The role of capsaicin-sensitive primary afferents in experimental sciatica induced by disc herniation in rats.


STUDY DESIGN:The topical capsaicin treatment of the sciatic nerve, which was proved to destroy capsaicin-sensitive primary afferent (CSPA) fibers, was performed to determine the effect on decreases in paw withdrawal mechanical threshold (PWMT) and changes in spatial expression pattern of spinal c-Fos protein induced by the direct compression of L5 nerve root with autologous disc. OBJECTIVE:To investigate the role of CSPA fibers in the development of mechanical hyperalgesia in the new sciatica model. SUMMARY OF BACKGROUND DATA:To date, CSPA fibers have been shown to be involved in development of thermal hyperalgesia in various pain models. But the controversy still exists as to whether CSPA fibers are involved in the development of mechanical hyperalgesia in different pain models. To our best knowledge, the role of CSPA in sciatica was not investigated. Therefore, the present study was designed to determine the role of CSPA fibers in the newly developed sciatica model. METHODS:All surgeries were performed in Sprague-Dawley rats. PWMT was measured at the different time points postsurgery and presurgery. The changes in spatial expression pattern of c-Fos protein in the spinal cord were also determined at 3 weeks when PWMT decreased to the peak. RESULTS:The pretreatment with capsaicin produced a complete prevention of mechanical hyperalgesia induced by disc compression. The direct compression of L5 nerve root produced an obvious expression of Fos-like immunoreactivity neurons in the dorsal horn of the spinal cord, which was significantly decreased by pretreatment with capsaicin. CONCLUSION:We conclude that CSPA fibers, which mainly terminated in superficial layers of dorsal horn, may play a key role in mechanical hyperalgesia in the new sciatica model.


Spine (Phila Pa 1976)




Tang JG,Chen HS,Yuan W,Hou S,Wang X,Zhou X




Has Abstract


2008-01-15 00:00:00
















  • Segmental ("floating") lumbar spine fusions.

    abstract::A traditional teaching in orthopaedic surgery has been that, in cases of fusion for L4-5 discopathy or instability, one must include the lumbosacral joint. There is nothing in the literature to support this time-honored dictum. The senior author, among others, has rejected this concept; and, the authors are, therefore...


    pub_type: 杂志文章


    authors: Brodsky AE,Hendricks RL,Khalil MA,Darden BV,Brotzman TT

    更新日期:1989-04-01 00:00:00

  • Absence of biglycan accelerates the degenerative process in mouse intervertebral disc.

    abstract:STUDY DESIGN:A study of the histologic changes of the intervertebral discs (IVDs) in biglycan (Bgn)-deficient mice. OBJECTIVE:In this study, we investigate whether the absence of Bgn accelerates the degenerative process in mouse intervertebral disc (IVD). SUMMARY OF BACKGROUND DATA:Proteoglycans and collagen fibrils ...


    pub_type: 杂志文章


    authors: Furukawa T,Ito K,Nuka S,Hashimoto J,Takei H,Takahara M,Ogino T,Young MF,Shinomura T

    更新日期:2009-12-01 00:00:00

  • The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality.

    abstract:STUDY DESIGN:Cross-sectional cohort study of chronic low back pain (CLBP) patients and matched controls. OBJECTIVE:To explore the interplay between vertebral endplate damage and adjacent paraspinal muscle (PSM) quality, and to test their association in a cohort of patients with CLBP and matched controls. SUMMARY OF B...


    pub_type: 杂志文章


    authors: Bailey JF,Fields AJ,Ballatori A,Cohen D,Jain D,Coughlin D,O'Neill C,McCormick Z,Han M,Krug R,Demir-Deviren S,Lotz JC

    更新日期:2019-07-15 00:00:00

  • Facet Sagittal Orientation: Possible Role in the Pathology of Degenerative Lumbar Spinal Stenosis.

    abstract:STUDY DESIGN:A retrospective case-control study. OBJECTIVE:This study aimed to elucidate the association between facet joint orientation and degenerative lumbar spinal stenosis (DLSS). SUMMARY OF BACKGROUND DATA:Many studies have demonstrated the relationship between sagittal facet orientation and degenerative lumbar...


