Antioxidant therapy for chronic hepatitis C after failure of interferon: results of phase II randomized, double-blind placebo controlled clinical trial.

Abstract:

AIM:To assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus (HCV) infection. METHODS:One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo, or oral treatment alone. Primary end points were liver enzymes, HCV-RNA levels and histology. RESULTS:Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo (P = 0.05). Histology activity index (HAI) score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo (P = 0.21). HCV-RNA levels decreased by 1-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo (P = NS). In part II of the trial, oral administration of antioxidants was not associated with significant alterations in any of the end points. CONCLUSION:Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients.

journal_name

World J Gastroenterol

authors

Gabbay E,Zigmond E,Pappo O,Hemed N,Rowe M,Zabrecky G,Cohen R,Ilan Y

doi

10.3748/wjg.v13.i40.5317

subject

Has Abstract

pub_date

2007-10-28 00:00:00

pages

5317-23

issue

40

eissn

1007-9327

issn

2219-2840

journal_volume

13

pub_type

杂志文章,随机对照试验
  • Air leak syndrome after endoscopic retrograde cholangiopancreatography: a rare and fatal complication.

    abstract::Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v21.i15.4770

    authors: Yilmaz B,Roach EC,Koklu S,Aydin O,Unlu O,Kilic YA

    更新日期:2015-04-21 00:00:00

  • Cooperative inhibitory effects of antisense oligonucleotide of cell adhesion molecules and cimetidine on cancer cell adhesion.

    abstract:AIM:To explore the cooperative effects of antisense oligonucleotide (ASON) of cell adhesion molecules and cimetidine on the expression of E-selectin and ICAM-1 in endothelial cells and their adhesion to tumor cells. METHODS:After treatment of endothelial cells with ASON and/or cimetidine and induction with TNF-alpha, ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v10.i1.62

    authors: Tang NH,Chen YL,Wang XQ,Li XJ,Yin FZ,Wang XZ

    更新日期:2004-01-01 00:00:00

  • Endoscopic diverticulotomy with an isolated-tip needle-knife papillotome (Iso-Tome) and a fitted overtube for the treatment of a Killian-Jamieson diverticulum.

    abstract::A Killian-Jamieson diverticulum (KJD) is an unfamiliar and rare cervical esophageal diverticulum. This diverticulum originates on the anterolateral wall of the proximal cervical esophagus through a muscular gap (the Killian-Jamieson space) below the cricopharyngeal muscle and lateral to the longitudinal muscle of the ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.14.6589

    authors: Lee CK,Chung IK,Park JY,Lee TH,Lee SH,Park SH,Kim HS,Kim SJ

    更新日期:2008-11-14 00:00:00

  • Effects of CPG ODN on biological behavior of PANC-1 and expression of TLR9 in pancreatic cancer.

    abstract:AIM:To determine the expression of toll-like receptor 9 (TLR9) in pancreatic tumor and the effects of cytosine phosphate-guanosine oligodeoxynucleotides 2216 (CPG ODN2216) on biological behavior of pancreatic carcinoma cell line PANC-1 and explore their clinical significance. METHODS:The immunohistochemistry and Weste...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i8.996

    authors: Wu HQ,Wang B,Zhu SK,Tian Y,Zhang JH,Wu HS

    更新日期:2011-02-28 00:00:00

  • Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study.

    abstract:AIM:To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass (n = 121) or lymph node (n = 101). The c...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3748/wjg.15.1587

    authors: Giovannini M,Thomas B,Erwan B,Christian P,Fabrice C,Benjamin E,Geneviève M,Paolo A,Pierre D,Robert Y,Walter S,Hanz S,Carl S,Christoph D,Pierre E,Jean-Luc VL,Jacques D,Peter V,Andrian S

    更新日期:2009-04-07 00:00:00

  • Laparoscopic finding of a hepatic subcapsular spider-like telangiectasis sign in biliary atresia.

