Abstract:
:Interleukin-1 beta (IL-1β), IL-6, tumour necrosis factor-alpha (TNF-α) and epidermal growth factor (EGF) play important roles in the wound healing process. In the present study, human wound specimens (n = 50) were collected from cases of death due to injuries from firearms, penetrating trauma by sharp objects and blunt trauma with a known time of injury and death identified by forensic autopsy. Full-thickness tissue specimens were obtained from injured skin sites, and equally sized intact tissues obtained from the same person were used as controls. Protein determination was performed using ELISA according to the Bradford method for each specimen, and results were provided for individual proteins. IL-1β levels did not reach statistical significance in any of the wound groups and were not markedly higher than those in the control group. However, IL-6 showed a biphasic pattern and reached statistical significance in the group with wounds less than 30 min old and in the group with wounds more than 18 h old. IL-6 was consistently higher in all wound groups than in the control group. TNF-α showed a statistically significant increase within the first 30 min and remained at a high level in all groups except for those with wounds 2-4 h old. On the other hand, EGF was high in all groups excluding those with wounds 2-4 h old and more than 18 h old, but statistical significance was not reached. Our results suggest that IL-6 and TNF-α in particular may be used as early-phase markers. We believe that IL-1β and EGF should be more extensively evaluated in further studies.
journal_name
J Forensic Leg Medjournal_title
Journal of forensic and legal medicineauthors
Birincioğlu İ,Akbaba M,Alver A,Kul S,Özer E,Turan N,Şentürk A,İnce İdoi
10.1016/j.jflm.2016.08.011subject
Has Abstractpub_date
2016-11-01 00:00:00pages
14-19eissn
1752-928Xissn
1878-7487pii
S1752-928X(16)30098-1journal_volume
44pub_type
杂志文章abstract::A young woman's death at home was attributed to new onset diabetic ketoacidosis with subsequent litigation supported by several expert consultants, despite a history and postmortem findings inconsistent with this diagnosis. More thorough tissue study of the heart and analysis of the circumstances led to a credible exp...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.09.028
更新日期:2013-11-01 00:00:00
abstract::My experience of the new Diploma in the Forensic and Clinical aspects of Sexual Assault and how this could be used as guidance for future candidates. ...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2011.09.007
更新日期:2012-01-01 00:00:00
abstract::Intimate partner violence (IPV) is an important cause of women's health and socio-familial severe problems, the most extreme being the victims' homicide. This is the first nationwide Portuguese autopsy-based and judicial-proven study about female intimate partner homicide. At least 62 women over 15 years old were kill...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.09.015
更新日期:2013-11-01 00:00:00
abstract::A 5-year-old boy with a chromosome-9 abnormality and multiple external and visceral malformations was found in cardiopulmonary arrest during a regular visit to the hospital; he did not respond to cardiopulmonary resuscitation and died. An odontoid process fracture and calcification and fibrosis of the muscles around t...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2018.11.011
更新日期:2019-02-01 00:00:00
abstract::Deaths that occur in prisons riots can be by extreme violence. When unrecognizable corpses are referred for examination, the process of human identification is hampered. The aim of this study is to present applicability in human identification by ear individual signs in an inmate beheaded in Brazil prison riot. Ten pr...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2019.101870
更新日期:2019-11-01 00:00:00
abstract::Body fluids detected on commonly found crime scene substrates require extraction, purification and quantitation of DNA prior to amplification and generation of short tandem repeat (STR) DNA profiles. In this research Y-STR profiles were generated via direct amplification of blood and saliva deposited on 12 different s...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2016.01.012
更新日期:2016-04-01 00:00:00
abstract::The antioxidant properties of the black and green tea are well known. The latent bloodstains are detectable by luminol. The bloodstains also can be cover up by drinks and foods containing the antioxidants; thus their presence can cause a decrease of the luminol light emission (false-negative results). The aim of this ...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.03.027
更新日期:2013-08-01 00:00:00
abstract::The presence of semen is generally accepted as evidence in sexual assault cases prosecution. Detection of sperm is confirmation of semen; however, sperm cannot always be detected. Prostate specific antigen (PSA) and semenogelin (Sg) are used as semen biomarkers. We compared the detection rate and persistence of sperm,...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2017.12.017
更新日期:2018-02-01 00:00:00
abstract::An investigation was performed with the aim of assessing the success rate of the examination of penile swabs or imprints for the detection of the female DNA profile. Two hundred twenty seven cases from a 3-year period were retrospectively reviewed. In 57% of the cases, no suitable material was available. Of the remain...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jcfm.2006.05.003
更新日期:2007-04-01 00:00:00
abstract::Various commercially available one-step immunoassays for detection of human (primate) blood have been developed. This study evaluated two hemoglobin tests, ABAcard(®) HemaTrace(®) and HemDirect Hemoglobin against glycophorin A test-RSID™-Blood for following parameters: sensitivity, specificity, effectiveness using var...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2015.11.021
更新日期:2016-02-01 00:00:00
abstract::A rodent model was used to evaluate the association between hypothermia and basal vacuolization in renal tubular epithelial cells. 28 Sprague Dawley rats were anaesthetized in non-stressful conditions and placed two at a time into a cooling chamber. Body core temperatures dropped to a minimum of 7-10 °C, causing death...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.10.014
更新日期:2014-01-01 00:00:00
abstract::Legal medicine addresses the interface between medicine and law in health care. The Australian College of Legal Medicine (ACLM) established itself as the peak body in legal and forensic medicine in Australia. It helped establish the Expert Witness Institute of Australia (EWIA), the legal medicine programme at Griffith...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2007.08.003
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:In recent years, suicide in children and adolescents has increased considerably, becoming the second cause of death in this age group. Therefore, the aim of this study was to identify characteristics and factors that could precipitate deaths by suicide in children and adolescents. METHODS:Using the psycholog...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2017.10.002