    pub_type: 杂志文章


    authors: Liu X,Zhao X,Long Y,Huang K,Xie D,Wang F,Chen G,Yuan Z,Wang J

    更新日期:2018-07-15 00:00:00

  • Antimicrobial Effect of Polymer-Based Silver Nanoparticle Coated Pedicle Screws: Experimental Research on Biofilm Inhibition in Rabbits.

    abstract:STUDY DESIGN:Antimicrobial effect of a novel silver-impregnated pedicle screw in rabbits. OBJECTIVE:A novel spine implant model was designed to study the antimicrobial effect of a modified Titanium (Ti) pedicle screws with methicillin-resistant Staphylococcus aureus (MRSA) in multiple surgical sites in the lumbar spin...


    pub_type: 杂志文章


    authors: Hazer DB,Sakar M,Dere Y,Altinkanat G,Ziyal MI,Hazer B

    更新日期:2016-03-01 00:00:00

  • Injection Drug Use in Patients With Spinal Epidural Abscess: Nationwide Data, 2000 to 2013.

    abstract:STUDY DESIGN:Retrospective review of the Healthcare Cost and Utilization Project National Inpatient Sample, 2000 to 2013. OBJECTIVE:To determine the proportion of spinal epidural abscess (SEA) cases that were related to injection drug use (IDU) and to compare length of stay, leaving against medical advice, paralysis, ...


    pub_type: 杂志文章


    authors: Toppo AJ,Rogerson A,Oh DHW,Tybor DJ,Wurcel AG,Salzler MJ

    更新日期:2020-06-15 00:00:00

  • Opioid Use in Adults With Low Back or Lower Extremity Pain Who Undergo Spine Surgical Treatment Within 1 Year of Diagnosis.

    abstract:STUDY DESIGN:Retrospective longitudinal cohort. OBJECTIVE:We investigated opioid prescribing patterns amongst adults in the United States diagnosed with low back or lower extremity pain (LBP/LEP) who underwent spine surgery. SUMMARY OF BACKGROUND DATA:Opioid-based treatment of LBP/LEP and postsurgical pain has separa...


    pub_type: 杂志文章


    authors: Fatemi P,Zhang Y,Ho A,Lama R,Jin M,Veeravagu A,Desai A,Ratliff JK

    更新日期:2020-12-15 00:00:00

  • Function Preservation or Oncological Appropriateness in Spinal Bone Tumors?: A Case Series of Segmental Resection of the Spinal Canal Content (Spinal Amputation).

    abstract:STUDY DESIGN:Retrospective review of prospectively collected data. OBJECTIVE:To evaluate (1) if the segmental resection of the content of the spinal canal could provide an Enneking appropriate tumor-free margin for local control of primary bone tumors surrounding and invading the canal and (2) the safety profile of th...


    pub_type: 杂志文章


    authors: Girolami M,Boriani S,Ghermandi R,Bandiera S,Barbanti-Brodano G,Terzi S,Tedesco G,Evangelisti G,Pipola V,Ricci A,Cecchinato R,Gasbarrini A

    更新日期:2020-05-15 00:00:00

  • Minimally Invasive Surgery for Neuromuscular Scoliosis: Results and Complications in a Series of One Hundred Patients.

    abstract:STUDY DESIGN:A retrospective review. OBJECTIVE:To report the results of an alternative technique using a minimally invasive fusionless surgery. The originality is based on the progressive correction of the deformities with proximal and distal fixation and on the reliability of the pelvic fixation using iliosacral scre...


    pub_type: 杂志文章


    authors: Miladi L,Gaume M,Khouri N,Johnson M,Topouchian V,Glorion C

    更新日期:2018-08-01 00:00:00

  • The Relationship Between MRI Signal Intensity Changes, Clinical Presentation, and Surgical Outcome in Degenerative Cervical Myelopathy: Analysis of a Global Cohort.

