Human intestine epithelial cell acetyl- and butyrylcholinesterase.

abstract：:Cardiac hypertrophy in rats was produced by aortic banding for 6 weeks and regression of hypertrophy in these experimental animals was induced by administration of angiotensin converting enzyme inhibitor, enalapril (10 mg/kg/day) for 6 weeks. The left ventricular muscle mass and systolic pressure were decrease upon tr...

journal_title：Molecular and cellular biochemistry

authors： Makino N,Matsui H,Masutomo K,Hata T,Yanaga T

更新日期：1993-02-17 00:00:00

abstract：:The role of C-X-C chemokine receptor type 4 (CXCR4) in umbilical mesenchymal stem cells (UMSCs) as therapy for liver disease is ill understood. The aim of the study was to evaluate rat UMSCs (rUMSCs) on CXCR4 expression and homing to injured liver tissue. rUMSCs were isolated from umbilical cords of pregnant rats. Acu...

journal_title：Molecular and cellular biochemistry

authors： Deng C,Qin A,Zhao W,Feng T,Shi C,Liu T

更新日期：2014-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) are major receptors that mediate the innate immune and inflammatory responses, of which TLR4 has been found most closely related to human atherosclerosis. After ligands are polymerized and activated by TLR, the mitogen-activated protein kinase and nuclear factor-κB (NF-κB) pathways are activ...

journal_title：Molecular and cellular biochemistry

authors： Yang B,Zhou Z,Li X,Niu J

更新日期：2016-11-01 00:00:00

abstract：:Saccharomyces cerevisiae contains vacuoles corresponding to lysosomes in higher eukaryotes. Lysosomes are dynamic (not silent) organelles in which enzymes can be easily integrated or released when exposed to stressful conditions. Changes in lysosomal enzymes have been observed due to oxidative stress, resulting in an ...

journal_title：Molecular and cellular biochemistry

authors： Yoon J,Sekhon SS,Kim YH,Min J

更新日期：2016-06-01 00:00:00

abstract：:Cataract is the most common eye disease that causes blindness in patients. Ultraviolet B (UVB) irradiation is considered an important factor leading to cataract by inducing apoptosis in human lens epithelial cells (HLECs), but the mechanism is currently unclear. In this study, we investigated HLECs under different int...

journal_title：Molecular and cellular biochemistry

authors： Ji Y,Cai L,Zheng T,Ye H,Rong X,Rao J,Lu Y

更新日期：2015-03-01 00:00:00

abstract：:Pre-steady-state and steady-state kinetics for the p.p. elastase-catalysed hydrolysis of ZAlaONp, one of the most favourable substrates for this serine protease, have been studied between pH 4.0 and 8.0. The results are consistent with the minimum three-step mechanism: (formula; see text) Under pre-steady-state condit...

journal_title：Molecular and cellular biochemistry

authors： Ascenzi P,Menegatti E,Guarneri M,Antonini E

更新日期：1983-01-01 00:00:00

abstract：:Brain-type creatine kinases B-CK (cytosolic) and UbCKmit (mitochondrial) are considered important for the maintenance and distribution of cellular energy in the central nervous system. Previously, we have demonstrated an abnormal behavioral phenotype in mice lacking the B-CK creatine kinase isoform, regarding explorat...

journal_title：Molecular and cellular biochemistry

authors： Streijger F,Jost CR,Oerlemans F,Ellenbroek BA,Cools AR,Wieringa B,Van der Zee CE

更新日期：2004-01-01 00:00:00

abstract：:Myostatin belongs to the Transforming Growth Factor-beta (TGF-beta) superfamily and is expressed in developing and mature skeletal muscle. Biologically, the role of myostatin seems to be extremely well conserved during evolution since inactivating mutations in myostatin gene cause similar phenotype of heavy muscling i...

journal_title：Molecular and cellular biochemistry

authors： Jeanplong F,Sharma M,Somers WG,Bass JJ,Kambadur R

更新日期：2001-04-01 00:00:00

abstract：:MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicates that miR-143 plays causal roles in cancer tumorigenesis as a tumor suppress gene; however, its role in prostate cancer tumorigenesis remains largely unknown. The aims of this study were to verify the effect of miR-143 o...

journal_title：Molecular and cellular biochemistry

authors： Xu B,Niu X,Zhang X,Tao J,Wu D,Wang Z,Li P,Zhang W,Wu H,Feng N,Wang Z,Hua L,Wang X

更新日期：2011-04-01 00:00:00

abstract：:Clinically significant occlusive vascular lesions contain more extracellular matrix (ECM) proteins and lipid deposition than healthy vascular tissue. The events leading to this condition remain unresolved. One possibility is that ECM deposition may exceed ECM degradation which would contribute to the expansion of the ...

