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Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

Abstract：

:Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has now been described globally, as a clinically significant pathogen, particularly associated with skin and soft tissue infections, including abscesses, cellulitis and furunculosis. The recent emergence of CA-MRSA combined with its predominant presentation associated with skin and soft tissue infection, the previous literature indicating honey as an effective treatment of healthcare-associated HA-MRSA-related wound infection, as well as honey's ease of topical application, make the current study timely and of interest to healthcare practitioners involved with wound management. Although previous studies have examined the antimicrobial activity of honey against HA-MRSA, such data are limited regarding the activity of honey against this emerging type of MRSA. CA-MRSA (n=6 isolates), was examined for its susceptibility to natural honey (n=3 honey produced from bees in Northern Ireland and one commercial French honey). Results demonstrated that all honey was able to reduce the cultural count of all CA-MRSA from approximately 10(6) colony-forming units (cfus) (mean = 6.46 log10 cfu/g) to none detectable within 24h of co-culture of separate CA-MRSA organisms individually with all four-honey types examined. Subsequent non-selective enrichment of honey demonstrated that inoculated honey remained positive for CA-MRSA until 72h postinoculation, after which point no culturable organisms could be detected. This study demonstrated that, in vitro, these natural products had an antimicrobial activity against the CA-MRSA organisms tested. Further studies are now required to demonstrate if this antimicrobial activity has any clinical application.

journal_name

Complement Ther Clin Pract

journal_title

Complementary therapies in clinical practice

authors

Maeda Y,Loughrey A,Earle JA,Millar BC,Rao JR,Kearns A,McConville O,Goldsmith CE,Rooney PJ,Dooley JS,Lowery CJ,Snelling WJ,McMahon A,McDowell D,Moore JE

doi

10.1016/j.ctcp.2007.11.004

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

77-82

issue

eissn

1744-3881

issn

1873-6947

pii

S1744-3881(07)00077-1

journal_volume

pub_type

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Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).