    abstract:STUDY DESIGN:Retrospective analysis of prospective data. OBJECTIVE:To assess the relationship between MRI signal intensity changes, clinical presentation, and surgical outcome in degenerative cervical myelopathy (DCM). SUMMARY OF BACKGROUND DATA:Several studies have sought to assess the extent of spinal cord dysfunct...


    pub_type: 杂志文章,多中心研究


    authors: Nouri A,Martin AR,Kato S,Reihani-Kermani H,Riehm LE,Fehlings MG

    更新日期:2017-12-15 00:00:00

  • Post-poliomyelitis paralytic scoliosis. A review of curve patterns and results of surgical treatments in 118 consecutive patients.

    abstract::Curve patterns and surgical treatment in 118 consecutive patients with post-poliomyelitic paralytic scoliosis are reviewed. The typical curve pattern was double structural curves, usually including the lumbar spine. Modifying the incision and altering the sequence of instrumentation facilitated both the exposure and i...


    pub_type: 杂志文章


    authors: Mayer PJ,Dove J,Ditmanson M,Shen YS

    更新日期:1981-11-01 00:00:00

  • Can we predict the ultimate lumbar curve in adolescent idiopathic scoliosis patients undergoing a selective fusion with undercorrection of the thoracic curve?

    abstract:STUDY DESIGN:Retrospective review of anterior and posterior fusions for treatment of adolescent idiopathic thoracic scoliosis. OBJECTIVES:To delineate the best factors determining final lumbar curve magnitude in patients with adolescent idiopathic scoliosis undergoing a selective thoracic anterior or posterior spinal ...


    pub_type: 杂志文章


    authors: Dobbs MB,Lenke LG,Walton T,Peelle M,Della Rocca G,Steger-May K,Bridwell KH

    更新日期:2004-02-01 00:00:00

  • Upper extremity palsy following cervical decompression surgery results from a transient spinal cord lesion.

    abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To test the hypothesis that spinal cord lesions cause postoperative upper extremity palsy. SUMMARY OF BACKGROUND DATA:Postoperative paresis, so-called C5 palsy, of the upper extremities is a common complication of cervical surgery. Although there are several hypotheses r...


    pub_type: 杂志文章,多中心研究


    authors: Hasegawa K,Homma T,Chiba Y

    更新日期:2007-03-15 00:00:00

  • Anatomical and pathological considerations in percutaneous vertebroplasty and kyphoplasty: a reappraisal of the vertebral venous system.

    abstract:OBJECTIVES:To focus attention of the clinician on the anatomy and (patho)physiology of the vertebral venous system, so as to offer a tool to better understand and anticipate (potential) complications that are related to the application of percutaneous vertebroplasty and kyphoplasty. BACKGROUND:Percutaneous vertebropla...


    pub_type: 杂志文章,评审


    authors: Groen RJ,du Toit DF,Phillips FM,Hoogland PV,Kuizenga K,Coppes MH,Muller CJ,Grobbelaar M,Mattyssen J

    更新日期:2004-07-01 00:00:00

  • Prone position endoscopic transthoracic release with simultaneous posterior instrumentation for spinal deformity: a description of the technique.

    abstract:STUDY DESIGN:A prospective series of 15 consecutive adult patients with spinal deformity who underwent endoscopic transthoracic release with simultaneous posterior instrumentation while positioned prone. OBJECTIVES:To describe the technique and clinical results of endoscopic transthoracic release performed with the pa...


    pub_type: 杂志文章


    authors: Lieberman IH,Salo PT,Orr RD,Kraetschmer B

    更新日期:2000-09-01 00:00:00

  • Metastatic pancreatic endocrine tumor presenting as thoracic spinal cord compression.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:The authors present a rare case of metastatic nonfunctioning neuroendocrine tumor of the pancreas presenting as thoracic spinal cord compression. SUMMARY OF BACKGROUND DATA:Pancreatic endocrine tumors (PETs) are a slow-growing subset of pancreatic tumors. They can be classified a...


