Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases.

Abstract:

BACKGROUND:Negative myoclonus is rarely seen in the clinical setting. It can be involved in some central nervous system pathologies. It has also been observed after antipsychotic treatment. CASE REPORTS:In this article, we will present 3 cases diagnosed with negative myoclonus in a 120-bed university-affiliated hospital within the past 7 years. Based on our clinical experience, it was observed that myoclonic jerk was a rare condition that started with suddenly dose changes. Patients showed good improvement in response to dose reduction. CONCLUSIONS:Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose.

journal_name

Clin Neuropharmacol

authors

Uzun Ö,Bolu A,Taşçi AB,Oğur B

doi

10.1097/WNF.0000000000000370

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

26-27

issue

1

eissn

0362-5664

issn

1537-162X

journal_volume

43

pub_type

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