Abstract:
:Regulated on activation, normal T-cell expressed and presumably secreted (RANTES), which generally mediates monocyte-macrophage (MO) activation and recruitment, is a protein of 8-10 kD that chemoattracts eosinophils, monocytes and certain T leukocyte subsets. RANTES is coded for by a gene cluster located on human chromosome 17 and is a human T-cell specific molecule. RANTES is a member of a beta intercrine subfamily reported to be a selective chemoattractant for human monocytes rather than neutrophils, and is also a chemoattractant for memory T lymphocytes, CD4+ cells. RANTES is a modulator of many important macrophage functions in addition to aggregation, such as chemotaxis and phagocytosis. Our investigations focussed on the ability to modulate the aggregation of macrophages induced by calcium ionophore A23187. The ionophore A23187 directly induced potent aggregation of MO which was markedly enhanced when the cells were pretreated with RANTES. However, the addition of RANTES in the absence of other co-stimuli did not directly induce aggregation. Additional cytokines examined for possible induction of macrophage aggregation were interleukin-1 (IL-1), tumor necrosis alpha (TNF-alpha), and IL-6; all proved to be incapable of inducing aggregation directly, nor did they enhance the effects of A23187 on macrophage aggregation. Additionally, we found that RANTES can directly stimulate MO to activate specific pathways of arachidonic acid cascade, inducing a synthesis and release of thromboxane (TxA2) and leukotriene B4 (LTB4). RANTES did not augment the potent ability of A23187 to induce increased production of LTB4 or TxA2 by human MO. These data suggest that RANTES can contribute directly to monocyte-leukocyte-activation during inflammatory responses, resulting in greater cell aggregation, activation, and specific pro-inflammatory arachidonic acid products release, such as TxA2 and LTB4.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Shanmugham LN,Petrarca C,Castellani ML,Frydas S,Vecchiet J,Conti P,Tete Ssubject
Has Abstractpub_date
2006-01-01 00:00:00pages
15-23issue
1-2eissn
0393-974Xissn
1724-6083pii
3journal_volume
20pub_type
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,杂志文章
doi:
更新日期:2018-03-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2019-05-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2017-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论,评审
doi:
更新日期:2012-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验,信件,多中心研究
doi:
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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更新日期:2018-09-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2017-04-07 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 临床试验
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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