    pub_type: 杂志文章


    authors: Eads TA,Hattab EM,Rodgers RB

    更新日期:2010-05-15 00:00:00

  • Progressive disc herniation: an investigation of the mechanism using radiologic, histochemical, and microscopic dissection techniques on a porcine model.

    abstract:STUDY DESIGN:Basic scientific investigation using radiologic, histochemical, and microscopic dissection techniques. OBJECTIVE:To document the process of mechanically induced disc herniation from repetitive loading exposure. SUMMARY OF BACKGROUND DATA:Current knowledge of the mechanism of disc herniation is limited to...


    pub_type: 杂志文章


    authors: Tampier C,Drake JD,Callaghan JP,McGill SM

    更新日期:2007-12-01 00:00:00

  • Repeat use of human recombinant bone morphogenetic protein-2 for second level lumbar arthrodesis.

    abstract:STUDY DESIGN:Prospective randomized controlled animal model. OBJECTIVE:The purpose of this study is to determine whether the readministration of human recombinant bone morphogenetic protein-2 (rhBMP-2) induces an immune response and inhibits successful fusion in repeat posterolateral spinal surgery. SUMMARY OF BACKGR...


    pub_type: 杂志文章,随机对照试验


    authors: Singh K,Dumonski M,Stanley T,Ponnappan R,Phillips FM

    更新日期:2011-02-01 00:00:00

  • A new concept for making decisions regarding the surgical approach for cervical ossification of the posterior longitudinal ligament: the K-line.

    abstract:STUDY DESIGN:To report a new index, the K-line, for deciding the surgical approach for cervical ossification of the posterior longitudinal ligament (OPLL). OBJECTIVE:To analyze the correlation between the K-line-based classification of cervical OPLL patients and their surgical outcome. SUMMARY OF BACKGROUND DATA:Prev...


    pub_type: 杂志文章


    authors: Fujiyoshi T,Yamazaki M,Kawabe J,Endo T,Furuya T,Koda M,Okawa A,Takahashi K,Konishi H

    更新日期:2008-12-15 00:00:00

  • Trunk stresses in construction and other industrial workers.

    abstract::One of the problems arising from the consideration of safely during manual handling in industry has been, firstly, a definition of those workers at risk and, secondly, a definition of safely. To be able objectively to identify those a risk and quantify the stress to which they are exposed, a more rigorous series of cr...


    pub_type: 杂志文章


    authors: Stubbs DA

    更新日期:1981-01-01 00:00:00

  • One-stage total en bloc sacrectomy: a novel technique and report of 9 cases.

    abstract:STUDY DESIGN:Nine patients with malignant sacral tumor underwent 1-stage total sacrectomy. The oncological and functional results are analyzed. OBJECTIVE:To describe the surgical technique and evaluate the clinical outcome of the surgery. SUMMARY OF BACKGROUND DATA:Very few reports specifically address total sacrecto...


    pub_type: 杂志文章


    authors: Guo W,Tang X,Zang J,Ji T

    更新日期:2013-05-01 00:00:00

  • Creep and fatigue development in the low back in static flexion.

    abstract:STUDY DESIGN:In vivo measurements of low back flexion posture and muscle activity before, during, and after static flexion. OBJECTIVE:To identify the occurrence of creep and muscle fatigue development in the low back during static upper body deep flexion that resembled an above ground work posture. SUMMARY OF BACKGRO...


    pub_type: 杂志文章


    authors: Shin G,D'Souza C,Liu YH

    更新日期:2009-08-01 00:00:00

  • Incidence of intravascular penetration in transforaminal cervical epidural steroid injections.

    abstract::STUDY DESIGN A prospective, observational, human, study was conducted. OBJECTIVES To evaluate the incidence of vascular penetration during fluoroscopically guided, contrast-enhanced transforaminal cervical epidural steroid injections, and to determine whether the observation of blood in the needle hub can be used to p...


    pub_type: 杂志文章


    authors: Furman MB,Giovanniello MT,O'Brien EM

    更新日期:2003-01-01 00:00:00

  • New interspinous implant evaluation using an in vitro biomechanical study combined with a finite-element analysis.

