Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle.

abstract：:Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality during embryonic development and at birth. The majority of Cx40(-/-)/C...

journal_title：Journal of molecular and cellular cardiology

authors： Krüger O,Maxeiner S,Kim JS,van Rijen HV,de Bakker JM,Eckardt D,Tiemann K,Lewalter T,Ghanem A,Lüderitz B,Willecke K

更新日期：2006-11-01 00:00:00

abstract：:We hypothesized that chronic xanthine oxidase inhibition (XOI) would have favorable effects on both ventricular and vascular performance in evolving heart failure (HF), thereby preserving ventricular-vascular coupling. In HF, XOI reduces oxidative stress and improves both vascular and myocardial function. Dogs were ra...

journal_title：Journal of molecular and cellular cardiology

authors： Amado LC,Saliaris AP,Raju SV,Lehrke S,St John M,Xie J,Stewart G,Fitton T,Minhas KM,Brawn J,Hare JM

更新日期：2005-09-01 00:00:00

abstract：:The myosin heavy chain (MHC) isoforms, alpha- and beta-MHC, are expressed in developmental- and chamber-specific patterns. Healthy human ventricle contains approximately 2-10% alpha-MHC and these levels are reduced even further in the failing ventricle. While down-regulation of alpha-MHC in failing myocardium is consi...

journal_title：Journal of molecular and cellular cardiology

authors： James J,Hor K,Moga MA,Martin LA,Robbins J

更新日期：2010-05-01 00:00:00

abstract：:Acute right ventricular (RV) failure following pulmonary embolism (PE) is a strong predictor of poor clinical outcome. Present studies test for an association between RV failure from experimental PE, inflammation, and upregulated chemokine expression. Additional experiments test if neutrophil influx contributes to RV ...

journal_title：Journal of molecular and cellular cardiology

authors： Watts JA,Zagorski J,Gellar MA,Stevinson BG,Kline JA

更新日期：2006-08-01 00:00:00

abstract：:Leptin is a 16 kDa product of the obesity gene secreted primarily by adipocytes. We recently identified cardiomyocytes as a target for the direct hypertrophic effects of leptin and suggested that leptin may be a biological link between obesity and cardiovascular pathologies. Activation of the renin-angiotensin and end...

journal_title：Journal of molecular and cellular cardiology

authors： Rajapurohitam V,Javadov S,Purdham DM,Kirshenbaum LA,Karmazyn M

更新日期：2006-08-01 00:00:00

abstract：:The mechanism responsible for cardiac depression in septic shock remains unknown. The present study examined whether nitric oxide (NO) overproduced by inducible NO synthase (iNOS) can inhibit aerobic energy metabolism and impair the myocardial function in endotoxin-treated rat hearts. Lipopolysaccharide (LPS) signific...

journal_title：Journal of molecular and cellular cardiology

authors： Tatsumi T,Akashi K,Keira N,Matoba S,Mano A,Shiraishi J,Yamanaka S,Kobara M,Hibino N,Hosokawa S,Asayama J,Fushiki S,Fliss H,Nakagawa M,Matsubara H

更新日期：2004-09-01 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) has been linked to variants in the coding sequence of desmosomal genes. The potential contribution of non-coding desmoglein-2 (DSG2) variants for development of ARVC is undescribed. We sequenced 1450 base pairs upstream of ATG in the DSG2 gene in 65 unrelated pati...

journal_title：Journal of molecular and cellular cardiology

authors： Christensen AH,Andersen CB,Wassilew K,Svendsen JH,Bundgaard H,Brand SM,Schmitz B

更新日期：2019-06-01 00:00:00

abstract：:Recently discovered endothelin is a powerful vasoconstrictor of vascular smooth muscle in vitro, which also profoundly affects the mechanical function of the heart. An increased level of plasma endothelin in patients with acute myocardial infarction suggests the enhanced release of endothelin from vascular endothelium...

journal_title：Journal of molecular and cellular cardiology

authors： Prasad MR,Jones RM,Kreutzer DL

更新日期：1991-06-01 00:00:00

abstract：:Lack of endothelial nitric oxide synthase (eNOS) may affect the sensitivity of cyclic GMP signaling through soluble guanylyl cyclase (sGC). We hypothesized that in eNOS knockout (eNOS-/-) mice, stimulation of guanylyl cyclase would have enhanced effects inhibiting cardiac contraction. We measured cell shortening and c...

journal_title：Journal of molecular and cellular cardiology

authors： Su J,Tse J,Scholz PM,Weiss HR

更新日期：2005-12-01 00:00:00

abstract：:The role of protein kinase C (PKC) in the protection of ischemic preconditioning (PC) is still controversial, partly because of the multiple isozymes of PKC and the inability to directly measure PKC activity in vivo. In this study we have used novel peptide inhibitors which correspond to part of the amino acid sequenc...

