Delivery of nicotine aerosol to mice via a modified electronic cigarette device.

Abstract:

BACKGROUND:Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) injection, and to examine sex differences in the model. METHODS:Hypothermia and locomotor suppression were assessed following aerosol exposure or s.c. injection with nicotine in female and male mice. Subsequently, plasma and brain concentrations of nicotine and cotinine were measured. RESULTS:Passive exposure to nicotine aerosol produced concentration-dependent and mecamylamine reversible hypothermic and locomotor suppressant effects in female and male mice, as did s.c. nicotine injection. In plasma and brain, nicotine and cotinine concentrations showed dose/concentration-dependent increases in both sexes following each route of administration. Sex differences in nicotine-induced hypothermia were dependent upon route of administration, with females showing greater hypothermia following aerosol exposure and males showing greater hypothermia following injection. In contrast, when they occurred, sex differences in nicotine and cotinine levels in brain and plasma consistently showed greater concentrations in females than males, regardless of route of administration. DISCUSSION:In summary, the e-cigarette exposure device described herein was used successfully to deliver pharmacologically active doses of nicotine to female and male mice. Further, plasma nicotine concentrations following exposure were similar to those after s.c. injection with nicotine and within the range observed in human smokers. Future research on vaped products can be strengthened by inclusion of translationally relevant routes of administration.

journal_name

Drug Alcohol Depend

authors

Lefever TW,Lee YO,Kovach AL,Silinski MA,Marusich JA,Thomas BF,Wiley JL

doi

10.1016/j.drugalcdep.2016.12.004

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

80-87

eissn

0376-8716

issn

1879-0046

pii

S0376-8716(17)30020-0

journal_volume

172

pub_type

杂志文章
  • A randomized, controlled trial of NRT-aided gradual vs. abrupt cessation in smokers actively trying to quit.

    abstract::Most smoking cessation programs advise abrupt rather than gradual cessation. We conducted a randomized, controlled trial of gradual cessation (n=297) vs. abrupt cessation (n=299) vs. minimal treatment (n=150) among smokers who wanted to quit now and preferred to quit gradually. Participants were recruited via newspape...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2010.04.007

    authors: Hughes JR,Solomon LJ,Livingston AE,Callas PW,Peters EN

    更新日期:2010-09-01 00:00:00

  • Nicotine dependence and psychiatric and substance use disorder comorbidities among American Indians/Alaska Natives: findings from the National Epidemiologic Survey on Alcohol and Related Conditions.

    abstract:BACKGROUND:American Indians and Alaska Natives (AI/ANs) have high rates of tobacco use compared to the general population. AI/ANs also have elevated rates of psychiatric and substance use disorders associated with nicotine dependence. However, very few studies have examined the comorbidity between nicotine dependence a...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2014.08.017

    authors: Moghaddam JF,Dickerson DL,Yoon G,Westermeyer J

    更新日期:2014-11-01 00:00:00

  • A randomized controlled trial to influence client language in substance use disorder treatment.

    abstract:BACKGROUND:Client language is hypothesized to be a mechanism of action in motivational interviewing (MI). Despite the association of change and sustain talk with substance treatment outcomes, it not known whether providers can intentionally influence this language as hypothesized. OBJECTIVE:This is a randomized contro...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2016.11.036

    authors: Moyers TB,Houck J,Glynn LH,Hallgren KA,Manuel JK

    更新日期:2017-03-01 00:00:00

  • Pyrazole-insensitive alcohol dehydrogenase activity in human serum.

    abstract::Serum alcohol dehydrogenase (ADH) activity in some individuals contains a fraction that is not inhibited by pyrazole. This might be due to the presence in those sera of pi-ADH, a unique isoenzyme found recently in human liver, and which, according to one hypothesis, could be co-responsible for the development of alcoh...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(80)90457-3

    authors: Skurský L,Khayrollah A

    更新日期:1980-09-01 00:00:00

  • Drug-related deaths and the sales of needles through pharmacies.

    abstract:BACKGROUND:Providing needles to people who inject drugs is a well-proven public health response to the transmission of HIV and other blood borne viruses. Despite over a quarter of a century of research, new concerns about potential unintended negative consequences of needle distribution continue to emerge. Specifically...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2014.11.022

    authors: Davidson PJ,Martinez A,Lutnick A,Kral AH,Bluthenthal RN

    更新日期:2015-02-01 00:00:00

  • Motivation for alcohol in rats: position and bottle preferences do not cause drinking.

