Abstract:
OBJECTIVES:To determine the genetic and environmental influence on the liability for stress urinary incontinence and pelvic organ prolapse surgery. METHODS:We used the Swedish Twin Registry to identify all same-sex female twin pairs with known zygosity born from 1926 to 1958. Occurrence of stress urinary incontinence and pelvic organ prolapse surgery was determined by cross-linkage to the Swedish Inpatient Registry. By comparing mono- and dizygotic female twins, we determined twin similarity and the relative proportions of phenotypic variance resulting from genetic and environmental factors. Using statistical modelling, the liability for pelvic floor surgery explained by heritability versus shared and non-shared environmental effects was estimated. RESULTS:We identified 3376 complete monozygotic and 5067 dizygotic same-sex female twin pairs. There was greater twin similarity among monozygotic compared with dizygotic twins, which indicates the influence of a genetic component to the aetiology of both stress urinary incontinence and pelvic organ prolapse surgery. For both disorders, genetic and non-shared environmental factors equally contributed about 40% of the variation in liability. Shared environment accounted for approximately one fifth of the total variance for the two disorders. CONCLUSIONS:Genetic effects contribute to the occurrence of both stress urinary incontinence and pelvic organ prolapse, but the influence of environmental factors is substantial. Significant environmental effects suggest that the liability for benign pelvic floor surgery is amenable to intervention.
journal_name
Eur Uroljournal_title
European urologyauthors
Altman D,Forsman M,Falconer C,Lichtenstein Pdoi
10.1016/j.eururo.2007.12.004subject
Has Abstractpub_date
2008-10-01 00:00:00pages
918-22issue
4eissn
0302-2838issn
1873-7560pii
S0302-2838(07)01541-2journal_volume
54pub_type
杂志文章相关文献
EUROPEAN UROLOGY文献大全abstract::The European Randomized study of Screening for Prostate Cancer (ERSPC) has shown a 20% relative reduction in prostate cancer mortality after 16yr [rate ratio (RR) 0.80], but centers varied by attendance, screen interval, biopsy compliance, contamination in the control arm, and treatments. We used a microsimulation mod...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1016/j.eururo.2019.04.007
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:To describe a new surgical technique for the repair of bulbar urethral strictures to preserve the bulbospongiosum muscle and its perineal innervation. OBJECTIVE:Surgical steps of muscle- and nerve-sparing bulbar urethroplasty are described. The outcome is provided regarding semen sequestration and postvoidi...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2008.03.018
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:To describe changes in untreated lower urinary tract symptoms (LUTS), levels of bothersomeness and interference in selected living activities arising from LUTS in a cohort of men followed up for a period of 5 years. METHODS:1,994 men aged 40-79 years registered in four health centres in Scotland completed a...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000019749
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the initial functional and oncologic results of 184 robot-assisted radical prostatectomies performed at our hospital. METHODS:A retrospective study was made of the first 184 consecutive robot-assisted radical prostatectomies performed at our hospital between February 2003 and December 2005. The p...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2007.02.029
更新日期:2007-09-01 00:00:00
abstract::A new method of quantitative analysis of bone metastasis in prostate cancer is described. By using a variance-dependent filter and a smoothing filter, the increased uptake lesions were distinctly demonstrated on the bone scintigraphy. The images were divided into several areas and analyzed. These procedures resulted i...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000474355
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Single-port robotic surgery is being adopted for various surgical procedures. There have been interest in and clinical use of single-port robot-assisted radical prostatectomy (spRARP), but little reported data on feasibility and early outcomes. OBJECTIVE:To describe our institution's initial experience with...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2019.04.001
更新日期:2020-03-01 00:00:00
abstract::Results from the ERA 223 trial of abiraterone combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events. We hypothesize that this finding might be attributable to bone loss induced by the con...
