Diagnosis, heritability, and outcome assessment in cervical myelopathy: a consensus statement.

Abstract:

:This section of the cervical spondylotic myelopathy (CSM) Spine focus issue collates evidence related to diagnosis, outcome assessment, and genetics. Given that a variety of different disease states can present similarly, a guide for diagnosing and differentiating CSM from other neurological conditions is initially presented. Although the value of magnetic resonance imaging in diagnosing CSM is cemented, its value as a tool to predict future outcome is less well established. To this end, the existing evidence suggests that although increased T2 cord signal is of limited value, the pairing of high T2 signal with low T1 signal, or a high T2 to T1 signal ratio, is associated with a reduced potential for neurological recovery at follow-up. Outcome assessment in CSM is of paramount importance when monitoring patients' clinical course or measuring the efficacy of therapeutic interventions. Here, the main outcome measures that have been used to assess patients with CSM are reviewed. At present, we recommend that clinicians acquire the modified Japanese Orthopaedic Association scale score and the Neck Disability Index on all patients with CSM at presentation and follow-up. Finally, in regard to genetics, the existing evidence seems to support the principle of an inherited predisposition to both CSM and ossification of the posterior longitudinal ligament. Although several genetic polymorphisms have been consistently associated with ossification of the posterior longitudinal ligament, no specific polymorphisms were consistently associated with CSM.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Wilson JR,Fehlings MG,Kalsi-Ryan S,Shamji MF,Tetreault LA,Rhee JM,Chapman JR

doi

10.1097/BRS.0b013e3182a7f4bf

subject

Has Abstract

pub_date

2013-10-15 00:00:00

pages

S76-7

issue

22 Suppl 1

eissn

0362-2436

issn

1528-1159

journal_volume

38

pub_type

杂志文章

相关文献

SPINE文献大全
  • Posterior Only Approach for Lumbar Pyogenic Spondylitis With Short Instrumentation and Prolonged Suction Drainage.

    abstract:STUDY DESIGN:A single-institution, single-surgeon retrospective review. OBJECTIVE:To assess the efficacy of posterior only approach with short instrumentation and prolonged suction drainage in managing lumbar pyogenic spondylitis. SUMMARY OF BACKGROUND DATA:Several methods of posterior surgical treatment for pyogenic...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001566

    authors: Kim YM,Choi SM

    更新日期:2016-09-01 00:00:00

  • Lumbar spinal fusion. Assessment of functional stability with magnetic resonance imaging.

    abstract::Segmental spinal instability was evaluated with magnetic resonance (MR) imaging, computed tomography (CT), and conventional radiography in 33 patients who had undergone surgical spinal fusion. In 16 of the 19 patients who had a diagnosis of solid fusion, the immobilized vertebral bodies demonstrated areas of high sign...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199006000-00028

    authors: Lang P,Chafetz N,Genant HK,Morris JM

    更新日期:1990-06-01 00:00:00

  • Dual growing rod technique followed for three to eleven years until final fusion: the effect of frequency of lengthening.

    abstract:STUDY DESIGN:Retrospective case review of children completing dual growing rod treatment at our institutions. Patients had a minimum of 2 years follow-up. OBJECTIVE:To identify the factors influencing dual growing rod treatment outcome followed to final fusion. SUMMARY OF BACKGROUND DATA:Published reports on dual gro...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31816c8b4e

    authors: Akbarnia BA,Breakwell LM,Marks DS,McCarthy RE,Thompson AG,Canale SK,Kostial PN,Tambe A,Asher MA,Growing Spine Study Group.

    更新日期:2008-04-20 00:00:00

  • The role of physical exercise and inactivity in pain recurrence and absenteeism from work after active outpatient rehabilitation for recurrent or chronic low back pain: a follow-up study.

    abstract:STUDY DESIGN:An observational follow-up. OBJECTIVES:To analyze the role of physical exercise and inactivity on the long-term outcome after active outpatient low back rehabilitation. SUMMARY OF BACKGROUND DATA:There is considerable evidence documenting the efficacy of exercise in the conservative treatment of chronic ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200007150-00012

    authors: Taimela S,Diederich C,Hubsch M,Heinricy M

    更新日期:2000-07-15 00:00:00

  • Opioid-free Analgesia for Posterior Spinal Fusion Surgery Using Erector Spinae Plane (ESP) Blocks in a Multimodal Anesthetic Regimen.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:The aim of this study was to report the use of erector spinae plane (ESP) blocks as part of an opioid-free multimodal anesthetic regimen and its impact on postoperative pain and opioid requirements following spine surgery. SUMMARY OF BACKGROUND DATA:Posterior spinal fusion surger...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002855

    authors: Chin KJ,Lewis S

    更新日期:2019-03-15 00:00:00

  • Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA:Results of studies analyzing the impact of smoking on complication and pseudarthr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000527

    authors: Bydon M,De la Garza-Ramos R,Abt NB,Gokaslan ZL,Wolinsky JP,Sciubba DM,Bydon A,Witham TF

