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Sport-related hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk.

Abstract：

OBJECTIVE:Regular physical activity is associated with a reduction of cardiovascular morbidity and mortality; however, evidence of unfortunate cardiovascular events accompanying elite sport involvement continues to accumulate. To date, no information is available on possible peculiarities of the cardiovascular risk profile in athletes. DESIGN:The aim of this study was to evaluate plasma homocysteine levels in a group of athletes and to search for relationship with vitamin status and other metabolic variables in order to confirm the existence of a "sport-related hyperhomocysteinaemia" and to explain its clinical significance. The study population was composed of 82 athletes (59 male and 23 female) practising different sports and 70 healthy age-matched subjects (40 male and 30 female) as a control group. Besides the general clinical and analytical determinations, the assessed variables included homocysteine, folate, vitamin B12, total and high-density lipoprotein (HDL) cholesterol, lactate dehydrogenase (LDH), creatine kinase (CPK) and interleukin-6 (IL-6). RESULTS:The prevalence of hyperhomocysteinaemia (>15 micromol/l) in athletes and controls was 47% and 15%, respectively. No correlation was found between homocysteine and any of the other investigated variables, in particular plasma folate, blood pressure, LDH, CPK, total and HDL cholesterol and IL-6. CONCLUSION:The results of this study confirm the existence of a sport-related hyperhomocysteinaemia which appears linked neither to the same variables found in the general population, nor to specific training-related variables. We suggest that it would represent an adaptation to training but the possibility of a secondary vascular damage cannot be excluded.

journal_name

Br J Sports Med

journal_title

British journal of sports medicine

authors

Borrione P,Rizzo M,Spaccamiglio A,Salvo RA,Dovio A,Termine A,Parisi A,Fagnani F,Angeli A,Pigozzi F

doi

10.1136/bjsm.2007.045021

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

894-900

issue

11

eissn

0306-3674

issn

1473-0480

pii

bjsm.2007.045021

journal_volume

42

pub_type

杂志文章

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