journal_title：Molecular and cellular biochemistry

authors： Wilson D,Massaeli H,Russell JC,Pierce GN,Zahradka P

更新日期：2003-07-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which participates in many important cellular processes such as cell adhesion and migration. However, the role of FAK in renal tubular epithelial-to-mesenchymal transition (EMT) is still unknown. FAK was knocked down by transfection of specific small interf...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Yang X,Liu J,He F,Zhu Z,Zhang C

更新日期：2010-07-01 00:00:00

abstract：:Purpurogallin (PPG) is a phenolic compound extracted from nutgalls formed on oak trees. It has been used as an additive to edible or nonedible oils or fats, and to hydrocarbon fuels or lubricants to retard their oxidation. We investigated by luminol-dependent chemiluminescence (PMNL-CL), the ability of PPG to scavenge...

journal_title：Molecular and cellular biochemistry

authors： Prasad K,Kapoor R,Lee P

更新日期：1994-10-12 00:00:00

abstract：:The present study was designed to induce massive accumulation of calcium in the myocardium and to evaluate the effect of calcium overload on myocardial contractile function and biochemical activity of cardiac subcellular membranes. Rats were treated with an oral administration of 500,000 units/kg of vitamin D3 for 3 c...

journal_title：Molecular and cellular biochemistry

authors： Takeo S,Tanonaka R,Tanonaka K,Miyake K,Hisayama H,Ueda N,Kawakami K,Tsumura H,Katsushika S,Taniguchi Y

更新日期：1991-10-16 00:00:00

abstract：:Ischemic heart disease is the leading cause of death for both men and women worldwide, accruing 7.4 million deaths in 2012. There has been a continued search for better cardioprotective modalities that would reduce myocardial ischemia-reperfusion injury. Among these attempts, a more convenient model of ischemic precon...

journal_title：Molecular and cellular biochemistry

authors： Gill R,Kuriakose R,Gertz ZM,Salloum FN,Xi L,Kukreja RC

更新日期：2015-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerases or PARPs are a family of NAD(+)-dependent enzymes that modify themselves and other substrate proteins with ADP-ribose polymers. The founding member PARP 1 is localized predominantly in the nucleus and is activated by binding to DNA lesions. Excessive PARP 1 activation following genotoxin t...

journal_title：Molecular and cellular biochemistry

authors： Yeh TY,Sbodio JI,Nguyen MT,Meyer TN,Lee RM,Chi NW

更新日期：2005-08-01 00:00:00

abstract：:In this study, we examined changes in the biochemical and inotropic events of the alpha(1)-adrenoceptor signaling pathway in hypothyroid rat hearts. Hypothyroidism was induced by treating experimental animals with 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 7 weeks. A significant decrease of beta- and an...

journal_title：Molecular and cellular biochemistry

authors： Jalali S,Durston M,Panagia V,Mesaeli N

更新日期：2006-02-01 00:00:00

abstract：:Yeast GTP-binding protein (YPT1 protein) has been reported to function in the early stages of the secretory pathway. Particularly, YPT1 protein is observed to regulate both the endoplasmic reticulum-to-Golgi transport and the autophagy. Therefore, the YPT1 protein overexpressed in yeast vacuoles is expected to enhance...

journal_title：Molecular and cellular biochemistry

authors： Tran le M,Bang SH,Yoon J,Kim YH,Min J

更新日期：2016-03-01 00:00:00

abstract：:We firstly characterized zinc uptake phenomenon across basolateral membrane vesicles (BLMVs) isolated from normal rat kidney. The process was found to be time, temperature, and substrate concentration dependent, and displayed saturability. Zn(2+) uptake was competitively inhibited in the presence of 2 mM Cd with Ki of...

journal_title：Molecular and cellular biochemistry

authors： Kaur J,Sharma N,Attri S,Gogia L,Prasad R

更新日期：2006-02-01 00:00:00

abstract：:Development and repair of the skeletal system and other organs are highly dependent on precise regulation of the bone morphogenetic protein (BMP) pathway. The use of BMPs clinically to induce bone formation has been limited in part by the requirement of much higher doses of recombinant proteins in primates than were n...

journal_title：Molecular and cellular biochemistry

authors： Sangadala S,Yoshioka K,Enyo Y,Liu Y,Titus L,Boden SD

更新日期：2014-01-01 00:00:00

abstract：:Parasitic nematodes have recently been found to produce proteins which represent two new classes of fatty acid and retinoid binding protein. The first is the nematode polyprotein allergens/antigens (NPAs) which, as their name suggests, are synthesised as large polyproteins which are subsequently cleaved at regularly s...

