Abstract:
OBJECTIVES:The units of different botulinum toxin products are not identical, and the dose equivalence has been debated for several years. In the year 2000, our clinic changed the recommended botulinum toxin product from Botox to Dysport for the treatment of cervical dystonia. Based on published reports, where dose conversion ratios from 1:1 to 1:6 (Botox:Dysport) had been used, and our own clinical experience, the dose conversion ratio was set to 1:2. The objective of this study was to retrospectively monitor the used doses of each product and the subsequent clinical effect. METHODS:A retrospective study, using casebook notes from 75 patients, was done to investigate treatment doses, subjective clinical effect, and the appearance of adverse events. RESULTS:The median dose conversion ratio that had been used at the product switch was 1:2.3 (Botox:Dysport). After clinical adjustment, the ratio was 1:2.1 at the next 3 treatments. There was a tendency for a more effective treatment and more adverse events after the product switch. A follow-up was performed 6.5 years later using casebook notes from 53 of the same patients. By this time, the doses had been reduced, and the median dose conversion ratio had decreased to 1:1.7 (Botox:Dysport). The adverse events reported at this point were fewer for the patients treated. CONCLUSIONS:In this study, the most appropriate dose conversion ratio to use when switching from Botox to Dysport was 1:1.7.
journal_name
Clin Neuropharmacoljournal_title
Clinical neuropharmacologyauthors
Rystedt A,Nyholm D,Naver Hdoi
10.1097/WNF.0b013e3182711fc0subject
Has Abstractpub_date
2012-11-01 00:00:00pages
278-82issue
6eissn
0362-5664issn
1537-162Xjournal_volume
35pub_type
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章,评审
doi:10.1097/00002826-199013003-00009
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abstract::Prion diseases are invariably fatal. Recently, quinacrine and chlorpromazine have been suggested as immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases. The objective of this paper was to report on 2 fatal familial insomnia patients whose overall condition worsened despite quin...
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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