当前位置： SCI文献检索 > DRUG AND ALCOHOL DEPENDENCE期刊下所有文献 > Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.

Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.

Abstract：

RATIONALE:Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence. OBJECTIVES:To test the acute effects of sublingual buprenorphine/naloxone tablets in volunteers with a higher level of physical dependence. The goal was to identify a dose that would precipitate withdrawal (Phase 1), then determine if withdrawal could be attenuated by splitting this dose (Phase 2). METHODS:Residential laboratory study; subjects (N=16) maintained on 100mg per day of methadone. Phase 1: randomized, double blind, triple dummy, within subject study. Conditions were sublingual buprenorphine/naloxone (4/1, 8/2, 16/4, 32mg/8mg), intramuscular naloxone (0.2mg), oral methadone (100mg), or placebo. Medication conditions were randomized, but buprenorphine/naloxone doses were ascending within the randomization. Phase 2: Conditions were methadone, placebo, naloxone, 100% of the buprenorphine/naloxone dose that precipitated withdrawal in Phase 1 (full dose), and 50% of this dose administered twice in a session (split dose). Analyses covaried by trough methadone serum levels. RESULTS:Six subjects did not complete the study. Of the 10 who completed, 3 tolerated up to 32mg/8mg of buprenorphine/naloxone without evidence of precipitated withdrawal. For the seven completing both phases, split doses generally produced less precipitated withdrawal compared to full doses. CONCLUSIONS:There is considerable between subject variability in sensitivity to buprenorphine's antagonist effects. Low, repeated doses of buprenorphine/naloxone (e.g., 2mg/0.5mg) may be an effective mechanism for safely dosing this medication in persons with higher levels of physical dependence.

journal_name

Drug Alcohol Depend

journal_title

Drug and alcohol dependence

authors

Rosado J,Walsh SL,Bigelow GE,Strain EC

doi

10.1016/j.drugalcdep.2007.04.006

subject

Has Abstract

pub_date

2007-10-08 00:00:00

pages

261-9

issue

2-3

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(07)00175-5

journal_volume

90

pub_type

杂志文章,随机对照试验

相关文献

DRUG AND ALCOHOL DEPENDENCE文献大全
  • Parent-based interventions on adolescent alcohol use outcomes: A systematic review and meta-analysis.

    abstract：BACKGROUND:The effects of parent-based interventions on adolescent alcohol use are unclear, including what factors moderate intervention effects. This study examines the effects of parent-based interventions on adolescent alcohol use and whether the treatment effects vary by participants' characteristics and interventi...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.drugalcdep.2018.05.031

    authors： Bo A,Hai AH,Jaccard J

    更新日期：2018-10-01 00:00:00

  • Methadone maintenance therapy service components linked to improvements in HIV care cascade outcomes: A systematic review of trials and observational studies.

    abstract：BACKGROUND:The beneficial links between engagement in methadone maintenance therapy (MMT) and HIV treatment outcomes have been extensively described. Nevertheless, people who use drugs (PWUD) continue to experience suboptimal HIV treatment outcomes. In this systematic review, we sought to identify components of MMT ser...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/j.drugalcdep.2020.108342

    authors： Mohd Salleh NA,Voon P,Karamouzian M,Milloy MJ,Richardson L

    更新日期：2021-01-01 00:00:00

  • Delivery of nicotine aerosol to mice via a modified electronic cigarette device.

    abstract：BACKGROUND:Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) inj...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2016.12.004

    authors： Lefever TW,Lee YO,Kovach AL,Silinski MA,Marusich JA,Thomas BF,Wiley JL

    更新日期：2017-03-01 00:00:00

  • Patterns of Kratom use and health impact in the US-Results from an online survey.

    abstract：BACKGROUND:Kratom preparations have raised concerns of public health and safety in the US. Investigation into the demographics, perceived beneficial and detrimental effects of Kratom as well as common doses and purposes of its use are important to properly evaluate its potential health impact. METHODS:An anonymous cro...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.03.007

    authors： Grundmann O

    更新日期：2017-07-01 00:00:00

  • Physicians-in-training are not prepared to prescribe medical marijuana.

    abstract：BACKGROUND:While medical marijuana use is legal in more than half of U.S. states, evidence is limited about the preparation of physicians-in-training to prescribe medical marijuana. We asked whether current medical school and graduate medical educational training prepare physicians to prescribe medical marijuana. METH...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.08.010

    authors： Evanoff AB,Quan T,Dufault C,Awad M,Bierut LJ

    更新日期：2017-11-01 00:00:00

  • A cluster analysis of drug use and sexual HIV risks and their correlates in a sample of African-American crack cocaine smokers with HIV infection.