    abstract::Position preference, i.e., the tendency to drink from onelocation rather than the other, was found to be relatively unimportant in determining the drinking behavior of rats presented with a choice between water and a 7% (v/v) ethanol solution in typical two-bottle choice situations. It accounted for essentially none o...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(76)90038-7

    authors: Sinclair JD

    更新日期:1976-06-01 00:00:00

  • Capturing habitualness of drinking and smoking behavior in humans.

    abstract:BACKGROUND:Recent findings suggest that overreliance on habit may be common in individuals diagnosed with addiction. To advance our understanding of habit in clinical samples and from behavioral measures, this study examines the interrelations between self-reported habit index for smoking and drinking as well as behavi...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.107738

    authors: Ray LA,Du H,Grodin E,Bujarski S,Meredith L,Ho D,Nieto S,Wassum K

    更新日期:2020-02-01 00:00:00

  • Drug dependence units in England and Wales. The results of a national survey.

    abstract::Drug dependence units (DDUs) form the cornerstone of government policy response to problem drug taking. Yet we know surprisingly little about the facilities that they can provide and what treatment policies they adopt. This paper constitutes a modest attempt to fill some of the gaps in our knowledge and points to the ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(85)90037-7

    authors: Smart C

    更新日期:1985-05-01 00:00:00

  • Punishing pregnant drug users: enhancing the flight from care.

    abstract::One hundred forty-two low income women were interviewed postpartum to determine their attitudes regarding the potential effects of a punitive law on the behavior of substance-using pregnant women. The convenience sample was primarily black (85.2%) and single (81%) and 14.8% admitted use of illicit drugs during pregnan...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(93)90001-7

    authors: Poland ML,Dombrowski MP,Ager JW,Sokol RJ

    更新日期:1993-02-01 00:00:00

  • An overview of the emergence of disparities in smoking prevalence, cessation, and adverse consequences among women.

    abstract::This report reviews epidemiologic findings demonstrating the emergence of disparities in smoking prevalence against the backdrop of general declines in smoking over time among women in the United States. In addition to socioeconomic differences in overall smoking prevalence, this report examines evidence of emerging d...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审

    doi:10.1016/j.drugalcdep.2009.06.002

    authors: Chilcoat HD

    更新日期:2009-10-01 00:00:00

  • Long-term effects of exposure to methamphetamine in adolescent rats.

    abstract:BACKGROUND:Flexible cognition is a set of processes mediated by the prefrontal cortex (PFC), an area of the brain that continues to develop during adolescence and into adulthood. Adult rodents exhibit impairments specific to reversal learning across various dosing regimens of methamphetamine (mAMPH). For adolescent rod...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2014.02.021

    authors: Ye T,Pozos H,Phillips TJ,Izquierdo A

    更新日期:2014-05-01 00:00:00

  • Treatment consumption and treatment re-enrollment in GHB-dependent patients in The Netherlands.

    abstract:BACKGROUND:The objective of this study was to assess treatment consumption and re-enrollment in treatment in patients with gamma-hydroxybutyrate (GHB)-dependence in Dutch Addiction Treatment Centers (ATCs) in comparison with other addictions. METHODS:A cohort-study using nationwide administrative data from regular Dut...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2017.02.026

    authors: van Noorden MS,Mol T,Wisselink J,Kuijpers W,Dijkstra BAG

    更新日期:2017-07-01 00:00:00

  • Circumstances surrounding the first injection experience and their association with future syringe sharing behaviors in young urban injection drug users.

    abstract::Young injection drug users are at heightened risk for acquisition of blood-borne infections because of their high rates of unsafe injection behaviors, yet there has been little research examining the circumstances surrounding injection drug users' first injection experience ('hit'). We examined the relationship betwee...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2004.08.021

    authors: Novelli LA,Sherman SG,Havens JR,Strathdee SA,Sapun M

    更新日期:2005-03-07 00:00:00

  • The Marijuana Ladder: measuring motivation to change marijuana use in incarcerated adolescents.

    abstract::The purpose of this study was to determine if a modified version of the Contemplation Ladder, a measure of motivation to change marijuana use among incarcerated adolescents (Marijuana Ladder; ML), was related to marijuana use and treatment engagement. Participants (N=122) in this study were all incarcerated at a state...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2005.10.007

    authors: Slavet JD,Stein LA,Colby SM,Barnett NP,Monti PM,Golembeske C Jr,Lebeau-Craven R