journal_title：Journal of molecular and cellular cardiology

authors： Liu GS,Cohen MV,Mochly-Rosen D,Downey JM

更新日期：1999-10-01 00:00:00

abstract：:(1) The effects of norepinephrine on protein phosphorylation in isolated rat cardiac ventricular myocytes were determined by autoradiography on 32P-labelled proteins separated by electrophoresis; (2) In cells from young adult rats (6 months old) there was a marked increase due to norepinephrine (10(-8) to 10(-4) M) in...

journal_title：Journal of molecular and cellular cardiology

authors： Sakai M,Danziger RS,Staddon JM,Lakatta EG,Hansford RG

更新日期：1989-12-01 00:00:00

abstract：:The purposes of this study were to: (1) assess myocardial pyruvate dehydrogenase (PDH) activity and substrate exchange under well-perfused and ischemic conditions; (2) determine the metabolic effects of an intra-coronary infusion of the PDH activator, dichloroacetate (DCA); and (3) measure the effects of ischemia and ...

journal_title：Journal of molecular and cellular cardiology

authors： Stanley WC,Hernandez LA,Spires D,Bringas J,Wallace S,McCormack JG

更新日期：1996-05-01 00:00:00

abstract：:The modulating effects of Ca2+ on single K+ channel currents in canine heart sarcoplasmic reticulum were studied using a planar lipid bilayer technique. The open-state probability and the unitary open-state current both decreased gradually as the Ca2+ concentration was reduced from pCa 3 to pCa 7.5. Each single-channe...

journal_title：Journal of molecular and cellular cardiology

authors： Uehara A,Yasukochi M,Imanaga I

更新日期：1994-02-01 00:00:00

abstract：:The mechanisms by which beta-adrenergic receptor (beta-AR) blockade modulates apoptosis in heart failure (HF) are unclear. We examined the impact of beta-AR blockade with metoprolol on myocardial remodeling, apoptosis, pro-apoptotic (Fas, Fas ligand, Bax, and Bcl-X(S)) and anti-apoptotic (Bcl-X(L)and Bcl-2) gene expre...

journal_title：Journal of molecular and cellular cardiology

authors： Prabhu SD,Wang G,Luo J,Gu Y,Ping P,Chandrasekar B

更新日期：2003-05-01 00:00:00

abstract：:Activation of adenosine A(3) receptor (A(3)AR) protects against ischemia/reperfusion injury in the heart. However, the downstream signaling mechanisms leading to its delayed anti-ischemic effects remain unclear. We hypothesized that A(3)AR stimulation protects the heart via activation of nuclear transcription factor k...

journal_title：Journal of molecular and cellular cardiology

authors： Zhao TC,Kukreja RC

更新日期：2002-03-01 00:00:00

abstract：:Familial hypertrophic cardiomyopathy (HCM), linked to mutations in myosin, myosin-binding proteins and other sarcolemmal proteins, is associated with increased risk of life threatening ventricular arrhythmias, and a number of animal models have been developed to facilitate analysis of disease progression and mechanism...

journal_title：Journal of molecular and cellular cardiology

authors： Hueneke R,Adenwala A,Mellor RL,Seidman JG,Seidman CE,Nerbonne JM

更新日期：2017-02-01 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress ...

journal_title：Journal of molecular and cellular cardiology

authors： Escobales N,Nuñez RE,Jang S,Parodi-Rullan R,Ayala-Peña S,Sacher JR,Skoda EM,Wipf P,Frontera W,Javadov S

更新日期：2014-12-01 00:00:00

abstract：:Adaptive cardiac hypertrophy in the rat has been characterized as pathological or physiological reflecting the nature of the inciting stimulus. These two adaptations are distinguished by alterations in contractility and in the myosin ATPase composition of the affected muscle. We investigated the relative amounts of th...

journal_title：Journal of molecular and cellular cardiology

authors： Buttrick PM,Kaplan M,Leinwand LA,Scheuer J

更新日期：1994-01-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM), a relatively common disease, is diagnosed clinically by unexplained cardiac hypertrophy and pathologically by myocyte hypertrophy, disarray, and interstitial fibrosis. HCM is the most common cause of sudden cardiac death (SCD) in the young and a major cause of morbidity and mortality...

journal_title：Journal of molecular and cellular cardiology

authors： Marian AJ,Roberts R

更新日期：2001-04-01 00:00:00

abstract：:Micromolar concentrations of lipoic acid racemate added to a working rat heart during hypoxia have been previously found to improve aortic flow during subsequent reoxygenation. Since the R-form represents the naturally occurring form of lipoic acid, and the S-form does not reveal a positive influence on ATP synthesis ...

