implicated agent in rural parts of India. However, lately, liquid mosquito repellent ingestion is emerging as an important cause of hydrocarbon (kerosene) poisoning in urban households. METHODS:This is a retros...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-019-03088-y
更新日期：2020-01-01 00:00:00