    更新日期:2014-10-01 00:00:00

  • Timing of activation of the erector spinae and hamstrings during a trunk flexion and extension task.

    abstract:STUDY DESIGN:Timing of activation of the hamstrings and erector spinae was assessed using surface electromyography. OBJECTIVES:To investigate the influence of posture and movement speed during trunk flexion-extension on the flexion-relaxation response and trunk muscle activation patterns. SUMMARY OF BACKGROUND DATA:T...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200102150-00019

    authors: McGorry RW,Hsiang SM,Fathallah FA,Clancy EA

    更新日期:2001-02-15 00:00:00

  • Comparison of Smith-Petersen versus pedicle subtraction osteotomy for the correction of fixed sagittal imbalance.

    abstract:STUDY DESIGN:Clinical, radiographic, and outcomes assessment comparing two surgical techniques. Clinical data were collected prospectively. The radiographic analysis was done retrospectively. OBJECTIVES:Smith-Petersen (chevron type) osteotomy (SPO) and pedicle subtraction osteotomy (PSO) have been used to correct fixe...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000179085.92998.ee

    authors: Cho KJ,Bridwell KH,Lenke LG,Berra A,Baldus C

    更新日期:2005-09-15 00:00:00

  • Effect of core stability exercises on feed-forward activation of deep abdominal muscles in chronic low back pain: a randomized controlled trial.

    abstract:STUDY DESIGN:A randomized controlled trial. OBJECTIVE:To investigate feed-forward activation or timing of abdominal muscle activation in response to rapid shoulder flexion after 8 weeks with core stability exercises, sling exercises, or general exercises in chronic nonspecific low back pain (LBP) patients. SUMMARY OF...

    journal_title:Spine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/BRS.0b013e318241377c

    authors: Vasseljen O,Unsgaard-Tøndel M,Westad C,Mork PJ

    更新日期:2012-06-01 00:00:00

  • Posterior osteosynthesis of the atlas for nonconsolidated Jefferson fractures: a new surgical technique.

    abstract:STUDY DESIGN:Case report and surgical technique. OBJECTIVE:To describe a new technique to treat atlas burst fractures by selectively reconstructing the atlas from a posterior approach. SUMMARY OF BACKGROUND DATA:The two surgical techniques reported until now for stabilizing atlas burst fractures are associated with s...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318206cf63

    authors: Abeloos L,De Witte O,Walsdorff M,Delpierre I,Bruneau M

    更新日期:2011-09-15 00:00:00

  • Virtual fluoroscopy: computer-assisted fluoroscopic navigation.

    abstract:STUDY DESIGN:In vitro accuracy assessment of a novel virtual fluoroscopy system. OBJECTIVES:To investigate a new technology combining image-guided surgery with C-arm fluoroscopy. SUMMARY OF BACKGROUND DATA:Fluoroscopy is a useful and familiar technology to all musculoskeletal surgeons. Its limitations include radiati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200102150-00009

    authors: Foley KT,Simon DA,Rampersaud YR

    更新日期:2001-02-15 00:00:00

  • Open reduction of irreducible atlantoaxial dislocation by transoral anterior atlantoaxial release and posterior internal fixation.

    abstract:STUDY DESIGN:A retrospective study of surgical outcome of 33 patients with irreducible atlantoaxial dislocation (IAAD). OBJECTIVE:To evaluate the safety efficacy of one stage anterior release and posterior fixation and fusion to reduce and stabilize IAAD. SUMMARY OF BACKGROUND DATA:The traditional treatment of sympto...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000217686.80327.e4

    authors: Wang C,Yan M,Zhou HT,Wang SL,Dang GT

    更新日期:2006-05-15 00:00:00

  • The long-term follow-up of surgical treatment for cervical myelopathy with severe nape and upper arm pain caused by the anomalous vertebral artery: case report.

    abstract:STUDY DESIGN:A case of cervical myelopathy with a severe nape and upper arm pain caused by anomalous bilateral vertebral arteries is reported. OBJECTIVE:To report over six and a half years results of a microsurgical decompression for high cervical myelopathy with a severe pain of nape and upper arm resulting from spin...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31817c6c17

    authors: Takei H,Sagae M,Chiba K,Ogino T

    更新日期:2008-08-01 00:00:00

  • An anatomic, radiographic, and biomechanical assessment of extrapedicular screw fixation in the thoracic spine.