journal_title：Journal of molecular and cellular cardiology

authors： Zimmer G,Beikler TK,Schneider M,Ibel J,Tritschler H,Ulrich H

更新日期：1995-09-01 00:00:00

abstract：:We hypothesized that after a Ca2+-free period the magnitude of the Na+ gradient at the onset of Ca2+ reperfusion would grade the ensuing cell Ca2+ gain. Rabbit interventricular septa perfused with Hepes buffered solution (pH 7.4, [Ca2+] = 1.0 mM) and stimulated to contract isometrically at 60 min-1 at 30 degrees C wer...

journal_title：Journal of molecular and cellular cardiology

authors： Ruaño-Arroyo G,Gerstenblith G,Lakatta EG

更新日期：1984-09-01 00:00:00

abstract：:The metabolism of pantothenic acid (Pa) by cardiac muscle was studied in normal and diabetic rats. Tissue levels of Coenzyme A (CoA) are elevated in the heart during early (6 to 12 h) diabetes, remains at a high level for several days, and then returns to normal or below normal levels. The increase in total tissue CoA...

journal_title：Journal of molecular and cellular cardiology

authors： Beinlich CJ,Robishaw JD,Neely JR

更新日期：1989-07-01 00:00:00

abstract：:Nkx2.5 and serum response factor (SRF) are critically important transcription factors in cardiac morphogenesis. They are also widely expressed in adult cardiomyocytes, but there is little data to indicate their possible role in adult cardiac cells. In this paper we demonstrate that the interaction of Nkx2.5 and SRF in...

journal_title：Journal of molecular and cellular cardiology

authors： Müller JG,Thompson JT,Edmonson AM,Rackley MS,Kasahara H,Izumo S,McQuinn TC,Menick DR,O'Brien TX

更新日期：2002-07-01 00:00:00

abstract：:During the past decade, the crucial role of microRNAs (miRs) controlling tissue homeostasis and disease in the cardiovascular system has become widely recognized. By controlling the expression levels of their targets, several miRs have been shown to modulate the function of endothelial cells, vascular smooth muscle ce...

journal_title：Journal of molecular and cellular cardiology

authors： Nazari-Jahantigh M,Egea V,Schober A,Weber C

更新日期：2015-12-01 00:00:00

abstract：:Cardiac fibrosis is implicated in numerous physiologic and pathologic conditions, including scar formation, heart failure and cardiac arrhythmias. However the specific cells and signaling pathways mediating this process are poorly understood. Lysine acetylation of nucleosomal histone tails is an important mechanism fo...

journal_title：Journal of molecular and cellular cardiology

authors： Schuetze KB,McKinsey TA,Long CS

更新日期：2014-05-01 00:00:00

abstract：RATIONALE:Circulating monocytes play pivotal roles in chronic inflammatory diseases. Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid, are known to have anti-inflammatory effects and are hydrolyzed by soluble epoxide hydrolase (sEH). OBJECTIVE:We aimed to investigate the effect of sEH inhibition in at...

journal_title：Journal of molecular and cellular cardiology

authors： Li D,Liu Y,Zhang X,Lv H,Pang W,Sun X,Gan LM,Hammock BD,Ai D,Zhu Y

更新日期：2016-09-01 00:00:00

abstract：:Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure (HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic cardiomyopathy, much of the evidence lacks specificity. Furthermore, whether alterations occur at the cardiac proteome level in diabetic car...

journal_title：Journal of molecular and cellular cardiology

authors： Hamblin M,Friedman DB,Hill S,Caprioli RM,Smith HM,Hill MF

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. M...

journal_title：Journal of molecular and cellular cardiology

authors： Borgdorff MA,Koop AM,Bloks VW,Dickinson MG,Steendijk P,Sillje HH,van Wiechen MP,Berger RM,Bartelds B

更新日期：2015-02-01 00:00:00

abstract：:In cardiomyocytes, Ca(2+) plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical functions is achieved by segregating Ca(2+) within subcellular microdomains: transcription is regulated by Ca(2+) re...

journal_title：Journal of molecular and cellular cardiology

authors： Ibarra C,Vicencio JM,Varas-Godoy M,Jaimovich E,Rothermel BA,Uhlén P,Hill JA,Lavandero S

更新日期：2014-10-01 00:00:00

abstract：:Mutations causing familial hypertrophic cardiomyopathy (HCM) have been described in at least 11 genes encoding cardiac sarcomeric proteins. In this study, three previously unknown deletions have been identified in the human cardiac genes coding for beta-myosin heavy chain (MYH7 on chromosome 14) and myosin-binding pro...

journal_title：Journal of molecular and cellular cardiology

authors： Waldmüller S,Sakthivel S,Saadi AV,Selignow C,Rakesh PG,Golubenko M,Joseph PK,Padmakumar R,Richard P,Schwartz K,Tharakan JM,Rajamanickam C,Vosberg HP

更新日期：2003-06-01 00:00:00