    abstract:STUDY DESIGN:A combined in vitro and finite-element analysis was completed to assess the biomechanical effect of a new interspinous implant on the lumbar spine. OBJECTIVE:The aim was to investigate the effect of an interspinous implant on the biomechanical behavior of a vertebral segment. METHODS:An in vitro study on...


    pub_type: 杂志文章


    authors: Lafage V,Gangnet N,Sénégas J,Lavaste F,Skalli W

    更新日期:2007-07-15 00:00:00

  • Evidence-Based Recommendations for Spine Surgery.

    abstract::: This next issue of Evidence-Based Recommendations for Spine Surgery examines six articles that seek to address pressing and relevant issues in contemporary spine surgery. These articles explore the safety and efficacy of tranexamic acid during lumbar surgery, the utility of post-operative MRI after spinal decompress...


    pub_type: 杂志文章


    authors: Fisher CG,Vaccaro AR,Patel AA,Whang PG,Thomas KC,Chi J,Mulpuri K,Prasad SK

    更新日期:2020-06-15 00:00:00

  • Congenital dumbbell neuroblastoma.

    abstract:STUDY DESIGN:New babies with neurologic deficits resulting from intraspinal extension of congenital neuroblastoma is very unusual. Two patients with congenital dumbbell neuroblastoma with paraplegia are described, and 16 other cases are reviewed. OBJECTIVE:To study the clinical features and prognosis of congenital dum...


    pub_type: 杂志文章,评审


    authors: Shimada Y,Sato K,Abe E,Suzuki T,Ishihara Y

    更新日期:1995-06-01 00:00:00

  • Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes.

    abstract:STUDY DESIGN:Descriptive histologic analysis of spinal cord gene therapy. OBJECTIVE:To maximize protein expression in rat spinal cord using recombinant adenoassociate virus viral vector. SUMMARY OF BACKGROUND DATA:There are few reports of spinal cord genetic transfer. There have been no reports that compare technique...


    pub_type: 杂志文章


    authors: Harrop JS,Poulsen DJ,Xiao W,Freese A,During MJ

    更新日期:2004-12-15 00:00:00

  • Surgical versus nonoperative treatment for lumbar disc herniation: four-year results for the Spine Patient Outcomes Research Trial (SPORT).

    abstract:STUDY DESIGN:Concurrent, prospective, randomized, and observational cohort study. OBJECTIVE:To assess the 4-year outcomes of surgery versus nonoperative care. SUMMARY OF BACKGROUND DATA:Although randomized trials have demonstrated small short-term differences in favor of surgery, long-term outcomes comparing surgical...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Weinstein JN,Lurie JD,Tosteson TD,Tosteson AN,Blood EA,Abdu WA,Herkowitz H,Hilibrand A,Albert T,Fischgrund J

    更新日期:2008-12-01 00:00:00

  • Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report.

    abstract:STUDY DESIGN:Case report. OBJECTIVE:To describe a rare case of tenosynovial giant cell tumor, diffuse type/pigmented villonodular synovitis (PVNS) in a pars defect in a patient with lumbar spondylolysis. SUMMARY OF BACKGROUND DATE:PVNS rarely occurred in lumbar spine, and no studies in the English literature have rep...


    pub_type: 杂志文章


    authors: Kimura T,Nishisho T,Sakai T,Miyagi R,Takao S,Iwamoto S,Higashino K,Takata Y,Goda Y,Toki S,Sairyo K

    更新日期:2015-06-15 00:00:00

  • Quantitation of three-dimensional deformity of idiopathic scoliosis.

    abstract::Three-dimensional deformities in vertebrae of patients with idiopathic scoliosis were analyzed quantitatively using three-dimensional computed tomography. To evaluate the deformities, the vertebral lordosis and scoliosis were defined clearly. An average lordosis of 7.9 degrees and an average scoliosis of 6.8 degrees w...


    pub_type: 杂志文章


    authors: Kojima T,Kurokawa T

    更新日期:1992-03-01 00:00:00