journal_title:European urology
pub_type: 评论,社论
doi:10.1016/j.eururo.2019.01.026
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVE:The methodology of corpus cavernosum electromyography (CC-EMG) was revisited, in order to overcome current methodological difficulties that hinder its clinical application. MATERIALS AND METHODS:Using an 8-channel device, CC-EMG was performed in 12 healthy volunteers. Surface electrodes were placed bilateral...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2004.04.002
更新日期:2004-09-01 00:00:00
abstract::7 children, 20 months to 11 years old, with cystinuria and renal calculi were studied. Surgical treatment and alpha-mercaptopropionylglycine (MPG) gave satisfactory results in 5 children. The causes of the recurrences in the other 2 children are discussed. MPG therapy is effective but can cause a nephrotic syndrome at...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473204
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVE:The long-term outcome of artificial urinary sphincter (AUS) is unpredictable because of, among others, the risk of breakdown of one of its components. Our objective was to define a strategy for an accurate diagnosis and an appropriate management of these problems. PATIENTS AND METHODS:From 1985 to 2000, 298 ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2004.01.017
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:To perform a prospective, placebo-controlled study to examine the efficacy of alpha-blocker compared with triple therapy (alpha-blocker, anti-inflammatory, and muscle relaxant) in the treatment of Category IIIB chronic pelvic pain syndrome (Category IIIB CPPS). MATERIALS AND METHODS:The study was conducted ...
journal_title:European urology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.eururo.2006.09.036
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the relationship between neuroendocrine differentiation (NED) status and hormone refractory prostate cancer (HRPC) following hormone therapy based on immunohistochemical study. METHODS:Seventy-two prostate cancer specimens obtained at radical prostatectomy and 21 prostate cancer autopsy specimens...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2003.11.032
更新日期:2004-05-01 00:00:00
abstract::In a group of 17 patients of postpubertal age with unilateral (n = 15) or bilateral (n = 2) cryptorchism, a significant decrease in the tubular diameter was observed, in addition to Leydig cell hyperplasia (many with cytoplasm vacuolization and/or atrophy) in both the cryptorchid testes and in the contralateral scrota...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000471635
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:We examined the coexistence of nitric oxide synthase (NOS) and vasoactive intestinal peptide (VIP) in the efferent pathway to the rat corpus cavernosum. METHODS:We used NADPH diaphorase (ND) histochemical staining, a specific marker of neuronal NOS, in combination with retrograde axonal transport of True Blu...
journal_title:European urology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::When a scrotal affection cannot be diagnosed confidently by correlation of clinical history and physical examination, testicular scanning with 99mTc is a useful adjunct diagnostic modality. In vivo labelling of red blood cells with 99mTc was achieved by prior oral administration of 200 mg of stannous chloride. This he...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473354
更新日期:1980-01-01 00:00:00
abstract::We present a case of villous adenoma of the prostatic urethra, without malignant transformation. A review of the diagnostic and therapeutic criteria and pathogenic hypotheses on this kind of lesion in the lower urinary tract are made. ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472952
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Robot-assisted thrombectomy (RAT) for inferior vena cava (IVC) thrombus (RAT-IVCT) is being increasingly reported. However, the techniques and indications for robot-assisted cavectomy (RAC) for IVC thrombus are not well described. OBJECTIVE:To develop a decision-making program and analyze multi-institutiona...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2020.03.020
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Ischemic injury impacts renal function outcomes following partial nephrectomy. Efforts to minimize, better yet, eliminate renal ischemia are imperative. OBJECTIVE:Describe a novel technique of "zero ischemia" laparoscopic (LPN) and robotic-assisted (RAPN) partial nephrectomy. DESIGN, SETTING, AND PARTICIPA...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2010.10.002
更新日期:2011-01-01 00:00:00
