Efavirenz: a review.

abstract：INTRODUCTION:Immune-checkpoint inhibitor (ICPI) drugs, which include antibodies against CTLA-4, PD-1 and PD-L1, have been shown to induce durable complete responses in a proportion of patients with particular efficacy demonstrated in both the first line and refractory setting in advanced NSCLC and melanoma. However, th...

journal_title：Expert opinion on pharmacotherapy

authors： Flynn MJ,Larkin JMG

更新日期：2017-10-01 00:00:00

abstract：:Elevated blood pressure levels are highly prevalent and are a major reason for cardiovascular events and thus place a significant financial burden on healthcare systems worldwide. Guidelines recommend five first-line anti-hypertensive drug classes, but compelling indications may indicate favoring one drug class over a...

journal_title：Expert opinion on pharmacotherapy

authors： Bramlage P,Durand-Zaleski I,Desai N,Pirk O,Hacker C

更新日期：2009-08-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Gestational trophoblastic disease is one of the few human malignancies that is curable, even in advanced stages of the disease. However, appropriate management and follow-up are essential components in curing this disease. AREAS COVERED IN THIS REVIEW:Observational, retrospective and prospectiv...

journal_title：Expert opinion on pharmacotherapy

authors： Rodriguez N,Goldstein DP,Berkowitz RS

更新日期：2010-12-01 00:00:00

abstract：:Despite recent evidence suggesting that Bell's palsy is associated with reactivation of alfa-herpes viruses, the disease has been treated empirically, and the use of valacyclovir has not been definitively established. In 2007, two prospective, randomised, placebo-controlled trials evaluating valacyclovir were reported...

journal_title：Expert opinion on pharmacotherapy

authors： Hato N,Sawai N,Teraoka M,Wakisaka H,Takahashi H,Hinohira Y,Gyo K

更新日期：2008-10-01 00:00:00

abstract：:Accumulating evidence suggests that HIV-infected individuals have an increased risk of cardiovascular events. This risk seems to be at least partially mediated by dyslipidaemia, which is related to the use of highly active antiretroviral therapy (HAART). As HIV-infected individuals live longer due to HAART, their card...

journal_title：Expert opinion on pharmacotherapy

authors： Manuel O,Thiébaut R,Darioli R,Tarr PE

更新日期：2005-08-01 00:00:00

abstract：:Introduction: Ventricular arrhythmias are often seen in association with structural heart disease. However, approximately a tenth of affected patients have apparently normal hearts, where such arrhythmias typically occur in young patients, are sometimes inherited and can occasionally lead to sudden cardiac death (SCD)...

journal_title：Expert opinion on pharmacotherapy

authors： Ortmans S,Daval C,Aguilar M,Compagno P,Cadrin-Tourigny J,Dyrda K,Rivard L,Tadros R

更新日期：2019-12-01 00:00:00

abstract：:Acinetobacter baumannii is an important cause of nosocomial infections, mainly in patients in intensive care units. This microorganism, although with slight differences depending on the country, presents resistance to multiple antimicrobial agents, occasionally including resistance to colistin: hence, it can be consid...

journal_title：Expert opinion on pharmacotherapy

authors： Vila J,Pachón J

更新日期：2008-03-01 00:00:00

abstract：:Chronic refractory angina is a term used to describe patients who, despite optimal medical therapy, have both angina and objective evidence of ischaemia. It is estimated that 5-15% of the 12 million patients with chronic angina in the US meet the criteria for having refractory angina. This review focuses on the follow...

journal_title：Expert opinion on pharmacotherapy

authors： Yang EH,Barsness GW

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Acute decompensated heart failure (ADHF) contributes largely to the burden of heart failure and is associated with a poorer prognosis. Although numerous clinical trials evaluated the benefit of newer medications for ADHF, most of them were not successful. Areas covered: This review focusses on the updates ...

journal_title：Expert opinion on pharmacotherapy

authors： Yandrapalli S,Tariq S,Aronow WS

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results. Sorafenib is the first compound to demonstrate a significant effect on survival in HCC...

journal_title：Expert opinion on pharmacotherapy

authors： Guan YS,He Q

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Adjunctive pharmacotherapy is of key importance in determining the outcomes of percutaneous coronary intervention (PCI). In parallel, there has been an increasing body of evidence indicating that the aggressive management of coronary risk factors and changes in lifestyle behavior yield additional positive ...

journal_title：Expert opinion on pharmacotherapy

authors： Capodanno D,Tamburino C,Dangas G

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Treatment of complicated intra-abdominal infections (cIAIs) is becoming increasingly difficult because of the widespread emergence of multidrug-resistant organisms. AREAS COVERED:In this review, we discuss the effectiveness of several new antibiotics for the treatment of cIAIs, including new β-lactamase i...

journal_title：Expert opinion on pharmacotherapy

authors： Lin SY,Huang CH,Ko WC,Chen YH,Hsueh PR

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) causes substantial morbidity and mortality worldwide. The traditional treatment of VTE, with an initial therapy with (low molecular weight) heparin or fondaparinux and a continued treatment with vitamin K antagonists, is effective but has limitations. AREAS COVERED:The current...

journal_title：Expert opinion on pharmacotherapy

authors： Vanassche T,Vandenbriele C,Peerlinck K,Verhamme P

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Graves' hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing a...

journal_title：Expert opinion on pharmacotherapy

authors： Okosieme OE,Lazarus JH

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Short bowel syndrome (SBS) has traditionally been regarded as a rapidly fatal medical catastrophe. The advent of pharmacological options directly targeting disease pathophysiology justified this review. AREAS COVERED:Since the 1970s, home parenteral nutrition has reduced mortality, converting SBS into a c...