    更新日期:2006-06-09 00:00:00

  • Emerging adults' treatment outcomes in relation to 12-step mutual-help attendance and active involvement.

    abstract:BACKGROUND:Participation in Alcoholics Anonymous (AA) and Narcotics Anonymous (NA) during and following treatment has been found to confer recovery-related benefit among adults and adolescents, but little is known about emerging adults (18-24 years). This transitional life-stage is distinctive for greater distress, hig...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2012.10.005

    authors: Kelly JF,Stout RL,Slaymaker V

    更新日期:2013-04-01 00:00:00

  • Prevalence and correlates of waterpipe tobacco smoking by college students in North Carolina.

    abstract:BACKGROUND:Known most commonly in the U.S. as "hookah," waterpipe tobacco smoking appears to be growing among college students. Despite beliefs that waterpipe use is safer than cigarette smoking, research to date (albeit limited) has found health risks of waterpipe smoking are similar to those associated with cigarette...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.drugalcdep.2011.01.018

    authors: Sutfin EL,McCoy TP,Reboussin BA,Wagoner KG,Spangler J,Wolfson M

    更新日期:2011-05-01 00:00:00

  • Association between breath alcohol concentration and waterpipe lounge patrons' carbon monoxide exposure: A field investigation.

    abstract:BACKGROUND AND AIMS:Concurrent alcohol use and waterpipe (WP) smoking is common among young adults. WP smokers are more than twice as likely to use alcohol as non-users and frequently consume alcohol immediately before and during a WP smoking session. It is unclear what impact alcohol has on WP smoking patterns and res...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2016.11.010

    authors: Leavens EL,Brett EI,Frank S,Shaikh RA,Leffingwell TR,Croff JM,Wagener TL

    更新日期:2017-01-01 00:00:00

  • Evaluation of a structured alcohol education course in a secondary school system in north Italy.

    abstract::The authors describe the results of an alcohol education course given to 2166 high school students in the area of Padua, Italy. An evaluation was performed, utilizing a before and after technique: it was shown that baseline knowledge of relevant information on alcohology was similar among younger and older teenagers; ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(83)90043-1

    authors: Salvagnini M,Gallimberti L,Benussi G,Del Borello A,Dell'Oro A,Orlandini D,Piccoli A,Ricci GP,Sciarrone R,Naccarato R

    更新日期:1983-10-01 00:00:00

  • Proximal and distal social influence on alcohol consumption and marijuana use among middle school adolescents.

    abstract:OBJECTIVES:This study assesses the independent and combined effects of (1) perceived peer norms, (2) best friend use, and (3) being in the presence of others who use on middle school adolescents' consumption of marijuana and alcohol, and how the effects of these sources of social influence evolve over time as youth pro...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2014.08.012

    authors: Salvy SJ,Pedersen ER,Miles JN,Tucker JS,D'Amico EJ

    更新日期:2014-11-01 00:00:00

  • Twenty years of take-home naloxone for the prevention of overdose deaths from heroin and other opioids-Conception and maturation.

    abstract:BACKGROUND:Opioid overdose is a major cause of mortality, but injury and fatal outcomes can be prevented by timely administration of the opioid antagonist naloxone. Pre-provision of naloxone to opioid users and family members (take-home naloxone, THN) was first proposed in 1996, and WHO Guidelines were issued in 2014. ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审

    doi:10.1016/j.drugalcdep.2017.05.001

    authors: McDonald R,Campbell ND,Strang J

    更新日期:2017-09-01 00:00:00

  • Relationships between drinking quantity and frequency and behavioral and hippocampal BOLD responses during working memory performance involving allocentric spatial navigation in college students.

    abstract:BACKGROUND:Quantity and frequency of drinking may be used to effectively quantify the severity of alcohol-use. Drinking-severity has been related to neurocognitive impairments in such domains as spatial working memory (SWM). Youth drinking has been associated with altered neurofunctional underpinnings of SWM. The curre...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2019.03.030

    authors: Banz BC,Worhunsky PD,Pittman BP,Astur RS,Tennen HA,Raskin SA,Austad CS,Wood RM,Fallahi CR,Potenza MN,Pearlson GD

    更新日期:2019-08-01 00:00:00

  • Treatment of adolescent tobacco smokers: issues and opportunities for exposure reduction approaches.

