Abstract:
BACKGROUND:Overweight and obesity have been associated with better survival in patients with chronic obstructive pulmonary disease (COPD). On the other hand, excess body weight is associated with abnormal metabolic and inflammatory profiles that define the metabolic syndrome and predispose to cardiovascular diseases. This study was undertaken to evaluate the impact of overweight and obesity on the prevalence of the metabolic syndrome and on the metabolic and inflammatory profiles in patients with COPD. METHODS:Twenty-eight male patients with COPD were divided into an overweight/obese group [ n = 16, body mass index (BMI) = 33.5 +/- 4.2 kg/m(2)] and normal weight group (n = 12, BMI = 21.1 +/- 2.6 kg/m(2)). Anthropometry, pulmonary function and body composition were assessed. The metabolic syndrome was diagnosed according to waist circumference, circulating levels of triglyceride and high-density lipoprotein cholesterol levels, fasting glycemia and blood pressure. C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), leptin and adiponectin plasma levels were measured. RESULTS:Airflow obstruction was less severe in overweight/obese compared with normal weight patients (forced expiratory volume(1): 51 +/- 19% versus 31 +/- 12% predicted, respectively, P < 0.01). The metabolic syndrome was diagnosed in 50% of overweight/obese patients and in none of the normal weight patients. TNF-alpha, IL-6 and leptin were significantly higher in overweight/obese patients whereas the adiponectin levels were reduced in the presence of excess weight. CONCLUSIONS:The metabolic syndrome was frequent in overweight/obese patients with COPD. Obesity in COPD was associated with a spectrum of metabolic and inflammatory abnormalities.
journal_name
Chron Respir Disjournal_title
Chronic respiratory diseaseauthors
Poulain M,Doucet M,Drapeau V,Fournier G,Tremblay A,Poirier P,Maltais Fdoi
10.1177/1479972307087205subject
Has Abstractpub_date
2008-01-01 00:00:00pages
35-41issue
1eissn
1479-9723issn
1479-9731pii
5/1/35journal_volume
5pub_type
杂志文章abstract::It has been well defined that obesity is strongly linked with several respiratory symptoms and diseases, but no convincing evidence has been provided for chronic obstructive pulmonary disease (COPD). In the current study, we aim to assess the possible prevalence of obesity in patients with COPD in a cross-sectional ca...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972313504940
更新日期:2013-01-01 00:00:00
abstract::One of the primary objectives in management of chronic obstructive pulmonary disease (COPD) is preventing decrease in lung function and reducing the annual number of acute exacerbations of COPD (AECOPD). An oral course of systemic corticosteroids is a commonly used treatment in AECOPD. We hypothesize that this treatme...
journal_title:Chronic respiratory disease
pub_type: 信件,随机对照试验
doi:10.1177/1479972317721929
更新日期:2018-05-01 00:00:00
abstract::The objective of this study was to evaluate task performance and handling errors with soft mist inhalers (SMIs) or pressurized metered-dose inhalers (pMDIs) among patients with chronic obstructive pulmonary disease (COPD) experienced with, but not recently trained in, using these devices. This exploratory, noninterven...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,多中心研究
doi:10.1177/1479972318787914
更新日期:2019-01-01 00:00:00
abstract::Dyspnea-related anxiety may lead to reduced quality of life and functional disability through fearful avoidance of dyspnea-evoking activity. We describe the validation of a generic - diagnosis-independent - instrument assessing dyspnea-related anxiety. A total of 187 patients with respiratory diseases completed the Br...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972310383592
更新日期:2011-01-01 00:00:00
abstract::Acute effects of music and relaxation have not been evaluated in hospitalized subjects with chronic obstructive pulmonary disease (COPD). This study aims to evaluate the acute effects of music and progressive muscle relaxation (PMR) in hospitalized COPD subjects after a recent episode of exacerbation. A Randomized con...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1479972309346754
更新日期:2009-01-01 00:00:00
abstract::The spread of the SARS-CoV-2 infection among population has imposed a re-organization of healthcare services, aiming at stratifying patients and dedicating specific areas where patients with suspected COVID-related respiratory disease could receive the necessary health care assistance while waiting for the confirmatio...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973120961843
更新日期:2020-01-01 00:00:00
abstract::Shifts in natural or spontaneous language have been reported with psychological and physical changes, as well as shifts in predetermined words selected to describe dyspnea. Less evidence exists for natural language shifts and breathing intensity, particularly for everyday life and for negative emotion. Therefore, this...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972308096710
