Hemoglobin F in sudden infant death syndrome: a San Diego SIDS/SUDC Research Project report.

Abstract:

:Whether levels of fetal hemoglobin (HbF), a possible marker of antecedent hypoxemia, are increased in sudden infant death syndrome (SIDS) compared to controls is unresolved. Our aims are to: (1) Compare percent fetal hemoglobin (%HbF) levels in SIDS and control cases, and (2) compare our findings with those reported in previous studies. Using Triton-acid-urea gel electrophoresis and quantitative densitometry, %HbF was determined in whole blood specimens obtained at autopsy from SIDS and control cases accessioned into the San Diego SIDS/SUDC Research Project database. The SIDS and control cases were not different with respect to mean age, gender, gestational age, method of delivery, birth weight, or mean autopsy interval; %HbF levels in SIDS and control cases were not significantly different. Given that our results were obtained using optimal methods in well-defined SIDS and control cases, we concur with others that %HbF is not elevated in SIDS.

journal_name

J Forensic Leg Med

authors

Krous HF,Haas EA,Chadwick AE,Masoumi H,Stanley C,Perry GW

doi

10.1016/j.jflm.2006.11.005

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

456-60

issue

8

eissn

1752-928X

issn

1878-7487

pii

S1752-928X(07)00003-0

journal_volume

14

pub_type

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