    abstract:AIM:To assess the diagnostic value of a laparoscopic finding of a hepatic subcapsular spider-like telangiectasis (HSST) sign in biliary atresia. METHODS:A retrospective study was conducted first and then a validation set was used to investigate the value of an HSST sign in predicting biliary atresia (BA). In the retro...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v23.i39.7119

    authors: Zhou Y,Jiang M,Tang ST,Yang L,Zhang X,Yang DH,Xiong M,Li S,Cao GQ,Wang Y

    更新日期:2017-10-21 00:00:00

  • Pattern and distribution of colonic diverticulosis: analysis of 2877 barium enemas in Thailand.

    abstract:AIM:To determine the pattern and distribution of colonic diverticulosis in Thai adults. METHODS:A review of the computerized radiology database for double contrast barium enema (DCBE) in Thai adults was performed at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Incomplete studies and...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i46.8709

    authors: Lohsiriwat V,Suthikeeree W

    更新日期:2013-12-14 00:00:00

  • Diagnosis and evaluation of gastric cancer by positron emission tomography.

    abstract::Gastric cancer is the second leading cause of cancer mortality worldwide. The diagnosis of gastric cancer has been significantly improved with the broad availability of gastrointestinal endoscopy. Effective technologies for accurate staging and quantitative evaluation are still in demand to merit reasonable treatment ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i16.4574

    authors: Wu CX,Zhu ZH

    更新日期:2014-04-28 00:00:00

  • Incidence and clinical features of endoscopic ulcers developing after gastrectomy.

    abstract:AIM:To determine the precise incidence and clinical features of endoscopic ulcers following gastrectomy. METHODS:A consecutive series of patients who underwent endoscopic examination following gastrectomy between 2005 and 2010 was retrospectively analyzed. A total of 78 patients with endoscopic ulcers and 759 without ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i25.3260

    authors: Chung WC,Jeon EJ,Lee KM,Paik CN,Jung SH,Oh JH,Kim JH,Jun KH,Chin HM

    更新日期:2012-07-07 00:00:00

  • Prediction of risk factors for lymph node metastasis in early gastric cancer.

    abstract:AIM:To explore risk factors for lymph node metastases in early gastric cancer (EGC) and to confirm the appropriate range of lymph node dissection. METHODS:A total of 202 patients with EGC who underwent curative gastrectomy with lymphadenectomy in the Department of Surgery, Xinhua Hospital and Ruijin Hospital of Shangh...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i20.3096

    authors: Ren G,Cai R,Zhang WJ,Ou JM,Jin YN,Li WH

    更新日期:2013-05-28 00:00:00

  • Coexistence of esophageal superficial carcinoma and multiple leiomyomas: A case report.

    abstract::Leiomyomas are the most common benign tumors of the esophagus. They usually occur as a single lesion or as two or three nodules. Only two cases of esophageal multiple leiomyomas comprising more than 10 nodules have been reported previously. Moreover, there have been few reports of esophageal squamous cell carcinoma ov...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v12.i28.4588

    authors: Iwaya T,Maesawa C,Uesugi N,Kimura T,Ikeda K,Kimura Y,Mitomo S,Ishida K,Sato N,Wakabayashi G

    更新日期:2006-07-28 00:00:00

  • Sclerosing encapsulating peritonitis in a liver transplant patient: a case report.

    abstract::We report a patient with HBV-related hepatocellular carcinoma (HCC) and refractory ascites who had received a peritoneal-venous shunt (PVS) 1 year before liver transplantation. Urgent surgical intervention following bowel obstruction and failure of immunosuppression therapy. No intestinal obstruction was found during ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i34.5412

    authors: Lin CH,Yu JC,Chen TW,Chan DC,Chen CJ,Hsieh CB

    更新日期:2005-09-14 00:00:00

  • Practical approaches to effective management of intestinal radiation injury: benefit of resectional surgery.

    abstract:AIM:To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative management. METHODS:During a 7-year period we operated on 17 cases (5 male, 12 female) admitted to our surgical department with intestinal radiation injury (IRI). They were...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i35.4013

    authors: Perrakis N,Athanassiou E,Vamvakopoulou D,Kyriazi M,Kappos H,Vamvakopoulos NC,Nomikos I

    更新日期:2011-09-21 00:00:00

  • Gene expression profiles of hepatoma cell line HLE.

