当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Circulating human CD34+ progenitor cells modulate neovascularization and inflammation in a nude mouse model.

Circulating human CD34+ progenitor cells modulate neovascularization and inflammation in a nude mouse model.

Abstract：

:CD34+ progenitor cells hold promise for therapeutic neovascularization in various settings. In this study, the role of human peripheral blood CD34+ cells in neovascularization and inflammatory cell recruitment was longitudinally studied in vivo. Human CD34+ cells were incorporated in Matrigel, implanted subcutaneously in nude mice, and explanted after 2, 4, 7, or 14 days. Cell-free Matrigels served as controls. Histochemical analyses demonstrated that neovascularization occurred almost exclusively in CD34+ implants. Cellular and capillary density were increased in cell-loaded Matrigels after 2 days and further increased at 14 days. Human CD34+ cells did not incorporate in neovessels, but formed vWF+/CD31+/VEGF+ cell clusters that were present up to day 14. However, CD34+ cells induced host neovascularization, as demonstrated by increased presence of murine CD31+ and vWF+ vasculature from day 7 to 14. Moreover, recruitment of murine monocytes/macrophages was significantly enhanced in CD34+ implants at all time points. Gene expression of chemotactic cytokines MCP-1 and IL-8 was detected on CD34+ cells in vitro and confirmed immunohistochemically in cell-loaded explants at all time points. Our data indicate that human CD34+ cells, implanted in a hypoxic environment, generate an angiogenic niche by secreting chemotactic and angiogenic factors, enabling rapid neovascularization, possibly via recruitment of monocytes/macrophages.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

van der Strate BW,Popa ER,Schipper M,Brouwer LA,Hendriks M,Harmsen MC,van Luyn MJ

doi

10.1016/j.yjmcc.2007.03.907

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

1086-97

issue

6

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(07)00973-X

journal_volume

42

pub_type

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