Interactions of sleep and clonidine on daytime prolactin secretion in humans.

Abstract:

:The suppressive roles of adrenergic stimulation and rapid eye movement (REM) sleep on human prolactin (PRL) secretion are controversial. We examined the effects of sleep, clonidine (an alpha 2-adrenergic agonist), and their interaction on PRL secretion. Two groups of normal men (nine each) were studied in two morning sessions. Each group received either placebo or clonidine in both sessions. Subjects remained awake in the first session and in the next session they were asked to sleep for 3 h after the test dose was given. Blood samples were drawn at 30-min intervals and polysomnographic recordings were obtained at each session. PRL concentrations remained at baseline and no clonidine effect was detected while awake. PRL concentrations increased in placebo and clonidine groups during sleep. Despite significant suppression of REM sleep in the clonidine group, no differences were detected between the placebo and clonidine groups in peak PRL or mean PRL concentrations during the study. Also, no significant difference was detected in comparing PRL responses during non-REM sleep in both groups. The results suggest that alpha 2-adrenergic stimulation does not have a significant role in modulating human PRL secretion during sleep.

journal_name

Clin Neuropharmacol

authors

Cavallo A,Carskadon MA,Grocer P

doi

10.1097/00002826-199110000-00005

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

420-6

issue

5

eissn

0362-5664

issn

1537-162X

journal_volume

14

pub_type

临床试验,杂志文章
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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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  • Spiking fevers with clozapine treatment.

    abstract::Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Po...

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  • Midazolam in the treatment of refractory neonatal seizures.

    abstract::Midazolam, a potent short-acting benzodiazepine, is a safe and highly effective agent for the control of status epilepticus. Its efficacy in the control of neonatal seizures, however, has not been determined. Six neonates (aged 1-9 days; gestation, 30-41 weeks) developed seizures from a variety of causes. In each case...

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    pub_type: 临床试验,杂志文章

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    journal_title:Clinical neuropharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

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    更新日期:1991-01-01 00:00:00

  • Acute dystonic reaction in normal humans caused by catecholamine depletion.

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    更新日期:1990-12-01 00:00:00

  • Curcumin as Add-On to Antipsychotic Treatment in Patients With Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study.

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    journal_title:Clinical neuropharmacology

    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.1097/00002826-199619040-00010

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    更新日期:1996-08-01 00:00:00

  • Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases.

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    pub_type: 杂志文章

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