    abstract::The cycle of tobacco dependence typically begins with the initiation of tobacco use during adolescence. Many teenagers try to quit smoking, fail and subsequently desire treatment for their tobacco dependence. Adolescents do not currently benefit from the same level of societal support for quit attempts as adults, and ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章,评审

    doi:10.1016/s0376-8716(03)00012-7

    authors: Moolchan ET,Aung AT,Henningfield JE

    更新日期:2003-06-05 00:00:00

  • [Primary prevention in the area of drug addiction: perspectives, errors and fallacies].

    abstract::Primary prevention in drug abuse has been, most of the time, reduced to its informational aspect. This paper points out some of the errors made in this field, both by contributing to the 'inflation' of the drug problem and by using scare tactics as preventive arguments. It invites consideration of drug addiction not a...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(83)90099-6

    authors: Bergeret J

    更新日期:1983-02-01 00:00:00

  • Snus use and risk of schizophrenia and non-affective psychosis.

    abstract:BACKGROUND:Recent studies suggest a possible causal role for smoking in schizophrenia and psychosis. Most studies have focused on cigarette smoking, the most common form of tobacco use, but other forms of tobacco exist, including smokeless products such as Swedish snuff (or "snus"). METHODS:We explored whether snus us...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2016.04.035

    authors: Munafò MR,Larsson Lönn S,Sundquist J,Sundquist K,Kendler K

    更新日期:2016-07-01 00:00:00

  • beta-carboline binding to imidazoline receptors.

    abstract::A series of beta-carbolines were prepared and their affinities for imidazoline (I(1) and I(2)) sites evaluated. Selected compounds were also examined at alpha(2)-adrenoceptors. Some of the beta-carbolines were found to bind with high affinity to I(2)-sites and this affinity was dependent on both the planarity of the m...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/s0376-8716(01)00123-5

    authors: Husbands SM,Glennon RA,Gorgerat S,Gough R,Tyacke R,Crosby J,Nutt DJ,Lewis JW,Hudson AL

    更新日期:2001-10-01 00:00:00

  • Understanding emerging forms of cannabis use through an online cannabis community: An analysis of relative post volume and subjective highness ratings.

    abstract:BACKGROUND:Legalization of medical and recreational cannabis has coincided with an increase in novel forms of cannabis use and a burgeoning cannabis product industry. This research seeks to understand the occurrence of discussions about these emerging and traditional forms of use in an online social media discussion fo...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2018.03.041

    authors: Meacham MC,Paul MJ,Ramo DE

    更新日期:2018-07-01 00:00:00

  • Lifecourse socioeconomic predictors of midlife drinking patterns, problems and abstention: findings from the 1958 British Birth Cohort Study.

    abstract:BACKGROUND:Research suggests that outcomes associated with drinking may differ depending upon patterns of consumption, drinking related symptoms and social problems. This paper investigated socioeconomic predictors (measuring multiple indices, period and consistency of disadvantage) of midlife drinking patterns. METHO...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2008.01.014

    authors: Caldwell TM,Rodgers B,Clark C,Jefferis BJ,Stansfeld SA,Power C

    更新日期:2008-06-01 00:00:00

  • The structure of cannabis dependence in the community.

    abstract:BACKGROUND:Cannabis is the most widely used illicit drug in developed countries, and has a significant impact on mental and physical health in the general population. However, the validity of common diagnostic schemes and their applicability to cannabis abuse and dependence is poorly understood. This paper describes a ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/s0376-8716(02)00223-5

    authors: Teesson M,Lynskey M,Manor B,Baillie A

    更新日期:2002-12-01 00:00:00

  • Prevalence and motivations for kratom use in a sample of substance users enrolled in a residential treatment program.

    abstract:BACKGROUND:Kratom use in the West has increased recently, yet the prevalence and motives for use among individuals with a history of substance use disorder (SUD) have not been fully examined. Kratom has been documented as a means of treating chronic pain, mitigating drug dependence, and easing withdrawal symptoms, yet ...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/j.drugalcdep.2017.08.034

    authors: Smith KE,Lawson T

    更新日期:2017-11-01 00:00:00

  • Evaluation of Wistar rats' individual sensitivity to the development of physical dependence on morphine.

    abstract::Behavioral and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (1) by i.p. injection of increasing doses of the drug; (2) by i.p. injection of morphine as a reward o...

    journal_title:Drug and alcohol dependence

    pub_type: 杂志文章

    doi:10.1016/0376-8716(91)90023-r

    authors: Sudakov SK,Konstantinopolsky MA,Surkova LA,Tyurina IV,Borisova EV

    更新日期:1991-12-01 00:00:00