Abstract:
:Hydroponics studies were conducted to investigate the antioxidant adaptations, ascorbate and glutathione metabolism in hyperaccumulating ecotype of Sedum alfredii (HE) exposed to high Cd environment, when compared with its nonhyperaccumulating ecotype (NHE). Exposure to Cd induced a burst of oxidative stress in both ecotypes which was evident by the sharp increase in hydrogen peroxide (H(2)O(2)) contents and lipid peroxidation. Buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, did not affect H(2)O(2) concentrations as well as growth of both ecotypes in the absence of Cd. However, compared with Cd application alone, BSO combined with Cd treatment caused a substantial augmentation of H(2)O(2) accumulation accompanied by a reduction in Cd concentrations in roots and leaves of HE at the end of treatment, which may rule out the possibility that GSH biosynthesis may play an important role as a signal of the stress regulation. No efficient and superior enzymatic antioxidant defense mechanisms against Cd-imposed oxidative stress existed in both NHE and HE, but the essential nonenzymatic components like ascorbic acid (AsA) and GSH played a prominent role in tolerance against Cd. Cadmium stimulated a notable rise in AsA concentration in both ecotypes soon after the application of treatment. A preferential Cd-stress response in HE was suggested to changes in the GSH pool, where acclimation was marked by increased GSH concentrations.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Jin X,Yang X,Mahmood Q,Islam E,Liu D,Li Hdoi
10.1002/tox.20362subject
Has Abstractpub_date
2008-08-01 00:00:00pages
517-29issue
4eissn
1520-4081issn
1522-7278journal_volume
23pub_type
杂志文章abstract::In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated gro...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22690
更新日期:2019-04-01 00:00:00
abstract::The toxicity of petroleum hydrocarbons to marine aquatic organisms has been widely investigated; however, the effects on freshwater environments have largely been ignored. Selected biomarkers were measured in a freshwater species, the crimson-spotted rainbowfish (Melanotaenia fluviatilis). Fish were exposed to either ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10098
更新日期:2003-02-01 00:00:00
abstract::Lead is a major heavy-metal contaminant in the environment that has various anthropogenic and natural sources. To study the phytotoxic effects of Pb on the popular vegetable Chinese cabbage (Brassica pekinensis Rupr.) via depression of nitrogen assimilation, pot culture experiments with three concentrations of treatme...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20167
更新日期:2006-04-01 00:00:00
abstract::The present study was designed to understand the oxidative stress potential of fenthion, an organophosphate (OP) pesticide and its involvement in glutathione metabolism modulated buthionine sulfoximine (BSO, 50 mg/kg) and N-acetylcysteine (NAC, 100 mg/kg) in the brain of fish, Oreochromis niloticus. A sublethal fenthi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20286
更新日期:2007-12-01 00:00:00
abstract::Contamination of the urban aquatic environment with chemical and biological substances could have a long-term impact on human health because these substances threaten the integrity of the urban ecosystem and the availability of high-quality water for recreation and consumption. In light of this, the aim of the present...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20067
更新日期:2004-12-01 00:00:00
abstract::Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22033
更新日期:2016-02-01 00:00:00
abstract::Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22371
更新日期:2017-05-01 00:00:00
abstract::Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20731
更新日期:2013-07-01 00:00:00
abstract::Long-term exposure of agriculturally used organochloride and organophosphate pesticides have been shown to cause long-lasting hematotoxicity and increased incidence of aplastic anemia in humans. The mechanisms involved in pesticide induced hematotoxicity and the features of toxicity that may play a major role in bone ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20775
更新日期:2014-01-01 00:00:00
abstract::The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21867
更新日期:2014-12-01 00:00:00
abstract::Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22565
更新日期:2018-07-01 00:00:00
abstract::The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22459
更新日期:2017-12-01 00:00:00
abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21814
更新日期:2014-08-01 00:00:00
abstract::Experiments were carried out with neonates of the freshwater ostracod Heterocypris incongruens to verify and complete previous choices of test parameters for a new culture/maintenance-free solid-phase microbiotest for freshwater sediments. From trials with increasing volumes of reference sediment, it was concluded tha...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10086