    abstract：:The purpose of this cross-sectional study was to classify a sample of HIV-seropositive African-American crack cocaine smokers into homogenous HIV drug use and sexual risk groups using a two step multivariate cluster analysis. Two hundred and fifty-eight crack cocaine smokers participated in the study. Cluster analysis...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2008.03.023

    authors： Schönnesson LN,Atkinson J,Williams ML,Bowen A,Ross MW,Timpson SC

    更新日期：2008-09-01 00:00:00

  • Benzodiazepines and drug abuse: clinical observations in chemically dependent persons before and during abstinence.

    abstract：:Sixty-nine (9.2%) of 750 consecutive persons entering a chemical-dependence treatment hospital had urinary evidence of benzodiazepines, a somewhat higher proportion than in the general adult American population. The 54 subjects in whose urine benzodiazepines, but not the other commonly abused psychoactive drugs, were ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(80)90019-8

    authors： Cushman P,Benzer D

    更新日期：1980-12-01 00:00:00

  • Transitions in the use of multiple substances from adolescence to young adulthood.

    abstract：BACKGROUND:Research indicates that many adolescents frequently use multiple substances. This study examines stability and transitions in the use and co-use of multiple substances (cigarette, alcohol, marijuana, illicit drugs) from adolescence to young adulthood. METHODS:Data were collected biennially from 662 youth in...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2018.05.015

    authors： Merrin GJ,Thompson K,Leadbeater BJ

    更新日期：2018-08-01 00:00:00

  • The introduction of a potentially abuse deterrent oxycodone formulation: Early findings from the Australian National Opioid Medications Abuse Deterrence (NOMAD) study.

    abstract：BACKGROUND:There is increasing concern about tampering of pharmaceutical opioids. We describe early findings from an Australian study examining the potential impact of the April 2014 introduction of an abuse-deterrent sustained-release oxycodone formulation (Reformulated OxyContin(®)). METHODS:Data on pharmaceutical o...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2015.02.038

    authors： Degenhardt L,Bruno R,Ali R,Lintzeris N,Farrell M,Larance B

    更新日期：2015-06-01 00:00:00

  • Longitudinal associations between marijuana and cigar use in young adults.

    abstract：BACKGROUND:We assess the longitudinal associations between marijuana and cigar (little cigars and cigarillos [LCCs] and large cigars) use on subsequent initiation of marijuana and cigar use. METHODS:Data are from a cohort study of 2189 young adults recruited in fall 2010 from 11 colleges in the Southeast. We used disc...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.107964

    authors： Cornacchione Ross J,Sutfin EL,Suerken C,Walker S,Wolfson M,Reboussin BA

    更新日期：2020-03-23 00:00:00

  • Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones.

    abstract：:Physical dependence on alcohol was observed previously at the cellular level in cultured IM-9 human lymphoblast cells. To answer the question whether physical dependence can also develop in neurones and to investigate the neuronal processes involved in the development of alcohol dependence and withdrawal symptoms, cul...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(00)00132-0

    authors： Nagy J,Müller F,László L

    更新日期：2001-01-01 00:00:00

  • Brief intervention in general hospital for problematic prescription drug use: 12-month outcome.

    abstract：BACKGROUND:The problematic use of prescription drugs (PDs) and related disorders are considerably prevalent but evidence concerning brief intervention for problematic PD users is sparse. A previous analysis of the present study on the effectiveness of brief intervention for problematic PD use in a general hospital reve...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2009.07.010

    authors： Otto C,Crackau B,Löhrmann I,Zahradnik A,Bischof G,John U,Rumpf HJ

    更新日期：2009-12-01 00:00:00

  • Beliefs and opinions about drugs and their users as predictors of drug-user status of adolescents in post-revolutionary Iran.

    abstract：:In a sample survey of 712 Iranian male adolescents, aged 14-18, it was found that drugs users differed in only some of theirs beliefs about drug substances and their use from their non-drug-using contemporaries; and that both sub-samples had, in their agreement about the drug problem in post-revolutionary Iran, been e...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(82)90001-1

    authors： Agahi C,Spencer C

    更新日期：1982-10-01 00:00:00

  • The use of psychoactive substances by female Egyptian university students, compared with their male colleagues on selected items.

    abstract：:A standardized questionnaire, with satisfactory retake item reliabilities and well established validities, was administered to a representative sample of female university students (N = 2366), drawn from Cairo and Ein-Shams Universities, both located in Greater Cairo. Results, relevant to demographic and drug related ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(87)90043-3

    authors： Soueif MI,Hannourah MA,Darweesh ZA,el-Sayed AM,Yunis FA,Taha HS

    更新日期：1987-05-01 00:00:00

  • Impulsivity differences in recreational cannabis users and binge drinkers in a university population.