更新日期:2008-01-01 00:00:00
abstract::There should be a clear pathway through pulmonary rehabilitation and follow-on services. The aim of this survey was to determine the characteristics of the different components of the patient pathway, that is, pulmonary rehabilitation programs, ongoing exercise facilities, and support networks in Northern Ireland. Que...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972308091825
更新日期:2008-01-01 00:00:00
abstract::Nutritional status has been associated with clinical outcome in chronic airflow limitation (CAL), but epidemiological studies are scarce. We aimed to assess the relationship between body mass index (BMI) and CAL, taking into account confounding factors. 18,606 participants (49% male, 21% smokers, mean age: 55.8 ± 11.2...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315626012
更新日期:2016-05-01 00:00:00
abstract::Health-related quality of life (HRQoL) measurement in cystic fibrosis (CF) allows the inclusion of the patient's perspective in research and clinical practice. HRQoL scales have been used for many purposes and this review focuses on how HRQoL measurement has been implemented in CF research and care. Specifically, the ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972308098159
更新日期:2009-01-01 00:00:00
abstract::Patients with chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) commonly suffer from exertional symptoms of breathlessness and fatigue. The similar systemic manifestations of the conditions, including skeletal muscle dysfunction, are a major contributing factor to the limitation in exercise ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972311423111
更新日期:2011-01-01 00:00:00
abstract::The association between motor vehicle accidents (MVAs) and obstructive sleep apnea syndrome (OSAS) has always been quantified as risk of MVAs for individual drivers with OSAS. We evaluated the expected injured patients per year attributable to OSAS-dependent MVAs in a general population. By combining OSAS prevalence a...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315594624
更新日期:2015-11-01 00:00:00
abstract::Home noninvasive ventilation (NIV) is widely used to correct nocturnal alveolar hypoventilation in patients with chronic respiratory failure of various etiologies. The most commonly used ventilation mode is pressure support with a backup respiratory rate. This mode requires six main settings, as well as some additiona...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479973119844090
更新日期:2019-01-01 00:00:00
abstract::There is a growing understanding that chronic respiratory diseases in adults have their origins in early life. Adverse environmental exposures occurring in vulnerable periods during lung growth and development in the fetal period and in early childhood that alter lung structure and limit the growth in lung function ma...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972309345929
更新日期:2010-08-01 00:00:00
abstract::Self-management (SM) is defined as the provision of interventions to increase patients' skills and confidence, empowering the individual to take an active part in their disease management. There is uncertainty regarding the optimal format and the short- and long-term benefits of chronic obstructive pulmonary disease (...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972316687208
更新日期:2017-08-01 00:00:00
abstract::Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating condition that frequently occurs in the advanced stage of IPF. However, the clinical features in AE of connective tissue disease-associated interstitial pneumonia (AE-CTD-IP) have not been well-established. The aim of this study was to clari...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972318809476
更新日期:2019-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) imposes a costly burden on healthcare. Pulmonary rehabilitation (PR) is the best practice to better manage COPD to improve patient outcomes and reduce acute hospital care utilization. To evaluate the impact of a once-weekly, eight-week multidisciplinary PR program as an int...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972309104419
更新日期:2009-01-01 00:00:00
abstract:AIMS:Benefits of long acting beta 2 agonists are unclear for severe chronic obstructive pulmonary disease (COPD) patients with poor response to short acting bronchodilators. We aimed to evaluate 1) effects of eformoterol in such patients using a 'n-of-1' double crossover study design, and 2) aggregate data as a double-...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,随机对照试验
doi:10.1191/1479972304cd028oa
更新日期:2004-01-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease of unknown origin. Despite recent advancements, the diagnosis and management of IPF remains a distinct clinical challenge; as a result, patients often experience considerable delays in receiving an accurate diagnosis and confusion re...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972311416382
