Abstract:
:Seventy pediatric patients with brain and spinal cord tumors had cytogenetic analysis of 99 samples of their tumors. Successful analysis was accomplished in 95%. Tumors included 43 gliomas, 9 medulloblastomas and a variety of other lesions. Forty-three patients had normal chromosomes; 28 of these had benign tumors and good outcomes. Of 11 patients with malignant tumors and normal chromosomes, 8 have no disease or stable disease during the period of follow-up. Outcomes of the 23 patients with abnormal chromosomes were poor; 17 had malignant pathology. Six patients with 'benign' disease and abnormal chromosomes died or have progressive disease. A relationship between outcome and pathologic diagnosis is often enhanced by cytogenetic findings. The study indicated specific chromosome abnormalities in certain pediatric brain tumors, such as chromosome 1 abnormalities in gliomas and isochromosome 17 abnormalities in medulloblastomas. It is recommended that cytogenetic studied be included in cooperative therapeutic trials. The clastogenic effects of treatment on the cytogenetic characteristics of tumors sequentially studied were demonstrated, as was the role of sampling variations. Attention to the treatment history of tumor samples, as well as evaluation of multiple samples from each tumor, may improve the reliability of cytogenetic studies.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Chadduck WM,Boop FA,Sawyer JRdoi
10.1159/000120569subject
Has Abstractpub_date
1991-01-01 00:00:00pages
57-65issue
2eissn
1016-2291issn
1423-0305journal_volume
17pub_type
杂志文章abstract::Thirty-six cases of pilocytic astrocytomas treated at the Childrens Hospital of Los Angeles from 1984 through 1995 were reviewed. The mean age at initial presentation was 8 years (range 15 months to 14 years). These patients were followed for an average of 5.5 years. No patient was given chemotherapy or radiation ther...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000121218
更新日期:1997-07-01 00:00:00
abstract::Tumors of the pineal region in children often belong to 2 categories, namely germ cell tumors and pineal parenchymal tumors. Very rare pathologies have previously been reported in this region. Most of these tumors may be similar radiologically, while their management differs. The present series reports 2 children with...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000369033
更新日期:2015-01-01 00:00:00
abstract::Traumatic acute subdural hematoma is associated with high mortality in the pediatric population, yet the pathophysiology remains poorly understood. The objective of this study was to develop a pediatric model of acute subdural hematoma, and to evaluate the resultant histopathological changes in the brain. Ten 3-week-o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121109
更新日期:1996-09-01 00:00:00
abstract::Pineal region lesions consist of a wide variety of rare tumor types, including deep midline cysts, intrinsic pineal tumors, germ cell tumors and vascular lesions. Advances in microsurgical, endoscopic and stereotactic techniques have helped to lower morbidity and mortality in the care of patients harboring these lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000070415
更新日期:2003-06-01 00:00:00
abstract::Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to pro...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120762
更新日期:1994-01-01 00:00:00
abstract::Early diagnosis of skull fibrous dysplasia in children is relatively easy, based on a history of painless progressive bony bulging. The therapeutic approach is still controversial, due to the benignity of the lesion. However, the clinical course may be unpredictable, with sudden appearance of symptoms, some of which c...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120649
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:The perception of a surgical complication may differ between surgeons and patients. In pediatric spine surgery, the perception of the parent or primary caregiver may also differ. In order to better define these relationships, we performed a pilot study surveying a convenience sample of pediatric spinal ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000319364
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Surgical treatment options are limited for medically and endovascular refractory cerebral venous sinus thrombosis (CVT). We describe the technical feasibility of open, direct sinus thrombectomy in a pediatric patient with medically and endovascular refractory CVT. METHODS:A 15-year-old patient with superior ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000495808
更新日期:2019-01-01 00:00:00
abstract::Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are dire neurological disorders, characterized by severe damage to the myelin sheath of neurons, which typically result from rapid correction or overcorrection of systemic hyponatremia. For many years, both conditions have been considered universal...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000320146
更新日期:2010-01-01 00:00:00
abstract::Aicardi syndrome is an X-linked dominant disorder primarily defined by the triad of corpus callosum agenesis, infantile spasms and a pathognomonic lacunar chorioretinopathy. Papillomas of the choroid plexus have been reported in affected patients. We report an Aicardi syndrome patient who had three separate choroid pl...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000055956
更新日期:2000-10-01 00:00:00
abstract::Gastric perforation is a complication that can arise from ventriculo-peritoneal (VP) shunting. Careful examination of a newborn girl admitted to our department revealed several neurological problems. A VP shunt was inserted under direct visualization, leaving 20 cm of the catheter in the peritoneal cavity. The infant ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120834
更新日期:1994-01-01 00:00:00
abstract::The epidemiology of cerebrospinal fluid (CSF) shunting in the United States is not well known; however, with recent national surveys, the prevalence, incidence, and cost of these procedures can be estimated. The prevalence of CSF shunts in the United States appears to be greater than 125,000, though this is likely an ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120968
更新日期:1995-01-01 00:00:00