    abstract：BACKGROUND:Recreational cannabis use and alcohol binge drinking are the most common drug consumption patterns in young adults. Impulsivity and several psychopathological signs are increased in chronic drug users, but the implications of recreational use are still poorly understood. METHODS:We evaluated impulsivity, se...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2012.02.011

    authors： Moreno M,Estevez AF,Zaldivar F,Montes JM,Gutiérrez-Ferre VE,Esteban L,Sánchez-Santed F,Flores P

    更新日期：2012-08-01 00:00:00

  • Factors associated with substance use during pregnancy: results from a national sample.

    abstract：OBJECTIVE:To examine the prevalence and correlates of substance use during pregnancy among women in the United States. METHODS:We analyzed data from pregnant (n=1800) and non-pregnant women (n=37,527) aged 15-44 years who participated in the 2002 or 2003 National Survey on Drug Use and Health, a nationally representat...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2008.07.010

    authors： Havens JR,Simmons LA,Shannon LM,Hansen WF

    更新日期：2009-01-01 00:00:00

  • Inter-relationship between serum potassium and plasma catecholamines and 3':5' cyclic monophosphate in alcohol withdrawal.

    abstract：:Serial analyses of serum potassium and plasma epinephrine, norepinephrine and adenosine 3':5'-cyclic monophosphate (cyclic AMP) concentrations were measured in 13 patients with alcohol withdrawal, six of whom presented delirium tremens. Patients with delirium showed at admission levels of potassium (3.45 +/- 0.45 mmol...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/0376-8716(90)90126-y

    authors： Laso FJ,González-Buitrago JM,Martin-Ruiz C,Vicens E,Moyano JC

    更新日期：1990-10-01 00:00:00

  • The applicability of the dependence syndrome to amphetamine.

    abstract：:While current psychiatric taxonomies recognise a classification of amphetamine dependence, derived from the notion of an alcohol dependence syndrome, little research has validated that such a condition exists for this drug. Current amphetamine users (N = 331), were interviewed using the World Health Organization opera...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(97)00111-7

    authors： Topp L,Darke S

    更新日期：1997-11-25 00:00:00

  • The impact of opioid use disorder on levels of educational attainment: Perceived benefits and consequences.

    abstract：BACKGROUND/AIMS:Adolescents and young adults have the highest rates of opioid use, and despite shared risk-factors such as mental health and social pressures, there is little information on the relationship between education and opioid use disorder. In this study, we sought to assess differences in educational attainme...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2019.107618

    authors： Ellis MS,Kasper ZA,Cicero TJ

    更新日期：2020-01-01 00:00:00

  • Contingency management treatment in cocaine using methadone maintained patients with and without legal problems.

    abstract：BACKGROUND:Legal difficulties and cocaine use are prevalent in methadone maintenance patients, and they are related to one another, as well as to poor response to methadone treatment. Contingency management (CM) is efficacious for decreasing cocaine use, but the relation of CM treatment to criminal activities has rarel...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2017.08.014

    authors： Ginley MK,Rash CJ,Olmstead TA,Petry NM

    更新日期：2017-11-01 00:00:00

  • Differential effects of cocaine exposure on the abundance of phospholipid species in rat brain and blood.

    abstract：BACKGROUND:Lipid profiles in the blood are altered in human cocaine users, suggesting that cocaine exposure can induce lipid remodeling. METHODS:Lipid changes in the brain tissues of rats sensitized to cocaine were determined through shotgun lipidomics using electrospray ionization-mass spectrometry (ESI-MS). We also ...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2015.04.009

    authors： Cummings BS,Pati S,Sahin S,Scholpa NE,Monian P,Trinquero PM,Clark JK,Wagner JJ

    更新日期：2015-07-01 00:00:00

  • Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.

    abstract：BACKGROUND:Cocaine-related deaths are continuously rising and its overdose is often associated with lethal cardiotoxic effects. METHODS AND RESULTS:Our approach, employing isothermal titration calorimetry (ITC) and light scattering in parallel, has confirmed the significant affinity of human cardiac calsequestrin (CAS...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2013.06.012

    authors： Sanchez EJ,Hayes RP,Barr JT,Lewis KM,Webb BN,Subramanian AK,Nissen MS,Jones JP,Shelden EA,Sorg BA,Fill M,Schenk JO,Kang C