更新日期:2011-01-01 00:00:00
abstract::Recent advances in information communication technology allow contact with patients at home through e-Health services (telemedicine, in particular). We provide insights on the state of the art of e-Health and telemedicine for possible wider future clinical use. Telemedicine opportunities are summarized as i) home tele...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,评审
doi:10.1177/1479972309102805
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Effective asthma management requires a multidisciplinary approach that includes; the physician, the patient, and the patient's family. OBJECTIVES:The current study aimed to assess the roles played by community pharmacists toward asthma control together with the barriers hindering their practice and possible...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479973120952679
更新日期:2020-01-01 00:00:00
abstract::Emphysema on high-resolution computed tomography of the chest is the recent focus in the general practice in idiopathic pulmonary fibrosis (IPF). However, adequate attention has not been paid to obstructive disorder. Therefore, we retrospectively evaluated the association between the degree of airway obstruction and l...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315603714
更新日期:2016-02-01 00:00:00
abstract::Pulmonary rehabilitation (PR) can improve aerobic exercise capacity, health-related quality of life and dyspnoea in patients with chronic obstructive pulmonary disease (COPD). Recent studies have suggested that exercise training may improve blood pressure and arterial stiffness, albeit in small highly selected cohorts...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315587515
更新日期:2015-08-01 00:00:00
abstract::Time until the subsequent exacerbation (PEx) in cystic fibrosis (CF) is a significant health outcome and one of the significant end points in clinical trials. Risk factors associated with shorter time until the next exacerbation (TUNE) have not been reported. This is a prospective study. TUNE was the number of days fr...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972311433575
更新日期:2012-02-01 00:00:00
abstract::To help answer the question of length of intravenous antibiotics during an acute exacerbation of cystic fibrosis (CF), we had subjects to follow daily home spirometry while on intravenous antibiotics. CF patients, 18 and older, with an acute exacerbation requiring intravenous antibiotics had a daily FEV1. The average ...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972317743756
更新日期:2018-08-01 00:00:00
abstract::Cough-suppression physiotherapy is a novel self-help therapy for chronic cough. We evaluated the effectiveness of cough physiotherapy in a pilot prospective observational study. We assessed cough-specific health-related quality of life (HRQOL) with the Leicester Cough Questionnaire (LCQ) and subjectively reported coug...
journal_title:Chronic respiratory disease
pub_type: 临床试验,杂志文章
doi:10.1177/1479972311422547
更新日期:2011-01-01 00:00:00
abstract::Recent randomized controlled studies have reported success for hospital at home for prevention and early discharge of chronic obstructive pulmonary disease (COPD) patients using hospital based respiratory nurse specialists. This observational study reports results using an integrated hospital and community based gener...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972306070074
更新日期:2006-01-01 00:00:00
abstract::We report here an unusual case of a 25-year old male with juvenile onset recurrent respiratory papillomatosis who developed an infestation of papillomata 'papillomatization' of an old abscess cavity that, when removed, was coincidently found to contain a 2 cm well differentiated squamous cell carcinoma. The abscess ca...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1191/1479972304cd042cr
更新日期:2004-01-01 00:00:00
abstract::The objective of this study was to investigate the discriminant validity of commonly used depression and anxiety screening tools in order to determine the most suitable tool for patients with chronic obstructive pulmonary disease (COPD). COPD patients (n = 56) completed the Hospital Anxiety and Depression Scale (HADS)...
journal_title:Chronic respiratory disease
pub_type: 杂志文章,多中心研究
doi:10.1177/1479972316634604
更新日期:2016-08-01 00:00:00
abstract::Pulmonary rehabilitation (PR) is recommended for people with interstitial lung disease (ILD); however, the educational content of PR was not designed for this group. This study explored the perspectives of patients and ILD clinicians regarding the educational content of PR for ILD. A qualitative study using individual...
journal_title:Chronic respiratory disease
pub_type: 杂志文章
doi:10.1177/1479972315571925
更新日期:2015-05-01 00:00:00