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Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups.

Abstract：

:Tethered dimers incorporating natural alpha-amino acid end groups were synthesized, including examples in which the previously reported esterase-sensitive ester linker was replaced with more stable amide or ether linkers. These compounds remained effective both as inhibitors of NAD synthetase and as potent antibacterial agents for Gram-positive strains. Studies on nonspecific effects, including detergent properties and promiscuous inhibition, suggested little contribution to observed activities.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Velu SE,Mou L,Luan CH,Yang ZW,DeLucas LJ,Brouillette CG,Brouillette WJ

doi

10.1021/jm061349l

subject

Has Abstract

pub_date

2007-05-31 00:00:00

pages

2612-21

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

50

pub_type

杂志文章

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