    abstract::This study performed a thorough review of the pertinent thoracic spine anatomy to determine the appropriate landmarks for extrapedicular screw placement and indentified the anatomic structures at risk; assessed the safety and accuracy of the newly proposed screw insertion technique; determined the stability and streng...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199309000-00018

    authors: Dvorak M,MacDonald S,Gurr KR,Bailey SI,Haddad RG

    更新日期:1993-09-15 00:00:00

  • Intersegmental spinal flexibility with lumbosacral instrumentation. An in vitro biomechanical investigation.

    abstract::Flexibility of the porcine lumbosacral spine was measured after application of six different types of surgical instrumentation, and in a control state. Fifteen adult pig spines were tested with flexion, extension, lateral bending, and axial rotation torques applied to the upper end with the pelvis fixed. Instrumentati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199011010-00013

    authors: Asazuma T,Stokes IA,Moreland MS,Suzuki N

    更新日期:1990-11-01 00:00:00

  • Reversal of neurologic deficit in an adult gorilla with severe symptomatic lumbar stenosis.

    abstract:STUDY DESIGN:A case report is presented. OBJECTIVE:To describe a case of severe symptomatic lumbar stenosis in an adult gorilla successfully treated with decompressive surgery. SUMMARY OF BACKGROUND DATA:Although spinal degenerative disease is thought to be less common in apes than in humans, gorillas and bonobos are...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000112075.03500.5b

    authors: Wolfla CE,Puckett TA

    更新日期:2004-03-01 00:00:00

  • The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures.

    abstract:STUDY DESIGN:A biomechanical study comparing two materials for augmentation of osteoporotic vertebral bodies and vertebral bodies after compression fracture. OBJECTIVES:To compare an injected, biodegradable calcium phosphate bone substitute with injected polymethylmethacrylate bone cement for strengthening osteoporoti...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199908010-00004

    authors: Bai B,Jazrawi LM,Kummer FJ,Spivak JM

    更新日期:1999-08-01 00:00:00

  • Short-term Outcomes Following Cervical Laminoplasty and Decompression and Fusion With Instrumentation.

    abstract:STUDY DESIGN:Retrospective review of the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database years 2010 to 2015. OBJECTIVE:Investigate which short-term outcomes differ for cervical laminoplasty and laminectomy and fusion surgeries. SUMMARY OF BACKGROUND DATA:Conflicting rep...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003057

    authors: Boniello A,Petrucelli P,Kerbel Y,Horn S,Bortz CA,Brown AE,Pierce KE,Alas H,Khalsa A,Passias P

    更新日期:2019-09-01 00:00:00

  • Percutaneous Endoscopic Lumbar Discectomy for L5-S1 Disc Herniation Via an Interlaminar Approach Versus a Transforaminal Approach: A Prospective Randomized Controlled Study With 2-Year Follow Up.

    abstract:STUDY DESIGN:A prospective, randomized controlled study of patients with L5-S1 lumbar disc herniations, operated with endoscopic discectomy through an interlaminar or transforaminal approach. OBJECTIVE:To compare the results of percutaneous endoscopic lumbar discectomy in L5-S1 disc herniation through an interlaminar ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001810

    authors: Nie H,Zeng J,Song Y,Chen G,Wang X,Li Z,Jiang H,Kong Q

    更新日期:2016-10-01 00:00:00

  • Cognitive-behavioral therapy and psychosocial factors in low back pain: directions for the future.

    abstract:STUDY DESIGN:An amalgamated review of the current state of knowledge about psychosocial factors in low back pain (LBP), as presented at the plenary session at the Fourth International Forum on LBP Research in Primary Care (March 16-18, 2000, Israel). OBJECTIVES:To outline evidence-based theories that have lead to the ...

    journal_title:Spine

    pub_type:

    doi:10.1097/00007632-200203010-00020

    authors: Pincus T,Vlaeyen JW,Kendall NA,Von Korff MR,Kalauokalani DA,Reis S

    更新日期:2002-03-01 00:00:00

  • C1 lateral mass screw insertion with protection of C1-C2 venous sinus: technical note and review of the literature.

    abstract:STUDY DESIGN:This is a technical note and review of the literature. OBJECTIVE:We propose to describe a revised surgical technique of C1 lateral mass screw insertion with protection of C1-C2 venous sinus surrounding the C2 nerve root. SUMMARY OF BACKGROUND DATA:During C1 lateral mass screw insertion and in posterior C...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181e215ff

    authors: Pan J,Li L,Qian L,Tan J,Sun G,Li X

    更新日期:2010-10-01 00:00:00

  • Three-dimensional computed tomography-based, personalized drill guide for posterior cervical stabilization at C1-C2.