journal_title：Expert opinion on pharmacotherapy

authors： Hollanda Martins Da Rocha M,Lee ADW,Marin MLM,Faintuch S,Mishaly A,Faintuch J

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worldwide and has contributed to over 650,000 deaths. This review synthesizes the literature on COVID-19 pharmacotherapy to inform practice and policymaking. A...

journal_title：Expert opinion on pharmacotherapy

authors： Khan S,Gionfriddo MR,Cortes-Penfield N,Thunga G,Rashid M

更新日期：2020-10-01 00:00:00

abstract：:ABSTARCT Introduction: Cardiovascular disease (CVD) continues to be an essential cause of morbidity and mortality among people living with human immunodeficiency virus infection (PLWH). Since the bulk of cardiovascular risk (CVR) factors are shared between PLWH and the general population, prevention and treatment stra...

journal_title：Expert opinion on pharmacotherapy

authors： Corbacho N,Mur I,Molas ME,Vidal F,Domingo P

更新日期：2021-01-04 00:00:00

abstract：INTRODUCTION:In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future. AREAS COVERED:Recent (post 2013) phase III clinical trials of schizophrenia-targeted the...

journal_title：Expert opinion on pharmacotherapy

authors： Garay RP,Citrome L,Samalin L,Liu CC,Thomsen MS,Correll CU,Hameg A,Llorca PM

更新日期：2016-01-01 00:00:00

abstract：:Introduction: Influenza represents a major public health threat worldwide. Implementation of good personal health and hygiene habits, together with vaccination, is the most effective tools to reduce influenza burden both in community and in healthcare setting. However, achieving adequate vaccination rates is challengi...

journal_title：Expert opinion on pharmacotherapy

authors： Bassetti M,Castaldo N,Carnelutti A

更新日期：2019-10-01 00:00:00

abstract：:The adrenal steroidal hormone dehydroepiandrosterone (DHEA) has been studied as a potential pharmacological agent in the treatment of the autoimmune disease systemic lupus erythematosus (SLE). Both the endocrine effects (the ability to be converted peripherally to androgenic and oestrogenic sex steroids) and the immun...

journal_title：Expert opinion on pharmacotherapy

authors： van Vollenhoven RF

更新日期：2002-01-01 00:00:00

abstract：:The development of effective treatments for opioid dependence is of great importance given the devastating consequences of the disease. Pharmacotherapies for opioid addiction include opioid agonists, partial agonists, opioid antagonists, and alpha-2-adrenergic agonists, which are targeted toward either detoxification ...

journal_title：Expert opinion on pharmacotherapy

authors： Stotts AL,Dodrill CL,Kosten TR

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Clostridium difficile has become the most important healthcare-associated infection worldwide within the past decade. This is in part due to the emergence of a highly virulent epidemic strain of C. difficile as well as the relative ineffectiveness of current therapies at producing a sustained response. Fid...

journal_title：Expert opinion on pharmacotherapy

authors： Hostler CJ,Chen LF

更新日期：2013-08-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Intravenous (I.V.) morphine administered through a patient-controlled system currently represents the gold standard treatment for moderate to severe acute postoperative pain. To fix the limitations showed by the available I.V. patient-controlled analgesia (PCA) systems that may restrict its use in the clin...

journal_title：Expert opinion on pharmacotherapy

authors： Fanelli A,Sorella MC,Chelly JE

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Phosphodiesterase type 5 inhibitors (PDE5-i) are used for the oral treatment of erectile dysfunction (ED). Since the launch of sildenafil more than 15 years ago, new molecules have become available. At present, in addition to tadalafil and vardenafil, there are three other drugs, udenafil, avanafil and mir...

journal_title：Expert opinion on pharmacotherapy

authors： Bruzziches R,Francomano D,Gareri P,Lenzi A,Aversa A

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:Following more than 20 years of Interferon (IFN)-based treatment for hepatitis C virus (HCV), the understanding of viral life cycle led to the development of new antiviral drugs directly targeting HCV replication steps. Daclatasvir (DCV) is a potent inhibitor of non-structural NS5A HCV protein with pangeno...

journal_title：Expert opinion on pharmacotherapy

authors： Degasperi E,Aghemo A,Colombo M

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:In the 40-50% of advanced melanoma patients with tumors harboring BRAF V600E and V600 K mutations, BRAF inhibitors such as dabrafenib are a highly effective treatment. However, most patients develop resistance after several months on treatment. The addition of a MEK inhibitor, such as trametinib, to BRAF i...

journal_title：Expert opinion on pharmacotherapy

authors： Spain L,Julve M,Larkin J

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Myoclonic seizures are brief, involuntary muscular jerks arising from the central nervous system that can occur in different epilepsy syndromes, including idiopathic generalized epilepsies or the most severe group of epileptic encephalopathies. Valproate is commonly the first choice alone or in combination...

journal_title：Expert opinion on pharmacotherapy

authors： Striano P,Belcastro V

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In the first decade of the 21st century, worm infections are still very common, especially--but not exclusively--in the developing world. OBJECTIVE:To review the current pharmacotherapy of the major trematode, cestode and nematode infections of humans. METHODS:A systematic search of the Cochrane Databank o...

journal_title：Expert opinion on pharmacotherapy

authors： van den Enden E

更新日期：2009-02-01 00:00:00

abstract：:Interstitial cystitis is a clinical condition occurring predominantly in women characterised by irritative voiding symptoms in the form of urinary frequency, urgency and pain. Patient symptoms have the potential to significantly affect quality of life, posing a challenge to some to perform activities of daily living. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lukban JC

更新日期：2003-11-01 00:00:00