journal_title：Molecular and cellular biochemistry

authors： McDermott L,Cooper A,Kennedy MW

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Chronic adenosine A2b receptor stimulation has been shown to prevent ventricular remodelling after myocardial infarction (MI). We hypothesized that this effect is due to the inhibition of cardiac myocyte apoptosis in the myocardium remote from the infarction. METHODS:Rats were subjected to MI by LAD ligation...

journal_title：Molecular and cellular biochemistry

authors： Simonis G,Wiedemann S,Joachim D,Weinbrenner C,Marquetant R,Strasser RH

更新日期：2009-08-01 00:00:00

abstract：:Tedisamil is antiarrhythmic class III drug with antifibrillating/defibrillating potency linked to enhancement of intermyocyte gap junctional electrical coupling most likely via its sympathomimetic cAMP-related mechanisms. This study was designed to examine the effect of tedisamil on cAMP level in guinea pig hearts in ...

journal_title：Molecular and cellular biochemistry

authors： Tribulova N,Ravingerova T,Okruhlicova L,Gabauer I,Fickova M,Pancza D,Slezak J,Manoach M

更新日期：2000-07-01 00:00:00

abstract：:The NGF secretion from cultured mouse astrocytes was enhanced by sublethal concentrations of phosphatidic acid (PA), ceramide, or sphingosine (Sph), and concentration dependently by lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC), or sphingosine-1-phosphate (S1P), but was unaffected by any concentration...

journal_title：Molecular and cellular biochemistry

authors： Furukawa A,Kita K,Toyomoto M,Fujii S,Inoue S,Hayashi K,Ikeda K

更新日期：2007-11-01 00:00:00

abstract：:Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenopr...

journal_title：Molecular and cellular biochemistry

authors： Kameshwar VH,R KJ,Priya BS,Swamy SN

更新日期：2017-02-01 00:00:00

abstract：:In this study, the effect of (Boc-Lys (Boc)-Arg-Asp-Ser (tBu)-OtBu), a tetrapeptide derivative (PEP1261) was examined for antiproliferative potency and apoptotic induction. Synovial fibroblasts were isolated from collagen-induced arthritic (CIA) rats and exposed to peptides viz., PEP1261, and parental peptides (KRDS a...

journal_title：Molecular and cellular biochemistry

authors： Kumar DA,Settu K,Raju KV,Kumanan K,Manohar BM,Puvanakrishnan R

更新日期：2006-01-01 00:00:00

abstract：:To define metabolic influences on cardiac myosin expression and sarcoplasmic reticulum (SR) Ca(2+)-stimulated ATPase streptozotocin-diabetic rats were treated for 9-10 wk with etomoxir, an inhibitor of carnitine palmitoyl transferase I (CPT-1) and fatty acid synthesis, or an antilipolytic drug, acipimox. Etomoxir redu...

journal_title：Molecular and cellular biochemistry

authors： Rupp H,Elimban V,Dhalla NS

更新日期：1994-03-16 00:00:00

abstract：:CYP3A5 is an important genetic contributor to inter-individual differences in CYP3A-dependent clinically important drugs of metabolism and also of various endogenous compounds and environmental contaminants. The CYP3A5*3 allele results in a truncated protein with loss of CYP3A5 expression and CYP3A5*6 is associated wi...

journal_title：Molecular and cellular biochemistry

authors： Bajpai P,Tripathi AK,Agrawal D

更新日期：2010-03-01 00:00:00

abstract：:The rapid repair of gastric mucosa is critical upon exposure to injurious agents. Intestinal trefoil factor (ITF) is a member of the trefoil factor family domain peptides, which play an important role in the cytoprotection of gastric epithelium. However, the underlying molecular mechanisms that are responsible for ITF...

journal_title：Molecular and cellular biochemistry

authors： Lin J,Sun Z,Zhang W,Liu H,Shao D,Ren Y,Wen Y,Cao L,Wolfram J,Yang Z,Nie S

更新日期：2015-06-01 00:00:00

abstract：:DNA methylation plays an important role in regulation of gene expression and is increasingly being recognized as a determinant of chemosensitivity of human cancers. With the aim of improving the chemotherapeutic efficacy of breast carcinoma, the effect of DNA methyltransferase inhibitor, 5-Aza-2'-deoxycytidine (5-aza-...

journal_title：Molecular and cellular biochemistry

authors： Mirza S,Sharma G,Pandya P,Ralhan R

更新日期：2010-09-01 00:00:00

abstract：:β-Adrenergic receptor (β-AR) stimulation induces cardiac myocyte apoptosis and plays an important role in myocardial remodeling. Here we investigated expression of various apoptosis-related genes affected by β-AR stimulation, and examined first time the role of ataxia telangiectasia mutated kinase (ATM) in cardiac myo...

journal_title：Molecular and cellular biochemistry

authors： Foster CR,Singh M,Subramanian V,Singh K

更新日期：2011-07-01 00:00:00