abstract::Posterior fossa syndrome (PFS), also known as cerebellar affective syndrome, is characterized by emotional lability and decreased speech production following injury or surgery to the cerebellum. Rarely, oculomotor dysfunction has been described in association with PFS. Here, we report a case of complete ocular paresis...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339382
更新日期:2012-01-01 00:00:00
abstract::A needle for intravenous fluid administration in a newborn was accidentally placed in the sagittal sinus and resulted in dural sinus air embolism. CT findings are described and the risks for venous air embolism are discussed. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120606
更新日期:1991-01-01 00:00:00
abstract::The cloverleaf skull deformity, or Kleeblattschädel, is a rare malformation caused by synostosis of multiple cranial sutures. This anomaly has been reported to carry a dismal prognosis both in terms of neurological outcome as well as cosmetic appearance if treatment is delayed. Due to the paucity of data concerning th...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121296
更新日期:1995-01-01 00:00:00
abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120605
更新日期:1991-01-01 00:00:00
abstract::Hemifacial spasm (HFS), generally a disease of the elderly, is caused by vascular compression of the seventh nerve. Vascular compression is thought to result from atherosclerotic changes within the vessels of the posterior fossa, and therefore rarely presents in childhood. Here we describe our experience with 12 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121260
更新日期:1997-11-01 00:00:00
abstract::A 4-year-old child with AIDS developed encephalitis 2 months prior to death. Adenovirus was cultured from the cerebrospinal fluid. At autopsy, sections of the brain revealed complete sloughing of the intracranial ependyma, with marked gliosis and edema of the periventricular white matter. Cells with large, dark, smudg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120551
更新日期:1990-01-01 00:00:00
abstract::A 1-month-old boy was evaluated after a fall from a height of 3 feet and found to have right parietal skull fracture as well as right and left frontal traumatic hemorrhage. Ten days after the injury, he represented with a persistent left gaze preference. Further workup including MRI and EEG determined that this findin...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000441680
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The cavum veli interpositi (CVI) usually is a small CSF-containing abnormality of septum pellucidum, asymptomatic and rare after the age of 3 years. When symptomatic, it is large and can be related to psychiatric disorders, syndromic association of mental retardation and seizures or to hydrocephalus. METHOD...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336881
更新日期:2011-01-01 00:00:00
abstract::The endoscopic method is used to treat suprasellar arachnoid cysts (SACs) but it is sometimes difficult to make sufficiently sized fenestrations. Creating a larger fenestration on the cyst wall is preferable to prevent closure of the stoma. In this paper, we report a novel endoscopic approach for SAC treatment in whic...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000440811
更新日期:2016-01-01 00:00:00
abstract::There are several treatment modalities for Langerhans' cell histiocytosis (LCH) of bone, formerly usually referred to as eosinophilic granuloma, including surgery, radiotherapy and chemotherapy. In spinal lesions, surgery is not recommended generally, because of the potential for reconstitution of vertebral height. We...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000069100
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000495790
更新日期:2019-01-01 00:00:00
abstract::Fifty consecutive children are described with spastic cerebral palsy treated with selective functional lumbar and sacral rhizotomy and followed for a minimum of 6 months. In all patients, spasticity improved postoperatively, but this was not necessarily accompanied by a functional improvement. Eighteen children who co...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120639
更新日期:1992-01-01 00:00:00
abstract::Cystoperitoneal (CP) shunting is minimally invasive and achieves a high rate of resolution on neuroimaging. However, in the absence of definite symptoms, shunting should be reconsidered, because some patients can experience shunt dependency after CP shunting. In this study, the risk of shunt dependency in patients wit...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000065393
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000504060
更新日期:2020-01-01 00:00:00
abstract::Tuberculous infection of the cavernous sinus and Meckel's cave is extremely rare. In this report, we describe a patient with tuberculoma of the cavernous sinus and Meckel's cave, extending to the petrous apex. The patient underwent microsurgical excision of the lesion and antitubercular chemotherapy resulting in a goo...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000369030
更新日期:2013-01-01 00:00:00
abstract::We have reviewed 16 children with extradural spinal tumors, both benign and malignant, treated from 1998 to 2006 in Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. The duration of symptomatology, clinical signs, radiological investigations, surgical approach, outcome and histopathological var...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120147
更新日期:2008-01-01 00:00:00
abstract::There have been numerous reported cases of diffuse intravascular coagulation (DIC) or defibrination syndrome associated with head trauma, but very few reported cases associated with primary brain tumor. This report concerns the findings in a case of DIC associated with brain tumor surgery in an infant. The patient die...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120504
更新日期:1990-01-01 00:00:00
abstract::Cervical spine injuries occur infrequently in children but are associated with significant disability and mortality. A retrospective analysis was performed of 84 consecutive pediatric spine injuries treated at our institute from January 2002 to December 2011. The mean age was 14.7 years. There were 18 patients (21%) i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000439540
更新日期:2016-01-01 00:00:00