更新日期:2002-12-01 00:00:00
abstract::Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 m...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22492
更新日期:2017-12-01 00:00:00
abstract::Sick building syndrome (SBS) is a set of several clinically recognizable symptoms reported by occupants of a building without a clear cause. Neuropathy target esterase (NTE) is a membrane bound serine esterase and its reaction with organophosphates (OPs) can lead to OP-induced delayed neuropathy (OPIDN) and nerve axon...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21839
更新日期:2014-10-01 00:00:00
abstract::The chronic effect of p-nonylphenol on survival and reproduction for two generations of the freshwater cladoceran Daphnia galeata was examined by life table experiments. The effects on survival and reproduction were used as the intrinsic rate of natural increase, r, with the Euler-Lotka equation and were analyzed with...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10083
更新日期:2002-10-01 00:00:00
abstract::The use of malachite green (MG) in fish farming is prohibited in China due to its potentially toxicological and carcinogenic nature, but it is still illegally used in some places. The aim of this study was to investigate the time and concentration-dependent responses of xenobiotic metabolizing and detoxification-relat...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20706
更新日期:2013-03-01 00:00:00
abstract::Seasonal changes in developmental stages, condition factor (CF), gonadosomatic index, and plasma vitellogenin (Vtg) concentrations in male and female hornyhead turbot were examined at the wastewater outfall (T1) of the Orange County Sanitation District, and two farfield sites T11 (7.7 km northwest of the outfall) and ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20287
更新日期:2007-10-01 00:00:00
abstract::Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22374
更新日期:2017-08-01 00:00:00
abstract::Exposure to sublethal hexavalent chromium (as 2 and 4 mg L⁻¹ potassium dichromate for 1 and 2 months) during late preparatory to mid prespawning phase of annual reproductive cycle severely affected the pituitary-ovarian axis of a teleost Channa punctatus. Gonadosomatic index (GSI), ovarian histopathology, immunocytoch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20654
更新日期:2012-07-01 00:00:00
abstract::Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10142
更新日期:2003-12-01 00:00:00
abstract::Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21891
更新日期:2015-01-01 00:00:00
abstract::The incidence of type 1 diabetes (T1D) and its associated risks of chronic kidney disease or end-stage renal disease development are on the rise. T1D is an autoimmune disease in which insulin-producing beta cells are destroyed. Increased incidence of T1D has been suggested to be a result of environmental factors such ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22857
更新日期:2020-02-01 00:00:00
abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22210
更新日期:2017-01-01 00:00:00
abstract::Nanoparticulate titanium dioxide (nano-TiO2 ) has been widely used in industry, medicine and daily life. However, assessment of nano-TiO2 toxicity on health is an important occupational safety issue. Numerous studies have demonstrated that nano-TiO2 can induced sustained pulmonary inflammation, but whether chronic exp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22493
更新日期:2017-09-25 00:00:00
abstract::Effects of perchlorate on sodium-iodide symporter (NIS) and pendrin gene expression in deer mice kidney and stomach were investigated. This was accomplished by isolating a partial cDNA sequence of deer mice NIS gene of 425 bps, and quantitatively analyzing NIS mRNA expression in various deer mouse tissues. The highest...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20271
更新日期:2007-08-01 00:00:00
abstract::Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22545
更新日期:2018-05-01 00:00:00
abstract::The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage, but might also be a risk factor for many diseases including cancer. Elevated level of urinary 8-OHdG has been detected in patients with various malignanci...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20447
更新日期:2009-10-01 00:00:00
abstract::Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti-inflammation, anti-adipogenesis, and anti-angiogenesis. In the study, we demonstrated the anti-proliferative effect of butein in human osteosarcoma U-2 OS cells. Our data showed that butein ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23079
更新日期:2020-12-16 00:00:00