Abstract:
:Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti-D preparation revealed reactivity against the neutrophil FcgammaRIIIb. A postinfusion serum sample contained antibodies against class I human HLA-A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti-D.
journal_name
Am J Hematoljournal_title
American journal of hematologyauthors
Berger-Achituv S,Ellis MH,Curtis BR,Wolach Bdoi
10.1002/ajh.21185subject
Has Abstractpub_date
2008-08-01 00:00:00pages
676-8issue
8eissn
0361-8609issn
1096-8652journal_volume
83pub_type
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