    abstract:AIM:To investigate the global gene expression of cancer related genes in hepatoma cell line HLE using Atlas Human Cancer Array membranes with 588 well-characterized human genes related with cancer and tumor biology. METHODS:Hybridization of cDNA blotting membrane was performed with (32)P-labeled cDNA probes synthesize...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i4.683

    authors: Liu LX,Liu ZH,Jiang HC,Zhang WH,Qi SY,Hu J,Wang XQ,Wu M

    更新日期:2003-04-01 00:00:00

  • Relationship between insulin A chain regions and insulin biological activities.

    abstract::AIM:To study the relationship between insulin A chain regions and insulin biological activities, we designed a series of insulin analogues with changes at A21, A12-18 of C terminal helical region and A8-10 located in the region of A6-A11 intra-chain disulphide bond.METHODS:Insulin A-chain analogues were prepared by st...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v6.i3.371

    authors: Yang SZ,Huang YD,Jie XF,Feng YM,Niu JY

    更新日期:2000-06-01 00:00:00

  • Molecular aspects of intestinal calcium absorption.

    abstract::Intestinal Ca(2+) absorption is a crucial physiological process for maintaining bone mineralization and Ca(2+) homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3 steps: the entrance of Ca(2+) across the brush border membranes (BBM) of enterocytes through epithelial ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i23.7142

    authors: Diaz de Barboza G,Guizzardi S,Tolosa de Talamoni N

    更新日期:2015-06-21 00:00:00

  • Multiphoton microscopy for tumor regression grading after neoadjuvant treatment for colorectal carcinoma.

    abstract:AIM:To evaluate the feasibility of using multiphoton microscopy (MPM) to assess a tumor regression grading (TRG) system. METHODS:Fresh specimens from seven patients with colorectal carcinoma undergoing neoadjuvant radiochemotherapy at the Fujian Medical University Union Hospital were obtained immediately after proctec...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i14.4210

    authors: Li LH,Chen ZF,Wang XF,Zhuo SM,Li HS,Jiang WZ,Guan GX,Chen JX

    更新日期:2015-04-14 00:00:00

  • Laser ablation of hepatocellular carcinoma--a review.

    abstract::A wide range of local thermal ablative therapies have been developed in the treatment of non resectable hepatocellular carcinoma (HCC) in the last decade. Laser ablation (LA) and radiofrequency ablation (RFA) are the two most widely used of these. This article provides an up to date overview of the role of laser ablat...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.14.7170

    authors: Gough-Palmer AL,Gedroyc WM

    更新日期:2008-12-21 00:00:00

  • Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice.

    abstract:AIM:To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets. METHODS:Intraperitoneal injections of acetaminophen (250 mg/kg) were used to induce acute liver injury in male C57BL/6 mice. A total of 24 healthy mice were randomly assigned to two groups: an acute liv...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i26.8089

    authors: Lei YC,Li W,Luo P

    更新日期:2015-07-14 00:00:00

  • Downregulation of electroacupuncture at ST36 on TNF-alpha in rats with ulcerative colitis.

    abstract:AIM:To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNF-alpha) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC. METHODS:Thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups (n=...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v9.i5.1028

    authors: Tian L,Huang YX,Tian M,Gao W,Chang Q

    更新日期:2003-05-01 00:00:00

  • Pediatric non-alcoholic steatohepatitis: the first report on the ultrastructure of hepatocyte mitochondria.

    abstract:AIM:To investigate the ultrastructure of abnormal hepatocyte mitochondria, including their cellular and hepatic zonal distribution, in bioptates in pediatric non-alcoholic steatohepatitis (NASH). METHODS:Ultrastructural investigations were conducted on biopsy liver specimens obtained from 10 children (6 boys and 4 gir...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i15.4335

    authors: Lotowska JM,Sobaniec-Lotowska ME,Bockowska SB,Lebensztejn DM

    更新日期:2014-04-21 00:00:00

  • P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection.

