Administration of sodium ibandronate in the treatment of complicated giant cell tumor of the spine.

Abstract:

STUDY DESIGN:Case study. OBJECTIVE:To present three complicated cases of giant cell tumor of the spine treated with sodium ibandronate. SUMMARY OF BACKGROUND DATA:Spinal giant cell tumors are a rare clinical entity with a high recurrence rate after operation. Furthermore, complete resection of such lesions remains a challenging surgical problem. Up to this point, no effective adjuvant therapy has been reported for primary or recurrent spinal giant cell tumors. METHODS:One patient with a recurrent giant cell tumor of the seventh thoracic vertebra, one patient with a fifth lumbar vertebral giant cell tumor, and one patient with recurrent giant cell tumor of the sacrum were treated with sodium ibandronate either postoperatively or upon recurrence of the tumor. RESULTS:The first patient with recurrent thoracic giant cell tumor recovered both clinically and radiologically after treatment with sodium ibandronate without reoperation at 6-years follow-up. The second patient also recovered with no recurrence of the tumor at 4-years follow-up. In the third case, although not fully recovered, the recurrent sacral tumor was under control after treatment with sodium ibandronate at 2-years follow-up. CONCLUSION:These case studies demonstrate the potential promise of using sodium ibandronate in the treatment of primary and recurrent giant cell tumors of the spine. Furthermore, clinical evaluation should be performed in future studies.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Zhang W,Zhang Y,Li P,Rhodesm SD,Wang Y,Xue X,Dong Y,Ding W,Shen Y,Zhang B

doi

10.1097/BRS.0b013e3182127f91

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

E1166-72

issue

17

eissn

0362-2436

issn

1528-1159

pii

00007632-201108010-00022

journal_volume

36

pub_type

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