abstract::A new technique for fashioning an ileocecal pouch, applicable for both bladder augmentation and continent urinary diversion, is described. A low pressure reservoir is achieved by antimesenteric longitudinal transsection of ileum and cecum and formation of a pouch from the cecum and two ileal loops. The antireflux proc...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472481
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The role of elective whole-pelvis radiotherapy (WPRT) remains controversial. Few studies have investigated it in Gleason grade group (GG) 5 prostate cancer (PCa), known to have a high risk of nodal metastases. OBJECTIVE:To assess the impact of WPRT on patients with GG 5 PCa treated with external-beam radiot...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2019.03.022
更新日期:2020-01-01 00:00:00
abstract::The first 400 patients treated on an inpatient basis at our center underwent bacteriological follow-up after extracorporeal lithotripsy (ECL) for ureteric or renal stones. 278 patients did not have any urinary tract infection on the urine culture before ECL. They did not receive any antibiotic prophylaxis and 4.8% of ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000464021
更新日期:1990-01-01 00:00:00
abstract:CONTEXT:Conservative therapies for Peyronie's disease (PD) aim to treat early-stage disease by improving clinical outcomes such as penile curvature, penile length erectile dysfunction, and pain. OBJECTIVE:To summarise the available evidence regarding injection and mechanical therapies for PD treatment. EVIDENCE ACQUI...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2018.07.005
更新日期:2018-12-01 00:00:00
abstract::In making treatment decisions for patients with benign prostatic hyperplasia (BPH), physicians have to rely on the efficacy data published in the literature and adapt this to individual patient's needs. Criticism can be made, however, of the randomised clinical trials (RCTs) that are performed, as the patients enrolle...
journal_title:European urology
pub_type: 杂志文章,评审
doi:10.1159/000049884
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:It is unknown whether lymph node metastases (LNM) and their localization negatively affect clinical outcome in metastatic renal cell carcinoma (mRCC) patients. OBJECTIVE:To evaluate the clinicopathological features, survival outcome, and treatment response in mRCC patients with LNM versus those without LNM ...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2014.11.054
更新日期:2015-09-01 00:00:00
abstract::A comparative retrospective study was performed on 100 patients who had undergone transurethral resection of a superficial bladder tumor (Ta-Tl) with no associated carcinoma in situ (group 1) and 100 patients who had undergone simultaneous transurethral resection of a superficial bladder tumor (Ta-Tl), with no associa...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000473392
更新日期:1988-01-01 00:00:00
abstract::Univariate and multivariate analyses were performed in 632 patients treated with cisplatin combination chemotherapy for metastatic non-seminomatous testicular germ cell tumours. Multivariately, the most important poor prognosis factors for the prediction of survival were: HCG > or = 10,000 IU/l, lung metastases > or =...
journal_title:European urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000474594
更新日期:1993-01-01 00:00:00
abstract::A consecutive series of 29 patients (33 pelviureteric units) with urographic signs of altered passage through the pelviureteric junction underwent diuresis renography performed by means of an intravenous injection of 99mTc-diethylenetriamine pentaacetic acid/kg body weight followed by intravenous administration of fru...
journal_title:European urology
pub_type: 杂志文章
doi:10.1159/000472543
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). OBJECTIVE:The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. DESIGN, SETTING, AND...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.02.018
更新日期:2012-10-01 00:00:00
abstract::Urinary incontinence is a common condition affecting hundreds of millions of people worldwide but for which up to 70% of sufferers seek no help. Continence promotion activities must target not only the incontinence sufferers and their families but also the general community, health professionals, the industry that man...
journal_title:European urology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Open partial nephrectomy (OPN) remains the gold standard for treatment of small renal masses (SRMs). Laparoscopic cryoablation (LCA) has provided encouraging outcomes. Robotic partial nephrectomy (RPN) represents a new promising option but is still under evaluation. OBJECTIVE:Compare the outcomes of RPN and...
journal_title:European urology
pub_type: 杂志文章
doi:10.1016/j.eururo.2012.01.007
更新日期:2012-05-01 00:00:00