    更新日期：2013-12-01 00:00:00

  • Oral delta-9-tetrahydrocannabinol suppresses cannabis withdrawal symptoms.

    abstract：BACKGROUND:This study assessed whether oral administration of delta-9-tetrahydrocannbinol (THC) effectively suppressed cannabis withdrawal in an outpatient environment. The primary aims were to establish the pharmacological specificity of the withdrawal syndrome and to obtain information relevant to determining the pot...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2006.04.014

    authors： Budney AJ,Vandrey RG,Hughes JR,Moore BA,Bahrenburg B

    更新日期：2007-01-05 00:00:00

  • Effects of chronic cocaine use on physical health: a prospective study in a general population sample.

    abstract：:Few studies have examined long-term effects of chronic cocaine use on physical health in the general population. The current study assesses the effects of chronic cocaine use by the late twenties on physical health by the mid thirties in a longitudinal cohort from the general population. Measures of physical health in...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/s0376-8716(96)01285-9

    authors： Chen K,Scheier LM,Kandel DB

    更新日期：1996-12-02 00:00:00

  • Neural activation during anticipation of monetary gain or loss does not associate with positive subjective response to alcohol in binge drinkers.

    abstract：BACKGROUND:Alcohol use disorder (AUD) remains an unresolved source of morbidity and mortality. Psychopharmacological challenge studies and neuroimaging experiments are two methods used to identify risk of problematic substance use. The present study combined these two approaches by examining associations between self-r...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2020.108432

    authors： Pabon E,Crane NA,Radoman M,Weafer J,Langenecker SA,Phan KL,de Wit H

    更新日期：2021-01-01 00:00:00

  • Controlled opioid withdrawal evaluation during 72 h dose omission in buprenorphine-maintained patients.

    abstract：:Buprenorphine's clinical utility as an opioid dependence pharmacotherapy may be enhanced with less-than-daily dosing. This study assessed opioid withdrawal after an acute 72 h dose omission in buprenorphine-maintained patients (8 mg/day s.l.). Eight outpatients required to remain free of opioids, cocaine and benzodiaz...

    journal_title：Drug and alcohol dependence

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0376-8716(97)01347-1

    authors： Eissenberg T,Johnson RE,Bigelow GE,Walsh SL,Liebson IA,Strain EC,Stitzer ML

    更新日期：1997-04-14 00:00:00

  • Efficacy of the Community Reinforcement and Family Training for concerned significant others of treatment-refusing individuals with alcohol dependence: A randomized controlled trial.

    abstract：BACKGROUND:The Community Reinforcement and Family Training (CRAFT) is a promising approach for Concerned Significant Others (CSOs) of alcohol-dependent individuals (ADI) that aims to engage treatment-refusing patients in alcohol treatment and to improve CSO functioning. To date, only two randomized controlled trials (R...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.drugalcdep.2016.04.015

    authors： Bischof G,Iwen J,Freyer-Adam J,Rumpf HJ

    更新日期：2016-06-01 00:00:00

  • Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.

    abstract：BACKGROUND:Genetic influences on smoking cessation treatment outcome may be affected by pretreatment patient characteristics. Nicotine dependence is arguably the most salient clinical factor in smoking cessation. METHODS:In this secondary analysis of clinical trial data (N=793), we examined nicotine dependence severit...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章

    doi：10.1016/j.drugalcdep.2014.02.016

    authors： Leventhal AM,Lee W,Bergen AW,Swan GE,Tyndale RF,Lerman C,Conti DV

    更新日期：2014-05-01 00:00:00

  • Gender differences in cocaine dependence.

    abstract：AIMS:This study examined gender differences among treatment-seeking cocaine-dependent outpatients (e.g., on demographics, psychopathology, and substance abuse). PARTICIPANTS:Participants were 2376 adults with cocaine dependence entering a multisite randomized controlled trial of psychosocial therapies. FINDINGS:Women...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.drugalcdep.2008.04.012

    authors： Najavits LM,Lester KM

    更新日期：2008-09-01 00:00:00

  • Systematic review and meta-analysis of socio-cognitive and socio-affective processes association with adolescent substance use.

    abstract：BACKGROUND:Social impairments are important features of a substance use disorder diagnosis; and recent models suggest early impairments in socio-cognitive and -affective processes may predict future use. However, no systematic reviews are available on this topic. METHODS:We conducted a systematic review and meta-analy...

    journal_title：Drug and alcohol dependence

    pub_type： 杂志文章,评审

    doi：10.1016/j.drugalcdep.2020.108479

    authors： Winters DE,Brandon-Friedman R,Yepes G,Hinckley JD

    更新日期：2021-02-01 00:00:00