更新日期:2017-11-01 00:00:00
abstract::Magnetic resonance imaging (MRI) for forensic age estimation is among the research issues since it does not lead to radiation exposure. In this study, the ossification stage of the proximal humeral epiphysis was determined retrospectively in 178 male and 109 female individuals in the 12 to 30-year age group using 3.0 ...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2020.102095
更新日期:2021-01-01 00:00:00
abstract::The determination of sex is an important part of building the biological profile for unknown human remains. Many of the bones traditionally used for the determination of sex are often found fragmented or incomplete in forensic and archaeological cases. The goal of the present research was to derive discriminant functi...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2015.03.011
更新日期:2015-07-01 00:00:00
abstract::The current study examines the content of autopsy reports (N = 184) for deaths that occurred following TASER exposure by police. Guided by previous research and national autopsy standards for other weapon-specific deaths, we evaluate 1) whether reports document situational characteristics of the police-citizen encount...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2015.06.010
更新日期:2015-10-01 00:00:00
abstract::The purpose of the study was to describe toxicological findings among women seeking health care after sexual assault, and to assess the relationship with so-called proactive DFSA (drug facilitated sexual assault). We also explored associations between ethanol in blood/urine and background data, assault characteristics...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.05.005
更新日期:2013-08-01 00:00:00
abstract::Traumatic (crush) asphyxia is a rare condition caused by severe compression of the chest and trunk leading to often extreme so-called asphyxial signs, including cyanosis in head and neck regions, multiple petechiae, and subconjunctival haemorrhage as well as neurological manifestations. AIMS:To investigate the neurop...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2017.08.009
更新日期:2017-11-01 00:00:00
abstract::We report for the first time the lack of therapeutic effects after the switch from a brand formulation of allopurinol to a generic one. A 56-year-old man, with a 5 years history of well-treated gout arthropathy with allopurinol (Zyloric(®) 300 mg/die), developed acute gout arthropathy after the switch from the brand f...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2013.02.007
更新日期:2013-07-01 00:00:00
abstract::Measurements of hand bones length have been shown to be sexually dimorphic in many nationalities. The aim of this study is to assess the accuracy of sex determination from the length of all metacarpals and phalanges of right and left hands using X-ray radiographs and to develop a discriminant formula that can be used ...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2012.04.020
更新日期:2013-01-01 00:00:00
abstract::Many environmental and intrinsic factors (e.g. limited access to the body) can disrupt insect activity, causing a delay in the colonization of a corpse. These elements could hinder an accurate estimation of the minimum Post-mortem Interval (minPMI), raising questions about the limits of forensic entomology. Blow fly a...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2016.09.009
更新日期:2016-11-01 00:00:00
abstract::During the investigation of sexual assault, penile swabs from an alleged perpetrator are processed as part of the routine procedure. The results of the forensic DNA analysis may subsequently be presented in court. Documentation on the expectancy of finding female cells on post-coital penile swabs is scarce. Reviews fr...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2012.02.029
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Statistics on death are the basis of a country's health, safety, and welfare policies. Emergency physicians issue a postmortem examination certificate (PEC) for death outside the hospital as well as a death certificate (DC) for death in the hospital. This study investigated the actual conditions and criter...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2020.101960
更新日期:2020-05-01 00:00:00
abstract::We report a case with an atypical entrance wound as a result of a destabilized full metal jacket bullet penetration. The destabilized bullet by an impact with the dorsal hand experiences a yawing to tumbling motion in flight. The large angle of yaw induces a larger presenting profile upon impact that contributes, asso...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2009.01.012
更新日期:2009-10-01 00:00:00
abstract::In medico-legal autopsies, establishing personal identity of the victims is often required. Estimation of stature from extremities and their parts plays an important role in identifying the dead in forensic examinations. The study examines the relationship between stature and dimensions of hands and feet among Rajputs...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jcfm.2006.10.008
更新日期:2007-08-01 00:00:00
abstract::The skull and pelvis have been used for the estimation of sex for unknown human remains. However, in forensic cases where skeletal remains often exhibit postmortem damage and taphonomic changes the patella may be used for the estimation of sex as it is a preservationally favoured bone. The goal of the present research...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2017.12.002
更新日期:2018-02-01 00:00:00
abstract::The study of cause-specific mortality data is one of the main sources of information for public health monitoring. In most industrialized countries, when a death occurs, it is a legal requirement that a medical certificate based on the international form recommended by World Health Organization's (WHO) is filled in by...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2016.12.004
更新日期:2018-07-01 00:00:00
abstract::In the daily practice of external post-mortem examinations and dealing with surviving dependents, striking failures can be observed regularly, pointing to an increased demand for training of the various professional groups involved. In this study, the experience gained from using simulation mannequins and actors for p...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2020.102102
更新日期:2021-01-01 00:00:00
abstract::A retrospective study was undertaken of all cases of deaths due to electrocution which were autopsied at the Mortuary of Pravara Rural Hospital, Loni a rural area in Western Maharashtra over a period of 10 years from July 2004 to June 2014. Data of the study was gathered from autopsy reports and hospital records. The ...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2015.02.002
更新日期:2015-05-01 00:00:00
abstract::Paternity disputes and other forms of kinship testing are routinely resolved using short tandem repeat (STR) DNA loci. Sibship determination is encountered in instances where the DNA profiles of two individuals are compared to determine if they are siblings. If either parent is available for testing then the situation...
journal_title:Journal of forensic and legal medicine
pub_type: 杂志文章
doi:10.1016/j.jflm.2007.12.018
更新日期:2008-07-01 00:00:00