    abstract:STUDY DESIGN:Cadaver and preliminary clinical study. OBJECTIVES:To enhance the precision of screw positions for posterior transarticular fixations according to Magerl at C1-C2. SUMMARY OF BACKGROUND DATA:The vertebral arteries are at risk during the Magerl operation and may be damaged in up to 4.1% of cases. Even int...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200106150-00017

    authors: Goffin J,Van Brussel K,Martens K,Vander Sloten J,Van Audekercke R,Smet MH

    更新日期:2001-06-15 00:00:00

  • Sacropelvic fixation: techniques and complications.

    abstract:STUDY DESIGN:Literature-based topic review. OBJECTIVE:To review the indications and techniques for different sacropelvic fixation methods and to outline important associated complications. SUMMARY OF BACKGROUND DATA:Despite all the advances and new developments in spinal instrumentation techniques, fixation at the lu...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e3181f5cfae

    authors: Kebaish KM

    更新日期:2010-12-01 00:00:00

  • Does maintained spinal manipulation therapy for chronic nonspecific low back pain result in better long-term outcome?

    abstract:STUDY DESIGN:A prospective single blinded placebo controlled study was conducted. OBJECTIVE:To assess the effectiveness of spinal manipulation therapy (SMT) for the management of chronic nonspecific low back pain (LBP) and to determine the effectiveness of maintenance SMT in long-term reduction of pain and disability ...

    journal_title:Spine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/BRS.0b013e3181f5dfe0

    authors: Senna MK,Machaly SA

    更新日期:2011-08-15 00:00:00

  • Muscle spindles in the paraspinal musculature of patients with adolescent idiopathic scoliosis.

    abstract::Electromyographic studies have determined that muscle imbalance and asymmetry of stretch receptors in the paraspinal muscle of patients with idiopathic scoliosis may have a large role to play in the development and production of the deformity. This project consisted of a detailed histologic and histochemical analysis ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198805000-00004

    authors: Ford DM,Bagnall KM,Clements CA,McFadden KD

    更新日期:1988-05-01 00:00:00

  • A comparative study of chemonucleolysis with recombinant human cathepsin L and chymopapain. A radiologic, histologic, and immunohistochemical assessment.

    abstract:STUDY DESIGN:Investigation of the effects of recombinant human cathepsin L on intervertebral discs and comparison with the effects of chymopapain. OBJECTIVE:To evaluate the effects of cathepsin L on intervertebral discs as an agent for chemonucleolysis. SUMMARY BACKGROUND DATA:Cathepsin L is a typical cysteine protei...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199901150-00004

    authors: Kubo S,Tajima N,Katunuma N,Fukuda K,Kuroki H

    更新日期:1999-01-15 00:00:00

  • Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature.

    abstract:STUDY DESIGN:Review of the literature. OBJECTIVES:Review the definition, etiology, incidence, and risk factors associated with as well as potential treatment options. SUMMARY OF BACKGROUND DATA:The development of pathology at the mobile segment next to a lumbar or lumbosacral spinal fusion has been termed adjacent se...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/01.brs.0000137069.88904.03

    authors: Park P,Garton HJ,Gala VC,Hoff JT,McGillicuddy JE

    更新日期:2004-09-01 00:00:00

  • Minimal clinically important change of the Neck Disability Index and the Numerical Rating Scale for patients with neck pain.

    abstract:STUDY DESIGN:Prospective, single-cohort study. OBJECTIVE:To assess the minimal clinically important change (MCIC) on the Neck Disability Index (NDI) and the Numerical Rating Scale (NRS) for pain in patients with neck pain. SUMMARY OF BACKGROUND DATA:Both measurement instruments are frequently used in research and cli...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31815cf75b

    authors: Pool JJ,Ostelo RW,Hoving JL,Bouter LM,de Vet HC

    更新日期:2007-12-15 00:00:00

  • Surgical treatment of vertebral osteomyelitis with recombinant human bone morphogenetic protein-2.

    abstract:STUDY DESIGN:A retrospective clinical study. OBJECTIVE:To evaluate the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) as the primary graft material for the surgical treatment of vertebral osteomyelitis. SUMMARY OF BACKGROUND DATA:The clinical and radiographic results using allograft, autograft, and v...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0b013e3181657ee3

    authors: O'Shaughnessy BA,Kuklo TR,Ondra SL

    更新日期:2008-03-01 00:00:00

  • Evidence of an inherited predisposition for cervical spondylotic myelopathy.

    abstract:STUDY DESIGN:A retrospective, population-based study cross-referencing a genealogic database of over 2 million Utah residents with 10 years of clinical diagnosis data from a large tertiary hospital. OBJECTIVE:The objective of this study is to determine the presence or absence of an inherited predisposition to the deve...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182102ede

    authors: Patel AA,Spiker WR,Daubs M,Brodke DS,Cannon-Albright LA

    更新日期:2012-01-01 00:00:00