    abstract:AIM:To confirm if p53 mutation could be a routine predictive marker for the prognosis of hepatocellular carcinoma (HCC) patients. METHODS:Two hundreds and forty-four formalin-fixed paraffin-embedded tumor samples of the patients with HCC receiving liver resection were detected for nuclear accumulation of p53. The perc...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v8.i3.459

    authors: Qin LX,Tang ZY,Ma ZC,Wu ZQ,Zhou XD,Ye QH,Ji Y,Huang LW,Jia HL,Sun HC,Wang L

    更新日期:2002-06-01 00:00:00

  • Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis.

    abstract:AIM:To define probiotic monotherapy effect on Helicobacter pylori (H. pylori) status by performing a systematic review. METHODS:Methods of analysis and inclusion criteria were based on PRISMA recommendations. Relevant publications were identified by searching PubMed, MEDLINE, Science Direct, and EMBASE. The end-point ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v24.i1.139

    authors: Losurdo G,Cubisino R,Barone M,Principi M,Leandro G,Ierardi E,Di Leo A

    更新日期:2018-01-07 00:00:00

  • Left ventricular assist device hemolysis leading to dysphagia.

    abstract::A 41-year-old man with a continuous-flow left ventricular assist device presented for evaluation of dysphagia and dark urine. He was found to have a significantly elevated L-lactate dehydrogenase and an elevated plasma free hemoglobin consistent with intravascular hemolysis. After the hemolysis ceased, both the black ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i18.5735

    authors: Wuschek A,Iqbal S,Estep J,Quigley E,Richards D

    更新日期:2015-05-14 00:00:00

  • Successful isolation of Helicobacter pylori after prolonged incubation from a patient with failed eradication therapy.

    abstract::Helicobacter pylori (H pylori), a gastric pathogen, is a major cause of chronic gastritis and peptic ulcer disease, and is an important risk factor for the development of gastric malignancies. Culture of the bacterium from gastric biopsy is essential for the determination of drug resistance of H pylori. However, the i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.15.1528

    authors: Yin Y,He LH,Zhang JZ

    更新日期:2009-03-28 00:00:00

  • Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer.

    abstract::Metastatic colorectal cancer (mCRC) continues to be counted as a major health problem. The introduction of newer cytotoxics, irinotecan and oxaliplatin, has achieved a significant improvement in survival rates. Novel targeted therapies (bevacizumab, and cetuximab) in combination with most efficient chemotherapy regime...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v16.i10.1177

    authors: Saridaki Z,Georgoulias V,Souglakos J

    更新日期:2010-03-14 00:00:00

  • Role of autophagy in the pathogenesis of inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v23.i11.1944

    authors: Iida T,Onodera K,Nakase H

    更新日期:2017-03-21 00:00:00

  • Promoter hypermethylation and loss of CD133 gene expression in colorectal cancers.

    abstract:AIM:To understand CD133 promoter hypermethylation and expression in 32 colorectal cancer cell lines. METHODS:Nucleic acid was isolated from 32 colorectal cancer cell lines and CD133 expression levels were measured by reverse transcription-polymerase chain reaction (RT-PCR) and real-time PCR. Promoter methylation statu...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v16.i25.3153

    authors: Jeon YK,Kim SH,Choi SH,Kim KH,Yoo BC,Ku JL,Park JG

    更新日期:2010-07-07 00:00:00

  • Gastrointestinal stromal tumors of the duodenum: surgical management and survival results.

    abstract:AIM:To provide long-term survival results of operable duodenal gastrointestinal stromal tumors (DGISTs) in a tertiary center in China. METHODS:In this retrospective study, the pathological data of 28 patients with DGISTs who had been treated surgically at the Second Department of General Surgery, Sir Run Run Shaw Hosp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i36.6000

    authors: Liang X,Yu H,Zhu LH,Wang XF,Cai XJ

    更新日期:2013-09-28 00:00:00

  • Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction.

    abstract:AIM:To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clini...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i30.9134

    authors: Kim SH,Chun HJ,Yoo IK,Lee JM,Nam SJ,Choi HS,Kim ES,Keum B,Seo YS,Jeen YT,Lee HS,Um SH,Kim CD

    更新日期:2015-08-14 00:00:00